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1. 发明授权

US09006456B2 Processes for the preparation of thietanamine 有权
标题翻译：制备泰安胺的方法
公开(公告)号：US09006456B2
公开(公告)日：2015-04-14
申请号：US14131284
申请日：2012-07-05
申请人： Jerome Yves Cassayre , Edouard Godineau , Mohamed Abdelouahab Boussemghoune , Helmars Smits
发明人： Jerome Yves Cassayre , Edouard Godineau , Mohamed Abdelouahab Boussemghoune , Helmars Smits
IPC分类号： C07D331/04 , C07D409/12 , C07D409/04
CPC分类号： C07D331/04 , C07D409/04 , C07D409/12
摘要： The present invention provides processes for the preparation of compounds of formula (I) including processes comprising a. reacting a compound of formula (II) with a nucleophile in the presence of water to give a compound comprising a thietane moiety in which the carbon atom at the 3 position of the thietane moiety is bonded to a nitrogen atom; wherein the nucleophile is selected the group consisting of: N3−, a sulfonamide having two hydrogen atoms bound to the nitrogen atom, a diimide having a hydrogen atom bound to the nitrogen atom or an anion thereof, NH2OH and NH3; and b. when the nucleophile used in step a. is N3− or NH2OH, reacting the compound produced in step a. with a suitable reducing agent to give a compound of formula (I); or when the nucleophile used in step a. is a sulfonamide, reacting the compound produced in step a. with a reagent suitable for cleaving the S—N bond of the sulfonamide group to give a compound of formula (I); or when the nucleophile used in step a. is a diimide, reacting the compound produced in step a. with a reagent suitable for cleaving the C—N bond of the amide group to give a compound of formula (I). The invention also relates to intermediates useful for the preparation of compounds of formula (I).
摘要翻译：本发明提供制备式（I）化合物的方法，包括以下步骤：a。在水存在下使式（II）化合物与亲核试剂反应，得到包含硫杂环丁烷部分的化合物，其中硫杂环丁烷部分的3位的碳原子与氮原子结合; 其中所述亲核试剂选自：N 3 - ，具有与氮原子结合的2个氢原子的磺酰胺，具有与氮原子结合的氢原子的二酰亚胺或其阴离子，NH 2 OH和NH 3; 和b。当步骤a中使用亲核试剂时。是N 3 - 或NH 2 OH，使步骤a中制备的化合物。与合适的还原剂反应，得到式（I）化合物; 或当步骤a中使用的亲核试剂时。是磺酰胺，使步骤a中制备的化合物反应。用适于切割磺酰胺基团的S-N键的试剂得到式（I）化合物; 或当步骤a中使用的亲核试剂时。是二酰亚胺，使步骤a中制备的化合物反应。用适于切割酰胺基团的C-N键的试剂得到式（I）的化合物。本发明还涉及可用于制备式（I）化合物的中间体。

2. 发明申请

US20140187788A1 PROCESSES FOR THE PREPARATION OF THIETANAMINE 有权
标题翻译：制备噻吩胺的方法
公开(公告)号：US20140187788A1
公开(公告)日：2014-07-03
申请号：US14131284
申请日：2012-07-05
申请人： Jerome Yves Cassayre , Edouard Godineau , Mohamed Abdelouahab Boussemghoune , Helmars Smits
发明人： Jerome Yves Cassayre , Edouard Godineau , Mohamed Abdelouahab Boussemghoune , Helmars Smits
IPC分类号： C07D331/04 , C07D409/04
CPC分类号： C07D331/04 , C07D409/04 , C07D409/12
摘要： The present invention provides processes for the preparation of compounds of formula (I) including processes comprising a. reacting a a compound comprising a thietane moiety in which the carbon atom at the 3 position of the thietane moiety is bonded to a nitrogen atom; wherein the nucleophile is selected the group consisting of: N3−, a sulfonamide having two hydrogen atoms bound to the nitrogen atom, a diimide having a hydrogen atom bound to the nitrogen atom or an anion thereof, NH2OH and NH3; and b. when the nucleophile used in step a. is N3− or NH2OH, reacting the compound produced in step a. with a suitable reducing agent to give a compound of formula (I); or when the nucleophile used in step a. is a sulfonamide, reacting the compound produced in step a. with a reagent suitable for cleaving the S—N bond of the sulfonamide group to give a compound of formula (I); or when the nucleophile used in step a. is a diimide, reacting the compound produced in step a. with a reagent suitable for cleaving the C—N bond of the amide group to give a compound of formula (I). The invention also relates to intermediates useful for the preparation of compounds of formula (I).
摘要翻译：本发明提供制备式（I）化合物的方法，包括以下步骤：a。使含有硫杂环丁烷部分的化合物与硫原子部分3位的碳原子键合在氮原子上; 其中所述亲核试剂选自：N 3 - ，具有与氮原子结合的2个氢原子的磺酰胺，具有与氮原子结合的氢原子的二酰亚胺或其阴离子，NH 2 OH和NH 3; 和b。当步骤a中使用亲核试剂时。是N 3 - 或NH 2 OH，使步骤a中制备的化合物。与合适的还原剂反应，得到式（I）化合物; 或当步骤a中使用的亲核试剂时。是磺酰胺，使步骤a中制备的化合物反应。用适于切割磺酰胺基团的S-N键的试剂得到式（I）化合物; 或当步骤a中使用的亲核试剂时。是二酰亚胺，使步骤a中制备的化合物反应。用适于切割酰胺基团的C-N键的试剂得到式（I）的化合物。本发明还涉及可用于制备式（I）化合物的中间体。

3. 发明申请

US20120053053A1 PYRIMIDINE DERIVATIVES AND THEIR USE AS HERBICIDES 审中-公开
标题翻译：吡嗪衍生物及其作为除草剂的用途
公开(公告)号：US20120053053A1
公开(公告)日：2012-03-01
申请号：US13201101
申请日：2010-02-11
申请人： Mohamed Abdelouahab Boussemghoune , William Guy Whittingham , Caroline Louise Winn , Harry Glithro , Mary Bernadette Aspinall
发明人： Mohamed Abdelouahab Boussemghoune , William Guy Whittingham , Caroline Louise Winn , Harry Glithro , Mary Bernadette Aspinall
IPC分类号： A01N43/54 , C07D239/42 , C07D239/38 , C07D239/34 , C07D239/52 , A01P13/00 , C07C257/18 , A01N25/32 , C07D239/28 , C07D405/10 , C07D239/30 , C07D239/56
CPC分类号： C07D239/34 , A01N43/54 , C07D239/32 , C07D239/36 , C07D239/42
摘要： The present invention relates to substituted pyrimidine derivatives, as well as N-oxides thereof and agriculturally acceptable salts thereof, and their use to control undesired plant growth, in particular in crops of useful plants. The invention extends to herbicidal compositions comprising such compounds, N-oxides and/or salts as well as mixtures of the same with one or more further active ingredient (such as, for example, an herbicide, fungicide, insecticide and/or plant growth regulator) and/or a safener. The invention further relates to intermediates useful in the preparation of such compounds, and to processes for their preparation.
摘要翻译：本发明涉及取代的嘧啶衍生物及其N-氧化物及其农业上可接受的盐，以及它们用于控制不期望的植物生长，特别是在有用植物的作物中的用途。本发明涉及除草组合物，其包含这些化合物，N-氧化物和/或盐以及其与一种或多种其它活性成分（例如除草剂，杀真菌剂，杀虫剂和/或植物生长调节剂）的混合物）和/或安全剂。本发明还涉及可用于制备这些化合物的中间体及其制备方法。

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