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1. 发明申请

US20090270625A1 FUSED QUINOLINE DERIVATIVE AND USE THEREOF 失效
标题翻译：熔融喹啉衍生物及其用途
公开(公告)号：US20090270625A1
公开(公告)日：2009-10-29
申请号：US12476619
申请日：2009-06-02
申请人： Masahiro Kajino , Nicholas William Hird , Naoki Tarui , Hiroshi Banno , Yasuhiko Kawano , Nobuhiro Inatomi
发明人： Masahiro Kajino , Nicholas William Hird , Naoki Tarui , Hiroshi Banno , Yasuhiko Kawano , Nobuhiro Inatomi
IPC分类号： C07D471/04
CPC分类号： C07D471/04
摘要： The present invention aims at provision of a quinoline derivative having a neurokinin 2 (NK2) receptor antagonistic action and relates to a compound represented by the formula (I) wherein R1 is a hydrogen atom and the like; R2 is a hydrogen atom, a hydrocarbon group optionally having substituent(s) and the like; R3 is unsubstituted (i.e., absence), a hydrogen atom and the like; R4 and R5 are the same or different and each is a hydrogen atom, a hydrocarbon group optionally having substituent(s), and the like; R6 is (cyclic group optionally having substituent(s))-carbonyl, and the like; R7, R8, R9 and R10 are the same or different and each is a hydrogen atom, halogen and the like; or R7 and R8, R8 and R9, and R9 and R10 may form a ring together with the adjacent carbon atoms; n is an integer of 1 to 5; — --- represents unsubstituted (i.e., absence) or a single bond; and represents a single bond or a double bond, or a salt thereof, and the like.
摘要翻译：本发明旨在提供具有神经激肽2（NK2）受体拮抗作用的喹啉衍生物，其涉及式（I）表示的化合物，其中R1为氢原子等; R2是氢原子，任选具有取代基的烃基等; R3是未取代的（即不存在），氢原子等; R 4和R 5相同或不同，各自为氢原子，任选具有取代基的烃基等; R6是（任选具有取代基的环状基团） - 羰基等; R 7，R 8，R 9和R 10相同或不同，各自为氢原子，卤素等; 或R 7和R 8，R 8和R 9，并且R 9和R 10可与相邻碳原子一起形成环; n为1〜5的整数， ---表示未取代（即不存在）或单键; ＆lt; img id =“CUSTOM-CHARACTER-00001”he =“2.79mm”wi =“7.03mm”file =“US20090270625A1-20091029-P00001.TIF”img-content =“character”img-format =“tif”/ >表示单键或双键，或其盐等。

2. 发明申请

US20090258893A1 FUSED QUINOLINE DERIVATIVE AND USE THEREOF 失效
标题翻译：熔融喹啉衍生物及其用途
公开(公告)号：US20090258893A1
公开(公告)日：2009-10-15
申请号：US12476626
申请日：2009-06-02
申请人： Masahiro Kajino , Nicholas William Hird , Naoki Tarui , Hiroshi Banno , Yasuhiko Kawano , Nobuhiro Inatomi
发明人： Masahiro Kajino , Nicholas William Hird , Naoki Tarui , Hiroshi Banno , Yasuhiko Kawano , Nobuhiro Inatomi
IPC分类号： A61K31/437 , C07D471/04 , A61P1/00
CPC分类号： C07D471/04
摘要： The present invention aims at provision of a quinoline derivative having a neurokinin 2 (NK2) receptor antagonistic action and relates to a compound represented by the formula (I) wherein R1 is a hydrogen atom and the like; R2 is a hydrogen atom, a hydrocarbon group optionally having substituent(s) and the like; R3 is unsubstituted (i.e., absence), a hydrogen atom and the like; R4 and R5 are the same or different and each is a hydrogen atom, a hydrocarbon group optionally having substituent(s), and the like; R6 is (cyclic group optionally having substituent(s))-carbonyl, and the like; R7, R8, R9 and R10 are the same or different and each is a hydrogen atom, halogen and the like; or R7 and R8, R8 and R9, and R9 and R10 may form a ring together with the adjacent carbon atoms; n is an integer of 1 to 5; represents unsubstituted (i.e., absence) or a single bond; and represents a single bond or a double bond, or a salt thereof, and the like.
摘要翻译：本发明旨在提供具有神经激肽2（NK2）受体拮抗作用的喹啉衍生物，其涉及式（I）表示的化合物，其中R1为氢原子等; R2是氢原子，任选具有取代基的烃基等; R3是未取代的（即不存在），氢原子等; R 4和R 5相同或不同，各自为氢原子，任选具有取代基的烃基等; R6是（任选具有取代基的环状基团） - 羰基等; R 7，R 8，R 9和R 10相同或不同，各自为氢原子，卤素等; 或R 7和R 8，R 8和R 9，并且R 9和R 10可与相邻碳原子一起形成环; n为1〜5的整数， “img id =”CUSTOM-CHARACTER-00001“he =”0.68mm“wi =”3.13mm“file =”US20090258893A1-20091015-P00001.TIF“img-content =”character“img-format =”tif“/> 表示未取代的（即不存在）或单键; ＆lt; img id =“CUSTOM-CHARACTER-00002”he =“1.02mm”wi =“3.13mm”file =“US20090258893A1-20091015-P00002.TIF”img-content =“character”img-format =“tif”/ >表示单键或双键，或其盐等。

3. 发明申请

US20090275568A1 FUSED QUINOLINE DERIVATIVE AND USE THEREOF 审中-公开
标题翻译：熔融喹啉衍生物及其用途
公开(公告)号：US20090275568A1
公开(公告)日：2009-11-05
申请号：US12498629
申请日：2009-07-07
申请人： Masahiro Kajino , Nicholas William Hird , Naoki Tarui , Hiroshi Banno , Yasuhiko Kawano , Nobuhiro Inatomi
发明人： Masahiro Kajino , Nicholas William Hird , Naoki Tarui , Hiroshi Banno , Yasuhiko Kawano , Nobuhiro Inatomi
IPC分类号： A61K31/437 , C07D471/04 , C07D413/14 , C07D417/14 , A61K31/5377 , A61K31/538 , A61K31/541 , A61P1/00 , A61P25/24
CPC分类号： C07D471/04
摘要： The present invention aims at provision of a quinoline derivative having a neurokinin 2 (NK2) receptor antagonistic action and relates to a compound represented by the formula (I) wherein R1 is a hydrogen atom and the like; R2 is a hydrogen atom, a hydrocarbon group optionally having substituent(s) and the like; R3 is unsubstituted (i.e., absence), a hydrogen atom and the like; R4 and R5 are the same or different and each is a hydrogen atom, a hydrocarbon group optionally having substituent(s), and the like; R6 is (cyclic group optionally having substituent(s))-carbonyl, and the like; R7, R8, R9 and R10 are the same or different and each is a hydrogen atom, halogen and the like; or R7 and R8, R8 and R9, and R9 and R10 may form a ring together with the adjacent carbon atoms; n is an integer of 1 to 5; represents unsubstituted (i.e., absence) or a single bond; and represents a single bond or a double bond, or a salt thereof, and the like.
摘要翻译：本发明旨在提供具有神经激肽2（NK2）受体拮抗作用的喹啉衍生物，其涉及式（I）表示的化合物，其中R1为氢原子等; R2是氢原子，任选具有取代基的烃基等; R3是未取代的（即不存在），氢原子等; R 4和R 5相同或不同，各自为氢原子，任选具有取代基的烃基等; R6是（任选具有取代基的环状基团） - 羰基等; R 7，R 8，R 9和R 10相同或不同，各自为氢原子，卤素等; 或R 7和R 8，R 8和R 9，并且R 9和R 10可与相邻碳原子一起形成环; n为1〜5的整数，表示未取代的（即不存在）或单键; ＆lt; img id =“CUSTOM-CHARACTER-00002”he =“2.46mm”wi =“4.23mm”file =“US20090275568A1-20091105-P00002.TIF”img-content =“character”img-format =“tif”/ >表示单键或双键，或其盐等。

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