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1. 发明申请

US20120128762A1 Sphingomyelin Liposomes for the Treatment of Hyperactive Bladder Disorders 审中-公开
标题翻译：鞘磷脂脂质体治疗膀胱过多活动障碍
公开(公告)号：US20120128762A1
公开(公告)日：2012-05-24
申请号：US13350326
申请日：2012-01-13
申请人： Michael B. Chancellor , Pradeep Tyagi , Matthew O. Fraser , Yao-Chi Chuang , William C. de Groat , Leaf Huang , Naoki Yoshimura
发明人： Michael B. Chancellor , Pradeep Tyagi , Matthew O. Fraser , Yao-Chi Chuang , William C. de Groat , Leaf Huang , Naoki Yoshimura
IPC分类号： A61K9/127 , A61K31/575 , A61K31/683 , A61K31/70 , A61P13/10 , A61K31/685
CPC分类号： A61K9/127 , A61K9/0034 , A61K9/1272
摘要： The present invention provides pharmaceutical compositions and methods for the instillation of lipid vehicles comprised of liposomes containing sphingomyelin or sphingomyelin metabolites to prevent, manage, ameliorate and/or treat disorders involving neuropathic pain and aberrant muscle contractions, such as what occurs in bladder hyperactivity disorders such as interstitial cystitis (IC) in animals or humans in need thereof. Also provided is a liposome-based delivery of drugs, e.g., antibiotics, pain treatments and anticancer agents, to the bladder, genitourinary tract, gastrointestinal system, pulmonary system and other organs or body systems. In particular, liposome-based delivery of vanilloid compounds, such as resiniferatoxin, capsaicin, or tinyatoxin and toxins, such as botulinum toxin is provided for the treatment of bladder conditions, including pain, inflammation, incontinence and voiding dysfunction.
摘要翻译：本发明提供用于滴注含有鞘磷脂或鞘磷脂代谢物的脂质体的脂质载体的药物组合物和方法，以预防，治疗，改善和/或治疗涉及神经性疼痛和异常肌肉收缩的疾病，例如膀胱多动障碍作为有需要的动物或人类的间质性膀胱炎（IC）。还提供了对膀胱，泌尿生殖道，胃肠系统，肺系统和其他器官或身体系统的基于脂质体的药物递送，例如抗生素，疼痛治疗和抗癌剂。特别地，提供了基于脂质体的递送香草素化合物，例如树脂毒素，辣椒素或微量毒素和毒素，例如肉毒杆菌毒素，用于治疗膀胱状况，包括疼痛，炎症，失禁和排尿功能障碍。

2. 发明授权

US07858997B2 Light emitting apparatus and light emitting method 有权
标题翻译：发光装置及发光方法
公开(公告)号：US07858997B2
公开(公告)日：2010-12-28
申请号：US11717050
申请日：2007-03-13
申请人： Naoki Yoshimura , Yoshinobu Suehiro , Yuji Takahashi , Koichi Ota , Mamoru Mitomo , Tadashi Endo , Masakazu Komatsu
发明人： Naoki Yoshimura , Yoshinobu Suehiro , Yuji Takahashi , Koichi Ota , Mamoru Mitomo , Tadashi Endo , Masakazu Komatsu
IPC分类号： H01L29/22
CPC分类号： C04B35/597 , C04B35/584 , C04B35/6455 , C04B2235/3208 , C04B2235/3217 , C04B2235/3224 , C04B2235/3225 , C04B2235/3852 , C04B2235/3865 , C04B2235/3869 , C04B2235/3873 , C04B2235/766 , C04B2235/80 , C09K11/0883 , C09K11/7734 , G02F2001/133614 , H01L33/502 , H01L2224/49107 , H01L2924/01019 , H01L2924/01025 , H01L2924/01066 , H01L2924/01068 , H01L2924/01079 , H01L2924/12041 , Y02B20/181
摘要： A light emitting apparatus has a light emitting element with an emission wavelength in the range of 360 to 550 nm and a rare-earth element doped oxide nitride phosphor or cerium ion doped lanthanum silicon nitride phosphor. Part of light radiated from the light emitting element is wavelength-converted by the phosphor. The light emitting apparatus radiates white light generated by a mixture of the wavelength-converted light and the other part of light radiated from the light emitting element.
摘要翻译：发光装置具有发光波长在360〜550nm范围内的发光元件和稀土元素掺杂氧化物氮化物荧光体或铈离子掺杂氮化镧氮化镓荧光体。从发光元件辐射的光的一部分被磷光体波长转换。发光装置照射由波长转换光和从发光元件辐射的光的另一部分的混合产生的白光。

3. 发明申请

US20070164308A1 Light emitting apparatus and light emitting method 有权
标题翻译：发光装置及发光方法
公开(公告)号：US20070164308A1
公开(公告)日：2007-07-19
申请号：US11717050
申请日：2007-03-13
申请人： Naoki Yoshimura , Yoshinobu Suehiro , Yuji Takahashi , Koichi Ota , Mamoru Mitomo , Tadashi Endo , Masakazu Komatsu
发明人： Naoki Yoshimura , Yoshinobu Suehiro , Yuji Takahashi , Koichi Ota , Mamoru Mitomo , Tadashi Endo , Masakazu Komatsu
IPC分类号： H01L33/00
CPC分类号： C04B35/597 , C04B35/584 , C04B35/6455 , C04B2235/3208 , C04B2235/3217 , C04B2235/3224 , C04B2235/3225 , C04B2235/3852 , C04B2235/3865 , C04B2235/3869 , C04B2235/3873 , C04B2235/766 , C04B2235/80 , C09K11/0883 , C09K11/7734 , G02F2001/133614 , H01L33/502 , H01L2224/49107 , H01L2924/01019 , H01L2924/01025 , H01L2924/01066 , H01L2924/01068 , H01L2924/01079 , H01L2924/12041 , Y02B20/181
摘要： A light emitting apparatus has a light emitting element with an emission wavelength in the range of 360 to 550 nm and a rare-earth element doped oxide nitride phosphor or cerium ion doped lanthanum silicon nitride phosphor. Part of light radiated from the light emitting element is wavelength-converted by the phosphor. The light emitting apparatus radiates white light generated by a mixture of the wavelength-converted light and the other part of light radiated from the light emitting element.
摘要翻译：发光装置具有发光波长在360〜550nm范围内的发光元件和稀土元素掺杂氧化物氮化物荧光体或铈离子掺杂氮化镧氮化镓荧光体。从发光元件辐射的光的一部分被磷光体波长转换。发光装置照射由波长转换光和从发光元件辐射的光的另一部分的混合产生的白光。

4. 发明申请

US20060276531A1 Agent for the treatment of bladder irritative symptoms accompanied by benign prostatic hyperplasia 审中-公开
标题翻译：代理治疗膀胱刺激症状伴有良性前列腺增生
公开(公告)号：US20060276531A1
公开(公告)日：2006-12-07
申请号：US11503067
申请日：2006-08-14
申请人： Tsuyoshi Yamagata , Kaoru Atsuki , Tetsuji Ohno , Shiro Shirakura , Akira Karasawa , William de Groat , Naoki Yoshimura , Adrian Sculptoreanu
发明人： Tsuyoshi Yamagata , Kaoru Atsuki , Tetsuji Ohno , Shiro Shirakura , Akira Karasawa , William de Groat , Naoki Yoshimura , Adrian Sculptoreanu
IPC分类号： A61K31/381
CPC分类号： A61K31/55 , A61K31/38 , A61K31/44
摘要： The present invention provides an agent for the treatment of bladder irritative symptoms accompanied by benign prostatic hyperplasia, comprising, as an active ingredient, a compound having a slowly-inactivating A-type K+ channel opening activity or a pharmaceutically acceptable salt thereof, and a method for screening agents for the treatment of bladder irritative symptoms accompanied by benign prostatic hyperplasia, comprising measuring a slowly-inactivating A-type K+ channel opening activity as an index.
摘要翻译：本发明提供了一种用于治疗伴有良性前列腺增生的膀胱刺激症状的药剂，其包含作为活性成分的具有缓慢失活的A型K + / O通道开放活性的化合物或以及用于治疗伴有良性前列腺增生的膀胱刺激症状的筛选剂的方法，包括测量缓慢失活的A型K +通道开放活性作为指标。

5. 发明授权

US4322327A Slow-curing water-curable urethane prepolymer composition 失效
标题翻译：缓慢固化的水可固化氨基甲酸酯预聚物组合物
公开(公告)号：US4322327A
公开(公告)日：1982-03-30
申请号：US196831
申请日：1980-10-14
申请人： Naoki Yoshimura , Kenji Hijikata , Noritaka Hosokawa
发明人： Naoki Yoshimura , Kenji Hijikata , Noritaka Hosokawa
IPC分类号： C08G18/08 , C08G18/10 , C08G18/48 , C08L75/00
CPC分类号： C08G18/4833 , C08G18/0819 , C08G18/10 , C08G2210/00 , Y10S524/916 , Y10S528/904
摘要： A novel slow-curing water-curable urethane prepolymer composition obtained by reacting (A) a hydrophilic urethane prepolymer which is a reaction product of a polyisocyanate and a hydrophilic polyol prepolymer and has at least two --NCO groups and (B) a blocking agent selected from a class consisting of heterocyclic compounds having an ##STR1## structure in the molecule thereof, hydroxypyridines and hydroxyquinolines in the proportion that the equivalent ratio of the .dbd.NH groups of the --OH groups in the blocking agent (B) to the --NCO groups in the hydrophilic urethane prepolymer (A), that is, --OH or .dbd.NH/--NCO ratio, is 0.05 to 2 is disclosed. This composition is remarkably useful as a grouting material, for forming hydrogel which is effective as a fixative or carrier of various materials, as a vehicle for coating materials, and as a stabilizer and thickener for aqueous resin emulsions.
摘要翻译：通过使（A）亲水性氨基甲酸酯预聚物（多异氰酸酯与亲水性多元醇预聚物的反应产物）与至少两个-NCO基团反应得到的新型慢硫化水可固化氨基甲酸酯预聚物组合物和（B）选择的封端剂由分子中具有结构的杂环化合物组成的类别，羟基吡啶类和羟基喹啉类，其中封闭剂（B）中-OH基团的= NH基团与-NCO基团的当量比在亲水性氨基甲酸酯预聚物（A）中，即-OH或= NH / -NCO比为0.05〜2。该组合物作为灌浆材料非常有用，用于形成作为各种材料的固定剂或载体，作为涂料的载体，作为水性树脂乳液的稳定剂和增稠剂有效的水凝胶。

6. 发明授权

US08110217B2 Sphingomyelin liposomes for the treatment of hyperactive bladder disorders 有权
标题翻译：鞘磷脂脂质体用于治疗膀胱过动症
公开(公告)号：US08110217B2
公开(公告)日：2012-02-07
申请号：US11546025
申请日：2006-10-11
申请人： Michael B. Chancellor , Pradeep Tyagi , Matthew O. Fraser , Yao-Chi Chuang , William C de Groat , Leaf Huang , Naoki Yoshimura
发明人： Michael B. Chancellor , Pradeep Tyagi , Matthew O. Fraser , Yao-Chi Chuang , William C de Groat , Leaf Huang , Naoki Yoshimura
IPC分类号： A61K9/127
CPC分类号： A61K9/127 , A61K9/0034 , A61K9/1272 , Y02A50/469
摘要： The present invention provides pharmaceutical compositions and methods for the instillation of lipid vehicles comprised of liposomes containing sphingomyelin or sphingomyelin metabolites to prevent, manage, ameliorate and/or treat disorders involving neuropathic pain and aberrant muscle contractions, such as what occurs in bladder hyperactivity disorders such as interstitial cystitis (IC) in animals or humans in need thereof. Also provided is a liposome-based delivery of drugs, e.g., antibiotics, pain treatments and anticancer agents, to the bladder, genitourinary tract, gastrointestinal system, pulmonary system and other organs or body systems. In particular, liposome-based delivery of vanilloid compounds, such as resiniferatoxin, capsaicin, or tinyatoxin and toxins, such as botulinum toxin is provided for the treatment of bladder conditions, including pain, inflammation, incontinence and voiding dysfunction.
摘要翻译：本发明提供用于滴注含有鞘磷脂或鞘磷脂代谢物的脂质体的脂质载体的药物组合物和方法，以预防，治疗，改善和/或治疗涉及神经性疼痛和异常肌肉收缩的疾病，例如膀胱多动障碍作为有需要的动物或人类的间质性膀胱炎（IC）。还提供了对膀胱，泌尿生殖道，胃肠系统，肺系统和其他器官或身体系统的基于脂质体的药物递送，例如抗生素，疼痛治疗和抗癌剂。特别地，提供了基于脂质体的递送香草素化合物，例如树脂毒素，辣椒素或微量毒素和毒素，例如肉毒杆菌毒素，用于治疗膀胱状况，包括疼痛，炎症，失禁和排尿功能障碍。

7. 发明授权

US07122173B2 Agent for the treatment of bladder irritative symptoms accompanied by benign prostatic hyperplasia 失效
公开(公告)号：US07122173B2
公开(公告)日：2006-10-17
申请号：US10473348
申请日：2002-03-29
申请人： Tsuyoshi Yamagata , Kaoru Atsuki , Tetsuji Ohno , Shiro Shirakura , Akira Karasawa , William C. de Groat , Naoki Yoshimura , Adrian Sculptoreanu
发明人： Tsuyoshi Yamagata , Kaoru Atsuki , Tetsuji Ohno , Shiro Shirakura , Akira Karasawa , William C. de Groat , Naoki Yoshimura , Adrian Sculptoreanu
IPC分类号： A61K10/00 , A61K49/00
CPC分类号： A61K31/55 , A61K31/38 , A61K31/44
摘要： The present invention provides an agent for the treatment of bladder irritative symptoms accompanied by benign prostatic hyperplasia, comprising, as an active ingredient, a compound having a slowly-inactivating A-type K+ channel opening activity or a pharmaceutically acceptable salt thereof, and a method for screening agents for the treatment of bladder irritative symptoms accompanied by benign prostatic hyperplasia, comprising measuring a slowly-inactivating A-type K+ channel opening activity as an index.

8. 发明授权

US06617787B2 Light-emitting system with alicyclic epoxy sealing member 失效
标题翻译：具有脂环族环氧树脂密封件的发光系统
公开(公告)号：US06617787B2
公开(公告)日：2003-09-09
申请号：US09755115
申请日：2001-01-08
申请人： Hisaki Kato , Kanae Matsumura , Akira Mabuchi , Naoki Yoshimura , Kazuhiro Sakai
发明人： Hisaki Kato , Kanae Matsumura , Akira Mabuchi , Naoki Yoshimura , Kazuhiro Sakai
IPC分类号： H05B3300
CPC分类号： H01L33/56 , H01L2224/32245 , H01L2224/32257 , H01L2224/48091 , H01L2224/48247 , H01L2224/48257 , H01L2224/49107 , H01L2224/73265 , H01L2924/00014 , H01L2924/00
摘要： An alicyclic epoxy resin is used as a material for forming a member for sealing a Group III nitride compound semiconductor light-emitting device.
摘要翻译：使用脂环式环氧树脂作为用于形成用于密封III族氮化物化合物半导体发光器件的部件的材料。

9. 发明授权

US07332746B1 Light-emitting apparatus 有权
标题翻译：发光装置
公开(公告)号：US07332746B1
公开(公告)日：2008-02-19
申请号：US09654501
申请日：2000-09-01
申请人： Yuji Takahashi , Koichi Ota , Naoki Yoshimura , Kuniyoshi Kondo
发明人： Yuji Takahashi , Koichi Ota , Naoki Yoshimura , Kuniyoshi Kondo
IPC分类号： H01L33/00
CPC分类号： H01L25/0753 , H01L33/50 , H01L2224/05124 , H01L2224/05568 , H01L2224/05573 , H01L2224/0558 , H01L2224/05624 , H01L2224/16145 , H01L2224/32245 , H01L2224/48091 , H01L2224/48137 , H01L2224/48247 , H01L2224/48257 , H01L2224/49107 , H01L2224/49113 , H01L2224/73265 , H01L2924/00014 , H01L2924/00
摘要： A novel configuration of a light-emitting apparatus that can emit white light, in which a primary light source composed of a group III nitride compound semiconductor is used in combination with a secondary light source including a fluorescent material which emits light of a green luminescent color when the fluorescent material is excited by light emitted from the primary light source. A tertiary light source for emitting red light may be further used in combination with the primary and secondary light sources.
摘要翻译：可以发射白光的发光装置的新颖结构，其中将由III族氮化物化合物半导体组成的初级光源与包括发出绿色发光颜色的荧光材料的二次光源组合使用当荧光材料被从一次光源发出的光激发时。用于发射红光的第三光源可以进一步与主光源和次光源组合使用。

10. 发明申请

US20070122466A1 Sphingomyelin liposomes for the treatment of hyperactive bladder disorders 有权
标题翻译：鞘磷脂脂质体用于治疗膀胱过动症
公开(公告)号：US20070122466A1
公开(公告)日：2007-05-31
申请号：US11546025
申请日：2006-10-11
申请人： Michael Chancellor , Pradeep Tyagi , Matthew Fraser , Yao-Chi Chuang , William de Groat , Leaf Huang , Naoki Yoshimura
发明人： Michael Chancellor , Pradeep Tyagi , Matthew Fraser , Yao-Chi Chuang , William de Groat , Leaf Huang , Naoki Yoshimura
IPC分类号： A61K9/127
CPC分类号： A61K9/127 , A61K9/0034 , A61K9/1272 , Y02A50/469
摘要： The present invention provides pharmaceutical compositions and methods for the instillation of lipid vehicles comprised of liposomes containing sphingomyelin or sphingomyelin metabolites to prevent, manage, ameliorate and/or treat disorders involving neuropathic pain and aberrant muscle contractions, such as what occurs in bladder hyperactivity disorders such as interstitial cystitis (IC) in animals or humans in need thereof. Also provided is a liposome-based delivery of drugs, e.g., antibiotics, pain treatments and anticancer agents, to the bladder, genitourinary tract, gastrointestinal system, pulmonary system and other organs or body systems. In particular, liposome-based delivery of vanilloid compounds, such as resiniferatoxin, capsaicin, or tinyatoxin and toxins, such as botulinum toxin is provided for the treatment of bladder conditions, including pain, inflammation, incontinence and voiding dysftunction.
摘要翻译：本发明提供用于滴注含有鞘磷脂或鞘磷脂代谢物的脂质体的脂质载体的药物组合物和方法，以预防，治疗，改善和/或治疗涉及神经性疼痛和异常肌肉收缩的疾病，例如膀胱多动障碍作为有需要的动物或人类的间质性膀胱炎（IC）。还提供了对膀胱，泌尿生殖道，胃肠系统，肺系统和其他器官或身体系统的基于脂质体的药物递送，例如抗生素，疼痛治疗和抗癌剂。特别地，为了治疗膀胱状况，包括疼痛，炎症，失禁和排尿功能障碍，提供了香草素化合物（例如树脂毒素，辣椒素或微量毒素）和毒素（例如肉毒杆菌毒素）的基于脂质体的递送。

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