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1. 发明授权

US06596267B1 Methods and compositions to prevent formation of adhesions in biological tissues 失效
标题翻译：防止生物组织粘连形成的方法和组合物
公开(公告)号：US06596267B1
公开(公告)日：2003-07-22
申请号：US09140781
申请日：1998-08-27
申请人： Jeffrey A. Hubbell , Natalie D. Winblade , Donald L. Elbert
发明人： Jeffrey A. Hubbell , Natalie D. Winblade , Donald L. Elbert
IPC分类号： A61K3180
CPC分类号： A61L31/06 , A61K31/77 , A61K31/78 , A61K31/79 , A61K31/80 , A61L27/34 , A61L31/10 , Y10S525/937 , Y10S977/931 , C08L71/02 , C08L101/02
摘要： The invention discloses materials that adsorb readily to the surfaces of body tissues in situ and provide a steric barrier between such tissues, so that tissue adhesions, which typically form following surgical procedures, are minimized. These materials contain a polymer of hydrophilic molecules such as polyethylene glycol (PEG) bound to a polymer that spontaneously adsorbs to biological tissue such as phenylboronic acid (PBA). The PEG-PBA co-polymer can be formed in a variety of geometries. The materials can also be used to coat prosthetics and other implants.
摘要翻译：本发明公开了容易吸附到身体组织表面的材料，并且在这些组织之间提供空间屏障，使得通常形成以下外科手术的组织粘连最小化。这些材料包含亲水性分子的聚合物，例如与自发吸附到生物组织如苯硼酸（PBA）的聚合物结合的聚乙二醇（PEG）。 PEG-PBA共聚物可以以各种几何形状形成。这些材料也可用于涂覆假体和其他植入物。

2. 发明授权

US07029688B2 Methods and compositions to prevent formation of adhesions in biological tissues 失效
公开(公告)号：US07029688B2
公开(公告)日：2006-04-18
申请号：US10403344
申请日：2003-03-28
申请人： Jeffrey A. Hubbell , Natalie D. Winblade , Donald L. Elbert
发明人： Jeffrey A. Hubbell , Natalie D. Winblade , Donald L. Elbert
IPC分类号： A61P2/02 , A61P17/02 , A61P29/00 , A61P35/00 , A61K47/30
CPC分类号： A61L31/06 , A61K31/77 , A61K31/78 , A61K31/79 , A61K31/80 , A61L27/34 , A61L31/10 , Y10S525/937 , Y10S977/931 , C08L71/02 , C08L101/02
摘要： The invention discloses materials that adsorb readily to the surfaces of body tissues in situ and provide a steric barrier between such tissues, so that tissue adhesions, which typically form following surgical procedures, are minimized. These materials contain a polymer of hydrophilic molecules such as polyethylene glycol (PEG) bound to a polymer that spontaneously adsorbs to biological tissue such as phenylboronic acid (PBA). The PEG-PBA co-polymer can be formed in a variety of geometries. The materials can also be used to coat prosthetics and other implants.

3. 发明授权

US06652902B2 Gels and multilayer surface structures from boronic acid containing polymers 有权
公开(公告)号：US06652902B2
公开(公告)日：2003-11-25
申请号：US10035625
申请日：2001-12-28
申请人： Jeffrey A. Hubbell , Donald L. Elbert , Natalie D. Winblade
发明人： Jeffrey A. Hubbell , Donald L. Elbert , Natalie D. Winblade
IPC分类号： B05D300
CPC分类号： A61L31/10 , A61L27/34 , A61L29/085 , C08L71/02
摘要： Boronic acid containing polymers are used to form bioinert gels and multilayer surface structures. These polymers form crosslinked hydrogels, which are highly swollen in water. The crosslinking can either be chemical or physical. Water soluble polymers containing boronic acid groups, such as phenylboronic acid (PBA), can be physically crosslinked by mixing the polymers in water with other polymers containing hydroxyls or carboxylic acids. Alternatively, surfaces can be treated by stepwise incubation with a solution of the boronic acid containing polymer, followed by incubation with a solution of a diol or carboxylic acid containing polymer. Many successive layers can be generated, increasing the thickness of the formed structure at each step. The bioinert gel or surface coating can be used for passivating the surfaces of medical implants (especially those based on transplanted tissue), or for passivating the surfaces of tissues in situ, decreasing the incidence or severity of such pathologic conditions as the formation of post-surgical adhesions, and thrombosis following angioplasty.

4. 发明授权

US06350527B1 Gels and multilayer surface structures from boronic acid containing polymers 有权
标题翻译：含有硼酸的聚合物的凝胶和多层表面结构
公开(公告)号：US06350527B1
公开(公告)日：2002-02-26
申请号：US09384888
申请日：1999-08-27
申请人： Jeffrey A. Hubbell , Donald L. Elbert , Natalie D. Winblade
发明人： Jeffrey A. Hubbell , Donald L. Elbert , Natalie D. Winblade
IPC分类号： B32B904
CPC分类号： A61L31/10 , A61L27/34 , A61L29/085 , C08L71/02
摘要： Boronic acid containing polymers are used to form bioinert gels and multilayer surface structures. These polymers form crosslinked hydrogels, which are highly swollen in water. The crosslinking can either be chemical or physical. Water soluble polymers containing boronic acid groups, such as phenylboronic acid (PBA), can be physically crosslinked by mixing the polymers in water with other polymers containing hydroxyls or carboxylic acids. Alternatively, surfaces can be treated by stepwise incubation with a solution of the boronic acid containing polymer, followed by incubation with a solution of a diol or carboxylic acid containing polymer. Many successive layers can be generated, increasing the thickness of the formed structure at each step. The bioinert gel or surface coating can be used for passivating the surfaces of medical implants (especially those based on transplanted tissue), or for passivating the surfaces of tissues in situ.
摘要翻译：含硼酸的聚合物用于形成生物凝胶和多层表面结构。这些聚合物形成在水中高度溶胀的交联水凝胶。交联可以是化学或物理的。含有硼酸基团的水溶性聚合物如苯基硼酸（PBA）可通过将水中的聚合物与含有羟基或羧酸的其它聚合物混合而物理交联。或者，可以通过与含硼酸的聚合物的溶液逐步温育，然后与含二醇或含羧酸的聚合物的溶液温育来处理表面。可以产生许多连续的层，从而在每个步骤增加形成的结构的厚度。生物测定凝胶或表面涂层可用于钝化医疗植入物（特别是基于移植组织的植入物）表面，或用于钝化组织表面的原位。

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