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1. 发明授权

US10619152B2 Isolation of cell-free nucleic acids from bodily fluid samples using solid chaotropic agents 有权
公开(公告)号：US10619152B2
公开(公告)日：2020-04-14
申请号：US15117569
申请日：2015-02-10
申请人： Nancy Quan
发明人： Nancy Quan
IPC分类号： C12N15/10 , C12Q1/6806
CPC分类号： C12N15/1013 , C12Q1/6806
摘要： Disclosed is a process for isolating cell-free nucleic acid (including both DNA and RNA) or an analog thereof from a bodily fluid, and which entails: a) mixing in a container the bodily fluid, a chaotropic agent in solid form, a detergent and a buffer, and a solid phase which includes magnetic particles, thus forming a reaction mixture containing the cell-free nucleic acid; b) magnetically separating the solid phase having the cell-free nucleic acid bound thereto from the reaction mixture; and optionally c) dissociating the nucleic acid from the solid phase. Compositions and kits are also disclosed.

2. 发明申请

US20080057468A1 Endodontic Instrument 审中-公开
标题翻译：牙髓器械
公开(公告)号：US20080057468A1
公开(公告)日：2008-03-06
申请号：US11927965
申请日：2007-10-30
申请人： Kenneth Rosenblood , Nancy Quan
发明人： Kenneth Rosenblood , Nancy Quan
IPC分类号： A61C5/02
CPC分类号： A61C5/42
摘要： The present invention provides an improved endodontic instrument. The instrument can be constructed of a ribbon of material such as any material that has a suitable edge for cutting and can be twisted or bent into any desired shape. The ribbon can be made of a metal, a polymeric film or combinations thereof. The ribbon can have a straight edge or a serrated one. The instrument is in the shape of a cone, tapering towards one end. It has a hollow interior and cutting edges disposed in a helical pattern along its length. The instrument can perform various or all of the functions of any endodontic instrument used in the root canal procedure.
摘要翻译：本发明提供了一种改进的根管器械。仪器可以由诸如任何具有合适的切割边缘的材料的材料带构成，并且可以被扭曲或弯曲成任何所需的形状。带可以由金属，聚合物膜或其组合制成。丝带可以具有直边或锯齿状。仪器呈锥形，朝向一端逐渐变细。它具有中空的内部和沿着其长度以螺旋形图案设置的切割边缘。该仪器可以执行根管手术中使用的任何牙髓器械的各种功能。

3. 发明申请

US20080050408A1 Dental Whitening Compositions 审中-公开
标题翻译：牙齿美白组合
公开(公告)号：US20080050408A1
公开(公告)日：2008-02-28
申请号：US11926776
申请日：2007-10-29
申请人： Robert Hayman , Nancy Quan , Jeff MacDonald
发明人： Robert Hayman , Nancy Quan , Jeff MacDonald
IPC分类号： A61K8/22 , A61K6/02 , A61Q11/00 , A61K8/02
CPC分类号： A61Q11/00 , A61K8/02 , A61K8/19 , A61K8/22 , A61K8/24 , A61K2800/88
摘要： A whitening system has a de-sensitizing effect as well as re-mineralizing capability. The system may be a one-component or a two-component composition. The system may also be an unfoamed, a foamed or a foamable composition. For a one-component system, a sparingly soluble calcium phosphate salt may be in dry particle form with at least one gelling agent, wherein the salt is capable of sustained release of both calcium and phosphate ions into saliva upon exposure of the particle thereto and providing a hydroxyapatite remineralization. In a two component system, a first component has at least one peroxide compound, at least one source of phosphate and at least one gelling agent; and a second component has at least one source of calcium, strontium and/or mixtures thereof. The second component may also contain at least one gelling agent, and the composition maybe present as a foam or is foamable. The composition may be packed in a two-compartment syringe, or be present in a carrier or coated onto a substrate.
摘要翻译：美白系统具有去敏化作用以及再矿化能力。该系统可以是单组分或双组分组合物。该系统也可以是未发泡的，发泡的或可发泡的组合物。对于单组分体系，微溶磷酸钙盐可以具有至少一种胶凝剂的干颗粒形式，其中所述盐在颗粒暴露时能够将钙和磷酸根离子缓慢释放到唾液中并提供羟基磷灰石再矿化。在双组分体系中，第一组分具有至少一种过氧化物化合物，至少一种磷酸盐源和至少一种胶凝剂; 并且第二组分具有至少一种钙，锶和/或其混合物来源。第二组分还可以含有至少一种胶凝剂，并且该组合物可以以泡沫形式存在或者是可发泡的。组合物可以包装在两室注射器中，或者存在于载体中或涂覆在基底上。

4. 发明申请

US20080047143A1 Endodontic Instrument 审中-公开
标题翻译：牙髓器械
公开(公告)号：US20080047143A1
公开(公告)日：2008-02-28
申请号：US11929437
申请日：2007-10-30
申请人： Nancy Quan , Ben Wu
发明人： Nancy Quan , Ben Wu
IPC分类号： B23P15/00
CPC分类号： A61C3/02 , A61C5/42 , Y10T29/49567
摘要： A method of manufacturing endodontic instruments is disclosed. Each of the instruments includes a substantially non-cutting pilot portion, a relatively short working portion, and a flexible shank portion which is of a substantially smaller average circumferential span than the working portion. The working portion of one instrument may have a maximum circumferential span as that of the blank from which it is made. The instrument may be treated with either a surface treatment and/or a bulk treatment. The instrument may have a handle at its distal end for manual manipulation, or may be adapted for attachment to a mechanical handpiece. The non-cutting pilot, the short length of the working portion, and the flexibility of the shank combine to allow the instrument to be used in curved root canals without causing undue change in the natural root canal contours.
摘要翻译：公开了一种制造牙髓器械的方法。每个仪器包括基本上不切割的先导部分，相对短的工作部分和与工作部分相比具有基本上更小的平均圆周跨度的柔性柄部分。一个仪器的工作部分可以具有与其制成的坯件的最大圆周跨度。可以用表面处理和/或批量处理来处理所述仪器。仪器可以在其远端处具有用于手动操纵的手柄，或者可以适于附接到机械手持件。非切割先导，工作部分的短长度以及柄部的柔性结合起来，使仪器能够在弯曲的根管中使用，而不会导致天然根管轮廓的不适当的变化。

5. 发明申请

US20070101797A1 Endodontic instruments 审中-公开
标题翻译：牙髓器械
公开(公告)号：US20070101797A1
公开(公告)日：2007-05-10
申请号：US11591797
申请日：2006-11-01
申请人： Nancy Quan , Ben Wu
发明人： Nancy Quan , Ben Wu
IPC分类号： B21D37/10
CPC分类号： A61C3/02 , A61C5/42 , Y10T29/49567
摘要： A method of manufacturing endodontic instruments is disclosed. Each of the instruments includes a substantially non-cutting pilot portion, a relatively short working portion, and a flexible shank portion which is of a substantially smaller average circumferential span than the working portion. The working portion of the instrument has a maximum circumferential span larger than that of the blank from which it is made. The instrument may have a handle at its distal end for manual manipulation, or may be adapted for attachment to a mechanical handpiece. The non-cutting pilot, the short length of the working portion, and the flexibility of the shank combine to allow the instrument to be used in curved root canals without causing undue change in the natural root canal contours.
摘要翻译：公开了一种制造牙髓器械的方法。每个仪器包括基本上不切割的先导部分，相对短的工作部分和与工作部分相比具有基本上较小的平均圆周跨度的柔性柄部分。仪器的工作部分的最大圆周距离大于制造它的坯料的最大圆周范围。仪器可以在其远端处具有用于手动操纵的手柄，或者可以适于附接到机械手持件。非切割先导，工作部分的短长度以及柄部的柔性结合起来，使仪器能够在弯曲的根管中使用，而不会引起天然根管轮廓的不适当的变化。

6. 发明申请

US20060127843A1 Endodontic instruments 审中-公开
标题翻译：牙髓器械
公开(公告)号：US20060127843A1
公开(公告)日：2006-06-15
申请号：US11305173
申请日：2005-12-15
申请人： Kenneth Rosenblood , Nancy Quan
发明人： Kenneth Rosenblood , Nancy Quan
IPC分类号： A61C5/02
CPC分类号： A61C5/42
摘要： The present invention provides an improved endodontic instrument. The instrument can be constructed of a ribbon of material such as any material that has a suitable edge for cutting and can be twisted or bent into any desired shape. The ribbon can be made of a metal, a polymeric film or combinations thereof. The ribbon can have a straight edge or a serrated one. The instrument is in the shape of a cone, tapering towards one end. It has a hollow interior and cutting edges disposed in a helical pattern along its length. The instrument can perform various or all of the functions of any endodontic instrument used in the root canal procedure.
摘要翻译：本发明提供了一种改进的根管器械。仪器可以由诸如任何具有合适的切割边缘的材料的材料带构成，并且可以被扭曲或弯曲成任何所需的形状。带可以由金属，聚合物膜或其组合制成。丝带可以具有直边或锯齿状。仪器呈锥形，朝向一端逐渐变细。它具有中空的内部和沿着其长度以螺旋形图案设置的切割边缘。该仪器可以执行根管手术中使用的任何牙髓器械的各种或全部功能。

7. 发明授权

US10844369B2 Isolation of cell-free nucleic acids from bodily fluid samples using solid chaotropic agents 有权
公开(公告)号：US10844369B2
公开(公告)日：2020-11-24
申请号：US16806817
申请日：2020-03-02
申请人： Nancy Quan
发明人： Nancy Quan
IPC分类号： C12N15/10 , C12Q1/6806
CPC分类号： C12N15/1013 , C12Q1/6806
摘要： Disclosed is a process for isolating cell-free nucleic acid (including both DNA and RNA) or an analog thereof from a bodily fluid, and which entails: a) mixing in a container the bodily fluid, a chaotropic agent in solid form, a detergent and a buffer, and a solid phase which includes magnetic particles, thus forming a reaction mixture containing the cell-free nucleic acid; b) magnetically separating the solid phase having the cell-free nucleic acid bound thereto from the reaction mixture; and optionally c) dissociating the nucleic acid from the solid phase. Compositions and kits are also disclosed.

8. 发明申请

US20160369263A1 ISOLATION OF CELL-FREE NUCLEIC ACIDS FROM BODILY FLUID SAMPLES USING SOLID CHAOTROPIC AGENTS 审中-公开
标题翻译：使用固体代谢试剂从体液样品中分离无细胞核酸
公开(公告)号：US20160369263A1
公开(公告)日：2016-12-22
申请号：US15117569
申请日：2015-02-10
申请人： Nancy QUAN
发明人： Nancy Quan
IPC分类号： C12N15/10 , C12Q1/68
CPC分类号： C12N15/1013 , C12Q1/6806
摘要： Disclosed is a process for isolating cell-free nucleic acid (including both DNA and RNA) or an analog thereof from a bodily fluid, and which entails: a) mixing in a container the bodily fluid, a chaotropic agent in solid form, a detergent and a buffer, and a solid phase which includes magnetic particles, thus forming a reaction mixture containing the cell-free nucleic acid; b) magnetically separating the solid phase having the cell-free nucleic acid bound thereto from the reaction mixture; and optionally c) dissociating the nucleic acid from the solid phase. Compositions and kits are also disclosed.
摘要翻译：公开了一种从体液中分离无细胞核酸（包括DNA和RNA两者）或其类似物的方法，其包括：a）在容器中混合体液，固体形式的离液剂，洗涤剂和缓冲液以及包含磁性颗粒的固相，从而形成含有无细胞核酸的反应混合物; b）将与其结合的无细胞核酸的固相从所述反应混合物中磁分离; 并且任选地c）使核酸与固相解离。还公开了组合物和试剂盒。

9. 发明申请

US20080096156A1 Illumination System for Dentistry Applications 有权
标题翻译：牙科照明系统应用
公开(公告)号：US20080096156A1
公开(公告)日：2008-04-24
申请号：US11925631
申请日：2007-10-26
申请人： Eric Rose , Robert Hayman , Stuart Karten , Dennis Schoreder , Steve Piorek , Douglas Grambush , Marc Orloff , Nancy Quan , Younes Shabany , William Dorfman , Kenneth Rosenblood , Dac Vu , Curt Deckert , Brian Kennedy , Christopher Quan
发明人： Eric Rose , Robert Hayman , Stuart Karten , Dennis Schoreder , Steve Piorek , Douglas Grambush , Marc Orloff , Nancy Quan , Younes Shabany , William Dorfman , Kenneth Rosenblood , Dac Vu , Curt Deckert , Brian Kennedy , Christopher Quan
IPC分类号： A61C3/00
CPC分类号： A61C1/088 , A61B1/0669 , A61B1/24 , A61C1/0007 , A61C1/0015 , A61C5/90 , A61C19/003 , A61C19/004 , A61C19/066 , A61N5/0603 , A61N5/062 , A61N2005/0606 , A61N2005/0633 , A61N2005/0661
摘要： A dental illumination system includes an adjustable self-supporting frame and a lamp head coupled to the frame. The lamp head includes a housing and a spacer having formations that is adapted to removably mechanically couple the lamp head to a reference device, again having formations, for facilitating illumination of a tooth by a light source contained within the lamp head. The spacer and lamp head may be formed integrally. If formed separately, both the lamp head and the spacer may include formations.
摘要翻译：牙科照明系统包括可调节的自支撑框架和联接到框架的灯头。灯头包括壳体和间隔物，其具有适于将灯头可移除地机械地联接到参考装置的结构，该基座装置再次具有结构，以便于由灯头内的光源照射牙齿。间隔件和灯头可以一体地形成。如果单独形成，则灯头和间隔物可以包括地层。

10. 发明申请

US20060099155A1 Dental whitening systems 审中-公开
标题翻译：牙齿美白系统
公开(公告)号：US20060099155A1
公开(公告)日：2006-05-11
申请号：US11271283
申请日：2005-11-09
申请人： Jeff MacDonald , Angela Jinmin Lee , Nancy Quan
发明人： Jeff MacDonald , Angela Jinmin Lee , Nancy Quan
IPC分类号： A61K8/22
CPC分类号： A61K8/22 , A61C19/066 , A61K8/19 , A61K8/60 , A61K2800/88 , A61Q11/00
摘要： A system and method for tooth whitening are disclosed wherein at least one peroxide-containing gel and at least one transition metal compound-containing gel, particularly at least one lower atomic number transition metal compound, more particularly at least a ferrous compound including gluconate, sulfate, nitrate, acetate or mixtures thereof, are applied to a patient's mouth. Gelling agent is also included. The activation of the peroxide whitens the patient's teeth. The system may be used with or without the application of light. The system further provides an additional gel including a sensitivity reduction compound including potassium nitrate, sodium nitrate or mixtures thereof for possible sensitivity treatment if needed.
摘要翻译：公开了一种用于牙齿美白的系统和方法，其中至少一种含过氧化物的凝胶和至少一种含过渡金属化合物的凝胶，特别是至少一种较低原子序数的过渡金属化合物，更特别是至少一种含葡萄糖酸盐，硫酸盐，硝酸盐，乙酸盐或其混合物施用于患者的口腔。还包括胶凝剂。过氧化物的激活使患者的牙齿变白。该系统可以在使用或不使用光的情况下使用。该系统还提供另外的凝胶，其包括包含硝酸钾，硝酸钠或其混合物的灵敏度降低化合物，以便在需要时进行敏感性处理。

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