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1. 发明授权

US06947619B2 Polarization independent waveguide optical isolator and circulator 有权
公开(公告)号：US06947619B2
公开(公告)日：2005-09-20
申请号：US11031932
申请日：2005-01-07
申请人： Junichiro Fujita , Reinald Gerhardt , Neil Lagali , Louay Eldada
发明人： Junichiro Fujita , Reinald Gerhardt , Neil Lagali , Louay Eldada
IPC分类号： G02F1/095 , G02F1/313 , G02B6/00 , F01B9/02 , G02B6/26 , G02B6/42
CPC分类号： G02F1/0955 , G02F1/3136 , G02F2001/212
摘要： Polarization independent optical isolator/circulator devices based on Mach-Zehnder interferometers. The devices utilize either polarization splitting and nonreciprocal polarization conversion or nonreciprocal phase shift within the interferometric arm. For devices with nonreciprocal phase shift, the relative phase difference is 0° in the forward propagation direction and 180° in the backward propagation direction, or vice versa, so that light goes into a bar or cross port depending on the propagation direction. The devices have advantages over previous designs in the use of inexpensive device components, simple alignment, minimal space requirement, and negligible polarization mode dispersion or polarization dependent loss. In addition, the devices can be made in a waveguide form with minimal loss and with high fabrication ease. An additional phase compensator and/or a variable attenuator can be integrated in order to relax the fabrication tolerances.

2. 发明申请

US20050134960A1 Polarization independent waveguide optical isolator and circulator 有权
标题翻译：偏振独立波导光隔离器和循环器
公开(公告)号：US20050134960A1
公开(公告)日：2005-06-23
申请号：US11031932
申请日：2005-01-07
申请人： Junichiro Fujita , Reinald Gerhardt , Neil Lagali , Louay Eldada
发明人： Junichiro Fujita , Reinald Gerhardt , Neil Lagali , Louay Eldada
IPC分类号： G02F1/095 , G02F1/313 , G02B5/30 , G02B27/28
CPC分类号： G02F1/0955 , G02F1/3136 , G02F2001/212
摘要： Polarization independent optical isolator/circulator devices based on Mach-Zehnder interferometers. The devices utilize either polarization splitting and nonreciprocal polarization conversion or nonreciprocal phase shift within the interferometric arm. For devices with nonreciprocal phase shift, the relative phase difference is 0° in the forward propagation direction and 180° in the backward propagation direction, or vice versa, so that light goes into a bar or cross port depending on the propagation direction. The devices have advantages over previous designs in the use of inexpensive device components, simple alignment, minimal space requirement, and negligible polarization mode dispersion or polarization dependent loss. In addition, the devices can be made in a waveguide form with minimal loss and with high fabrication ease. An additional phase compensator and/or a variable attenuator can be integrated in order to relax the fabrication tolerances.
摘要翻译：基于马赫 - 曾德尔干涉仪的偏振独立光隔离器/循环器。该器件利用干涉测量臂内的偏振分离和非互相偏振转换或非相互相移。对于具有不可逆相移的器件，正向传播方向的相对相位差为0°，反向传播方向的相对相位差为180°，反之亦然，因此根据传播方向，光线进入条形或交叉端口。这些器件在使用便宜的器件组件，简单校准，最小空间要求以及可忽略的偏振模色散或极化相关损耗方面具有优于先前设计的优点。此外，器件可以以最小的损耗和高的制造容易度以波导形式制造。可以集成附加的相位补偿器和/或可变衰减器以便放宽制造公差。

3. 发明授权

US08125623B2 Correlation technique for analysis of clinical condition 有权
标题翻译：临床情况分析的相关技术
公开(公告)号：US08125623B2
公开(公告)日：2012-02-28
申请号：US12383930
申请日：2009-03-30
申请人： Rejean Munger , Neil Lagali
发明人： Rejean Munger , Neil Lagali
IPC分类号： G01N33/48
CPC分类号： A61B5/14551 , A61B5/0059 , A61B5/0075 , A61B5/72 , G01N21/31 , G01N21/64 , G01N21/65
摘要： The present invention provides a correlation technique for analysis of changes in bodily fluid and/or tissue in order to identify or monitor appearance, progression or treatment of a disease or condition in a subject. The disclosed method involves measuring spectral properties or changes in bodily fluid and/or tissue of a subject using at least two optical techniques; and correlating the measured properties or changes to a corresponding clinical condition or change in clinical condition, respectively. The measure of spectral changes over time can be used as indicators of changes in the clinical condition, for example, in disease treatment and/or disease regulation. This method is particularly useful for identifying a disease state and for monitoring efficacies of therapies used to treat different diseases or disorders, for example, renal dialysis.
摘要翻译：本发明提供了用于分析体液和/或组织中的变化的相关技术，以便识别或监测受试者中疾病或病症的外观，进展或治疗。所公开的方法包括使用至少两种光学技术测量受试者的体液和/或组织的光谱性质或变化; 并将测量的性质或变化分别与相应的临床状况或临床状况的变化相关联。随着时间的推移，光谱变化的测量可用作临床病症变化的指标，例如疾病治疗和/或疾病调控。该方法对于鉴定疾病状态和监测用于治疗不同疾病或病症（例如肾透析）的疗法的功效特别有用。

4. 发明申请

US20120008130A9 CORRELATION TECHNIQUE FOR ANALYSIS OF CLINICAL CONDITION 有权
标题翻译：临床条件分析的相关技术
公开(公告)号：US20120008130A9
公开(公告)日：2012-01-12
申请号：US12383930
申请日：2009-03-30
申请人： Rejean Munger , Neil Lagali
发明人： Rejean Munger , Neil Lagali
IPC分类号： G01N33/48 , G01N21/00
CPC分类号： A61B5/14551 , A61B5/0059 , A61B5/0075 , A61B5/72 , G01N21/31 , G01N21/64 , G01N21/65
摘要： The present invention provides a correlation technique for analysis of changes in bodily fluid and/or tissue in order to identify or monitor appearance, progression or treatment of a disease or condition in a subject. The disclosed method involves measuring spectral properties or changes in bodily fluid and/or tissue of a subject using at least two optical techniques; and correlating the measured properties or changes to a corresponding clinical condition or change in clinical condition, respectively. The measure of spectral changes over time can be used as indicators of changes in the clinical condition, for example, in disease treatment and/or disease regulation. This method is particularly useful for identifying a disease state and for monitoring efficacies of therapies used to treat different diseases or disorders, for example, renal dialysis.
摘要翻译：本发明提供了用于分析体液和/或组织中的变化的相关技术，以便识别或监测受试者中疾病或病症的外观，进展或治疗。所公开的方法包括使用至少两种光学技术测量受试者的体液和/或组织的光谱性质或变化; 并将测量的性质或变化分别与相应的临床状况或临床状况的变化相关联。随着时间的推移，光谱变化的测量可用作临床病症变化的指标，例如疾病治疗和/或疾病调控。该方法对于鉴定疾病状态和监测用于治疗不同疾病或病症（例如肾透析）的疗法的功效特别有用。

5. 发明申请

US20100014077A1 METHOD FOR USING A PHOTONIC CRYSTAL FIBER AS A RAMAN BIOSENSOR 失效
标题翻译：使用光电晶体纤维作为拉曼生物传感器的方法
公开(公告)号：US20100014077A1
公开(公告)日：2010-01-21
申请号：US12174313
申请日：2008-07-16
申请人： Altaf Khetani , Majid Naji , Neil Lagali , Hanan Anis , Rejean Munger
发明人： Altaf Khetani , Majid Naji , Neil Lagali , Hanan Anis , Rejean Munger
IPC分类号： G01J3/44
CPC分类号： G01J3/44 , G01J3/02 , G01J3/0205 , G01J3/0218 , G01N21/0303 , G01N21/65 , G01N21/658 , G01N21/7703
摘要： A method is provided for biosensing using a photonic crystal fiber having a hollow core. The method includes: designating an analyte of interest; determining a wavelength for an excitation light source which generates a Raman spectrum when incident upon the analyte of interest; selecting a photonic crystal fiber that would guide the light when the fiber is non-selectively filled with a solvent hosting the analyte of interest; non-selectively filling a photonic crystal fiber with the solvent hosting the analyte of interest; interrogating the analyte of interest by coupling light from the light source to the photonic crystal fiber; and analyzing the light output from the photonic crystal fiber for Raman fingerprints.
摘要翻译：提供一种使用具有中空芯的光子晶体纤维进行生物传感的方法。该方法包括：指定感兴趣的分析物; 确定激发光源的波长，其在入射到感兴趣的分析物时产生拉曼光谱; 选择光纤晶体光纤，当光纤被非选择性地填充托管目标分析物的溶剂时，该光子晶体光纤将引导光; 用选择感兴趣的分析物的溶剂非选择性填充光子晶体纤维; 通过将来自光源的光耦合到光子晶体光纤来询问感兴趣的分析物; 并分析拉曼指纹光子晶体光纤的光输出。

6. 发明申请

US20100245764A1 APPARATUS AND METHOD FOR OPTICAL MEASUREMENTS 有权
标题翻译：用于光学测量的装置和方法
公开(公告)号：US20100245764A1
公开(公告)日：2010-09-30
申请号：US12414437
申请日：2009-03-30
申请人： Rejean Munger , Neil Lagali
发明人： Rejean Munger , Neil Lagali
IPC分类号： A61B3/14 , A61B3/10
CPC分类号： A61B5/0066 , A61B3/10 , A61B5/14555 , A61B5/14558
摘要： Disclosed are an apparatus and method for separately detecting and measuring specularly reflected light and diffusely reflected light following illumination of an eye by light. The apparatus and method of the present invention facilitates substantial separation of the diffusely reflected light from light specularly reflected from the eye after passing through one or more elements of the eye, for example, the cornea, lens, retinal vasculature, the nerve fibre layer and/or the photoreceptors. The collection of these separate streams of independent optical signals to appropriate detection systems provides specificity and accuracy in determination of optical properties of one or more elements of the eye.
摘要翻译：公开了一种用于分别检测和测量由光照射眼睛后的镜面反射光和漫反射光的装置和方法。本发明的装置和方法有助于在通过眼睛的一个或多个元件，例如角膜，晶状体，视网膜脉管系统，神经纤维层和 /或光感受器。将这些独立的光信号流集合到适当的检测系统中，在确定眼睛的一个或多个元件的光学性质方面提供了特异性和准确性。

7. 发明授权

US07738097B2 Method for using a photonic crystal fiber as a Raman biosensor 失效
标题翻译：使用光子晶体光纤作为拉曼生物传感器的方法
公开(公告)号：US07738097B2
公开(公告)日：2010-06-15
申请号：US12174313
申请日：2008-07-16
申请人： Altaf Khetani , Majid Naji , Neil Lagali , Hanan Anis , Rejean Munger
发明人： Altaf Khetani , Majid Naji , Neil Lagali , Hanan Anis , Rejean Munger
IPC分类号： G01J3/44 , G01N21/65 , G02B6/32
CPC分类号： G01J3/44 , G01J3/02 , G01J3/0205 , G01J3/0218 , G01N21/0303 , G01N21/65 , G01N21/658 , G01N21/7703
摘要： A method is provided for biosensing using a photonic crystal fiber having a hollow core. The method includes: designating an analyte of interest; determining a wavelength for an excitation light source which generates a Raman spectrum when incident upon the analyte of interest; selecting a photonic crystal fiber that would guide the light when the fiber is non-selectively filled with a solvent hosting the analyte of interest; non-selectively filling a photonic crystal fiber with the solvent hosting the analyte of interest; interrogating the analyte of interest by coupling light from the light source to the photonic crystal fiber; and analyzing the light output from the photonic crystal fiber for Raman fingerprints.
摘要翻译：提供一种使用具有中空芯的光子晶体纤维进行生物传感的方法。该方法包括：指定感兴趣的分析物; 确定激发光源的波长，其在入射到感兴趣的分析物时产生拉曼光谱; 选择光纤晶体光纤，当光纤被非选择性地填充托管目标分析物的溶剂时，该光子晶体光纤将引导光; 用选择感兴趣的分析物的溶剂非选择性填充光子晶体纤维; 通过将来自光源的光耦合到光子晶体光纤来询问感兴趣的分析物; 并分析拉曼指纹光子晶体光纤的光输出。

8. 发明申请

US20090303462A1 Correlation technique for analysis of clinical condition 有权
标题翻译：临床情况分析的相关技术
公开(公告)号：US20090303462A1
公开(公告)日：2009-12-10
申请号：US12383930
申请日：2009-03-30
申请人： Rejean Munger , Neil Lagali
发明人： Rejean Munger , Neil Lagali
IPC分类号： G01N33/48 , G01N21/00
CPC分类号： A61B5/14551 , A61B5/0059 , A61B5/0075 , A61B5/72 , G01N21/31 , G01N21/64 , G01N21/65
摘要： The present invention provides a correlation technique for analysis of changes in bodily fluid and/or tissue in order to identify or monitor appearance, progression or treatment of a disease or condition in a subject. The disclosed method involves measuring spectral properties or changes in bodily fluid and/or tissue of a subject using at least two optical techniques; and correlating the measured properties or changes to a corresponding clinical condition or change in clinical condition, respectively. The measure of spectral changes over time can be used as indicators of changes in the clinical condition, for example, in disease treatment and/or disease regulation. This method is particularly useful for identifying a disease state and for monitoring efficacies of therapies used to treat different diseases or disorders, for example, renal dialysis.
摘要翻译：本发明提供了用于分析体液和/或组织中的变化的相关技术，以便识别或监测受试者中疾病或病症的外观，进展或治疗。所公开的方法包括使用至少两种光学技术测量受试者的体液和/或组织的光谱性质或变化; 并将测量的性质或变化分别与相应的临床状况或临床状况的变化相关联。随着时间的推移，光谱变化的测量可用作临床病症变化的指标，例如疾病治疗和/或疾病调控。该方法对于鉴定疾病状态和监测用于治疗不同疾病或病症（例如肾透析）的疗法的功效特别有用。

9. 发明授权

US07043100B2 Polarization independent waveguide optical isolator and circulator 有权
公开(公告)号：US07043100B2
公开(公告)日：2006-05-09
申请号：US09965096
申请日：2001-09-27
申请人： Junichiro Fujita , Reinald Gerhardt , Neil Lagali , Louay Eldada
发明人： Junichiro Fujita , Reinald Gerhardt , Neil Lagali , Louay Eldada
IPC分类号： G02B6/27 , G02B6/26
CPC分类号： G02F1/0955 , G02F1/3136 , G02F2001/212
摘要： Polarization independent optical isolator/circulator devices based on Mach-Zehnder interferometers. The devices utilize either polarization splitting and nonreciprocal polarization conversion or nonreciprocal phase shift within the interferometric arm. For devices with nonreciprocal phase shift, the relative phase difference is 0° in the forward propagation direction and 180° in the backward propagation direction, or vice versa, so that light goes into a bar or cross port depending on the propagation direction. The devices have advantages over previous designs in the use of inexpensive device components, simple alignment, minimal space requirement, and negligible polarization mode dispersion or polarization dependent loss. In addition, the devices can be made in a waveguide form with minimal loss and with high fabrication ease. An additional phase compensator and/or a variable attenuator can be integrated in order to relax the fabrication tolerances.

10. 发明授权

US07896498B2 Apparatus and method for optical measurements 有权
标题翻译：用于光学测量的装置和方法
公开(公告)号：US07896498B2
公开(公告)日：2011-03-01
申请号：US12414437
申请日：2009-03-30
申请人： Rejean Munger , Neil Lagali
发明人： Rejean Munger , Neil Lagali
IPC分类号： A61B3/10 , A61B3/00
CPC分类号： A61B5/0066 , A61B3/10 , A61B5/14555 , A61B5/14558
摘要： Disclosed are an apparatus and method for separately detecting and measuring specularly reflected light and diffusely reflected light following illumination of an eye by light. The apparatus and method of the present invention facilitates substantial separation of the diffusely reflected light from light specularly reflected from the eye after passing through one or more elements of the eye, for example, the cornea, lens, retinal vasculature, the nerve fibre layer and/or the photoreceptors. The collection of these separate streams of independent optical signals to appropriate detection systems provides specificity and accuracy in determination of optical properties of one or more elements of the eye.
摘要翻译：公开了一种用于分别检测和测量由光照射眼睛后的镜面反射光和漫反射光的装置和方法。本发明的装置和方法有助于在通过眼睛的一个或多个元件，例如角膜，晶状体，视网膜脉管系统，神经纤维层和 /或光感受器。将这些独立的光信号流集合到适当的检测系统中，在确定眼睛的一个或多个元件的光学性质方面提供了特异性和准确性。

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