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1. 发明授权

US06943159B1 Compounds and their use as positive AMPA receptor modulators 失效
标题翻译：化合物及其作为阳性AMPA受体调节剂的用途
公开(公告)号：US06943159B1
公开(公告)日：2005-09-13
申请号：US09641814
申请日：2000-08-18
申请人： Alex Haahr Gouliaev , Mogens Larsen , Thomas Varming , Claus Mathiesen , Tina Holm Johansen , Jørgen Scheel-Krüger , Gunnar M. Olsen , Elsebet Østergaard Nielsen
发明人： Alex Haahr Gouliaev , Mogens Larsen , Thomas Varming , Claus Mathiesen , Tina Holm Johansen , Jørgen Scheel-Krüger , Gunnar M. Olsen , Elsebet Østergaard Nielsen
IPC分类号： C07D239/90 , C07D285/24 , C07D285/28 , C07D417/04 , C07D513/04 , A61K31/505 , A61K31/54 , C07D401/04 , C07D403/04
CPC分类号： C07D417/04 , C07D239/90 , C07D285/24 , C07D285/28 , C07D513/04
摘要： The invention provides novel compounds represented by general formula (I) wherein the bond represented by the broken line may be a single, double bond or absent; and if the bond is absent, then the nitrogen is substituted with a hydrogen and R2; X represents SO2 or C═O of CH2; Y represents —CH(R4)—, —N(R4)—CH2—, O; and the meaning of R2, R3, R4, R5, R6, R7, and R8 are as defined in the application. The compounds are useful as positive modulators of the AMPA-receptor.
摘要翻译：本发明提供由通式（I）表示的新型化合物，其中由虚线表示的键可以是单键或双键或不存在; 并且如果该键不存在，则氮被氢和R 2取代; X表示CH 2 2的SO 2或C-O; Y表示-CH（R 4） - ， - N（R 4） - CH 2 - ，O; 并且R 2，R 3，R 4，R 5，R 6，R 6， / SUP>，R 7和R 8如申请中所定义。该化合物可用作AMPA受体的阳性调节剂。

2. 发明申请

US20120196889A1 CATECHOLAMINE DERIVATIVES AND PRODRUGS THEREOF 审中-公开
标题翻译： CATECHOLAMINE衍生物及其制剂
公开(公告)号：US20120196889A1
公开(公告)日：2012-08-02
申请号：US13202579
申请日：2010-02-24
申请人： Benny Bang-Andersen , Mogens Larsen , Klaus Gundertofte , Morten Jorgensen , Jennifer Larsen , Niels Mork , HåKan Wikström
发明人： Benny Bang-Andersen , Mogens Larsen , Klaus Gundertofte , Morten Jorgensen , Jennifer Larsen , Niels Mork , HåKan Wikström
IPC分类号： A61K31/4741 , A61K31/407 , C07D209/80 , C07D491/056 , C07D221/06 , A61K31/473 , A61K31/404
CPC分类号： C07D221/10 , C07D491/08
摘要： The present invention relates to novel catecholamine derivatives of Formula I, to processes for their preparation, pharmaceutical compositions containing them and to their use in therapy.
摘要翻译：本发明涉及式I的新型儿茶酚胺衍生物，其制备方法，含有它们的药物组合物及其在治疗中的用途。

3. 发明申请

US20060264485A1 Pro-drugs of N-thiazol-2-yl-benzamide derivatives 失效
标题翻译： N-噻唑-2-基 - 苯甲酰胺衍生物的前药
公开(公告)号：US20060264485A1
公开(公告)日：2006-11-23
申请号：US11409884
申请日：2006-04-24
申请人： Anette Sams , Benny Bang-Andersen , Gitte Mikkelsen , Mogens Larsen
发明人： Anette Sams , Benny Bang-Andersen , Gitte Mikkelsen , Mogens Larsen
IPC分类号： A61K31/426
CPC分类号： C07D277/46 , C07D417/12
摘要： The invention relates to compounds of the formula I A-B-Z I wherein the variables are as defined in the claims. The compounds are pro-drugs of A2A-receptor ligands with improved aqueous solubility, and are useful in the treatment of neurological and psychiatric disorders where an A2A-receptor is implicated.
摘要翻译：本发明涉及式I的化合物<？in-line-formula description =“In-line Formulas”end =“lead”？> ABZ I <？in-line-formula description =“In-line Formulas”end = “尾”→其中变量如权利要求中所定义。这些化合物是具有改善的水溶性的A 2AA-受体配体的前药，并且可用于治疗其中涉及2A2受体的神经和精神障碍。

4. 发明申请

US20100093864A1 ANTI-INFECTIVE THIOUREA COMPOUNDS 审中-公开
标题翻译：抗感染性硫脲化合物
公开(公告)号：US20100093864A1
公开(公告)日：2010-04-15
申请号：US12445434
申请日：2007-10-12
申请人： Simon Feldbaek Nielsen , Arsalan Kharazmi , Mogens Larsen
发明人： Simon Feldbaek Nielsen , Arsalan Kharazmi , Mogens Larsen
IPC分类号： A61K31/17 , C07C335/16 , A61P31/04 , A61P31/10
CPC分类号： A61K31/17 , C07C335/16
摘要： The present application discloses thiourea compounds for use in the treatment of infections. The thiourea compounds have formula (I) wherein X1 and X2 each designate one or more substituents; and Z is —(CHR)—, —(CHR)2—, —O—(CHR)2—, —NH—(CHR)2—, or —S—(CHR)2—; including salts thereof.
摘要翻译：本申请公开了用于治疗感染的硫脲化合物。硫脲化合物具有式（I），其中X 1和X 2各自表示一个或多个取代基; 并且Z是 - （CHR） - ， - （CHR）2 - ， - （CHR）2 - ， - NH-（CHR）2 - 或-S-（CHR）包括其盐。

5. 发明申请

US20090247593A1 N-THIAZOL-2-YL-BENZAMIDE DERIVATIVES 审中-公开
公开(公告)号：US20090247593A1
公开(公告)日：2009-10-01
申请号：US12339438
申请日：2008-12-19
申请人： Anette Graven Sams , Mogens Larsen , Gitte Mikkelsen
发明人： Anette Graven Sams , Mogens Larsen , Gitte Mikkelsen
IPC分类号： A61K31/426 , C07D277/46 , A61P25/28 , A61P25/16 , A61P25/08 , A61P25/00 , A61P9/10 , A61P25/24 , A61P25/18
CPC分类号： C07D277/46 , A61K31/426
摘要： The invention relates to compounds of the formula I wherein the variables are as defined in the claims. The compounds are A2A-receptor ligands, such as antagonists, agonists, reverse agonists or partial agonists, and are useful in the treatment of neurological and psychiatric disorders where an A2A-receptor is implicated.
摘要翻译：本发明涉及式I化合物，其中变量如权利要求中所定义。化合物是A2A受体配体，例如拮抗剂，激动剂，反向激动剂或部分激动剂，并且可用于治疗涉及A2A受体的神经和精神疾病。

6. 发明申请

US20060235073A1 Diamino-functional chalcones 失效
标题翻译：二氨基功能查尔酮
公开(公告)号：US20060235073A1
公开(公告)日：2006-10-19
申请号：US10514821
申请日：2003-05-19
申请人： Simon Nielsen , Kristian Schønning , Hasse Kromann , Thomas Boesen , Mogens Larsen
发明人： Simon Nielsen , Kristian Schønning , Hasse Kromann , Thomas Boesen , Mogens Larsen
IPC分类号： A61K31/277 , A61K31/165 , A61K31/137 , C07C255/50 , C07C225/02
CPC分类号： C07C233/36 , C07C45/00 , C07C45/44 , C07C47/277 , C07C47/55 , C07C47/575 , C07C49/813 , C07C217/22 , C07C225/16 , C07C225/22 , C07C233/33 , C07C237/04 , C07C255/56 , C07C311/21 , C07C323/32 , C07D213/65 , C07D295/088 , C07D295/112 , C07D295/185 , C07D307/79 , C07D309/12 , C07D317/66
摘要： The invention provides novel diamino-functionalised chalcone derivatives and analogues thereof. Use of the compounds, or compositions comprising them, as pharmaceutically active agents, in particular against bacterial and parasitic infections, is also disclosed. The invention further relates to a method for detecting inhibitory effects against e.g., bacteria, parasites, fungi, and helminths. The chalcones of the invention carry amino substituents and exhibit enhanced biological effects combined with improved metabolic and physicochemical properties, making the compounds useful as drug substances, in particular as antiparasitic and bacteriostatic agents.
摘要翻译：本发明提供新的二氨基官能化查耳酮衍生物及其类似物。还公开了将化合物或其组合物用于药物活性剂，特别是抗细菌和寄生虫感染的用途。本发明还涉及用于检测对例如细菌，寄生虫，真菌和蠕虫的抑制作用的方法。本发明的查尔酮携带氨基取代基并表现出增强的生物效应以及改善的代谢和物理化学性质，使得该化合物可用作药物物质，特别是作为抗寄生虫和抑菌剂。

7. 发明授权

US06367712B1 Boom structure 有权
标题翻译：动臂结构
公开(公告)号：US06367712B1
公开(公告)日：2002-04-09
申请号：US09619291
申请日：2000-07-19
申请人： Mogens Larsen
发明人： Mogens Larsen
IPC分类号： B05B120
CPC分类号： A01M7/0071 , A01M7/0075
摘要： The present invention relates to a boom structure for an agricultural implement (1), wherein a pivot link connects a boom section (20) with a frame (10), and actuator means (18) being capable of generating a desired pivoting of the boom section (20) about an axis (A). The pivot link is characterized by comprising a first link part (40) which is connected with the actuator means (18), and which is pivotally secured to the frame (10) to be capable of pivoting about said pivot axis (A), a second link part (50) which is connected with the boom section (20), and which is pivotally secured to the frame (10) to be capable of pivoting about said pivot axis (A), and shock absorbing means (44, 44′, 46, 46′) arranged between the first link part (40) and the second link part (50), said pivot link (30) being moreover adapted, by activation of the actuator means (18), to generate said desired pivoting of the boom section (20) by pivoting about the pivoting axis (A) of the first link part (40) and the second link part (50).
摘要翻译：技术领域本发明涉及一种用于农具（1）的动臂结构，其中枢转连杆将动臂部分（20）与框架（10）连接，以及致动器装置（18）能够产生所需的枢轴（20）围绕轴线（A）。枢转连杆的特征在于包括与致动器装置（18）连接并且枢转地固定到框架（10）以能够围绕所述枢转轴线（A）枢转的第一连杆部分（40）第二连杆部分（50），其与所述悬臂部分（20）连接，并且枢转地固定到所述框架（10）以能够围绕所述枢转轴线（A）枢转;以及减震装置（44,44' ，46,46'），所述枢转连杆（30）还可以通过所述致动器装置（18）的启动而适于产生所述第一连杆部分（40）和所述第二连杆部分悬臂部分（20）通过围绕第一连杆部分（40）和第二连杆部分（50）的枢转轴线（A）枢转。

8. 发明授权

US07642367B2 Diamino-functional chalcones 失效
标题翻译：二氨基功能查尔酮
公开(公告)号：US07642367B2
公开(公告)日：2010-01-05
申请号：US10514821
申请日：2003-05-19
申请人： Simon Feldbæk Nielsen , Kristian Schønning , Hasse Kromann , Thomas Boesen , Mogens Larsen
发明人： Simon Feldbæk Nielsen , Kristian Schønning , Hasse Kromann , Thomas Boesen , Mogens Larsen
IPC分类号： C07C255/00 , C07C221/00 , C07C225/00
CPC分类号： C07C233/36 , C07C45/00 , C07C45/44 , C07C47/277 , C07C47/55 , C07C47/575 , C07C49/813 , C07C217/22 , C07C225/16 , C07C225/22 , C07C233/33 , C07C237/04 , C07C255/56 , C07C311/21 , C07C323/32 , C07D213/65 , C07D295/088 , C07D295/112 , C07D295/185 , C07D307/79 , C07D309/12 , C07D317/66
摘要： The invention provides novel diamino-functionalized chalcone derivatives and analogues thereof. Use of the compounds, or compositions comprising them, as pharmaceutically active agents, in particular against bacterial and parasitic infections, is also disclosed. The invention further relates to a method for detecting inhibitory effects against e.g., bacteria, parasites, fungi, and helminths. The chalcones of the invention carry amino substituents and exhibit enhanced biological effects combined with improved metabolic and physicochemical properties, making the compounds useful as drug substances, in particular as antiparasitic and bacteriostatic agents.
摘要翻译：本发明提供新的二氨基官能化查耳酮衍生物及其类似物。还公开了将化合物或其组合物用于药物活性剂，特别是抗细菌和寄生虫感染的用途。本发明还涉及用于检测对例如细菌，寄生虫，真菌和蠕虫的抑制作用的方法。本发明的查尔酮携带氨基取代基并表现出增强的生物效应以及改善的代谢和物理化学性质，使得该化合物可用作药物物质，特别是作为抗寄生虫和抑菌剂。

9. 发明授权

US07235548B2 Compounds and their use as positive AMPA receptor modulators 失效
标题翻译：化合物及其作为阳性AMPA受体调节剂的用途
公开(公告)号：US07235548B2
公开(公告)日：2007-06-26
申请号：US10642224
申请日：2003-08-18
申请人： Alex Haaht Gouliaev , Mogens Larsen , Thomas Varming , Claus Mathiesen , Tina Holm Johansen , Jorgen Scheel-Kruger , Gunnar M. Olsen , Elsesbet Ostergaard Nielsen
发明人： Alex Haaht Gouliaev , Mogens Larsen , Thomas Varming , Claus Mathiesen , Tina Holm Johansen , Jorgen Scheel-Kruger , Gunnar M. Olsen , Elsesbet Ostergaard Nielsen
IPC分类号： C07D285/26 , C07D417/12 , A61K31/5415
CPC分类号： C07D417/04 , C07D239/90 , C07D285/24 , C07D285/28 , C07D513/04
摘要： The invention provides novel compounds represented by the general formula compound represented by the formula: wherein the bond represented by the broken line may be a single, a double bond or absent; and if the bond is absent, then the nitrogen is substituted with a hydrogen and R2; X represents SO2 or C═O or CH2; Y represents —CH(R4)—, —N(R4)— or —N(R4)—CH2—, O; and the meaning of R2, R3, R4, R5, R6, R7, and R8 are as defined in the application The compounds are useful as positive modulators of the AMPA-receptor.
摘要翻译：本发明提供了由下式表示的通式化合物表示的新化合物：其中由虚线表示的键可以是单键，双键或不存在; 并且如果该键不存在，则氮被氢和R 2取代; X表示SO 2或C-O或CH 2 2; Y表示-CH（R 4） - ， - N（R 4） - 或-N（R 4） - CH 2， - O; 并且R 2，R 3，R 4，R 5，R 6，R 6， R 7，R 7和R 8如申请中所定义。化合物可用作AMPA受体的阳性调节剂。

10. 发明申请

US20060052600A1 Amino-functional chalcones 审中-公开
标题翻译：氨基功能查尔酮
公开(公告)号：US20060052600A1
公开(公告)日：2006-03-09
申请号：US10514625
申请日：2003-05-19
申请人： Simone Nielsen , Hasse Kromann , Mogens Larsen , Majbritt Hansen , Thomas Boesen
发明人： Simone Nielsen , Hasse Kromann , Mogens Larsen , Majbritt Hansen , Thomas Boesen
IPC分类号： C07D417/02 , C07D403/02 , C07D401/02
CPC分类号： C07C233/36 , C07C45/00 , C07C45/44 , C07C47/277 , C07C47/55 , C07C47/575 , C07C49/813 , C07C217/22 , C07C225/16 , C07C225/22 , C07C233/33 , C07C237/04 , C07C255/56 , C07C311/21 , C07C323/32 , C07D213/65 , C07D295/088 , C07D295/112 , C07D295/185 , C07D307/79 , C07D309/12 , C07D317/66
摘要： The invention provides novel amino-functionalised chalcone derivatives and analogues thereof. Use of the compounds, or compositions comprising them, as pharmaceutically active agents, in particular against bacterial and parasitic infections, is also disclosed. The invention further relates to a method for detecting inhibitory effects against e.g., bacteria, parasites, fungi, and helminths. The chalcones of the invention carry amino substituents and exhibit enhanced biological effects combined with improved metabolic and physicochemical properties, making the compounds useful as drug substances, in particular as antiparasitic, and bacteriocidal agents.
摘要翻译：本发明提供新的氨基官能化查耳酮衍生物及其类似物。还公开了将化合物或其组合物用于药物活性剂，特别是抗细菌和寄生虫感染的用途。本发明还涉及用于检测对例如细菌，寄生虫，真菌和蠕虫的抑制作用的方法。本发明的查尔酮携带氨基取代基并表现出增强的生物效应以及改善的代谢和物理化学性质，使得该化合物可用作药物物质，特别是作为抗寄生虫剂和杀菌剂。

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