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1. 发明授权

US06399189B1 Foamable thermoplastic sheet-like synthetic resin, thermoplastic foamed resin and their production method 失效
标题翻译：可发泡热塑性片状合成树脂，热塑性发泡树脂及其制造方法
公开(公告)号：US06399189B1
公开(公告)日：2002-06-04
申请号：US09125009
申请日：1998-08-25
申请人： Tomoyuki Kobayashi , Kenji Miyazaki , Eiji Nagara , Michiaki Sasayama , Mitsuo Okubo
发明人： Tomoyuki Kobayashi , Kenji Miyazaki , Eiji Nagara , Michiaki Sasayama , Mitsuo Okubo
IPC分类号： B32B312
CPC分类号： B29C44/3484 , B29C43/222 , B29C43/28 , B29C44/00 , B29C44/04 , B29C44/22 , B29C59/005 , B29C59/04 , B29C59/046 , B32B5/18 , B32B37/153 , B32B38/06 , B32B2305/022 , B32B2309/02 , B32B2309/04 , Y10T428/24496 , Y10T428/24661 , Y10T428/249953 , Y10T428/249958 , Y10T428/24996 , Y10T428/249981
摘要： A sheet-form structure of expandable thermoplastic resin is provided which is capable of undergoing a pseudo-one-dimensional expansion in its thickness direction and which enables manufacture of thermoplastic resin foams having reduced variations in thickness and weight precisions, increased compressive strength, and excellent properties such as surface smoothness. A method of manufacturing the sheet-form structure, as well as such thermoplastic resin foams, are also provided. A sheet-form structure 1 of expandable thermoplastic resin including granules 2 of expandable thermoplastic resin arranged generally uniformly for integral connection thereof through a thin film 3 of expandable thermoplastic resin. A thermoplastic resin foam including a continuous, thermoplastic resin foam layer, a number of highly-expanded, thermoplastic resin portions provided on at least one surface of the continuous foam layer, and slightly-expanded, thermoplastic resin thin films for covering outer surfaces of respective highly-expanded portions.
摘要翻译：提供了一种可膨胀热塑性树脂的片状结构，其能够在其厚度方向上进行假一维膨胀，并且能够制造厚度和重量精度变化减小，抗压强度提高以及优异的热塑性树脂泡沫性质如表面平滑度。还提供了制造片状结构的方法以及这种热塑性树脂泡沫体。一种可膨胀热塑性树脂的片状结构体1，包括可膨胀热塑性树脂的颗粒2，其通常均匀地布置，用于通过可膨胀热塑性树脂的薄膜3与其一体连接。一种热塑性树脂发泡体，包括连续的热塑性树脂泡沫层，设置在连续泡沫层的至少一个表面上的多个高度膨胀的热塑性树脂部分，以及用于覆盖相应的外部表面的略微膨胀的热塑性树脂薄膜高度扩张部分。

2. 发明授权

US08404803B2 Cancer-associated antigen analogue peptides and uses thereof 失效
标题翻译：癌相关抗原类似物肽及其用途
公开(公告)号：US08404803B2
公开(公告)日：2013-03-26
申请号：US11910129
申请日：2006-03-31
申请人： Mitsuo Okubo , Hiroo Maeda , Satoru Takeda
发明人： Mitsuo Okubo , Hiroo Maeda , Satoru Takeda
IPC分类号： C07K5/00
CPC分类号： G01N33/57449 , A61K38/00 , A61K39/0011 , A61K2039/5158 , C07K14/4727
摘要： First, to solve the problems of the present invention, the present inventors confirmed the presence of ovarian cancer antigen-specific T cells in the peripheral blood of ovarian cancer patients by using an experimental system that detects combinations of CD4 and IL-4 or IFNγ. Next, using analogue peptides of the core protein MUC 16 of the ovarian cancer-associated antigen CA 125, the present inventors revealed that antigen-specific CD4-positive T cells are present at an average frequency of about 4% in the peripheral mononuclear cells of patients and healthy subjects. Then, the present inventors analyzed the epitope for T cells in the core protein MUC 16 of the ovarian cancer-associated antigen CA 125, and determined the amino acid sequence FTLNFTITN (SEQ ID NO: 1) to be a shorter epitope. The present inventors further discovered that the analogue peptide OVCA11: GHTAPGPLLVPFTLNFTITN (SEQ ID NO:11) is suitable for T cell activation.
摘要翻译：首先，为了解决本发明的问题，本发明人通过使用检测CD4和IL-4或IFNγ的组合的实验系统，确认了卵巢癌患者的外周血中卵巢癌抗原特异性T细胞的存在。接下来，使用卵巢癌相关抗原CA125的核心蛋白MUC16的类似肽，本发明人发现抗原特异性CD4阳性T细胞在外周单核细胞中以约4％的平均频率存在患者和健康受试者。然后，本发明人分析了卵巢癌相关抗原CA125的核心蛋白MUC16中的T细胞的表位，并将氨基酸序列FTLNFTITN（SEQ ID NO：1）确定为较短的表位。本发明人进一步发现，类似物OVCA11：GHTAPGPLLVPFTLNFTITN（SEQ ID NO：11）适用于T细胞活化。

3. 发明申请

US20110229481A1 CANCER-ASSOCIATED ANTIGEN ANALOGUE PEPTIDES AND USES THEREOF 失效
标题翻译：癌症相关抗原肽模拟物及其用途
公开(公告)号：US20110229481A1
公开(公告)日：2011-09-22
申请号：US11910129
申请日：2006-03-31
申请人： Mitsuo Okubo , Hiroo Maeda , Satoru Takeda
发明人： Mitsuo Okubo , Hiroo Maeda , Satoru Takeda
IPC分类号： A61K39/395 , C07K7/06 , C07K7/08 , C07K14/47 , C07H21/04 , C12N15/63 , C12N5/10 , C12N1/00 , C12P21/02 , C07K16/18 , C12N5/0783 , G01N33/574 , G01N33/566 , A61K38/08 , A61K35/14 , A61P35/00
CPC分类号： G01N33/57449 , A61K38/00 , A61K39/0011 , A61K2039/5158 , C07K14/4727
摘要： First, to solve the problems of the present invention, the present inventors confirmed the presence of ovarian cancer antigen-specific T cells in the peripheral blood of ovarian cancer patients by using an experimental system that detects combinations of CD4 and IL-4 or IFNγ. Next, using analogue peptides of the core protein MUC16 of the ovarian cancer-associated antibody C125, the present inventors revealed that antigen-specific CD4-positive T cells are present at an average frequency of about 4% in the peripheral mononuclear cells of patients and healthy subjects. Then, the present inventors analyzed the epitope for T cells in the core protein MUC16 of the ovarian cancer-associated antigen CA125, and determined the amino acid sequence FTLNFTITN (SEQ ID NO: 1) to be a shorter epitope. The present inventors further discovered that the analogue peptide OVCA11: GHTAPOPLLVPFTLNFTITN (SEQ ID NO: 11) is suitable for T cell activation.
摘要翻译：首先，为了解决本发明的问题，本发明人通过使用检测CD4和IL-4或IFNγ的组合的实验系统，确认了卵巢癌患者的外周血中卵巢癌抗原特异性T细胞的存在。接下来，使用卵巢癌相关抗体C125的核心蛋白MUC16的类似肽，本发明人发现抗原特异性CD4阳性T细胞在患者的外周单核细胞中以约4％的平均频率存在，健康科目。然后，本发明人分析了卵巢癌相关抗原CA125的核心蛋白MUC16中的T细胞的表位，并将氨基酸序列FTLNFTITN（SEQ ID NO：1）确定为较短的表位。本发明人进一步发现，类似物肽OVCA11：GHTAPOPLLVPFTLNFTITN（SEQ ID NO：11）适用于T细胞活化。

4. 发明授权

US06716522B2 Molded article from thermoplastic composite material and method for producing the same 失效
标题翻译：热塑性复合材料的成型品及其制造方法
公开(公告)号：US06716522B2
公开(公告)日：2004-04-06
申请号：US10069065
申请日：2002-04-04
申请人： Koji Matsumoto , Masaki Ito , Koushi Kawabata , Keisuke Hashimoto , Mitsuo Okubo
发明人： Koji Matsumoto , Masaki Ito , Koushi Kawabata , Keisuke Hashimoto , Mitsuo Okubo
IPC分类号： B32B516
CPC分类号： B29C47/28 , B27N3/28 , B29C47/0016 , B29C47/003 , B29C47/025 , B29C47/128 , B29C47/822 , B29C47/86 , B29C47/862 , B29C47/864 , B29C70/58 , B29C2793/009 , B29K2711/00 , B29K2711/14 , Y10T428/253 , Y10T428/26 , Y10T428/31913 , Y10T428/31938 , Y10T428/31978 , Y10T428/31982 , Y10T428/31989
摘要： The present invention has for its object to provide a molded article of a thermoplastic composite material which is not only durable with little discoloration or fading even on prolonged outdoor exposure and is very satisfactory in physical properties and appearance qualities inclusive of wood-like texture but also has high productivity and good economics. The present invention is a method of producing a molded article of a thermoplastic composite material comprising extruding the thermoplastic composite material containing a thermoplastic resin and a vegetable filler, said vegetable filler content being 50 to 90 weight % of the total weight of said thermoplastic resin and said vegetable filler, wherein extrusion is carried out by means of an extrusion apparatus comprising at least an extruder, a hot shaping die, and a cooling die, said hot shaping die and cooling die being directly coupled.
摘要翻译：本发明的目的是提供一种热塑性复合材料的模制品，即使在长时间暴露于室外也不会变色或褪色，并且在物理性能和外观质量方面非常满意，包括木质纹理本发明是一种热塑性复合材料的成型体的制造方法，其特征在于，包括挤出含有热塑性树脂和植物填料的热塑性复合材料，所述植物填料含量为所述热塑性复合材料的50〜90重量％所述热塑性树脂和所述植物填料的总重量，其中通过至少包括挤出机，热成形模和冷却模的挤出装置进行挤出，所述热成型模和冷却模直接耦合。

5. 发明授权

US07048879B2 Sheet-form structure of expandable thermoplastic resin, thermoplastic resin foam and methods for manufacturing thereof 失效
公开(公告)号：US07048879B2
公开(公告)日：2006-05-23
申请号：US10310880
申请日：2002-12-06
申请人： Tomoyuki Kobayashi , Kenji Miyazaki , Eiji Nagara , Michiaki Sasayama , Mitsuo Okubo
发明人： Tomoyuki Kobayashi , Kenji Miyazaki , Eiji Nagara , Michiaki Sasayama , Mitsuo Okubo
IPC分类号： B29C44/06
CPC分类号： B29C44/3484 , B29C43/222 , B29C43/28 , B29C44/00 , B29C44/04 , B29C44/22 , B29C59/005 , B29C59/04 , B29C59/046 , B32B5/18 , B32B37/153 , B32B38/06 , B32B2305/022 , B32B2309/02 , B32B2309/04 , Y10T428/24496 , Y10T428/24661 , Y10T428/249953 , Y10T428/249958 , Y10T428/24996 , Y10T428/249981
摘要： A sheet-form structure of expandable thermoplastic resin is provided which is capable of undergoing a pseudo-one-dimensional expansion in its thickness direction and which enables manufacture of thermoplastic resin foams having reduced variations in thickness and weight precisions, increased compressive strength, and excellent properties such as surface smoothness. A method of manufacturing the sheet-form structure, as well as such thermoplastic resin foams, are also provided.A sheet-form structure 1 of expandable thermoplastic resin including granules 2 of expandable thermoplastic resin arranged generally uniformly for integral connection thereof through a thin film 3 of expandable thermoplastic resin. A thermoplastic resin foam including a continuous, thermoplastic resin foam layer, a number of highly-expanded, thermoplastic resin portions provided on at least one surface of the continuous foam layer, and slightly-expanded, thermoplastic resin thin films for covering outer surfaces of respective highly-expanded portions.

6. 发明授权

US06620495B1 Sheet-form structure of expandable thermoplastic resin, thermoplastic resin foam and methods for manufacturing thereof 失效
标题翻译：可膨胀热塑性树脂的片状结构，热塑性树脂发泡体及其制造方法
公开(公告)号：US06620495B1
公开(公告)日：2003-09-16
申请号：US09639889
申请日：2000-08-17
申请人： Tomoyuki Kobayashi , Kenji Miyazaki , Eiji Nagara , Michiaki Sasayama , Mitsuo Okubo
发明人： Tomoyuki Kobayashi , Kenji Miyazaki , Eiji Nagara , Michiaki Sasayama , Mitsuo Okubo
IPC分类号： B32B312
CPC分类号： B29C44/3484 , B29C44/00 , B29C44/04 , Y10T428/24496 , Y10T428/24661 , Y10T428/249953 , Y10T428/24996 , Y10T428/249981
摘要： A sheet-form structure of expandable thermoplastic resin is provided which is capable of undergoing a pseudo-one-dimensional expansion in its thickness direction and which enables manufacture of thermoplastic resin foams having reduced variations in thickness and weight precisions, increased compressive strength, and excellent properties such as surface smoothness. A method of manufacturing the sheet-form structure, as well as such thermoplastic resin foams, are also provided. A sheet-form structure 1 of expandable thermoplastic resin including granules 2 of expandable thermoplastic resin arranged generally uniformly for integral connection thereof through a thin film 3 of expandable thermoplastic resin. A thermoplastic resin foam including a continuous, thermoplastic resin foam layer, a number of highly-expanded, thermoplastic resin portions provided on at least one surface of the continuous foam layer, and slightly-expanded, thermoplastic resin thin films for covering outer surfaces of respective highly-expanded portions.
摘要翻译：提供了一种可膨胀热塑性树脂的片状结构，其能够在其厚度方向上进行假一维膨胀，并且能够制造厚度和重量精度变化减小，抗压强度提高以及优异的热塑性树脂泡沫性质如表面平滑度。还提供了一种制造片状结构体的方法以及这种热塑性树脂发泡体。1.一种可膨胀热塑性树脂的片状结构体1，其包括通常均匀地布置的可膨胀热塑性树脂的颗粒2，用于通过薄膜 3的可膨胀热塑性树脂。一种热塑性树脂发泡体，包括连续的热塑性树脂泡沫层，设置在连续泡沫层的至少一个表面上的多个高度膨胀的热塑性树脂部分，以及用于覆盖相应的外部表面的略微膨胀的热塑性树脂薄膜高度扩张部分。

7. 发明授权

US6059413A Projection-type display device 有权
标题翻译：投影式显示装置
公开(公告)号：US6059413A
公开(公告)日：2000-05-09
申请号：US163427
申请日：1998-09-30
申请人： Mitsuo Okubo
发明人： Mitsuo Okubo
IPC分类号： G03B21/00 , G03B21/10 , H04N5/74 , G03B21/22
CPC分类号： H04N9/3147 , H04N5/7408
摘要： A projection-type display device of the present invention includes a projection unit for projecting an image to be displayed on a screen and an angle-of-projection correcting mechanism supporting the projection unit. The angle-of-projection correcting mechanism is located at a side surface of the projection unit, instead of on a bottom surface thereof, to correct the projection angle of the image projected from the projection unit onto the screen, while reducing the size of the projection-type display device.
摘要翻译：本发明的投影式显示装置具有投影显示在画面上的图像的投影部和投影单元的投影角修正机构。投影角修正机构位于投影单元的侧面而不是在其底面上，以将从投影单元投射的图像的投影角度校正到屏幕上，同时减小投影单元的尺寸投影式显示装置。

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