专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20120150092A1 GUIDED PERCUTANEOUS BYPASS 审中-公开
标题翻译：指导的旁观者
公开(公告)号：US20120150092A1
公开(公告)日：2012-06-14
申请号：US13256409
申请日：2010-03-17
申请人： Todd N McAllister , Sergio A Garrido , Nicolas L'Heureux
发明人： Todd N McAllister , Sergio A Garrido , Nicolas L'Heureux
IPC分类号： A61M25/16 , A61M25/09
CPC分类号： A61B17/11 , A61B2017/00252 , A61B2017/00876 , A61B2017/1107 , A61B2017/1132 , A61B2017/1139 , A61F2/07
摘要： The invention includes methods and apparatus to deploy a blood vessel conduit via a catheter-based, percutaneous approach. In particular, a prosthetic blood conduit can be introduced around or through an arterial obstruction without requiring open bypass surgery. The technology includes coupling devices for docking the tips of two catheters, one situated inside a blood vessel, the other situated outside the blood vessel wall.
摘要翻译：本发明包括通过基于导管的经皮方式部署血管导管的方法和装置。特别地，假体血液导管可以引导到动脉阻塞周围或通过动脉阻塞，而不需要开放旁路手术。该技术包括用于对接两个导管的尖端的联接装置，一个位于血管内部，另一个位于血管壁外部。

2. 发明申请

US20100189712A1 Preparation And Use Of Cell-Synthesized Threads 审中-公开
标题翻译：细胞合成线的制备和使用
公开(公告)号：US20100189712A1
公开(公告)日：2010-07-29
申请号：US12515397
申请日：2007-11-19
申请人： Nicolas L'Heureux , Todd N. McAllister
发明人： Nicolas L'Heureux , Todd N. McAllister
IPC分类号： A61K35/12 , A61K39/395 , A61K35/76 , C12N5/071 , C12N5/0735 , C12N5/078 , C12N5/074 , C12M1/24 , C12N5/079 , A61K35/28 , A61K35/30 , A61K35/34 , A61K35/36 , A61P31/00
CPC分类号： A61L27/3895
摘要： The present technology provides for a cell-synthesized biological thread, processes for making a cell-synthesized thread, and an apparatus for carrying out a process used to engineer the cell-synthesized thread. The thread is produced from living cells in culture and can be grown around the outer surface of a cylindrical bioreactor. The tissue comprising the thread has mechanical and biological properties achieved by altering the climactic conditions, stresses and strains on the tissue and chemical composition that prove beneficial in the medical industry. This process results in a biological thread that has high mechanical strength, decreased immunogenic effect and decreased thrombogenic effect when combined with other tissue. It also results in a product which can be used to create more complex constructs that otherwise could not have been generated. The threads can be used to make sutures, patches, and tubes, for example.
摘要翻译：本技术提供细胞合成的生物线，细胞合成线的制造工序，以及用于进行用于工程化细胞合成线的工序的装置。丝线由培养物中的活细胞产生，并且可以在圆柱形生物反应器的外表面周围生长。包含丝线的组织具有通过改变在组织上的高度条件，应力和应变以及证明在医疗行业中有益的化学成分而获得的机械和生物特性。该过程产生具有高机械强度，降低的免疫原性效应和降低血栓形成作用的生物线，当与其他组织组合时。它还产生了一种产品，可用于创建更复杂的结构，否则无法生成。螺纹可用于制作缝线，贴片和管，例如。

3. 发明授权

US07744526B2 Bioreactor for the manufacture of tissue engineered blood vessels 有权
标题翻译：用于制造组织工程化血管的生物反应器
公开(公告)号：US07744526B2
公开(公告)日：2010-06-29
申请号：US11467519
申请日：2006-08-25
申请人： Todd N. McAllister , Nicolas L'Heureux
发明人： Todd N. McAllister , Nicolas L'Heureux
IPC分类号： A61F2/04
CPC分类号： A61L27/3886 , A61F2/06 , A61K35/12 , A61L27/3804 , A61L27/3808 , A61L27/507 , C12M21/08 , C12M23/06 , C12M27/12 , C12N5/0691 , C12N2502/1323 , Y10S623/916
摘要： The invention relates to bioreactors having an enclosed chamber, a sheet growth module, a rollable mandrel, and a clamp for holding the sheet to the mandrel for rolling for the manufacture of a tissue engineered blood vessel (TEBV). The TEBV is made from a cultured fibroblast sheet rolled into a multilayer vessel which has sufficient burst strength to withstand physiological blood pressure without the inclusion of smooth muscle cells or synthetic scaffolding.
摘要翻译：本发明涉及具有封闭室的生物反应器，片材生长模块，可滚动心轴和用于将片材保持在心轴上以用于制造组织工程化血管（TEBV）的夹具的夹具。 TEBV由经过培养的成纤维细胞片制成，该成纤维细胞片卷成多层容器，其具有足够的破裂强度以抵抗生理血压而不包括平滑肌细胞或合成脚手架。

4. 发明授权

US08076137B2 Tissue engineered cellular sheets, and methods of making same 失效
标题翻译：组织工程细胞片材及其制备方法
公开(公告)号：US08076137B2
公开(公告)日：2011-12-13
申请号：US12406007
申请日：2009-03-17
申请人： Todd N. McAllister , Nicolas L'Heureux
发明人： Todd N. McAllister , Nicolas L'Heureux
IPC分类号： C12N5/08
CPC分类号： A61L27/3886 , A61L27/3895 , A61L31/005 , A61L31/16 , C12N5/0062
摘要： The disclosure provides methods and compositions to build living tissue covered stents and the like. These tissue coated stents provide a barrier against cell migration to the lumen of the vessel. Since the tissue can surround and envelope the stent, foreign body responses to the stent material are reduced and delayed. The tissue coating is also relatively impermeable to transmural flow, so the wrapped stent can act as a bypass vessel. The tissue is also robust enough to act as a stand alone vessel, without requiring the presence of the metallic stent. These stents can be endothelialized to reduce thrombosis. The genetic modifications described in this disclosure allow for functional organs to be built that express agents that are anti-restenotic or anti-thrombogenic.
摘要翻译：本公开提供了构建活组织覆盖的支架等的方法和组合物。这些组织涂覆的支架提供了阻止细胞迁移到血管内腔的屏障。由于组织可以围绕和包围支架，异物对支架材料的反应减少和延迟。组织涂层对于透壁流也是相对不可渗透的，因此包裹的支架可以用作旁路容器。组织也足够坚固，用作独立容器，而不需要金属支架的存在。这些支架可以内皮化，以减少血栓形成。在本公开中描述的遗传修饰允许构建表达抗再狭窄或抗血栓形成的功能性器官。

5. 发明授权

US5618718A Production of a contractile smooth muscle 失效
标题翻译：生产收缩平滑肌
公开(公告)号：US5618718A
公开(公告)日：1997-04-08
申请号：US368205
申请日：1994-12-30
申请人： Fran.cedilla.ois A. Auger , Nicolas L'Heureux , Lucie Germain
发明人： Fran.cedilla.ois A. Auger , Nicolas L'Heureux , Lucie Germain
IPC分类号： A61L27/00 , C12N5/071 , C12N5/00 , A61F2/08 , C12N5/08
CPC分类号： C12N5/0691 , C12N2503/00
摘要： A contractile smooth muscle cell construct and a method for preparing the smooth muscle cell construct are described. The smooth muscle cell construct is comprised of (i) smooth muscle cells that have been cultured in vitro under conditions to allow the formation of a sheet of smooth muscle cells and (ii) an endogenous fibrous matrix formed by the smooth muscle cells, wherein the smooth muscle cell construct retains the ability to contract in response to vasoactive agonists. The smooth muscle cell construct may be prepared in planar or tubular form and can be used to study or evaluate the contractile responses of smooth muscle cells.
摘要翻译：描述了收缩性平滑肌细胞构建体和制备平滑肌细胞构建体的方法。平滑肌细胞构建体包括（i）已经在允许形成平滑肌细胞片的条件下体外培养的平滑肌细胞和（ii）由平滑肌细胞形成的内源性纤维基质，其中平滑肌细胞构建物保留响应于血管活性激动剂而收缩的能力。平滑肌细胞构建体可以以平面或管状形式制备，并且可用于研究或评估平滑肌细胞的收缩反应。

6. 发明申请

US20090233356A1 Tissue Engineered Cellular Sheets, Methods of Making and Use Thereof 失效
标题翻译：组织工程细胞片，其制作和使用方法
公开(公告)号：US20090233356A1
公开(公告)日：2009-09-17
申请号：US12406007
申请日：2009-03-17
申请人： Todd N. McAllister , Nicolas L'Heureux
发明人： Todd N. McAllister , Nicolas L'Heureux
IPC分类号： C12N5/06
CPC分类号： A61L27/3886 , A61L27/3895 , A61L31/005 , A61L31/16 , C12N5/0062
摘要： The disclosure provides methods and compositions to build living tissue covered stents and the like. These tissue coated stents provide a barrier against cell migration to the lumen of the vessel. Since the tissue can surround and envelope the stent, foreign body responses to the stent material are reduced and delayed. The tissue coating is also relatively impermeable to transmural flow, so the wrapped stent can act as a bypass vessel. The tissue is also robust enough to act as a stand alone vessel, without requiring the presence of the metallic stent. These stents can be endothelialized to reduce thrombosis. The genetic modifications described in this disclosure allow for functional organs to be built that express agents that are anti-restenotic or anti-thrombogenic.
摘要翻译：本公开提供了构建活组织覆盖的支架等的方法和组合物。这些组织涂覆的支架提供了阻止细胞迁移到血管内腔的屏障。由于组织可以围绕和包围支架，异物对支架材料的反应减少和延迟。组织涂层对于透壁流也是相对不可渗透的，因此包裹的支架可以用作旁路容器。组织也足够坚固，用作独立容器，而不需要金属支架的存在。这些支架可以内皮化，以减少血栓形成。在本公开中描述的遗传修饰允许构建表达抗再狭窄或抗血栓形成的功能性器官。

7. 发明申请

US20070178588A1 Tissue control rods for sheet-based tissue engineering 审中-公开
标题翻译：用于片材组织工程的组织控制棒
公开(公告)号：US20070178588A1
公开(公告)日：2007-08-02
申请号：US11640470
申请日：2006-12-14
申请人： Todd McAllister , Nicolas L'Heureux
发明人： Todd McAllister , Nicolas L'Heureux
IPC分类号： C12N5/00
CPC分类号： A61L27/3886 , A61L27/3895 , A61L31/005 , A61L31/16 , C12N5/0062
摘要： The disclosure provides methods and systems for tissue engineering including an apparatus and methods for the growth, maintenance, and use of robust tissue sheets using tissue manipulation devices. The tissue manipulation devices provide a method of anchoring the tissue sheets to the cell culture substrate to promote prolonged maturation and subsequent increased mechanical strength. The tissue manipulation devices also provide a technique to facilitate removal of the sheet from the culture container and subsequent production steps to assemble more complex three dimensional organs from the robust sheet. The tissue manipulation devices also facilitate automated handling of the sheets in the assembly processes. The disclosure provides methods and composition derived from robust human sheets to build tissue engineered blood vessels, heart valves, stents, and endarterectomy patches and the like. The use of these tissue manipulation devices facilitates the assembly of complex tissue engineered organs using the novel sheet-based tissue engineering approach.
摘要翻译：本公开提供了用于组织工程的方法和系统，包括使用组织操纵装置来生长，维护和使用强健的薄页纸的装置和方法。组织操作装置提供将组织片材固定到细胞培养基底以促进长期成熟和随后增加的机械强度的方法。组织操作装置还提供了便于从培养容器中去除片材的技术，并且随后的生产步骤从坚固的片材组装更复杂的三维器官。组织操作装置还便于在组装过程中纸张的自动处理。本公开提供了从健壮的人体片材衍生的构建组织工程化血管，心脏瓣膜，支架和内膜切除术补片等的方法和组合物。使用这些组织操作装置有助于使用新颖的基于片材的组织工程方法来组装复杂的组织工程化器官。

8. 发明申请

US20140271454A1 CELL-SYNTHESIZED PARTICLES 审中-公开
标题翻译：细胞合成颗粒
公开(公告)号：US20140271454A1
公开(公告)日：2014-09-18
申请号：US14113060
申请日：2012-04-23
申请人： Nicolas L'Heureux , Todd N McAllister
发明人： Nicolas L'Heureux , Todd N McAllister
IPC分类号： A61L27/36 , A61K45/06
CPC分类号： A61L27/3633 , A61K45/06 , A61L27/3691 , C12N5/0062
摘要： The present technology provides for a cell-synthesized biological particle, the processes for making a cell-synthesized particle, and a process for assembling such cell-synthesized particles into tissues and organs. The particles are synthesized in culture in vitro by living cells that produce natural extracellular matrix. Multiple particles can be assembled into tissues that have significant void space. The particles or tissues can act as a substrate for additional cell types. The particles or tissues can be further cultured in vitro to achieve favorable cell or extracellular matrix growth, organization or other desired characteristics. The particles or tissues can be devitalized or decellularized. The particles or tissues can be injected or implanted in a human to repair, enhance, or create a secretory, mechanical, or aesthetic function.
摘要翻译：本技术提供了细胞合成的生物颗粒，制备细胞合成颗粒的方法以及将这种细胞合成的颗粒组装到组织和器官中的方法。这些颗粒在体外通过产生天然细胞外基质的活细胞合成。多个颗粒可以组装成具有显着空隙空间的组织。颗粒或组织可以作为另外的细胞类型的底物。可以在体外进一步培养颗粒或组织以获得有利的细胞或细胞外基质生长，组织或其它所需特征。颗粒或组织可以失活或脱细胞。可以将颗粒或组织注射或植入人体以修复，增强或产生分泌，机械或美学功能。

9. 发明申请

US20100040663A1 Arterial Implants 审中-公开
标题翻译：动脉植入物
公开(公告)号：US20100040663A1
公开(公告)日：2010-02-18
申请号：US12485898
申请日：2009-06-16
申请人： Todd N. McAllister , Sergio A. Garrido , Nicolas L'Heureux
发明人： Todd N. McAllister , Sergio A. Garrido , Nicolas L'Heureux
IPC分类号： A61F2/00 , A61F2/06 , C12N11/02
CPC分类号： A61F2/856 , A61F2/062 , A61F2/07 , A61F2/89 , A61F2002/065 , A61F2002/072 , A61F2002/075 , A61F2220/005 , A61F2220/0066 , A61F2220/0075
摘要： The technology described herein generally relates to the field of tissue engineering and treatment of cardiovascular disease by endovascular repair. The technology more particularly relates to devices and methods to produce a tissue-based implant that can be used for abdominal aorta aneurysm, thoracic aorta aneurysm, or other cardiovascular repair.
摘要翻译：本文描述的技术通常涉及通过血管内修复的组织工程和心血管疾病治疗领域。该技术更特别涉及用于产生可用于腹主动脉瘤，胸主动脉瘤或其他心血管修复的基于组织的植入物的装置和方法。

10. 发明授权

US07504258B2 Tissue engineered cellular sheets, methods of making and use thereof 失效
标题翻译：组织工程细胞片材，其制备和使用方法
公开(公告)号：US07504258B2
公开(公告)日：2009-03-17
申请号：US10318285
申请日：2002-12-11
申请人： Todd N. McAllister , Nicolas L'Heureux
发明人： Todd N. McAllister , Nicolas L'Heureux
IPC分类号： C12N5/08
CPC分类号： A61L27/3886 , A61L27/3895 , A61L31/005 , A61L31/16 , C12N5/0062
摘要： The disclosure provides methods and composition to build living tissue covered stents and the like. These tissue coated stents provide a barrier against cell migration to the lumen of the vessel. Since the tissue can surround and envelope the stent, foreign body responses to the stent material are reduced and delayed. The tissue coating is also relatively impermeable to transmural flow, so the wrapped stent can act as a bypass vessel. The tissue is also robust enough to act as a stand alone vessel, without requiring the presence of the metallic stent. These stents can be endothelialized to reduce thrombosis. The genetic modifications described in this disclosure allow for functional organs to be built that express agents that are anti-restenotic or anti-thrombogenic. The use of tissue manipulation devices further allows for the assembly of complex tissue engineered organs. The tissue manipulation devices provide a method of anchoring the tissue sheets to the cell culture substrate to promote prolonged maturation and subsequent increased mechanical strength. The tissue manipulation devices also provide a technique to facilitate removal of the sheet from the culture container and subsequent production steps to assemble more complex three dimensional organs from the robust sheet. The tissue manipulation devices also facilitate automated handling of the sheets in the assembly processes.
摘要翻译：本公开提供了构建活组织覆盖的支架等的方法和组合。这些组织涂覆的支架提供了阻止细胞迁移到血管内腔的屏障。由于组织可以围绕和包围支架，异物对支架材料的反应减少和延迟。组织涂层对于透壁流也是相对不可渗透的，因此包裹的支架可以用作旁路容器。组织也足够坚固，用作独立容器，而不需要金属支架的存在。这些支架可以内皮化，以减少血栓形成。在本公开中描述的遗传修饰允许构建表达抗再狭窄或抗血栓形成的功能性器官。使用组织操作装置还允许组装复杂的组织工程化器官。组织操作装置提供将组织片材固定到细胞培养基底以促进长期成熟和随后增加的机械强度的方法。组织操作装置还提供了便于从培养容器中去除片材的技术，并且随后的生产步骤从坚固的片材组装更复杂的三维器官。组织操作装置还便于在组装过程中纸张的自动处理。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式