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1. 发明申请

US20110009491A1 PROCESS FOR PRODUCING 1,4-DIHYDROXY-2-NAPHTHOIC ACID 有权
标题翻译：生产1,4-二羟基-2-萘甲酸的方法
公开(公告)号：US20110009491A1
公开(公告)日：2011-01-13
申请号：US12877471
申请日：2010-09-08
申请人： Yoshio SATO , Seiya Makino , Nobuo Yoda , Kakuhei Isawa , Tomonori Kamiyama , Kenichi Hojo , Mizue Saito , Naoki Taketomo , Keisuke Furuichi , Shuji Ikegami
发明人： Yoshio SATO , Seiya Makino , Nobuo Yoda , Kakuhei Isawa , Tomonori Kamiyama , Kenichi Hojo , Mizue Saito , Naoki Taketomo , Keisuke Furuichi , Shuji Ikegami
IPC分类号： A61K31/192 , A61P1/00
CPC分类号： C12P7/42 , A23L33/10 , A61K31/192
摘要： A composition containing 1,4-dihydroxy-2-naphthoic acid at a high concentration is obtained by intracellularly and extracellularly producing 1,4-dihydroxy-2-naphthoic acid using a bacterium belonging to the genus Propionibacterium and collecting it. This composition is efficacious in improving intestinal flora, alleviating abdominal ailments in association with the intake of milk, and preventing metabolic bone diseases.
摘要翻译：通过使用属于丙酸杆菌属的细菌并通过细胞内和细胞外产生1,4-二羟基-2-萘甲酸，得到高浓度的含有1,4-二羟基-2-萘甲酸的组合物。该组合物有效改善肠道菌群，减轻与摄入牛奶相关的腹部疾病，并预防代谢性骨病。

2. 发明申请

US20090312425A1 PROCESS FOR PRODUCING 1,4-DIHYDROXY-2-NAPHTHOIC ACID 有权
标题翻译：生产1,4-二羟基-2-萘甲酸的方法
公开(公告)号：US20090312425A1
公开(公告)日：2009-12-17
申请号：US12543814
申请日：2009-08-19
申请人： Yoshio Sato , Seiya Makino , Nobuo Yoda , Kakuhei Isawa , Tomonori Kamiyama , Kenichi Hojo , Mizue Saito , Naoki Taketomo , Keisuke Furuichi , Shuji Ikegami
发明人： Yoshio Sato , Seiya Makino , Nobuo Yoda , Kakuhei Isawa , Tomonori Kamiyama , Kenichi Hojo , Mizue Saito , Naoki Taketomo , Keisuke Furuichi , Shuji Ikegami
IPC分类号： A61K31/192 , C12P7/42
CPC分类号： C12P7/42 , A23L33/10 , A61K31/192
摘要： A composition containing 1,4-dihydroxy-2-naphthoic acid at a high concentration is obtained by intracellularly and extracellularly producing 1,4-dihydroxy-2-naphthoic acid using a bacterium belonging to the genus Propionibacterium and collecting it. This composition is efficacious in improving intestinal flora, alleviating abdominal ailments in association with the intake of milk, and preventing metabolic bone diseases.
摘要翻译：通过使用属于丙酸杆菌属的细菌并通过细胞内和细胞外产生1,4-二羟基-2-萘甲酸，得到高浓度的含有1,4-二羟基-2-萘甲酸的组合物。该组合物有效改善肠道菌群，减轻与摄入牛奶相关的腹部疾病，并预防代谢性骨病。

3. 发明授权

US5281262A Aqueous pigment ink composition for ball-point pens 失效
标题翻译：用于圆珠笔的水性颜料墨水组合物
公开(公告)号：US5281262A
公开(公告)日：1994-01-25
申请号：US928943
申请日：1992-08-11
申请人： Mizue Saito
发明人： Mizue Saito
IPC分类号： C09D11/18
CPC分类号： C09D11/18
摘要： The present invention provides an aqueous pigment ink for ball-point pen which can inhibit surface tension from extremely deteriorating to protect written letters from blur and which is excellent in non-drying properties and which has lubricating properties enough to smoothly rotate a ball and to decrease friction of a ball seat, whereby a writing performance can be remarkably improved and a comfortable writing performance can be given.The aqueous pigment ink composition for ball-point pens of the present invention is characterized by comprising a pigment, a dispersant, water and an adduct of at least one polyhydric alcohol with an alkylene oxide, the polyhydric alcohol being selected from the group consisting of polyglycerin, glycerin, trimethylolpropane and a mixture thereof.
摘要翻译：本发明提供一种用于圆珠笔的水性颜料墨水，其可以抑制表面张力极度恶化，以保护书面字母免于模糊，并且具有优异的非干燥性能，并且具有足够的润滑性能以平滑地旋转球并减少一个球座的摩擦力，从而可以显着提高书写性能，并且可以提供舒适的写入性能。本发明的圆珠笔水性颜料墨水组合物的特征在于，含有颜料，分散剂，水和至少一种多元醇与烯化氧的加合物，所述多元醇选自聚甘油，甘油，三羟甲基丙烷及其混合物。

4. 发明授权

US08110607B2 Process for producing 1,4-dihydroxy-2-naphthoic acid 有权
标题翻译： 1,4-二羟基-2-萘甲酸的制造方法
公开(公告)号：US08110607B2
公开(公告)日：2012-02-07
申请号：US12877471
申请日：2010-09-08
申请人： Yoshio Sato , Seiya Makino , Nobuo Yoda , Kakuhei Isawa , Tomonori Kamiyama , Kenichi Hojo , Mizue Saito , Naoki Taketomo , Keisuke Furuichi , Shuji Ikegami
发明人： Yoshio Sato , Seiya Makino , Nobuo Yoda , Kakuhei Isawa , Tomonori Kamiyama , Kenichi Hojo , Mizue Saito , Naoki Taketomo , Keisuke Furuichi , Shuji Ikegami
IPC分类号： A61K31/19 , C12P7/40 , C07C63/34
CPC分类号： C12P7/42 , A23L33/10 , A61K31/192
摘要： A composition containing 1,4-dihydroxy-2-naphthoic acid at a high concentration is obtained by intracellularly and extracellularly producing 1,4-dihydroxy-2-naphthoic acid using a bacterium belonging to the genus Propionibacterium and collecting it. This composition is efficacious in improving intestinal flora, alleviating abdominal ailments in association with the intake of milk, and preventing metabolic bone diseases.
摘要翻译：通过使用属于丙酸杆菌属的细菌并通过细胞内和细胞外产生1,4-二羟基-2-萘甲酸，得到高浓度的含有1,4-二羟基-2-萘甲酸的组合物。该组合物有效改善肠道菌群，减轻与摄入牛奶相关的腹部疾病，并预防代谢性骨病。

5. 发明申请

US20080194688A1 PROCESS FOR PRODUCING 1,4-DIHYDROXY-2-NAPHTHOIC ACID 有权
标题翻译：生产1,4-二羟基-2-萘甲酸的方法
公开(公告)号：US20080194688A1
公开(公告)日：2008-08-14
申请号：US12100075
申请日：2008-04-09
申请人： Yoshio SATO , Seiya MAKINO , Nobuo YODA , Kakuhei ISAWA , Tomonori KAMIYAMA , Kenichi HOJO , Mizue SAITO , Naoki TAKETOMO , Keisuke FURUICHI , Shuji IKEGAMI
发明人： Yoshio SATO , Seiya MAKINO , Nobuo YODA , Kakuhei ISAWA , Tomonori KAMIYAMA , Kenichi HOJO , Mizue SAITO , Naoki TAKETOMO , Keisuke FURUICHI , Shuji IKEGAMI
IPC分类号： A61K31/192 , A61P1/00 , A61P19/08
CPC分类号： C12P7/42 , A23L33/10 , A61K31/192
摘要： A composition containing 1,4-dihydroxy-2-naphthoic acid at a high concentration is obtained by intracellularly and extracellularly producing 1,4-dihydroxy-2-naphthoic acid using a bacterium belonging to the genus Propionibacterium and collecting it. This composition is efficacious in improving intestinal flora, alleviating abdominal ailments in association with the intake of milk, and preventing metabolic bone diseases.
摘要翻译：通过使用属于丙酸杆菌属的细菌并通过细胞内和细胞外产生1,4-二羟基-2-萘甲酸，得到高浓度的含有1,4-二羟基-2-萘甲酸的组合物。该组合物有效改善肠道菌群，减轻与摄入牛奶相关的腹部疾病，并预防代谢性骨病。

6. 发明授权

US07374915B2 Process for producing 1,4-dihydroxy-2-naphthoic acid 有权
标题翻译： 1,4-二羟基-2-萘甲酸的制造方法
公开(公告)号：US07374915B2
公开(公告)日：2008-05-20
申请号：US10486421
申请日：2002-08-06
申请人： Yoshio Sato , Seiya Makino , Nobuo Yoda , Kakuhei Isawa , Tomonori Kamiyama , Kenichi Hojo , Mizue Saito , Naoki Taketomo , Keisuke Furuichi , Shuji Ikegami
发明人： Yoshio Sato , Seiya Makino , Nobuo Yoda , Kakuhei Isawa , Tomonori Kamiyama , Kenichi Hojo , Mizue Saito , Naoki Taketomo , Keisuke Furuichi , Shuji Ikegami
IPC分类号： C12P7/40 , A61K31/19
CPC分类号： C12P7/42 , A23L33/10 , A61K31/192
摘要： A composition containing 1,4-dihydroxy-2-naphthoic acid at a high concentration is obtained by intracellularly and extracellularly producing 1,4-dihydroxy-2-naphthoic acid using a bacterium belonging to the genus Propionibacterium and collecting it. This composition is efficacious in improving intestinal flora, alleviating abdominal ailments in association with the intake of milk, and preventing metabolic bone diseases.
摘要翻译：通过使用属于丙酸杆菌属的细菌并通过细胞内和细胞外产生1,4-二羟基-2-萘甲酸，得到高浓度的含有1,4-二羟基-2-萘甲酸的组合物。该组合物有效改善肠道菌群，减轻与摄入牛奶相关的腹部疾病，并预防代谢性骨病。

7. 发明授权

US07834061B2 Process for producing 1,4-dihydroxy-2-naphthoic acid 有权
标题翻译： 1,4-二羟基-2-萘甲酸的制造方法
公开(公告)号：US07834061B2
公开(公告)日：2010-11-16
申请号：US12543814
申请日：2009-08-19
申请人： Yoshio Sato , Seiya Makino , Nobuo Yoda , Kakuhei Isawa , Tomonori Kamiyama , Kenichi Hojo , Mizue Saito , Naoki Taketomo , Keisuke Furuichi , Shuji Ikegami
发明人： Yoshio Sato , Seiya Makino , Nobuo Yoda , Kakuhei Isawa , Tomonori Kamiyama , Kenichi Hojo , Mizue Saito , Naoki Taketomo , Keisuke Furuichi , Shuji Ikegami
IPC分类号： A61K31/19 , C12P7/40 , C07C63/34
CPC分类号： C12P7/42 , A23L33/10 , A61K31/192
摘要： A composition containing 1,4-dihydroxy-2-naphthoic acid at a high concentration is obtained by intracellularly and extracellularly producing 1,4-dihydroxy-2-naphthoic acid using a bacterium belonging to the genus Propionibacterium and collecting it. This composition is efficacious in improving intestinal flora, alleviating abdominal ailments in association with the intake of milk, and preventing metabolic bone diseases.
摘要翻译：通过使用属于丙酸杆菌属的细菌并通过细胞内和细胞外产生1,4-二羟基-2-萘甲酸，得到高浓度的含有1,4-二羟基-2-萘甲酸的组合物。该组合物有效改善肠道菌群，减轻与摄入牛奶相关的腹部疾病，并预防代谢性骨病。

8. 发明授权

US07629155B2 Process for producing 1,4-dihydroxy-2-naphthoic acid 有权
标题翻译： 1,4-二羟基-2-萘甲酸的制造方法
公开(公告)号：US07629155B2
公开(公告)日：2009-12-08
申请号：US12100075
申请日：2008-04-09
申请人： Yoshio Sato , Seiya Makino , Nobuo Yoda , Kakuhei Isawa , Tomonori Kamiyama , Kenichi Hojo , Mizue Saito , Naoki Taketomo , Keisuke Furuichi , Shuji Ikegami
发明人： Yoshio Sato , Seiya Makino , Nobuo Yoda , Kakuhei Isawa , Tomonori Kamiyama , Kenichi Hojo , Mizue Saito , Naoki Taketomo , Keisuke Furuichi , Shuji Ikegami
IPC分类号： C12P7/40 , C07C63/34
CPC分类号： C12P7/42 , A23L33/10 , A61K31/192
摘要： A composition containing 1,4-dihydroxy-2-naphthoic acid at a high concentration is obtained by intracellularly and extracellularly producing 1,4-dihydroxy-2-naphthoic acid using a bacterium belonging to the genus Propionibacterium and collecting it. This composition is efficacious in improving intestinal flora, alleviating abdominal ailments in association with the intake of milk, and preventing metabolic bone diseases.
摘要翻译：通过使用属于丙酸杆菌属的细菌并通过细胞内和细胞外产生1,4-二羟基-2-萘甲酸，得到高浓度的含有1,4-二羟基-2-萘甲酸的组合物。该组合物有效改善肠道菌群，减轻与摄入牛奶相关的腹部疾病，并预防代谢性骨病。

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