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1. 发明申请

US20150164814A1 APPARATUS AND PROCESS FOR ENCAPSULATING CAPSULES OR OTHER SOLID DOSAGE FORMS WITHIN CAPSULES 审中-公开
标题翻译：封装胶囊或其他固体剂型在胶囊中的装置和方法
公开(公告)号：US20150164814A1
公开(公告)日：2015-06-18
申请号：US14636013
申请日：2015-03-02
申请人： Carlos Salazar Altamar , Gustavo Anaya , Braulio Teran , Newman Aguas Navarro , Wilmer Herrera
发明人： Carlos Salazar Altamar , Gustavo Anaya , Braulio Teran , Newman Aguas Navarro , Wilmer Herrera
IPC分类号： A61K9/48 , B65D83/04 , A61J7/00 , A61K31/60 , A61K45/06
CPC分类号： A61K9/4808 , A61J3/07 , A61J7/0076 , A61K9/4833 , A61K31/60 , A61K45/06 , B65D83/04
摘要： The present invention provides an apparatus and process for making softgel capsules having incorporated therein other solid dosage forms selected from the group consisting of pellets, smaller capsules, smaller tablets, sustained release solid dosage forms, immediate release solid dosage forms, extended release solid dosage forms and zero order release solid dosage forms, said apparatus comprising: (a) two spreader boxes; (b) two casting drums; (c) a pair of rotary dies having means for suction; (d) a liquid fill system; (e) a wedge for heating gelatine ribbons and feeding said fill; and (f) two lateral dispensing devices said lateral dispensing devices including hoppers having said solid dosage forms, channelguides for transporting said solid dosage forms and a grasping claw for dispensing said solid dosage form into the softgel pocket formed in the rotary dies.
摘要翻译：本发明提供了一种用于制备其中掺入其中的其它固体剂型的软胶囊的装置和方法，其中选自丸粒，较小胶囊，较小片剂，缓释固体剂型，立即释放固体剂型，延长释放固体剂型和零级释放固体剂型，所述装置包括：（a）两个扩张器盒; （b）两个铸桶; （c）一对旋转模具，具有用于抽吸的装置; （d）液体填充系统; （e）用于加热明胶带并进料所述填充物的楔子; 和（f）两个侧向分配装置，所述侧向分配装置包括具有所述固体剂型的料斗，用于输送所述固体剂型的通道导向件和用于将所述固体剂型分配到形成在所述旋转模具中的软胶囊中的抓取爪。

2. 发明申请

US20120052118A1 Apparatus and process for encapsulating capsules or other solid dosage forms within capsules 审中-公开
标题翻译：将胶囊或其他固体剂型包封在胶囊内的装置和方法
公开(公告)号：US20120052118A1
公开(公告)日：2012-03-01
申请号：US13137045
申请日：2011-07-18
申请人： Carlos Salazar Altamar , Gustavo Anaya , Braulio Teran , Newman Aguas Navarro , Willmer Herrera
发明人： Carlos Salazar Altamar , Gustavo Anaya , Braulio Teran , Newman Aguas Navarro , Willmer Herrera
IPC分类号： A61K9/48 , A61K31/225 , A61K31/40 , A61K31/505 , A61K31/44 , A61K31/421 , A61K31/4035 , A61K31/403 , A61K31/4545 , A61K31/4965 , A61K31/445 , A61K31/4402 , A61K31/192 , A61K31/436 , A61K31/4184 , A61K31/381 , A61K31/196 , A61K31/4015 , A61K31/343 , A61K31/426 , A61K31/5415 , A61P29/00 , B65D83/00 , B29C39/12 , A61K31/351
CPC分类号： A61K9/4808 , A61J3/07 , A61J7/0076 , A61K9/4833 , A61K31/60 , A61K45/06 , B65D83/04
摘要： The present invention provides an apparatus and process for making softgel capsules having incorporated therein other solid dosage forms selected from the group consisting of pellets, smaller capsules, smaller tablets, sustained release solid dosage forms, immediate release solid dosage forms, extended release solid dosage forms and zero order release solid dosage forms, said apparatus comprising: (a) two spreader boxes; (b) two casting drums; (c) a pair of rotary dies having means for suction; (d) a liquid fill system; (e) a wedge for heating gelatine ribbons and feeding said fill; and (f) two lateral dispensing devices said lateral dispensing devices including hoppers having said solid dosage forms, channelguides for transporting said solid dosage forms and a grasping claw for dispensing said solid dosage form into the softgel pocket formed in the rotary dies.
摘要翻译：本发明提供了一种用于制备其中掺入其中的其它固体剂型的软胶囊的装置和方法，其中选自丸粒，较小胶囊，较小片剂，缓释固体剂型，立即释放固体剂型，延长释放固体剂型和零级释放固体剂型，所述装置包括：（a）两个扩张器盒; （b）两个铸桶; （c）一对旋转模具，具有用于抽吸的装置; （d）液体填充系统; （e）用于加热明胶带并进料所述填充物的楔子; 和（f）两个侧向分配装置，所述侧向分配装置包括具有所述固体剂型的料斗，用于输送所述固体剂型的通道导向件和用于将所述固体剂型分配到形成在所述旋转模具中的软胶囊中的抓取爪。

3. 发明申请

US20170095425A1 APPARATUS AND PROCESS FOR ENCAPSULATING CAPSULES OR OTHER SOLID DOSAGE FORMS WITHIN CAPSULES 审中-公开
公开(公告)号：US20170095425A1
公开(公告)日：2017-04-06
申请号：US15256709
申请日：2016-09-05
申请人： Carlos Salazar Altamar , Gustavo Anaya , Braulio Teran , Newman Aguas Navarro , Wilmer Herrera
发明人： Carlos Salazar Altamar , Gustavo Anaya , Braulio Teran , Newman Aguas Navarro , Wilmer Herrera
IPC分类号： A61K9/48 , A61J7/00 , A61J3/07 , A61K31/60 , A61K45/06
CPC分类号： A61K9/4808 , A61J3/07 , A61J7/0076 , A61K9/4833 , A61K31/60 , A61K45/06 , B65D83/04
摘要： The present invention provides an apparatus and process for making softgel capsules having incorporated therein other solid dosage forms selected from the group consisting of pellets, smaller capsules, smaller tablets, sustained release solid dosage forms, immediate release solid dosage forms, extended release solid dosage forms and zero order release solid dosage forms, said apparatus comprising: (a) two spreader boxes; (b) two casting drums; (c) a pair of rotary dies having means for suction; (d) a liquid fill system; (e) a wedge for heating gelatine ribbons and feeding said fill; and (f) two lateral dispensing devices said lateral dispensing devices including hoppers having said solid dosage forms, channel guides for transporting said solid dosage forms and a grasping claw for dispensing said solid dosage form into the softgel pocket formed in the rotary dies.

4. 发明授权

US08974820B2 Apparatus and process for encapsulating microparticles with liquid in soft gel capsules 有权
标题翻译：在软胶囊中用液体包裹微粒的装置和方法
公开(公告)号：US08974820B2
公开(公告)日：2015-03-10
申请号：US13137051
申请日：2011-07-18
申请人： Carlos Salazar Altamar , Gustavo Anaya , Braulio Teran , Newman Aguas Navarro , Willmer Herrera
发明人： Carlos Salazar Altamar , Gustavo Anaya , Braulio Teran , Newman Aguas Navarro , Willmer Herrera
IPC分类号： A61K9/64 , A61K9/48 , A61K9/52 , A61K9/54 , A61K9/56 , A61K9/58 , A61K9/60 , A61K9/62 , A61J3/07
CPC分类号： A61J3/07 , A61K9/16 , A61K9/4808 , A61K9/4833 , A61K9/4883 , A61K9/51
摘要： The invention provides an apparatus for producing soft gel capsules having encapsulated therein microparticles, nanoparticles and fluids, said apparatus comprising: (a) two spreader boxes; (b) two casting drums; (c) a pair of rotary dies; (d) a liquid fill system (medicine pump system); (e) a wedge for heating gelatine ribbons and feeding said fill; and (f) one or more microgranule or nanogranule feeders located on each side of the rotary dies, said feeders being synchronized to rotate at the same tangential speed as the rotary dies.
摘要翻译：本发明提供了一种用于生产软胶囊的装置，其中封装有微粒，纳米颗粒和流体，所述装置包括：（a）两个撒布盒; （b）两个铸桶; （c）一对旋转模具; （d）液体填充系统（药物泵系统）; （e）用于加热明胶带并进料所述填充物的楔子; 和（f）位于旋转模具的每一侧上的一个或多个微粒或纳米颗粒进料器，所述进料器同步以与旋转模具相同的切向速度旋转。

5. 发明授权

US08967989B2 Apparatus and process for encapsulating capsules or other solid dosage forms within capsules 有权
标题翻译：将胶囊或其他固体剂型包封在胶囊内的装置和方法
公开(公告)号：US08967989B2
公开(公告)日：2015-03-03
申请号：US13137045
申请日：2011-07-18
申请人： Carlos Salazar Altamar , Gustavo Anaya , Braulio Teran , Newman Aguas Navarro , Willmer Herrera
发明人： Carlos Salazar Altamar , Gustavo Anaya , Braulio Teran , Newman Aguas Navarro , Willmer Herrera
IPC分类号： A61K9/48 , A61J3/07
CPC分类号： A61K9/4808 , A61J3/07 , A61J7/0076 , A61K9/4833 , A61K31/60 , A61K45/06 , B65D83/04
摘要： The present invention provides an apparatus and process for making softgel capsules having incorporated therein other solid dosage forms selected from the group consisting of pellets, smaller capsules, smaller tablets, sustained release solid dosage forms, immediate release solid dosage forms, extended release solid dosage forms and zero order release solid dosage forms, said apparatus comprising: (a) two spreader boxes; (b) two casting drums; (c) a pair of rotary dies having means for suction; (d) a liquid fill system; (e) a wedge for heating gelatine ribbons and feeding said fill; and (f) two lateral dispensing devices said lateral dispensing devices including hoppers having said solid dosage forms, channelguides for transporting said solid dosage forms and a grasping claw for dispensing said solid dosage form into the softgel pocket formed in the rotary dies.
摘要翻译：本发明提供了一种用于制备其中掺入其中的其它固体剂型的软胶囊的装置和方法，其中选自丸粒，较小胶囊，较小片剂，缓释固体剂型，立即释放固体剂型，延长释放固体剂型和零级释放固体剂型，所述装置包括：（a）两个扩张器盒; （b）两个铸桶; （c）一对旋转模具，具有用于抽吸的装置; （d）液体填充系统; （e）用于加热明胶带并进料所述填充物的楔子; 和（f）两个侧向分配装置，所述侧向分配装置包括具有所述固体剂型的料斗，用于输送所述固体剂型的通道导向件和用于将所述固体剂型分配到形成在所述旋转模具中的软胶囊中的抓取爪。

6. 发明申请

US20120058179A1 Apparatus and process for encapsulating microparticles with liquid in soft gel capsules 审中-公开
标题翻译：在软胶囊中用液体包裹微粒的装置和方法
公开(公告)号：US20120058179A1
公开(公告)日：2012-03-08
申请号：US13137051
申请日：2011-07-18
申请人： Carlos Salazar Altamar , Gustavo Anaya , Braulio Teran , Newman Aguas Navarro , Willmer Herrera
发明人： Carlos Salazar Altamar , Gustavo Anaya , Braulio Teran , Newman Aguas Navarro , Willmer Herrera
IPC分类号： A61K9/48 , A61J3/07
CPC分类号： A61J3/07 , A61K9/16 , A61K9/4808 , A61K9/4833 , A61K9/4883 , A61K9/51
摘要： The invention provides an apparatus for producing soft gel capsules having encapsulated therein microparticles, nanoparticles and fluids, said apparatus comprising: (a) two spreader boxes; (b) two casting drums; (c) a pair of rotary dies; (d) a liquid fill system (medicine pump system); (e) a wedge for heating gelatine ribbons and feeding said fill; and (f) one or more microgranule or nanogranule feeders located on each side of the rotary dies, said feeders being synchronized to rotate at the same tangential speed as the rotary dies.
摘要翻译：本发明提供了一种用于生产软胶囊的装置，其中封装有微粒，纳米颗粒和流体，所述装置包括：（a）两个撒布盒; （b）两个铸桶; （c）一对旋转模具; （d）液体填充系统（药物泵系统）; （e）用于加热明胶带并进料所述填充物的楔子; 和（f）位于旋转模具的每一侧上的一个或多个微粒或纳米颗粒进料器，所述进料器同步以与旋转模具相同的切向速度旋转。

7. 发明申请

US20140352878A1 APPARATUS AND METHOD FOR CONTINUOUS COATING OF SOLID DOSAGE FORMS AND SOLID OBJECTS 审中-公开
标题翻译：固体剂型和固体物品的连续涂布的装置和方法
公开(公告)号：US20140352878A1
公开(公告)日：2014-12-04
申请号：US13903965
申请日：2013-05-28
申请人： Newman Aguas Navarro , Carlos Salazar Altamar
发明人： Daniel Contreras Julio , Newman Aguas Navarro , Carlos Salazar Altamar
IPC分类号： A61J3/00
CPC分类号： A61J3/005 , B30B11/16 , B30B11/34 , B30B15/308 , Y10T156/103
摘要： The invention provides a new method and apparatus for continuously coating solid dosage forms such as caplets by aligning and dispensing multiple solid dosage forms between two sheets of coating material as they enter cavities of a mold. The coating sheets must be flexible and ductile to practice the invention and must adhere to each other and to the solid dosage form, either because of their self-adhering nature or because of an additional adhering agent present in or on the coating sheet. The present invention also relates to a method and apparatus for orienting and molding an array of small solid products between two sheets, for example, in packaging. The present invention also related to a method for using material fabricated into a flexible, ductile sheet to coat solid objects in a mold. The apparatus of this invention can be linked to an overall system for continuously making coated solid dosage forms or other coated or packaged items.
摘要翻译：本发明提供了一种新的方法和装置，用于在两片涂层材料进入模具的空腔之间，通过对准和分配两片涂料之间的多个固体剂型，连续地涂覆固体剂型例如囊片。涂层片材必须具有柔韧性和延展性，以实践本发明，并且必须彼此粘附到固体剂型，或者由于其自身粘附性质或由于存在于涂层片材中或附着的附加粘合剂。本发明还涉及一种用于在例如包装之间的两片之间定向和模制小固体产品阵列的方法和装置。本发明还涉及一种使用制成柔性的延展性片材的材料来涂覆模具中的固体物体的方法。本发明的装置可以连接到用于连续制造涂覆的固体剂型或其它涂覆或包装物品的整个系统。

8. 发明申请

US20120049410A1 Apparatus and process for making soft gel capsules 审中-公开
标题翻译：制造软凝胶胶囊的装置和方法
公开(公告)号：US20120049410A1
公开(公告)日：2012-03-01
申请号：US13137046
申请日：2011-07-18
申请人： Carlos Salazar Altamar , Orlando Torres , Braulio Teran , Gustavo Anaya , Newman Aguas Navarro , Willmer Herrera
发明人： Carlos Salazar Altamar , Orlando Torres , Braulio Teran , Gustavo Anaya , Newman Aguas Navarro , Willmer Herrera
IPC分类号： B28B3/12 , B29C53/00
CPC分类号： A61J3/07 , A61K9/4833 , A61K9/4866
摘要： An apparatus for making softgel capsules comprising: two extrusion nozzles; two cooling and tension rollers; two rotary dies; a wedge; and a filling station. A method is also provided for for producing softgel capsules, comprising the steps of: (a) softening or melting a suitable film forming composition; (b) extruding said suitable film forming composition through two extrusion dies directly into two tension rollers; (c) passing the extruded films over rotating dies; (d) simultaneously forming, filling, heat-sealing and cutting capsules; and (e) washing and drying said capsules.
摘要翻译：一种用于制备软胶囊的装置，包括：两个挤出喷嘴; 两个冷却和张紧辊; 两个旋转模具; 一个楔子和一个加油站。还提供了一种用于生产软胶囊的方法，包括以下步骤：（a）软化或熔化合适的成膜组合物; （b）将所述合适的成膜组合物通过两个挤出模直接挤出到两个张力辊中; （c）将挤出的膜通过旋转模具; （d）同时成型，灌装，热封和切割胶囊; 和（e）洗涤和干燥所述胶囊。

9. 发明申请

US20220023225A1 SOFT SHELL GELATIN CAPSULES INCORPORATING IMMEDIATE AND EXTENDED RELEASE DOSAGE FORMS AND METHODS OF MANUFACTURING 有权
公开(公告)号：US20220023225A1
公开(公告)日：2022-01-27
申请号：US17483365
申请日：2021-09-23
申请人： Carlos Salazar Altamar , Gustavo Anaya , Braulio Teran , Newman Aguas Navarro , Wilmer Herrera , Pompilio Rafael Celedon Arrieta , Claudia Andrea Silva Blanco , Diego Rafael Monterroza Hernández , Rahumir Alfredo Gutierrez Castro
发明人： Carlos Salazar Altamar , Gustavo Anaya , Braulio Teran , Newman Aguas Navarro , Wilmer Herrera , Pompilio Rafael Celedon Arrieta , Claudia Andrea Silva Blanco , Diego Rafael Monterroza Hernández , Rahumir Alfredo Gutierrez Castro
IPC分类号： A61K9/48 , A61K31/192 , A61K31/196 , A61K31/415
摘要： A softgel capsule having incorporated within said capsule: (i) an active pharmaceutical ingredient in a liquid carrier exhibiting release profiles selected from the group consisting of immediate release, extended release and combinations thereof; and (ii) one or more smaller capsules or smaller solid dosage forms wherein said smaller capsules or smaller solid dosage forms have active ingredients that are compatible or not compatible with each other or with another active within the softgel capsule and wherein said smaller capsules or smaller solid dosage forms exhibit release profiles selected from the group consisting of extended release, and immediate release and combinations thereof.

10. 发明授权

US10383826B2 Apparatus and process for encapsulating capsules or other solid dosage forms within capsules 有权
公开(公告)号：US10383826B2
公开(公告)日：2019-08-20
申请号：US15256709
申请日：2016-09-05
申请人： Carlos Salazar Altamar , Gustavo Anaya , Braulio Teran , Newman Aguas Navarro , Wilmer Herrera
发明人： Carlos Salazar Altamar , Gustavo Anaya , Braulio Teran , Newman Aguas Navarro , Wilmer Herrera
IPC分类号： A61J3/07 , A61K9/48 , A61J7/00 , A61K31/60 , A61K45/06 , B65D83/04
摘要： The present invention provides an apparatus and process for making softgel capsules having incorporated therein other solid dosage forms selected from the group consisting of pellets, smaller capsules, smaller tablets, sustained release solid dosage forms, immediate release solid dosage forms, extended release solid dosage forms and zero order release solid dosage forms, said apparatus comprising: (a) two spreader boxes; (b) two casting drums; (c) a pair of rotary dies having means for suction; (d) a liquid fill system; (e) a wedge for heating gelatine ribbons and feeding said fill; and (f) two lateral dispensing devices said lateral dispensing devices including hoppers having said solid dosage forms, channel guides for transporting said solid dosage forms and a grasping claw for dispensing said solid dosage form into the softgel pocket formed in the rotary dies.

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