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1. 发明授权

US6008241A Green porphyrins as immunomodulators 失效
公开(公告)号：US6008241A
公开(公告)日：1999-12-28
申请号：US856921
申请日：1997-05-16
申请人： Agnes H. Chan , David W. C. Hunt , Julia G. Levy , Modestus O. K. Obochi , Anna M. Richter , Guillermo O. Simkin
发明人： Agnes H. Chan , David W. C. Hunt , Julia G. Levy , Modestus O. K. Obochi , Anna M. Richter , Guillermo O. Simkin
IPC分类号： A61K31/40 , A61K31/409 , A61K41/00 , A61P37/00 , A61P37/02 , C08F132/08
CPC分类号： A61K41/0071 , A61K31/40 , C08F132/08
摘要： Green porphyrins act as antigen-specific immunomodulators in the active phase of an immune response to a particular antigen. This effect occurs at ambient light levels.

2. 发明授权

US06677366B2 Methods, compositions and articles for reducing or preventing the effects of inflammation 有权
标题翻译：用于减少或预防炎症作用的方法，组合物和制品
公开(公告)号：US06677366B2
公开(公告)日：2004-01-13
申请号：US09929558
申请日：2001-08-13
申请人： Anna M. Richter , Julia G. Levy , Claude A. A. Hariton , Gustave Huber , William C. Stewart , Mario G. Fsadni , Modestus O. K. Obochi
发明人： Anna M. Richter , Julia G. Levy , Claude A. A. Hariton , Gustave Huber , William C. Stewart , Mario G. Fsadni , Modestus O. K. Obochi
IPC分类号： A61K3140
CPC分类号： A61K41/0071 , Y10S514/912
摘要： A method for reducing or preventing the effects of inflammation arising from injured tissue, which method comprises the steps of: a. bringing the injured tissue, or pre-injured tissue, into contact with a photosensitizing agent capable of penetrating into the tissue, resulting in the desired degree of biodistribution in less than one hour; and b. exposing the tissue thus contacted to light having a wavelength absorbed by the photosensitizing agent for a time sufficient to reduce or prevent inflammation in the exposed tissue, but not so long as to cause necrosis or erythema of the exposed tissue, or a pharmaceutical composition or an article for reducing or preventing the effects of inflammation arising from injured tissue. The composition comprises: a. from about 1 &mgr;g/mL to about 2 mg/mL of a photosensitizing agent capable of penetrating into the injured tissue, or pre-injured tissue, resulting in the desired degree of biodistribution less than one hour; and b. a pharmaceutically acceptable carrier. The article comprises: a. a photosensitizing agent capable of penetrating into the injured tissue, or pre-injured tissue, resulting in the desired degree of biodistribution in less than one hour; and b. an absorbent applicator.
摘要翻译：一种减少或防止受损组织引起的炎症影响的方法，该方法包括以下步骤：a。使损伤的组织或预损伤的组织与能够渗透到组织中的光敏剂接触，在少于1小时内产生所需程度的生物分布; 安布将由此与光敏剂吸收的波长接触的组织暴露于足以减少或防止暴露组织中的炎症的时间，但不会导致暴露组织的坏死或红斑，或药物组合物或用于减少或预防由损伤组织引起的炎症影响的制品。组合物包括：a。约1ml / mL至约2mg / mL的能够渗入损伤组织或预损伤组织的光敏剂，导致所需程度的生物分布小于1小时; 安布药学上可接受的载体。能够渗入损伤组织或预损伤组织的光敏剂，在少于1小时内产生所需程度的生物分布; 安布吸收性涂抹器。

3. 发明授权

US06659107B2 Method to prevent xenograft transplant rejection 失效
公开(公告)号：US06659107B2
公开(公告)日：2003-12-09
申请号：US10099755
申请日：2002-03-14
申请人： Modestus O. K. Obochi , Philippe Maria Clotaire Margaron , Christopher Richard Honey , Stephen Yip , Julia G. Levy
发明人： Modestus O. K. Obochi , Philippe Maria Clotaire Margaron , Christopher Richard Honey , Stephen Yip , Julia G. Levy
IPC分类号： A61B1900
CPC分类号： A61K41/0057 , A61K41/0071
摘要： Donor material from a xenogeneic source is modified to enhance its survival time in a recipient by treating the donor material using low-dose photodynamic therapy (PDT). The donor material, such as an organ or cell suspension, is treated with a photosensitizer and irradiated in a low-dose protocol before transplantation into a xenogeneic recipient.

4. 发明授权

US06364907B1 Method to prevent xenograft transplant rejection 失效
标题翻译：防止异种移植排斥反应的方法
公开(公告)号：US06364907B1
公开(公告)日：2002-04-02
申请号：US09169233
申请日：1998-10-09
申请人： Modestus O. K. Obochi , Philippe Maria Clotaire Margaron , Christopher Richard Honey , Stephen Yip , Julia G. Levy
发明人： Modestus O. K. Obochi , Philippe Maria Clotaire Margaron , Christopher Richard Honey , Stephen Yip , Julia G. Levy
IPC分类号： A61F202
CPC分类号： A61K41/0057 , A61K41/0071
摘要： Donor material from a xenogeneic source is modified to enhance its survival time in a recipient by treating the donor material using low-dose photodynamic therapy (PDT). The donor material, such as an organ or cell suspension, is treated with a photosensitizer and irradiated in a low-dose protocol before transplantation into a xenogeneic recipient.
摘要翻译：通过使用低剂量光动力治疗（PDT）治疗供体材料，修饰来自异种来源的供体材料以增强其在受体中的存活时间。供体材料，例如器官或细胞悬浮液，用光敏剂处理，并在移植到异种受体之前以低剂量方案照射。

5. 发明授权

US6107325A Green porphyrins as immunomodulators 失效
标题翻译：绿色卟啉作为免疫调节剂
公开(公告)号：US6107325A
公开(公告)日：2000-08-22
申请号：US80666
申请日：1998-05-18
申请人： Agnes H. Chan , David W. C. Hunt , Julia G. Levy , Modestus O. K. Obochi , Anna M. Richter , Guillermo O. Simkin
发明人： Agnes H. Chan , David W. C. Hunt , Julia G. Levy , Modestus O. K. Obochi , Anna M. Richter , Guillermo O. Simkin
IPC分类号： A61K31/409 , C08F132/08 , A01N43/38
CPC分类号： A61K31/409 , A61K31/40 , A61K41/0071 , C08F132/08
摘要： Green porphyrins act as antigen-specific immunomodulators in the active phase of an immune response to a particular antigen. This effect occurs at ambient light levels.
摘要翻译：绿卟啉作为抗原特异性免疫调节剂在对特定抗原的免疫应答的活性期中起作用。这种效应发生在环境光线水平。

6. 发明授权

US6096776A Green porphyrins as immunomodulators 失效
标题翻译：绿色卟啉作为免疫调节剂
公开(公告)号：US6096776A
公开(公告)日：2000-08-01
申请号：US164374
申请日：1998-10-01
申请人： Agnes H. Chan , David W. C. Hunt , Julia G. Levy , Modestus O. K. Obochi , Anna M. Richter , Guillermo O. Simkin
发明人： Agnes H. Chan , David W. C. Hunt , Julia G. Levy , Modestus O. K. Obochi , Anna M. Richter , Guillermo O. Simkin
IPC分类号： A61K31/409 , C08F132/08 , A61K31/40
CPC分类号： C08F132/08 , A61K31/409
摘要： Green porphyrins act as antigen-specific immunomodulators in the active phase of an immune response to a particular antigen, as well as to interfere with intercellular communication. These effects occur in the absence of radiation absorbed by the green porphyrin.
摘要翻译：绿卟啉在作用于特定抗原的免疫应答活性期的抗原特异性免疫调节剂，以及干扰细胞间通讯。这些影响发生在没有被绿色卟啉吸收的辐射的情况下。

7. 发明授权

US5882328A Method to prevent transplant rejection 失效
标题翻译：防止移植排斥的方法
公开(公告)号：US5882328A
公开(公告)日：1999-03-16
申请号：US759318
申请日：1996-12-02
申请人： Julia G. Levy , Modestus O. K. Obochi
发明人： Julia G. Levy , Modestus O. K. Obochi
IPC分类号： C07D487/22 , A61K41/00 , A61K45/00 , A61P37/06 , A61N1/30 , A61M31/00
CPC分类号： A61K41/0071 , Y10S424/81
摘要： Donor tissue containing antigen-presenting cells (APCs) can be modified to reduce rejection when the donor tissue is used as an allograft by exposing the donor tissue which has been treated with a photosensitizing agent having an absorption maximum between 400-900 nm to a wavelength absorbed by the photosensitizing agent so as to attenuate the APCs in the donor tissue but wherein the light is not cytotoxic to the APCs.
摘要翻译：当将供体组织用作同种异体移植物时，含有抗原呈递细胞（APCs）的供体组织可以被修饰以减少排斥，所述供体组织通过将已经用吸光度最大值在400-900nm之间的光敏剂处理的供体组织暴露于波长由光敏剂吸收，以减弱供体组织中的APC，但其中光不对APC产生细胞毒性。

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