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1. 发明授权

US08217222B2 Methods for identifying markers for early-stage human cancer, cancer progression and recurrence 失效
标题翻译：识别早期人类癌症标志物，癌症进展和复发的方法
公开(公告)号：US08217222B2
公开(公告)日：2012-07-10
申请号：US11529938
申请日：2006-09-29
申请人： Mingxu Xu , Yuying Tan , Levy Kopelovich
发明人： Mingxu Xu , Yuying Tan , Levy Kopelovich
IPC分类号： G01N33/00 , A01K67/00 , A01K67/033 , C12N5/00 , C12N5/02 , C12N15/00 , C12N15/87
CPC分类号： C12N15/1051 , C12N15/1086
摘要： A method is described to identify secreted proteins identified with stages of malignancy of cancer. The proteins are initially identified by trapping them with a fluorescent protein containing vector that can insert in any gene. The secreted proteins are initially identified by their fluorescence. Secreted proteins identifying tumors with specific degrees of malignancy are isolated to determine if they can serve as markers of cancer progression.
摘要翻译：描述了一种鉴定鉴定为癌症恶性程度的分泌蛋白的方法。最初通过用含有可插入任何基因的含荧光蛋白的载体捕获蛋白质来鉴定蛋白质。分泌的蛋白质最初通过其荧光来鉴定。分离识别具有特定恶性程度的肿瘤的分泌蛋白，以确定它们是否可以作为癌症进展的标志物。

2. 发明授权

US08148600B2 Immunocompromised rodents as dual color tumor models 失效
标题翻译：免疫受损的啮齿动物作为双色肿瘤模型
公开(公告)号：US08148600B2
公开(公告)日：2012-04-03
申请号：US10775554
申请日：2004-02-09
申请人： Meng Yang , Eligio Reynoso , Mingxu Xu , Ping Jiang
发明人： Meng Yang , Eligio Reynoso , Mingxu Xu , Ping Jiang
IPC分类号： A01K67/027 , A01K67/02
CPC分类号： A01K67/0275 , A01K67/0271 , A01K2217/05 , A01K2227/105 , A01K2267/03 , A01K2267/0393 , C07K14/43595 , C12N15/8509
摘要： Immunocompromised rodents that have been modified to express a fluorescent protein in substantially all tissues are described. These rodents are useful as models for gene expression, tumor progression and angiogenesis. Also provided are model systems where heterologous tissues fluorescing in a first color are transplanted into hosts that have been modified to fluoresce in substantially all tissues with a second color.
摘要翻译：描述了已在基本上所有组织中修饰以表达荧光蛋白的免疫受损啮齿动物。这些啮齿动物可用作基因表达，肿瘤进展和血管发生的模型。还提供了模型系统，其中以第一种颜色发荧光的异源组织移植到已被修饰为在基本上具有第二种颜色的所有组织中发荧光的宿主中。

3. 发明授权

US06653278B1 Selenium-containing pro-drugs for cancer therapy 失效
标题翻译：含硒的前药用于癌症治疗
公开(公告)号：US06653278B1
公开(公告)日：2003-11-25
申请号：US09568902
申请日：2000-05-11
申请人： Kenji Miki , Mingxu Xu , Yuying Tan
发明人： Kenji Miki , Mingxu Xu , Yuying Tan
IPC分类号： A01N3718
CPC分类号： A61K38/51 , A61K31/095 , A61K48/00 , A61K2300/00
摘要： Methods for inhibiting the growth of tumor cells by combination treatment with a selenium-containing prodrug and an enzyme for which it is a substrate are described. The treatment also enhances the effect of anti-tumor agents.
摘要翻译：描述了通过与含硒前体药物和其作为底物的酶联合治疗来抑制肿瘤细胞生长的方法。治疗也增强了抗肿瘤剂的作用。

4. 发明授权

US06632430B2 Modulators of methylation for control of bacterial virulence 失效
标题翻译：用于控制细菌毒力的甲基化调节剂
公开(公告)号：US06632430B2
公开(公告)日：2003-10-14
申请号：US10334532
申请日：2002-12-30
申请人： Mingxu Xu , Quinghong Han , Yuying Tan
发明人： Mingxu Xu , Quinghong Han , Yuying Tan
IPC分类号： A61K3851
CPC分类号： A61K31/7076 , A61K31/198 , A61K38/51
摘要： Compositions and methods which ameliorate the virulence of bacterial infection are described wherein the active ingredient modulates transmethylation reactions in bacterial cells. Particularly useful compounds are inhibitors of S-adenosyl methionine synthetase (SAMS), of S-adenosyl homocysteine hydrolase (SAHH) and of transmethylases.
摘要翻译：描述了改善细菌感染的毒力的组合物和方法，其中活性成分调节细菌细胞中的转甲基化反应。特别有用的化合物是S-腺苷甲硫氨酸合成酶（SAMS），S-腺苷同型半胱氨酸水解酶（SAHH）和转甲基酶的抑制剂。

5. 发明申请

US20090249500A1 SYSTEM FOR MONITORING BACTERIAL TUMOR TREATMENT 审中-公开
标题翻译：用于监测细菌性肿瘤治疗的系统
公开(公告)号：US20090249500A1
公开(公告)日：2009-10-01
申请号：US12422863
申请日：2009-04-13
申请人： Ming ZHAO , Xiao-MING LI , Meng YANG , Mingxu XU , Ping JIANG , Lingna LI
发明人： Ming ZHAO , Xiao-MING LI , Meng YANG , Mingxu XU , Ping JIANG , Lingna LI
IPC分类号： A01K67/027
CPC分类号： A61K49/0045 , A61K49/0008 , A61K49/0047 , A61K49/0097
摘要： A method to follow the progress of tumor treatment in subjects utilizes bacteria that have been modified to express a fluorescent protein. The method can also monitor expression of genes associated with the bacteria that produce therapeutic agents during the course of treatment, optionally against a background of fluorescence generated by the tumor itself. The method permits visualization of the progress of treatment in live subjects so that treatments can be modified according to their efficacy.
摘要翻译：用于跟踪肿瘤治疗进展的方法利用已被修饰以表达荧光蛋白的细菌。该方法还可以监测在治疗过程中产生治疗剂的细菌相关基因的表达，任选地与肿瘤本身产生的荧光背景相关。该方法允许对活体受试者的治疗进展的可视化，使得可以根据其疗效来修改治疗。

6. 发明授权

US06713273B2 High expression and production of high specific activity recombinant S-adenosyl homocysteinase (SAHH) and improved assays for S-adenosylmethionine (SAM) 失效
标题翻译：重组S-腺苷同型半胱氨酸酶（SAHH）和S-腺苷甲硫氨酸（SAM）的高表达和产生高比重活性
公开(公告)号：US06713273B2
公开(公告)日：2004-03-30
申请号：US09759990
申请日：2001-01-12
申请人： Mingxu Xu , Qinghong Han
发明人： Mingxu Xu , Qinghong Han
IPC分类号： C12Q148
CPC分类号： C12Q1/34 , A61K38/00 , C12N9/14 , C12Q1/48 , Y02A50/411
摘要： The invention provides novel methods relating to SAM detection and production as well as a novel SAHH enzymatic activity for use in such methods. Additional methods, compositions, and kits relating to the novel SAHH are also provided.
摘要翻译：本发明提供了与SAM检测和生产有关的新方法以及用于这些方法的新型SAHH酶活性。还提供了与新型SAHH相关的其它方法，组合物和试剂盒。

7. 发明授权

US06653092B2 Method to determine hydrogen peroxide 失效
标题翻译：测定过氧化氢的方法
公开(公告)号：US06653092B2
公开(公告)日：2003-11-25
申请号：US10003597
申请日：2001-10-30
申请人： Qinghong Han , Li Tang , Mingxu Xu , Yuying Tan , Shigeo Yagi
发明人： Qinghong Han , Li Tang , Mingxu Xu , Yuying Tan , Shigeo Yagi
IPC分类号： C12Q148
CPC分类号： C12Q1/48 , G01N2333/91011
摘要： A method to detect and measure the concentration of hydrogen peroxide comprises adding reagents consisting essentially of peroxidase and a dialkyl phenylenediamine and detecting any color generated by the interaction of hydrogen peroxide with these reagents.
摘要翻译：检测和测量过氧化氢浓度的方法包括加入基本上由过氧化物酶和二烷基苯二胺组成的试剂，并检测由过氧化氢与这些试剂的相互作用产生的任何颜色。

8. 发明授权

US06524571B1 Methioninase gene therapy for tumor treatment 失效
标题翻译：甲硫氨酸酶基因治疗肿瘤治疗
公开(公告)号：US06524571B1
公开(公告)日：2003-02-25
申请号：US09195055
申请日：1998-11-18
申请人： Mingxu Xu , Yuying Tan
发明人： Mingxu Xu , Yuying Tan
IPC分类号： A01N4304
CPC分类号： G02B5/32 , A01K67/0271 , A61K38/51 , A61K48/00
摘要： A depletion method to inhibit tumor growth includes introducing a viral expression system capable of expressing methioninase or a fusion protein containing methioninase into a tumor contained in a vertebrate subject or cells thereof. The fusion protein may contain a fluorescent protein to permit monitoring of the completeness of the depletion method. The fusion protein can be used in vivo as well as in vitro screening protocols which employ the viral expression system. The expression system includes control sequences and means to integrate the nucleotide sequence into the genome of a host cell for expression. The method may also include treating the cells with isolated methioninase and/or with a therapeutic cell. The depletion method can be with other known therapies, such as maintaining the animal having the tumor on a methionine depleted diet.
摘要翻译：抑制肿瘤生长的消耗方法包括将能够表达蛋氨酸酶的病毒表达系统或含有蛋氨酸酶的融合蛋白引入到脊椎动物对象或其细胞中所含的肿瘤中。融合蛋白可以含有荧光蛋白以允许监测耗尽方法的完整性。融合蛋白可以在体内以及使用病毒表达系统的体外筛选方案中使用。表达系统包括将核苷酸序列整合到宿主细胞的基因组中用于表达的控制序列和方法。该方法还可以包括用分离的蛋氨酸酶和/或用治疗细胞处理细胞。耗尽方法可以与其他已知的疗法一起使用，例如将具有肿瘤的动物维持在消耗蛋氨酸的饮食上。

9. 发明申请

US20120316321A1 METHODS FOR IDENTIFYING MARKERS FOR EARLY-STAGE HUMAN CANCER, CANCER PROGRESSION AND RECURRENCE 审中-公开
标题翻译：识别早期人类癌症标志物的方法，癌症进展和复发
公开(公告)号：US20120316321A1
公开(公告)日：2012-12-13
申请号：US13525174
申请日：2012-06-15
申请人： Mingxu XU , Yuying Tan , Levy Kopelovich
发明人： Mingxu XU , Yuying Tan , Levy Kopelovich
IPC分类号： C40B40/02 , C40B30/06 , C40B40/08 , C07K14/00
CPC分类号： C12N15/1051 , C12N15/1086
摘要： A method is described to identify secreted proteins identified with stages of malignancy of cancer. The proteins are initially identified by trapping them with a fluorescent protein containing vector that can insert in any gene. The secreted proteins are initially identified by their fluorescence. Secreted proteins identifying tumors with specific degrees of malignancy are isolated to determine if they can serve as markers of cancer progression.
摘要翻译：描述了一种鉴定鉴定为癌症恶性程度的分泌蛋白的方法。最初通过用含有可插入任何基因的含荧光蛋白的载体捕获蛋白质来鉴定蛋白质。分泌的蛋白质最初通过其荧光来鉴定。分离识别具有特定恶性程度的肿瘤的分泌蛋白，以确定它们是否可以作为癌症进展的标志物。

10. 发明授权

US07252941B2 Expression profiling based on histocultures 失效
标题翻译：基于组织培养的表达谱
公开(公告)号：US07252941B2
公开(公告)日：2007-08-07
申请号：US10712781
申请日：2003-11-12
申请人： Ping Jiang , Mingxu Xu , Yuying Tan
发明人： Ping Jiang , Mingxu Xu , Yuying Tan
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/158
摘要： Methods of obtaining faithful expression libraries from tissue samples comprise extraction of RNA from intact tissue cultured in three-dimensional sponge-gel based histocultures.
摘要翻译：从组织样品获得忠实表达文库的方法包括从在三维海绵凝胶基组织培养中培养的完整组织中提取RNA。

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