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1. 发明授权

US5308769A Cancer-related human galactosyltransferase GT-II 失效
标题翻译：癌症相关人类半乳糖基转移酶GT-II
公开(公告)号：US5308769A
公开(公告)日：1994-05-03
申请号：US911273
申请日：1992-07-09
申请人： Morito Uemura , Shinya Yoshida , Takao Uejima
发明人： Morito Uemura , Shinya Yoshida , Takao Uejima
IPC分类号： C07K16/40 , C12N9/10 , A61K39/00
CPC分类号： C12N9/1051 , C07K16/40 , Y10S435/815
摘要： A substantially purified cancer-related galactosyltransferase and a monoclonal antibody which may be used as a diagnostic reagent of cancer are disclosed. The galactosyltransferase of the present invention has a molecular weight of about 50,000 determined by SDS-polyacrylamide gel electrophoresis under reducing conditions and has a reactivity with MAb4880 under native conditions. A part of the galactosyltransferase self-associates and its reactivity with MAb4880 and the degree of self-association are promoted when it is reduced so that a part of which is detected in a fraction of a molecular weight of not less than 200,000 in gel permeation chromatography. The galactosyltransferase of the present invention can be used as a cancer marker or as a reagent for preparing a monoclonal antibody with a specificity to the galactosyltransferase, which monoclonal antibody can be used as a diagnostic of a cancer. The monoclonal antibody of the invention specifically reacts with the cancer-related galactosyltransferase of the invention.
摘要翻译：公开了可用作癌症诊断试剂的基本上纯化的癌相关半乳糖基转移酶和单克隆抗体。本发明的半乳糖基转移酶在还原条件下通过SDS-聚丙烯酰胺凝胶电泳测定的分子量约为50,000，并且在天然条件下具有与MAb4880的反应性。一部分半乳糖基转移酶自身缔合物及其与MAb4880的反应性和自身结合程度在减少时促进其部分在凝胶渗透色谱法中以分子量不低于20万的分数检测。本发明的半乳糖基转移酶可以用作癌症标记物或用作制备对半乳糖基转移酶特异性的单克隆抗体的试剂，该单克隆抗体可以用作癌症的诊断。本发明的单克隆抗体与本发明的与癌症相关的半乳糖基转移酶特异性地反应。

2. 发明授权

US4562138A Nitrogen-containing heterocyclic blocked mercapto development inhibitors 失效
标题翻译：含氮杂环阻断巯基显影抑制剂
公开(公告)号：US4562138A
公开(公告)日：1985-12-31
申请号：US642695
申请日：1984-08-21
申请人： Morito Uemura , Kaoru Onodera
发明人： Morito Uemura , Kaoru Onodera
IPC分类号： C07D257/04 , G03C7/305 , G03C8/08 , G03C5/54 , G03C1/34 , G03C1/40
CPC分类号： C07D257/04 , G03C7/305 , G03C8/08 , Y10S430/158 , Y10S430/161
摘要： This invention relates to nitrogen containing heterocyclic compounds represented by the general formula ##STR1## wherein Z is non-metallic atoms necessary to form a tetrazole, a benzotriazole or a benzothiazole, either substituted or unsubstituted, n is either 1 or 2 and R is alkyl or phenyl. The above mentioned compounds can be suitably used in a photographic material as a development inhibitor precursor.
摘要翻译：本发明涉及由通式“IMAGE”表示的含氮杂环化合物，其中Z是形成四唑，苯并三唑或苯并噻唑所需的非金属原子，其为取代或未取代的，n为1或2，R为烷基或苯基。上述化合物可以适合用于照相材料中作为显影抑制剂前体。

3. 发明授权

US4433046A Silver halide photographic material 失效
标题翻译：卤化银照相材料
公开(公告)号：US4433046A
公开(公告)日：1984-02-21
申请号：US383318
申请日：1982-05-28
申请人： Morito Uemura , Kenichi Kishi , Satoshi Nakagawa , Shuji Kida
发明人： Morito Uemura , Kenichi Kishi , Satoshi Nakagawa , Shuji Kida
IPC分类号： G03C7/34 , C07D231/22 , C07D231/26 , C09B26/02 , C09B53/00 , G03C7/305 , G03C7/16 , G03C7/26
CPC分类号： G03C7/30523 , C07D231/22 , C07D231/26
摘要： The invention relates to silver halide photographic materials comprising a support and a light sensitive silver halide emulsion layer containing as a cyan-dye-forming coupler a compound of the formula ##STR1## wherein R.sub.1 is a halogen atom, an alkyl, alkoxy or acylamino group; R.sub.2 and R.sub.3 are individually a hydrogen atom, an alkyl or aryl group and R.sub.2 and R.sub.3 may form a heterocyclic group by the condensation thereof; n is an integer of 0-3; R.sub.4 is an alkyl, aryl, acyl or heterocyclic group; R.sub.5 is an alkyl, aryl, alkoxy, amino, acylamino, sulfonamide, carboxy, alkoxycarbonyl, carbamoyl, cyano or halogenated alkyl group; and R.sub.6 is a hydrogen atom or an alkyl, alkoxy, carboxy, carbamoyl, hydroxy, acyloxy, nitro, amino, azo, acylamino, sulfonamide or acyl group.
摘要翻译：本发明涉及包含载体的卤化银照相材料和含有形成青色染料的成色剂的光敏卤化银乳剂层，其中式（Ⅰ）化合物（2）其中R1是卤素原子，烷基，烷氧基或酰氨基; R2和R3分别是氢原子，烷基或芳基，R2和R3可以通过其结合形成杂环基; n为0-3的整数; R4是烷基，芳基，酰基或杂环基; R5是烷基，芳基，烷氧基，氨基，酰氨基，磺酰胺，羧基，烷氧基羰基，氨基甲酰基，氰基或卤代烷基; 羧基，氨基甲酰基，羟基，酰氧基，硝基，氨基，偶氮，酰氨基，磺酰胺或酰基。

4. 发明授权

US4256831A Light-sensitive photographic element comprising a magenta image dye-providing compound 失效
公开(公告)号：US4256831A
公开(公告)日：1981-03-17
申请号：US68508
申请日：1979-08-22
申请人： Masaru Kanbe , Kazumasa Watanabe , Morito Uemura , Jiro Takahashi , Ryuichiro Kobayashi , Tatsuhiko Kobayashi
发明人： Masaru Kanbe , Kazumasa Watanabe , Morito Uemura , Jiro Takahashi , Ryuichiro Kobayashi , Tatsuhiko Kobayashi
IPC分类号： G03C7/00 , C09B29/01 , C09B29/28 , G03C8/10 , G03C1/10 , G03C1/40 , G03C5/54
CPC分类号： G03C8/10 , C09B29/0003 , C09B29/28
摘要： A light-sensitive photographic element comprising a support and at least one light-sensitive silver halide emulsion layer coated thereon having associated therewith a magenta image dye-providing compound which releases a magenta dye or a precursor thereof corresponding to the imagewise exposure of said emulsion layer, said magenta dye-providing compound being a compound represented by formula [I]: ##STR1## wherein Car represents a carrier moiety which can be oxidized under alkaline conditions to release a diffusible dye or a precursor thereof from said compound;R.sup.1 and R.sup.2, which may be the same or different, independently represent a hydrogen atom or an alkyl group having 1 to 3 carbon atoms (provided that the total sum of carbon atoms in R.sup.1 and R.sup.2 does not exceed 5), or R.sup.1 and R.sup.2 may form, together with the nitrogen atom, ##STR2## X represents a hydroxyl group, a salt thereof or a group, which can be converted into a hydroxyl group by hydrolysis, having the following formula: ##STR3## in which R.sup.3 represents an alkyl or haloalkyl group having 1 to 18 carbon atoms or a phenyl group which may be substituted; Y represents a ##STR4## group in which R.sup.4 and R.sup.5, which may be the same or different, independently represent a hydrogen atom, an alkyl group having 1 to 6 carbon atoms or a cycloalkyl group (provided that the total sum of carbon atoms in R.sup.4 and R.sup.5 does not exceed 6);Z represents a hydrogen atom, a chlorine atom, a methyl group or a methoxy group;l is 1 or 2 provided that when l is 2 each Z may be the same or different;m is 0 or 1;andJ represents a bivalent linking group having the formula --R.sup.6 --(O).sub.n --R.sub.p.sup.7 -- in which R.sup.6 and R.sup.7, which may be the same or different, independently represent an alkylene group having 1 to 8 carbon atoms, a phenylene group which may be substituted; n represents 0 or 1; p represents 0 or 1 provided that p is 1 when n is 1 and 1 or 0 when n is 0 (provided that, when p is 1, the total sum of carbon atoms in R.sup.6 and R.sup.7 does not exceed 13).

5. 发明授权

US4247629A Light-sensitive photographic element comprising a cyan image dye-providing compound 失效
标题翻译：感光照相材料，其包含提供青色图像染料的化合物
公开(公告)号：US4247629A
公开(公告)日：1981-01-27
申请号：US68517
申请日：1979-08-22
申请人： Masaru Kanbe , Kazumasa Watanabe , Morito Uemura , Jiro Takahashi , Ryuichiro Kobayashi , Tatsuhiko Kobayashi
发明人： Masaru Kanbe , Kazumasa Watanabe , Morito Uemura , Jiro Takahashi , Ryuichiro Kobayashi , Tatsuhiko Kobayashi
IPC分类号： G03C7/00 , C09B29/01 , C09B29/28 , G03C8/10 , G03C1/40 , G03C1/10
CPC分类号： C09B29/28 , C09B29/0003 , G03C8/10
摘要： A light-sensitive photographic element comprising a support and at least one light-sensitive silver halide emulsion layer coated thereon having associated therewith a cyan image dye-providing compound which releases a cyan dye or a precursor thereof corresponding to the imagewise exposure of said emulsion layer, said cyan image dye-providing compound being a compound represented by formula [I] or [II]: ##STR1## wherein Car, R.sup.1, R.sup.2, X, Y.sup.1, Y.sup.2, m, J.sup.1 and J.sup.2 are defined in the specification and claims.
摘要翻译：一种感光照相材料，其包括载体和涂覆有至少一种感光卤化银乳剂层，其上与其相关联的青色图像染料提供化合物，其释放相应于所述乳剂层的成像曝光的青色染料或其前体所述提供青色图像染料的化合物是由式[I]或[II]表示的化合物：其中Car，R 1，R 2，X，Y 1，Y 2，m，J 1 和J2在说明书和权利要求书中定义。

6. 发明授权

US4225708A 2-Sulfamoyl-5-sulfamido-1-naphthols 失效
标题翻译： 2-氨磺酰基-5-亚磺酰氨基-1-萘酚
公开(公告)号：US4225708A
公开(公告)日：1980-09-30
申请号：US68518
申请日：1979-08-22
申请人： Masaru Kanbe , Kazumasa Watanabe , Morito Uemura , Jiro Takahashi , Ryuichiro Kobayashi , Tatsuhiko Kobayashi
发明人： Masaru Kanbe , Kazumasa Watanabe , Morito Uemura , Jiro Takahashi , Ryuichiro Kobayashi , Tatsuhiko Kobayashi
IPC分类号： C07C67/00 , C07C301/00 , C07C307/10 , C07D295/26 , C09B29/01 , C09B29/28 , G03C8/10 , C07C143/78
CPC分类号： C07D295/26 , C09B29/0003 , C09B29/28 , G03C8/10
摘要： 2-Sulfamoyl-5-sulfamido-1-naphthols represented by the formula: ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 can be the same or different and each represent a hydrogen atom, a straight-chain alkyl group, a branched alkyl group or a cycloalkyl group; or R.sup.1 and R.sup.2 can be connected with each other, together with the nitrogen atom, to form a ##STR2##
摘要翻译：由下式表示的2-磺酰氨基-5-亚磺酰氨基-1-萘酚：其中R 1，R 2，R 3和R 4可以相同或不同，各自表示氢原子，直链烷基，支链烷基基团或环烷基; 或者R1和R2可以与氮原子一起彼此连接形成

7. 发明授权

US4797356A Monoclonal antibodies specific to glactosyltransferase isoenzyme II and their use in cancer immunoassays 失效
标题翻译：对乳糖基转移酶同工酶II特异性的单克隆抗体及其在癌症免疫测定中的应用
公开(公告)号：US4797356A
公开(公告)日：1989-01-10
申请号：US803818
申请日：1985-12-02
申请人： Alan E. Brandt , Morito Uemura
发明人： Alan E. Brandt , Morito Uemura
IPC分类号： G01N33/573 , C07K14/005 , C07K14/195 , C07K16/00 , C07K16/30 , C07K16/40 , C07K19/00 , C12N5/10 , C12N7/00 , C12N15/02 , C12P21/08 , C12R1/91 , G01N33/577 , G01N33/53
CPC分类号： C07K16/40 , C07K16/30 , Y10S436/813
摘要： Murine monoclonal antibodies specific to the tumor marker galactosyltransferase II (GT-II) which have no measurable cross-reactivity with galactosyltransferase I (GT-I) are described. These antibodies are used in assays to determine levels of GT-II in serum or other body fluid samples, which levels, depending on their magnitude, are indicators of cancer.
摘要翻译：描述了与半乳糖基转移酶I（GT-1）不具有可测量交叉反应性的肿瘤标志物半乳糖基转移酶II（GT-II）特异性的鼠单克隆抗体。这些抗体用于测定，以确定GT-II ikn血清或其他体液样品的水平，其水平取决于其大小，是癌症的指标。

8. 发明授权

US4482629A Light-sensitive silver halide color photographic material 失效
标题翻译：感光卤化银彩色照相材料
公开(公告)号：US4482629A
公开(公告)日：1984-11-13
申请号：US475857
申请日：1983-03-16
申请人： Satoshi Nakagawa , Hiroshi Sugita , Shuzi Kida , Morito Uemura , Ken-ichi Kishi
发明人： Satoshi Nakagawa , Hiroshi Sugita , Shuzi Kida , Morito Uemura , Ken-ichi Kishi
IPC分类号： G03C7/26 , C07D257/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D417/12 , C07D417/14 , G03C7/305 , G03C7/34
CPC分类号： C07D257/04 , C07C243/00 , G03C7/30523 , Y10S430/156 , Y10S430/158 , Y10S430/161
摘要： There is disclosed a light-sensitive silver halide photographic material containing a compound represented by the formula (I): ##STR1## wherein G, R.sub.1, R.sub.2 and X have the same meanings as defined in the specification.The 1-naphthol coupler which is contained in the light-sensitive silver halide photographic material is high in reactivity with an oxidized product of a color forming developing agent and can efficiently impart imagewise photographic effects to light-sensitive silver halide photographic materials.
摘要翻译：公开了含有式（I）表示的化合物的光敏卤化银照相材料：其中G，R 1，R 2和X具有与说明书中所定义相同的含义。包含在感光卤化银照相材料中的1-萘酚成色剂与成色显影剂的氧化产物的反应性高，并且可以有效地赋予感光卤化银照相材料成像照相效果。

9. 发明授权

US4438193A Silver halide photosensitive color photographic material 失效
标题翻译：卤化银感光彩色感光材料
公开(公告)号：US4438193A
公开(公告)日：1984-03-20
申请号：US332962
申请日：1981-12-21
申请人： Morito Uemura , Kenichi Kishi , Satoshi Nakagawa , Shuji Kida
发明人： Morito Uemura , Kenichi Kishi , Satoshi Nakagawa , Shuji Kida
IPC分类号： G03C7/26 , G03C7/305 , G03C7/32 , G03C1/46
CPC分类号： G03C7/305 , G03C7/32
摘要： There is disclosed a novel silver halide photosensitive color photographic material comprising a coupler which consists of a coupling component (A) which is capable of causing a coupling reaction with an oxidized color developing agent and a substituent component bonded at the coupling position of said coupling component (A), which substituent component is capable of being split off on coupling reaction, the improvement characterized in that said substituent comprises a coupling component (B) which can undergo coupling reaction with an oxidized color developing agent when released from said coupling component (A) and a photographically useful component which is capable of being released on coupling reaction of said coupling component (B).The color photographic material according to the present invention provides graininess, sharpness and color reproducibility which is sufficiently competent to the requirement of further miniturization of film size by use of a coupler having novel functions.
摘要翻译：公开了一种新型的卤化银感光彩色感光材料，其特征在于，包括一种耦合器，该耦合器由能够引起与氧化的彩色显影剂的偶联反应的偶合组分（A）和在所述偶合组分（A），该取代基组分能够在偶联反应中分裂，其改进之处在于所述取代基包括偶联组分（B），当从所述偶合组分（A）释放时，其可以与氧化的彩色显影剂发生偶联反应）和能够在所述偶联组分（B）的偶联反应时释放的照相有用组分。根据本发明的彩色照相材料提供了通过使用具有新功能的成色剂足以满足膜尺寸进一步微小化的要求的颗粒度，清晰度和颜色再现性。

10. 发明授权

US4421845A Silver halide photographic light-sensitive material 失效
标题翻译：卤化银照相感光材料
公开(公告)号：US4421845A
公开(公告)日：1983-12-20
申请号：US357149
申请日：1982-03-11
申请人： Morito Uemura , Kenichi Kishi , Satoshi Nakagawa , Shuji Kida , Hiroshi Sugita
发明人： Morito Uemura , Kenichi Kishi , Satoshi Nakagawa , Shuji Kida , Hiroshi Sugita
IPC分类号： G03C7/26 , C07D231/14 , C07D231/18 , C07D231/20 , C07D231/22 , C07D231/38 , C07D231/50 , C07D231/54 , C07D403/12 , C07D413/12 , C07D417/14 , C07D487/04 , G03C1/06 , G03C7/305 , G03C7/32 , G03C1/40
CPC分类号： C07D403/12 , C07D231/14 , C07D231/22 , G03C7/305 , Y02P20/55
摘要： A silver halide photographic light-sensitive material which comprises at least one of those pyrazole compounds represented by the following general formula: ##STR1## wherein A is a group which can be eliminated in a photographic process condition; X is ##STR2## wherein R.sub.5 is a hydrogen atom or an alkyl, an aryl, an acyl or a sulfone group, which R.sub.5 group may combine together with R.sub.1 to form a condensed ring; R.sub.1 is a hydrogen atom or an alkyl, an aryl, an acyl, a sulfone, an alkoxy, or a heterocyclic residue; R.sub.2 is a hydrogen atom or an alkyl, an aryl, an alkoxy, an amino, an acid amide, a sulfonamide, a carboxyl, an alkoxycarbonyl, a carbamoyl, a cyano, or a halogenated alkyl group, R.sub.3 and R.sub.4 each is a hydrogen atom or an alkyl or an aryl group; and PUG is a photographically useful group which is released after elimination of the A group in a photographic processing condition and which has a hetero atom directly combined with the carbon substituted in the fourth position of the pyrazole nucleus.
摘要翻译：一种卤化银照相感光材料，其包含由以下通式表示的那些吡唑化合物中的至少一种：其中A是在照相工艺条件下可被除去的基团; X为，其中R 5为氢原子或烷基，芳基，酰基或砜基，该R 5基团可与R 1一起形成稠环; R1是氢原子或烷基，芳基，酰基，砜，烷氧基或杂环残基; R2是氢原子或烷基，芳基，烷氧基，氨基，酰胺，磺酰胺，羧基，烷氧基羰基，氨基甲酰基，氰基或卤代烷基，R3和R4各自为氢原子或烷基或芳基; PUG是在摄影处理条件下消除A组后释放的具有照射有用的基团，其具有与在吡唑核的第四位置取代的碳直接结合的杂原子。

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