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1. 发明申请

US20110238322A1 METHODS OF SIMULATING CHEMOTHERAPY FOR A PATIENT 审中-公开
标题翻译：模拟患者化疗的方法
公开(公告)号：US20110238322A1
公开(公告)日：2011-09-29
申请号：US13127337
申请日：2009-11-03
申请人： Nan Song
发明人： Nan Song
IPC分类号： G06F19/00
CPC分类号： G16H50/50 , G01N33/5011 , G01N33/502 , G01N33/574 , G01N2800/52 , G01N2800/7028 , G06F19/3481
摘要： The present invention provides methods for predicting or modeling a chemotherapy outcome for a given patient The method produces chemoresponse data, and presents the chemoresponse data in a clinically meaningful context such that the data can be meaningfully interpreted and evaluated in a clinical context The method of the invention involves correlating in vitro chemoresponse results for a particular patient with historical treatment outcomes Where a population of historical outcomes are matched to the patient by one or more clinical variables and such outcomes are matched to a potential treatment by the in vitro efficacy of the agent received, a meaningful simulation of the potential treatment for the patient can be constructed Simulations, such as survival curves, for a plurality of potential treatments may be generated and compared to contrast the estimated outcomes for several potential treatments, thereby providing the information desirable to design an individualized treatment regimen.
摘要翻译：本发明提供了用于预测或建模给定患者的化疗结果的方法。该方法产生化学响应数据，并在临床有意义的上下文中呈现化学反应数据，使得可以在临床上下文中有意义地解释和评估数据。发明涉及将特定患者的体外化学反应结果与历史治疗结果相关联，其中历史结果的群体通过一个或多个临床变量与患者匹配，并且这些结果与接受的药剂的体外功效的潜在治疗相匹配可以构建对患者的潜在治疗的有意义的模拟可以产生用于多个潜在治疗的模拟，例如存活曲线，并将其进行比较以对比几个潜在治疗的估计结果，从而提供所需的信息来设计个性化治疗 gimen

2. 发明申请

US20110130302A1 BIOLOGICAL PATHWAYS ASSOCIATED WITH CHEMOTHERAPY OUTCOME FOR BREAST CANCER 审中-公开
标题翻译：与乳腺癌化疗相关的生物学途径
公开(公告)号：US20110130302A1
公开(公告)日：2011-06-02
申请号：US12957608
申请日：2010-12-01
申请人： Kui SHEN , Nan Song , Shara D. Rice , Dakun Wang , David A. Gingrich , Zhenyu Ding , Chunqiao Tian , Stacey L. Brower , Paul R. Ervin , Michael Gabrin
发明人： Kui SHEN , Nan Song , Shara D. Rice , Dakun Wang , David A. Gingrich , Zhenyu Ding , Chunqiao Tian , Stacey L. Brower , Paul R. Ervin , Michael Gabrin
IPC分类号： C40B30/04 , C12Q1/68 , C40B40/06
CPC分类号： C12Q1/6886 , C12Q2600/106
摘要： The present invention provides methods for preparing drug response and/or resistance profiles for breast tumor specimens, or cells derived therefrom. The drug response and/or resistance profiles are useful for determining effective chemotherapeutic agents for treatment of the tumor or cell to thereby individualize patient therapy. In other aspects, the invention provides a method for identifying a pathway or gene expression signature indicative of a breast cancer cell's sensitivity to a chemotherapeutic agent, which is useful for identifying a population response rate, or patient sub-population likely to respond to the drug candidate.
摘要翻译：本发明提供了用于制备用于乳腺肿瘤标本或由其衍生的细胞的药物反应和/或抗性谱的方法。药物反应和/或抗性谱可用于确定用于治疗肿瘤或细胞的有效化学治疗剂，从而个体化患者治疗。在其它方面，本发明提供了一种用于鉴定指示乳腺癌细胞对化学治疗剂的敏感性的途径或基因表达特征的方法，其可用于鉴定群体应答率，或可能对药物有反应的患者亚群候选人。

3. 发明申请

US20110129822A1 MULTI DRUG RESPONSE MARKERS FOR BREAST CANCER CELLS 审中-公开
标题翻译：多种药物对乳腺癌细胞的反应标记
公开(公告)号：US20110129822A1
公开(公告)日：2011-06-02
申请号：US12957604
申请日：2010-12-01
申请人： Kui SHEN , Nan Song , Shara D. Rice , Dakun Wang , David A. Gingrich , Zhenyu Ding , Chunqiao Tian , Stacey L. Brower , Paul R. Ervin , Michael Gabrin
发明人： Kui SHEN , Nan Song , Shara D. Rice , Dakun Wang , David A. Gingrich , Zhenyu Ding , Chunqiao Tian , Stacey L. Brower , Paul R. Ervin , Michael Gabrin
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/158
摘要： The present invention provides methods for preparing a gene expression profile of a breast cancer cell, tumor, or cell line, where the gene expression profile may be evaluated for one or more gene expression signatures indicative of multidrug resistance. The signature may be indicative of resistance to one or more chemotherapeutic agents selected from a Taxol (e.g., Docetaxel or Paclitaxel), an antibiotic (e.g., Doxorubicin or Epirubicin), an antimetabolite (e.g., Fluorouracil and/or Gemcitabine), and an alkylating agent (e.g., Cyclophosphamide). Generally, the gene expression profile contains the level of expression for a plurality of genes listed in FIGS. 3, 4, and/or 5. Gene expression profiles for evaluating multidrug resistance for ER positive and ER negative breast cancers are also provided.
摘要翻译：本发明提供了制备乳腺癌细胞，肿瘤或细胞系的基因表达谱的方法，其中基因表达谱可被评估表示多药耐药性的一种或多种基因表达特征。签名可以指示对一种或多种选自紫杉醇（例如多西紫杉醇或紫杉醇），抗生素（例如多柔比星或表柔比星），抗代谢药（例如氟尿嘧啶和/或吉西他滨）和化学治疗剂药剂（如环磷酰胺）。通常，基因表达谱包含图1和2中列出的多个基因的表达水平。还提供了评估ER阳性和ER阴性乳腺癌多药耐药性的基因表达谱。

4. 发明申请

US20100331210A1 METHODS AND SYSTEMS FOR EVALUATING THE SENSITIVITY OR RESISTANCE OF TUMOR SPECIMENS TO CHEMOTHERAPEUTIC AGENTS 审中-公开
标题翻译：用于评估肿瘤标本对化学治疗剂的敏感性或抗性的方法和系统
公开(公告)号：US20100331210A1
公开(公告)日：2010-12-30
申请号：US12791425
申请日：2010-06-01
申请人： Michael Gabrin , Kui Shen , Nan Song , Zhenyu Ding , David Gingrich
发明人： Michael Gabrin , Kui Shen , Nan Song , Zhenyu Ding , David Gingrich
IPC分类号： C40B30/06 , C12Q1/68 , C40B40/06
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/158
摘要： The present invention provides methods, systems, and kits for evaluating the sensitivity and/or resistance of tumor specimens to one or a combination of chemotherapeutic agents. Particularly, the invention provides malignant cell gene signatures that are predictive of a tumor's response to candidate chemotherapeutic regimens.
摘要翻译：本发明提供了用于评估肿瘤标本对化学治疗剂的一种或组合的敏感性和/或抗性的方法，系统和试剂盒。特别地，本发明提供可预测肿瘤对候选化疗方案的反应的恶性细胞基因特征。

5. 发明申请

US20140072999A1 METHODS OF SIMULATING CHEMOTHERAPY FOR A PATIENT 审中-公开
标题翻译：模拟患者化疗的方法
公开(公告)号：US20140072999A1
公开(公告)日：2014-03-13
申请号：US13855992
申请日：2013-04-03
申请人： Nan Song , Michael J. Gabrin , Chunqiao Tian , Shuguang Huang
发明人： Nan Song , Michael J. Gabrin , Chunqiao Tian , Shuguang Huang
IPC分类号： G01N33/50
CPC分类号： G16H50/50 , G01N33/5011 , G01N33/502 , G01N33/574 , G01N2800/52 , G01N2800/7028 , G06F19/3481
摘要： The present invention provides methods for predicting or modeling a chemotherapy outcome for a given patient, to assist physicians in the selection of chemotherapeutic agents for individualized cancer treatment.
摘要翻译：本发明提供了用于预测或建模给定患者的化疗结果的方法，以协助医生选择用于个体化癌症治疗的化学治疗剂。

6. 发明申请

US20130073691A1 File Processing Method, System and Server-clustered System for Cloud Storage 有权
标题翻译：云存储的文件处理方法，系统和服务器集群系统
公开(公告)号：US20130073691A1
公开(公告)日：2013-03-21
申请号：US13576213
申请日：2012-05-31
申请人： Xiao Fei Quan , Quirong Xue , Lei Zhuo , Nan Song , Wanli Song , Han Cheng
发明人： Xiao Fei Quan , Quirong Xue , Lei Zhuo , Nan Song , Wanli Song , Han Cheng
IPC分类号： G06F15/16
CPC分类号： H04L61/1582 , G06F17/30203 , H04L67/06 , H04L67/1097
摘要： A server receives a request to upload a file form a user device. The server may generate a unique file ID associated with the file based on the request, and transmit the file ID to the user device. The user device may divide the file to generate multiple slice files and their corresponding slice IDs. From the user device, the server receives the multiple slice files and the slice IDs. Based on the slice IDs, the server may determine storage addresses at which to store the multiple slice files in a distributed storage system using a consistent hash algorithm. The multiple slice files may be stored based on the corresponding storage addresses of the distrusted storage system.
摘要翻译：服务器从用户设备接收到上传文件的请求。服务器可以基于请求生成与文件相关联的唯一文件ID，并将文件ID发送到用户设备。用户设备可以划分文件以生成多个片文件及其相应片段ID。从用户设备，服务器接收多个片段文件和片段ID。基于片ID，服务器可以使用一致的散列算法来确定将多个片文件存储在分布式存储系统中的存储地址。可以基于不信任存储系统的相应存储地址来存储多个片文件。

7. 发明申请

US20120214679A1 METHODS AND SYSTEMS FOR EVALUATING THE SENSITIVITY OR RESISTANCE OF TUMOR SPECIMENS TO CHEMOTHERAPEUTIC AGENTS 审中-公开
标题翻译：用于评估肿瘤标本对化学治疗剂的敏感性或抗性的方法和系统
公开(公告)号：US20120214679A1
公开(公告)日：2012-08-23
申请号：US13304990
申请日：2011-11-28
申请人： Michael GABRIN , Kui Shen , Nan Song , Zhenyu Ding , David Gingrich
发明人： Michael GABRIN , Kui Shen , Nan Song , Zhenyu Ding , David Gingrich
IPC分类号： C40B30/04 , C40B40/06
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/136 , C12Q2600/158
摘要： The present invention provides methods, systems, and kits for evaluating the sensitivity and/or resistance of tumor specimens to one or a combination of chemotherapeutic agents. Particularly, the invention provides malignant cell gene signatures that are predictive of a tumor's response to candidate chemotherapeutic regimens.
摘要翻译：本发明提供了用于评估肿瘤标本对化学治疗剂的一种或组合的敏感性和/或抗性的方法，系统和试剂盒。特别地，本发明提供可预测肿瘤对候选化疗方案的反应的恶性细胞基因特征。

8. 发明授权

US09774564B2 File processing method, system and server-clustered system for cloud storage 有权
公开(公告)号：US09774564B2
公开(公告)日：2017-09-26
申请号：US13576213
申请日：2012-05-31
申请人： Xiao Fei Quan , Quirong Xue , Lei Zhuo , Nan Song , Wanli Song , Han Cheng
发明人： Xiao Fei Quan , Quirong Xue , Lei Zhuo , Nan Song , Wanli Song , Han Cheng
IPC分类号： H04L29/12 , G06F17/30 , H04L29/08
CPC分类号： H04L61/1582 , G06F17/30203 , H04L67/06 , H04L67/1097
摘要： A server receives a request to upload a file form a user device. The server may generate a unique file ID associated with the file based on the request, and transmit the file ID to the user device. The user device may divide the file to generate multiple slice files and their corresponding slice IDs. From the user device, the server receives the multiple slice files and the slice IDs. Based on the slice IDs, the server may determine storage addresses at which to store the multiple slice files in a distributed storage system using a consistent hash algorithm. The multiple slice files may be stored based on the corresponding storage addresses of the distrusted storage system.

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