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1. 发明授权

US07074589B1 Nucleic acids encoding BDP-1 失效
标题翻译：编码BDP-1的核酸
公开(公告)号：US07074589B1
公开(公告)日：2006-07-11
申请号：US08877150
申请日：1997-06-17
申请人： Axel Ullrich , Naohito Aoki , Yeong Woong Kim , Hong Yang Wang , Zhengjun Chen , Oliver Nayler , Alexei Kharitonenkov
发明人： Axel Ullrich , Naohito Aoki , Yeong Woong Kim , Hong Yang Wang , Zhengjun Chen , Oliver Nayler , Alexei Kharitonenkov
IPC分类号： C12P21/06
CPC分类号： C12N9/1205 , A61K38/00 , C07K14/4703 , C07K16/18 , C07K16/40 , C12N9/16
摘要： Nucleic acid molecules encoding full length PTP20, PCP-2, BDP1, mCLK2, mCLK3, mCLK4, and SIRP polypeptides, portions of such nucleic acid molecules, nucleic acid vectors containing such nucleic acid molecules, recombinant cells containing such nucleic acid vectors, polypeptides purified from such recombinant cells, antibodies to such polypeptides, and methods of identifying compounds that bind such polypeptides or abrogate their interactions with natural binding partners. Methods for diagnosing abnormal conditions in an organism with PTP20, PCP-2, BDP1, mCLK2, mCLK3, mCLK4, and SIRP related molecules or compounds. PTP20, PCP-2, BDP1, mCLK2, mCLK3, mCLK4, or SIRP polypeptides, nucleic acids encoding such polypeptides, cells, tissues and animals containing such nucleic acids, antibodies to such polypeptides, assays utilizing such polypeptides, and methods relating to all of the foregoing. Methods for treatment, diagnosis, and screening are provided for diseases related to PTP20, PCP-2, BDP1, mCLK2, mCLK3, mCLK4, and SIRP polypeptide or conditions characterized by an abnormal interaction between such a polypeptide and its binding partner.
摘要翻译：编码全长PTP20，PCP-2，BDP1，mCLK2，mCLK3，mCLK4和SIRP多肽的核酸分子，这些核酸分子的部分，含有该核酸分子的核酸载体，含有该核酸载体的重组细胞，纯化的多肽来自这样的重组细胞，对这些多肽的抗体，以及鉴定结合这些多肽的化合物或废除其与天然结合配偶体的相互作用的方法。用于诊断具有PTP20，PCP-2，BDP1，mCLK2，mCLK3，mCLK4和SIRP相关分子或化合物的生物体的异常状况的方法。 PTP20，PCP-2，BDP1，mCLK2，mCLK3，mCLK4或SIRP多肽，编码此类多肽的核酸，含有此类核酸的细胞，组织和动物，使用此类多肽的抗体，以及与所有这些多肽相关的方法以上。提供了与PTP20，PCP-2，BDP1，mCLK2，mCLK3，mCLK4和SIRP多肽有关的疾病或特征为这种多肽与其结合配偶体之间异常相互作用的病症的治疗，诊断和筛选方法。

2. 发明授权

US6004791A Protein tyrosine phosphatase PTP20 and related products and methods 失效
公开(公告)号：US6004791A
公开(公告)日：1999-12-21
申请号：US951260
申请日：1997-10-16
申请人： Naohito Aoki , Axel Ullrich
发明人： Naohito Aoki , Axel Ullrich
IPC分类号： A61K38/00 , C07K14/47 , C07K16/18 , C07K16/40 , C12N9/12 , C12N9/16 , C07H21/04 , C12N1/20
CPC分类号： C12N9/1205 , C07K14/4703 , C07K16/18 , C07K16/40 , C12N9/16 , A61K38/00
摘要： The present invention relates to a novel polypeptide, PTP20, and to nucleic acid molecules encoding the polypeptide. The invention also relates to nucleic acid molecules encoding portions of the phosphatase, nucleic acid vectors containing PTP20 related nucleic acid molecules, recombinant cells containing such nucleic acid vectors, polypeptides purified from such recombinant cells, antibodies to such polypeptides, and methods of identifying compounds that bind PTP20 or abrogate its interactions with natural binding partners. Also disclosed are methods for diagnosing abnormal conditions in an organism with PTP20 related molecules or compounds.

3. 发明授权

US09029110B2 Method for producing functional microbially fermented tea extract containing polyphenol derivative 有权
标题翻译：含有多酚衍生物的功能性微生物发酵茶提取物的制备方法
公开(公告)号：US09029110B2
公开(公告)日：2015-05-12
申请号：US13496389
申请日：2010-09-17
申请人： Teruyoshi Yanagita , Kanji Ishimaru , Takashi Tanaka , Kazunori Koba , Hitoshi Miyazaki , Naohito Aoki , Denbei Kawamura
发明人： Teruyoshi Yanagita , Kanji Ishimaru , Takashi Tanaka , Kazunori Koba , Hitoshi Miyazaki , Naohito Aoki , Denbei Kawamura
IPC分类号： C12P1/02 , A61K8/49 , A23K1/00 , A23K1/16 , A23L1/30 , A61Q19/00 , A61K8/97
CPC分类号： A61K8/498 , A23K10/12 , A23K20/10 , A23K20/111 , A23K20/121 , A23L33/105 , A61K8/97 , A61K2800/522 , A61K2800/85 , A61Q19/00
摘要： A functional microbially fermented tea extract containing a novel polyphenol derivative and a method for producing the same are provided. A functional microbially fermented tea extract containing various extracts and a novel polyphenol derivative is produced by subjecting, to an extraction treatment, a microbially fermented tea leaf obtained by culturing one species selected from Aspergillus sp. (PK-1), Aspergillus oryzae (NBRS 4214) sp. (AO-1), Aspergillus awamori (NBRS 4122) sp. (SK-1), and Eurotium sp. (KA-1) with a tea leaf. Furthermore, for example, a functional fermented tea extract enriched with a novel polyphenol derivative is produced.
摘要翻译：提供了含有新型多酚衍生物的功能性微生物发酵茶提取物及其制造方法。通过对通过培养从曲霉属（Aspergillus sp。）中选出的一种获得的微生物发酵的茶叶进行提取处理来制备含有各种提取物和新型多酚衍生物的功能性微生物发酵茶提取物。（PK-1），米曲霉（NBRS 4214）sp。（AO-1），泡盛曲霉（NBRS 4122）（SK-1）和Eurotium sp。（KA-1）与茶叶。此外，例如，生产富含新型多酚衍生物的功能性发酵茶提取物。

4. 发明申请

US20090249513A1 Method for Expression and Accumulation of Peptide in Plant 审中-公开
标题翻译：植物中肽的表达和积累方法
公开(公告)号：US20090249513A1
公开(公告)日：2009-10-01
申请号：US11885762
申请日：2006-03-01
申请人： Tsukasa Matsuda , Naohito Aoki , Fujio Hashizume , Shingo Hino , Misako Kakehashi
发明人： Tsukasa Matsuda , Naohito Aoki , Fujio Hashizume , Shingo Hino , Misako Kakehashi
IPC分类号： A01H1/00 , C12N15/63 , A01H5/00
CPC分类号： C12N15/8261 , C12N15/821 , Y02A40/146
摘要： The present invention relates to a method for expressing and accumulating a low-molecular peptide in plant seeds; a vector therefore; and a plant transformed with the vector. In the present invention, an intended peptide composed of 3 to 40 amino acid residues is expressed and accumulated in seeds of a plant by transforming the plant with a fusion protein expression vector comprising a gene encoding a member of the glutelin multigene family and two or more copies of a gene encoding the intended peptide ligated downstream of the gene under the control of a promoter.
摘要翻译：本发明涉及用于在植物种子中表达和积累低分子量肽的方法; 因此，和用该载体转化的植物。在本发明中，通过用包含编码谷蛋白多基因家族成员的基因和两个或更多个的融合蛋白质表达载体转化植物，将由3-40个氨基酸残基组成的预期肽表达并积累在植物的种子中在启动子控制下编码在基因下游连接的预期肽的基因的拷贝。

5. 发明申请

US20120220650A1 FUNCTIONAL MICROBIALLY FERMENTED TEA EXTRACT CONTAINING POLYPHENOL DERIVATIVE AND METHOD FOR PRODUCING THE SAME 有权
标题翻译：含有聚苯酚衍生物的功能性微生物发酵茶提取物及其生产方法
公开(公告)号：US20120220650A1
公开(公告)日：2012-08-30
申请号：US13496389
申请日：2010-09-17
申请人： Teruyoshi Yanagita , Kanji Ishimaru , Takashi Tanaka , Kazunori Koba , Hitoshi Miyazaki , Naohito Aoki , Denbei Kawamura
发明人： Teruyoshi Yanagita , Kanji Ishimaru , Takashi Tanaka , Kazunori Koba , Hitoshi Miyazaki , Naohito Aoki , Denbei Kawamura
IPC分类号： A61K31/353 , A61P3/04 , A61K8/49
CPC分类号： A61K8/498 , A23K10/12 , A23K20/10 , A23K20/111 , A23K20/121 , A23L33/105 , A61K8/97 , A61K2800/522 , A61K2800/85 , A61Q19/00
摘要： A functional microbially fermented tea extract containing a novel polyphenol derivative and a method for producing the same are provided. A functional microbially fermented tea extract containing various extracts and a novel polyphenol derivative is produced by subjecting, to an extraction treatment, a microbially fermented tea leaf obtained by culturing one species selected from Aspergillus sp. (PK-1), Aspergillus oryzae (NBRS 4214) sp. (AO-1), Aspergillus awamori (NBRS 4122) sp. (SK-1), and Eurotium sp. (KA-1) with a tea leaf. Furthermore, for example, a functional fermented tea extract enriched with a novel polyphenol derivative is produced.
摘要翻译：提供了含有新型多酚衍生物的功能性微生物发酵茶提取物及其制造方法。通过对通过培养从曲霉属（Aspergillus sp。）中选出的一种获得的微生物发酵的茶叶进行提取处理来制备含有各种提取物和新型多酚衍生物的功能性微生物发酵茶提取物。（PK-1），米曲霉（NBRS 4214）sp。（AO-1），泡盛曲霉（NBRS 4122）（SK-1）和Eurotium sp。（KA-1）与茶叶。此外，例如，生产富含新型多酚衍生物的功能性发酵茶提取物。

6. 发明申请

US20080051556A1 Novel PTP-20, PCP-2, BDP1, CLK, and SIRP proteins and related products and methods 审中-公开
标题翻译：新型PTP-20，PCP-2，BDP1，CLK和SIRP蛋白及相关产品及方法
公开(公告)号：US20080051556A1
公开(公告)日：2008-02-28
申请号：US11153918
申请日：2005-06-16
申请人： Axel Ullrich , Naohito Aoki , Yeong Woong Kim , Hong Yang Wang , Zhengjun Chen , Oliver Nayler , Alexei Kharitonenkov
发明人： Axel Ullrich , Naohito Aoki , Yeong Woong Kim , Hong Yang Wang , Zhengjun Chen , Oliver Nayler , Alexei Kharitonenkov
IPC分类号： C07K2/00 , C07H21/00 , C07K16/00
CPC分类号： C12N9/1205 , A61K38/00 , C07K14/4703 , C07K16/18 , C07K16/40 , C12N9/16
摘要： Nucleic acid molecules encoding full length PTP20, PCP-2, BDP1, mCLK2, mCLK3, mCLK4, and SIRP polypeptides, portions of such nucleic acid molecules, nucleic acid vectors containing such nucleic acid molecules, recombinant cells containing such nucleic acid vectors, polypeptides purified from such recombinant cells, antibodies to such polypeptides, and methods of identifying compounds that bind such polypeptides or abrogate their interactions with natural binding partners. Methods for diagnosing abnormal conditions in an organism with PTP20, PCP-2, BDP1, mCLK2, mCLK3, mCLK4, and SIRP related molecules or compounds. PTP20, PCP-2, BDP1, mCLK2, mCLK3, mCLK4, or SIRP polypeptides, nucleic acids encoding such polypeptides, cells, tissues and animals containing such nucleic acids, antibodies to such polypeptides, assays utilizing such polypeptides, and methods relating to all of the foregoing. Methods for treatment, diagnosis, and screening are provided for diseases related to PTP20, PCP-2, BDP1, mCLK2, mCLK3, mCLK4, and SIRP polypeptides or conditions characterized by an abnormal interaction between such a polypeptide and its binding partner.
摘要翻译：编码全长PTP20，PCP-2，BDP1，mCLK2，mCLK3，mCLK4和SIRP多肽的核酸分子，这些核酸分子的部分，含有该核酸分子的核酸载体，含有该核酸载体的重组细胞，纯化的多肽来自这样的重组细胞，对这些多肽的抗体，以及鉴定结合这些多肽的化合物或废除其与天然结合配偶体的相互作用的方法。用于诊断具有PTP20，PCP-2，BDP1，mCLK2，mCLK3，mCLK4和SIRP相关分子或化合物的生物体的异常状况的方法。 PTP20，PCP-2，BDP1，mCLK2，mCLK3，mCLK4或SIRP多肽，编码此类多肽的核酸，含有此类核酸的细胞，组织和动物，使用此类多肽的抗体，以及与所有这些多肽相关的方法以上。为与PTP20，PCP-2，BDP1，mCLK2，mCLK3，mCLK4和SIRP多肽相关的疾病或特征为这种多肽与其结合配偶体之间的异常相互作用的病症提供了治疗，诊断和筛选方法。

7. 发明授权

US08558016B2 Polyphenol derivative and method for producing the same 失效
标题翻译：多酚衍生物及其制备方法
公开(公告)号：US08558016B2
公开(公告)日：2013-10-15
申请号：US13496379
申请日：2010-09-17
申请人： Teruyoshi Yanagita , Kanji Ishimaru , Takashi Tanaka , Kazunori Koba , Hitoshi Miyazaki , Naohito Aoki , Denbei Kawamura
发明人： Teruyoshi Yanagita , Kanji Ishimaru , Takashi Tanaka , Kazunori Koba , Hitoshi Miyazaki , Naohito Aoki , Denbei Kawamura
IPC分类号： C07D493/04 , A23K1/16 , A23L1/30 , A61K8/49 , C12R1/66
CPC分类号： C07D493/04 , A23K10/12 , A23K20/10 , A23K20/111 , A23K20/121 , A23K50/40 , A23L33/105 , A23V2002/00 , A61K8/498 , A61K2800/522 , A61K2800/85 , A61Q19/00 , C12P17/181 , A23V2250/0632 , A23V2250/156 , A23V2250/1882 , A23V2250/2132 , A23V2250/214 , A23V2250/5108 , A23V2250/54246 , A23V2250/628 , A23V2250/70
摘要： A novel substance exhibiting physiologically active effects is produced from a tea leaf. A novel polyphenol derivative is produced, for example, by subjecting a microbially fermented tea leaf obtained by culturing Aspergillus sp. (PK-1) with a tea leaf, to an extraction treatment.
摘要翻译：从茶叶产生具有生理活性作用的新物质。例如，通过将通过培养曲霉属（Aspergillus sp。）获得的微生物发酵的茶叶进行生产，得到新的多酚衍生物。（PK-1）与茶叶进行提取处理。

8. 发明申请

US20120220789A1 POLYPHENOL DERIVATIVE AND METHOD FOR PRODUCING THE SAME 失效
标题翻译：聚苯酚衍生物及其制造方法
公开(公告)号：US20120220789A1
公开(公告)日：2012-08-30
申请号：US13496379
申请日：2010-09-17
申请人： Teruyoshi Yanagita , Kanji Ishimaru , Takashi Tanaka , Kazunori Koba , Hitoshi Miyazaki , Naohito Aoki , Denbei Kawamura
发明人： Teruyoshi Yanagita , Kanji Ishimaru , Takashi Tanaka , Kazunori Koba , Hitoshi Miyazaki , Naohito Aoki , Denbei Kawamura
IPC分类号： C07D493/04 , C12P17/18
CPC分类号： C07D493/04 , A23K10/12 , A23K20/10 , A23K20/111 , A23K20/121 , A23K50/40 , A23L33/105 , A23V2002/00 , A61K8/498 , A61K2800/522 , A61K2800/85 , A61Q19/00 , C12P17/181 , A23V2250/0632 , A23V2250/156 , A23V2250/1882 , A23V2250/2132 , A23V2250/214 , A23V2250/5108 , A23V2250/54246 , A23V2250/628 , A23V2250/70
摘要： A novel substance exhibiting physiologically active effects is produced from a tea leaf. A novel polyphenol derivative is produced, for example, by subjecting a microbially fermented tea leaf obtained by culturing Aspergillus sp. (PK-1) with a tea leaf, to an extraction treatment.
摘要翻译：从茶叶产生具有生理活性作用的新物质。例如，通过将通过培养曲霉属（Aspergillus sp。）获得的微生物发酵的茶叶进行生产，得到新的多酚衍生物。（PK-1）与茶叶进行提取处理。

9. 发明授权

US06482605B1 Protein tyrosine phosphatase PTP20 and related products and methods 失效
标题翻译：蛋白酪氨酸磷酸酶PTP20及相关产品及方法
公开(公告)号：US06482605B1
公开(公告)日：2002-11-19
申请号：US09430626
申请日：1999-10-29
申请人： Naohito Aoki , Axel Ullrich
发明人： Naohito Aoki , Axel Ullrich
IPC分类号： C12Q142
CPC分类号： C12N9/1205 , A61K38/00 , C07K14/4703 , C07K16/18 , C07K16/40 , C12N9/16
摘要： The present invention relates to a novel polypeptide, PTP20, and to nucleic acid molecules encoding the polypeptide . The invention also relates to nucleic acid molecules encoding portions of the phosphatase, nucleic acid vectors containing PTP20 related nucleic acid molecules, recombinant cells containing such nucleic acid vectors, polypeptides purified from such recombinant cells, antibodies to such polypeptides, and methods of identifying compounds that bind PTP20 or abrogate its interactions with natural binding partners. Also disclosed are methods for diagnosing abnormal conditions in an organism with PTP20 related molecules or compounds.
摘要翻译：本发明涉及新型多肽PTP20，以及编码该多肽的核酸分子。本发明还涉及编码部分磷酸酶的核酸分子，含有PTP20相关核酸分子的核酸载体，含有此类核酸载体的重组细胞，从这些重组细胞纯化的多肽，对这些多肽的抗体，以及鉴定化合物的方法结合PTP20或废除其与天然结合配偶体的相互作用。还公开了用PTP20相关分子或化合物诊断生物体中的异常状况的方法。

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