专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US09671276B1 Sterilizable wireless animal scale 有权
公开(公告)号：US09671276B1
公开(公告)日：2017-06-06
申请号：US14631230
申请日：2015-02-25
申请人： Mousera, Inc
发明人： Jonathan Betts-Lacroix , Alexander Izvorski , Kevin Harada
IPC分类号： G01G21/28 , A01K29/00 , A01K63/00
CPC分类号： G01G21/28 , A01K29/00 , A01K63/006 , G01G17/08
摘要： A wireless, sterilizable scale comprising a moving module, on which an animal sits or explores, and a fixed module that measures the weight of the animal on the moving module. The fixed module comprises a compliant membrane or gasket, through which the weight of the moving modules and animal is mechanically coupled. The fixed module comprises three load cells arranged in a triangle so as to support the moving module, through the membrane, such that its tilt is limited. The fixed module is sealed by the membrane and comprises the load cells, batteries and electronics. The fixed module, including an internal moving platform, may be chemically sterilized. The moving module may be sterilized using heat sterilization. IR communication transmits a series of weight values at two different data rates. The scale may be in a sterile cage free of electrical penetrations. A system comprises a vivarium comprising such cages.

2. 发明授权

US09485966B1 Device and method of animal reward 有权
标题翻译：动物奖励的设备和方法
公开(公告)号：US09485966B1
公开(公告)日：2016-11-08
申请号：US14675717
申请日：2015-03-31
申请人： Mousera, Inc
发明人： Jonathan Betts-Lacroix , Timothy L. Robertson , Laura R. Schaevitz
IPC分类号： A01K29/00 , A01K1/03 , A01K15/02 , H05B3/00 , G05D23/19 , H05B33/08
CPC分类号： A01K29/005 , A01K1/031 , A01K15/02 , G05D23/1917 , G05D23/27 , H05B3/0033 , H05B33/0854
摘要： The invention describes an automated method, device and system for both husbandry and study purposes of animals by providing a heat reward for specific behavior. Embodiments include maintaining the cage temperature at a normal, comfortable temperature for the animals, such as mice, using radiant heat rather than conducted heat to provide the reward, using home cages for the animals, detecting the behavior fully automated, operating in animal darkness, and using cages that are free of electrical penetrations. Some embodiments have one animal in a cage. Some embodiments have or support multiple animals in a cage and include methods to detect automatically identify animals, locate animals in the cage and associate a behavior and reward for a specific animal. Some embodiments place all sensors and radiant heat sources outside the cage, or use infrared sources for both heating and for IR camera lighting.
摘要翻译：本发明通过为特定行为提供热报酬来描述用于动物的饲养和研究目的的自动化方法，装置和系统。实施例包括使用辐射热将动物（例如小鼠）的笼温度保持在正常舒适的温度，而不是使用热量提供奖励，使用动物的家庭笼子，检测在动物黑暗中操作的完全自动化的行为，并使用没有电穿透的笼子。一些实施例在笼中具有一只动物。一些实施例具有或支持笼中的多个动物，并且包括检测自动识别动物，在笼中定位动物并关联特定动物的行为和报酬的方法。一些实施例将所有传感器和辐射热源放置在保持架外部，或者使用红外源用于加热和用于IR照相机照明。

3. 发明申请

US20190191665A1 SYSTEM AND METHOD OF MEASURED DRUG EFFICACY USING NON-INVASIVE TESTING 审中-公开
公开(公告)号：US20190191665A1
公开(公告)日：2019-06-27
申请号：US15851222
申请日：2017-12-21
申请人： Mousera, Inc
发明人： Laura Schaevitz , Daniel J. Ford , Jonathan Betts-LaCroix
IPC分类号： A01K1/03 , A01K11/00 , A01K29/00
CPC分类号： A01K1/031 , A01K11/001 , A01K11/005 , A01K11/006 , A01K29/005 , A01K2267/03 , A61B2503/40
摘要： Systems and methods of measuring drug efficacy and side effects using non-invasive or husbandry-only testing are described. Steps include testing a cohort with a proposed husbandry-only protocol against an existing gold-standard treatment, and then validating the use of a created surrogate, non-invasive metric in place of an invasive metric. Then, the validated non-invasive surrogate metric and the husbandry-only protocols are used with an animal treatment cohort to study a new proposed treatment. A control cohort is also used, subject to the same husbandry-only testing and the surrogate metric. A statistical difference in outcomes, using one or more surrogate metrics, between the treatment cohort and the control cohort is the drug efficacy, for a drug used to treat the treatment cohort.

4. 发明申请

US20170000906A1 SYSTEM AND METHOD OF MEASURING EFFICACY OF CANCER THERAPEUTICS 审中-公开
标题翻译：测量癌症治疗效果的系统与方法
公开(公告)号：US20170000906A1
公开(公告)日：2017-01-05
申请号：US14788064
申请日：2015-06-30
申请人： Mousera, Inc
发明人： Jonathan Betts-Lacroix , Laura Schaevitz
IPC分类号： A61K49/00 , H04N7/18 , H04N5/33 , A01K1/03 , A01K29/00
CPC分类号： A61K49/0008 , A01K1/031 , A01K29/005 , A61B5/4848
摘要： The field of this invention is measuring efficacy of cancer treatments. In particular the fields of this invention include studies of drug efficacy, use of animals in medical studies, use of animals in vivariums, and use of rodents, particularly mice. Cells from a neoplasm are injected into subject test animals in a specific organ or a specific location of a specific organ, such as the brain. Some of the subject animals receive therapeutic treatments. The behavior of the animals is observed using fully automatic, continuous monitoring using per-cage sensors, where behavior recording is free of human, manual actions. Observed behavior is consistent with healthy or unhealthy behaviors specific to the injection site. Both positive and negative baseline behaviors are collected, typically using the same system or method. Efficacy is measured by comparing treatments under test to both the positive and negative baselines, using multi-dimensional analysis.
摘要翻译：本发明的领域是测量癌症治疗的疗效。特别地，本发明的领域包括药物功效的研究，动物在医学研究中的使用，在生物体中使用动物，以及使用啮齿动物，特别是小鼠。将来自肿瘤的细胞注射到特定器官或特定器官（例如脑）的特定位置的受检试验动物中。一些受试动物接受治疗。使用全自动连续监测来观察动物的行为，使用每笼式传感器，其中行为记录不含人，手动操作。观察到的行为与注射部位特有的健康或不健康行为一致。收集正和负基线行为，通常使用相同的系统或方法。使用多维分析，通过比较正在进行的治疗与阳性和阴性基线测量功效。

5. 发明申请

US20170000081A1 SYSTEM AND METHOD OF AUTOMATIC CLASSIFICATION OF ANIMAL BEHAVIORS 审中-公开
标题翻译：动物行为自动分类系统与方法
公开(公告)号：US20170000081A1
公开(公告)日：2017-01-05
申请号：US14788094
申请日：2015-06-30
申请人： Mousera, Inc
发明人： Jonathan Betts-Lacroix , Laura Schaevitz
IPC分类号： A01K1/03 , A61M5/178 , A61B19/00 , A01K29/00 , A61B5/00
CPC分类号： A01K1/031 , A01K29/005 , A61B5/4848 , A61B5/6887 , A61B5/7264 , A61B90/11 , A61B90/98 , A61B2503/40 , A61B2503/42 , A61M5/178 , A61M2250/00
摘要： The field of this invention is classifying animal behaviors. In particular the fields of this invention include using animals in vivariums, such as rodents, particularly mice. Animal behaviors are classified according to behaviors consistent with healthy or unhealthy organs or locations within organs, such as the brain. Injected neoplastic cells may be used to create an unhealthy organ or location within an organ. Classifications also include responses to different therapies. The behavior of the animals is observed using fully automatic, continuous monitoring using per-cage sensors, where behavior recording is free of human, manual actions. Observed behavior is consistent with healthy or unhealthy behaviors specific to the injection site. Both positive and negative baseline behaviors are collected, typically using the same system or method. Classification is responsive to differences between treated and untreated animals, comparing to both the positive and negative baselines, using multi-dimensional analysis.
摘要翻译：本发明的领域是对动物行为进行分类。特别地，本发明的领域包括在生物体中使用动物，例如啮齿动物，特别是小鼠。动物行为根据与健康或不健康的器官或器官内的位置（如大脑）相一致的行为进行分类。注射的肿瘤细胞可用于在器官内产生不健康的器官或位置。分类还包括对不同疗法的回应。使用全自动连续监测来观察动物的行为，使用每笼式传感器，其中行为记录不含人，手动操作。观察到的行为与注射部位特有的健康或不健康行为一致。收集正和负基线行为，通常使用相同的系统或方法。使用多维分析，分类对治疗和未经治疗的动物之间的差异有反应，与阳性和阴性基线相比。

6. 发明授权

US09578853B1 Coding for animal ID marking 有权
标题翻译：编码动物标识
公开(公告)号：US09578853B1
公开(公告)日：2017-02-28
申请号：US14872053
申请日：2015-09-30
申请人： Mousera, Inc
发明人： Kyle Howard Heath , Jonathan Betts-Lacroix
IPC分类号： G06K7/10 , A01K11/00
CPC分类号： A01K11/005 , A01K11/006
摘要： Symbologies suitable for use marking codes on rodent tails are disclosed, for both machine-readable and human-readable codes, and those codes combined. Codes comprising both a human-readable and a machine-readable portion may associate with an animal ID within one study, and a study ID within a vivarium, respectively. A human-readable code uses a subset of an alphanumeric symbol set. A machine-readable code uses a vine-code with a visible spine aligned with the rodent's tail. Both symbologies support a system for deleting symbols and correcting codes marked in error. Both symbologies use symbol sets comprising only horizontal and vertical line segments. Both symbologies include a sparse mapping table for mapping marking codes to animal and study ID, and for error detection and for code re-use.
摘要翻译：公开了适用于啮齿动物尾部的标记代码的符号，用于机器可读和人类可读代码，并且这些代码组合在一起。包括人可读和机器可读部分的代码可分别与一个研究内的动物ID和生物体内的研究ID相关联。人类可读的代码使用字母数字符号集的子集。机器可读代码使用具有与啮齿动物尾部对准的可见脊椎的藤编码。两个符号系统都支持删除符号并纠正错误标记的代码。两个符号系统都使用仅包含水平和垂直线段的符号集。两个符号系统都包括用于将标记代码映射到动物和学习ID的稀疏映射表，以及用于错误检测和代码重用。

7. 发明申请

US20170000905A1 DEVICE AND METHOD OF PERSONALIZED MEDICINE 审中-公开
标题翻译：个体化药物的装置和方法
公开(公告)号：US20170000905A1
公开(公告)日：2017-01-05
申请号：US14788118
申请日：2015-06-30
申请人： Mousera, Inc
发明人： Jonathan Betts-Lacroix , Laura Schaevitz
IPC分类号： A61K49/00 , A01K29/00 , A01K1/03 , G01N33/493 , G01N33/497
CPC分类号： A01K29/005 , A01K1/031 , A61K49/0008 , G01N33/493 , G01N33/497
摘要： The field of this invention is personalized medicine. A tissue sample is taken from a patient, optionally amplified, and injected into animals, such as mice in a vivarium. Animals receive one or more therapeutic treatments. Animal behaviors are collected, measured and timed using fully automatic, continuous monitoring using per-cage sensors, where behavior recording is free of human, manual actions. Observed behavior is consistent with healthy or unhealthy behaviors specific to the injection site, typically in a specific organ or location in an organ, such as the brain. The injection site may be consistent with the source site from the patient. Both positive and negative baseline behaviors are collected, typically using the same device or method. Treatment selection is responsive to differences between treated and untreated animals, and between treatments, comparing to both the positive and negative baselines, using multi-dimensional analysis, including side effects.
摘要翻译：本发明的领域是个性化医学。取自患者的组织样品，任选地扩增，并注射到动物体内，如生殖细胞中的小鼠。动物接受一种或多种治疗方法。使用全笼式传感器进行全自动，连续监测来收集，测量和定时动物行为，其中行为记录不需要人工操作。观察到的行为与注射部位特异性的健康或不健康行为一致，通常在器官（如大脑）中的特定器官或位置。注射部位可能与来自患者的源部位一致。收集正和负基线行为，通常使用相同的设备或方法。治疗选择对治疗和未经治疗的动物之间以及处理之间的差异有反应，与正面和负面基线相比，使用多维分析（包括副作用）。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式