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    • 1. 发明授权
    • Method for detecting binding interactions between membrane proteins and analytes in a homogenous assay
    • 用于在同源测定中检测膜蛋白和分析物之间的结合相互作用的方法
    • US08450118B2
    • 2013-05-28
    • US12799689
    • 2010-04-28
    • Scot WeinbergerStephen DotsonNathan Harris
    • Scot WeinbergerStephen DotsonNathan Harris
    • G01N33/00G01N21/75
    • G01N33/54393G01N21/45G01N33/5432G01N33/54373G01N33/92
    • Devices and methods for detecting interaction between components associated with lipid membranes and analytes are described herein. In certain methods, a surface of a compartment of a device is coated with a material that attaches to lipid membrane from a sample. An analyte is introduced and interaction is detected, for example, by back scattering interferometry. In another method, a surface is passivated with a material that does not bind a lipid membrane. A sample is introduced that contains a membrane comprising a component for testing and an analyte. Interaction is detected. In a third method, a channel is filled with a first liquid that does not comprise a lipid membrane. A bolus of a second liquid that comprises a membrane comprising a component for testing and an analyte is introduced under laminar flow conditions so that a leading edge of the second liquid does not completely displace the first liquid in a sensing area that is interrogated by optical methods, for example, a laser. Interaction between the analyte and the component is detected.
    • 本文描述了用于检测与脂质膜和分析物相关的组分之间相互作用的装置和方法。 在某些方法中,装置的隔室的表面涂覆有从样品附着到脂质膜的材料。 引入分析物并检测相互作用,例如通过反向散射干涉测量。 在另一种方法中,用不结合脂质膜的材料钝化表面。 引入了包含含有用于测试的组分和分析物的膜的样品。 检测到相互作用。 在第三种方法中,通道填充有不包含脂质膜的第一液体。 在层流条件下引入包括包含用于测试的组分的膜和分析物的第二液体的推注,使得第二液体的前缘不会在通过光学方法询问的感测区域中完全置换第一液体 ,例如,激光。 检测分析物与组分之间的相互作用。
    • 4. 发明申请
    • Information processing and transmission systems
    • 信息处理和传输系统
    • US20100023616A1
    • 2010-01-28
    • US12322213
    • 2009-01-30
    • Nathan Harris
    • Nathan Harris
    • G06F15/16
    • G06Q30/04
    • Disclosed are systems and methods for transmitting information from a remote location to a financial decision system. In certain representative transmission methods machine readable content is generated that is adapted to be received by a financial decision system. The machine readable content is transmitted using a first protocol or standard. The transmission of machine readable content is received and converted from the first protocol to a second protocol or standard. The machine readable content is then transmitted using the second protocol. The first protocol can be a non-packet switched serial protocol, such as RS-232. The second protocol can be a packet-switched Internet Protocol (IP), such as for example, User Datagram Protocol (UDP) or Transmission Control Protocol (TCP).
    • 公开了用于将信息从远程位置传送到财务决策系统的系统和方法。 在某些代表性传输方法中,生成适于由财务决策系统接收的机器可读内容。 使用第一协议或标准传输机器可读内容。 机器可读内容的传输被接收并从第一协议转换成第二协议或标准。 然后使用第二协议传输机器可读内容。 第一协议可以是非分组交换串行协议,例如RS-232。 第二协议可以是分组交换因特网协议(IP),例如用户数据报协议(UDP)或传输控制协议(TCP)。
    • 8. 发明授权
    • Information processing and transmission systems
    • 信息处理和传输系统
    • US09202238B2
    • 2015-12-01
    • US12322213
    • 2009-01-30
    • Nathan Harris
    • Nathan Harris
    • G06F15/16G06Q30/04
    • G06Q30/04
    • Disclosed are systems and methods for transmitting information from a remote location to a financial decision system. In certain representative transmission methods machine readable content is generated that is adapted to be received by a financial decision system. The machine readable content is transmitted using a first protocol or standard. The transmission of machine readable content is received and converted from the first protocol to a second protocol or standard. The machine readable content is then transmitted using the second protocol. The first protocol can be a non-packet switched serial protocol, such as RS-232. The second protocol can be a packet-switched Internet Protocol (IP), such as for example, User Datagram Protocol (UDP) or Transmission Control Protocol (TCP).
    • 公开了用于将信息从远程位置传送到财务决策系统的系统和方法。 在某些代表性传输方法中,生成适于由财务决策系统接收的机器可读内容。 使用第一协议或标准传输机器可读内容。 机器可读内容的传输被接收并从第一协议转换成第二协议或标准。 然后使用第二协议传输机器可读内容。 第一协议可以是非分组交换串行协议,例如RS-232。 第二协议可以是分组交换因特网协议(IP),例如用户数据报协议(UDP)或传输控制协议(TCP)。
    • 10. 发明申请
    • Analysis of membrane component interactions
    • 膜组分相互作用分析
    • US20100291700A1
    • 2010-11-18
    • US12799689
    • 2010-04-28
    • Scot WeinbergerStephen DotsonNathan Harris
    • Scot WeinbergerStephen DotsonNathan Harris
    • G01N21/00G01N30/96
    • G01N33/54393G01N21/45G01N33/5432G01N33/54373G01N33/92
    • Devices and methods for detecting interaction between components associated with lipid membranes and analytes are described herein. In certain methods, a surface of a compartment of a device is coated with a material that attaches to lipid membrane from a sample. An analyte is introduced and interaction is detected, for example, by back scattering interferometry. In another method, a surface is passivated with a material that does not bind a lipid membrane. A sample is introduced that contains a membrane comprising a component for testing and an analyte. Interaction is detected. In a third method, a channel is filled with a first liquid that does not comprise a lipid membrane. A bolus of a second liquid that comprises a membrane comprising a component for testing and an analyte is introduced under laminar flow conditions so that a leading edge of the second liquid does not completely displace the first liquid in a sensing area that is interrogated by optical methods, for example, a laser. Interaction between the analyte and the component is detected.
    • 本文描述了用于检测与脂质膜和分析物相关的组分之间相互作用的装置和方法。 在某些方法中,装置的隔室的表面涂覆有从样品附着到脂质膜的材料。 引入分析物并检测相互作用,例如通过反向散射干涉测量。 在另一种方法中,用不结合脂质膜的材料钝化表面。 引入了包含含有用于测试的组分和分析物的膜的样品。 检测到相互作用。 在第三种方法中,通道填充有不包含脂质膜的第一液体。 在层流条件下引入包括包含用于测试的组分的膜和分析物的第二液体的推注,使得第二液体的前缘不会在通过光学方法询问的感测区域中完全置换第一液体 ,例如,激光。 检测分析物与组分之间的相互作用。