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1. 发明申请

US20120289578A1 USE OF RNA INTERFERENCE FOR TREATING OR REDUCING PAIN 有权
标题翻译：使用RNA干扰治疗或减轻疼痛
公开(公告)号：US20120289578A1
公开(公告)日：2012-11-15
申请号：US13182707
申请日：2011-07-14
申请人： Ming-Dar Tsai , Yih-Jing Lee
发明人： Ming-Dar Tsai , Yih-Jing Lee
IPC分类号： A61K31/7105 , A61P25/00 , A61P29/00 , C07H21/02
CPC分类号： C07H21/02 , A61K31/713
摘要： A use of a nucleic acid molecule mediating RNA interference for treating or reducing pain is disclosed. The nucleic acid molecule has a sequence selected from the group consisting of SEQ ID NO:1, SEQ ID NO:2, SEQ ID NO:3 and SEQ ID NO:4, and is used for effectively inhibiting expression of bradykinin B2 receptor, treating or reducing pain and preparing a pharmaceutical composition for reducing neuropathic pain.
摘要翻译：公开了介导RNA干扰的核酸分子用于治疗或减轻疼痛的用途。核酸分子具有选自SEQ ID NO：1，SEQ ID NO：2，SEQ ID NO：3和SEQ ID NO：4的序列，用于有效抑制缓激肽B2受体的表达，治疗或减轻疼痛并制备用于减少神经性疼痛的药物组合物。

2. 发明授权

US07806838B2 Image analysis method for abnormal hip structures based on transverse sections 有权
标题翻译：基于横截面的异常髋关节结构图像分析方法
公开(公告)号：US07806838B2
公开(公告)日：2010-10-05
申请号：US11140326
申请日：2005-05-27
申请人： Ming-Dar Tsai , Ming-Shium Hsieh
发明人： Ming-Dar Tsai , Ming-Shium Hsieh
IPC分类号： A61B5/103
CPC分类号： A61B5/103 , A61B5/055 , A61B5/4504 , A61B6/505
摘要： An image analysis method for abnormal hip structures. A plurality of transverse sections of a bone structure are provided. Structural features on the transverse sections are obtained. Abnormities of the structural features of the bone structure are recognized. Structural and feature properties of the bone structure are estimated according to recognition results, and corresponding structural parameters relating to the bond structure are obtained accordingly.
摘要翻译：异常髋关节结构的图像分析方法。提供骨结构的多个横截面。获得横截面上的结构特征。认识到骨结构的结构特征异常。根据识别结果估算骨结构的结构和特征，相应地获得与结构结构相关的相应结构参数。

3. 发明申请

US20070191741A1 Image analysis methods for gleno-humeral joint morphology 审中-公开
标题翻译：图像分析方法用于睑 - 肱骨关节形态学
公开(公告)号：US20070191741A1
公开(公告)日：2007-08-16
申请号：US11489798
申请日：2006-07-19
申请人： Ming-Dar Tsai , Ming-Shium Hsieh
发明人： Ming-Dar Tsai , Ming-Shium Hsieh
IPC分类号： A61B5/107 , A61B17/88
CPC分类号： A61B5/103 , A61B5/4528 , A61B34/10 , G06T7/0012 , G06T2207/30008 , G16H50/50
摘要： Image analysis methods for gleno-humeral joint morphology. At least one specific structure is approximated as an elliptical structure at a plurality of transverse sections. At least one pathological feature on the structure is recognized. At least one structural spatial property of a 3D structure is calculated based on the structural property of the elliptical structure, thus determining the morphology of the 3D structure. Structural deformities are evaluated according to the morphology of the 3D structure. The pathological features on the sections are integrated to obtain at least one 3D pathological feature property, and a treatment is determined accordingly.
摘要翻译：图像分析方法用于睑 - 肱骨关节形态学。至少一个特定结构近似为多个横截面处的椭圆结构。识别结构至少有一个病理特征。基于椭圆结构的结构特性，计算3D结构的至少一个结构空间属性，从而确定3D结构的形态。结构畸形根据3D结构的形态进行评估。整合切片的病理特征，以获得至少一个3D病理特征属性，并相应地确定治疗。

4. 发明申请

US20060110017A1 Method for spinal disease diagnosis based on image analysis of unaligned transversal slices 审中-公开
标题翻译：基于不对称横切片图像分析的脊柱疾病诊断方法
公开(公告)号：US20060110017A1
公开(公告)日：2006-05-25
申请号：US11178938
申请日：2005-07-11
申请人： Ming-Dar Tsai , Ming-Shium Hsieh
发明人： Ming-Dar Tsai , Ming-Shium Hsieh
IPC分类号： G06K9/00
CPC分类号： G06T7/0012 , G06T2207/30008
摘要： A method for spinal disease diagnosis based on image analysis of unaligned transversal slices, reconstructing a 3D image of a bone structure. At least one transverse slice is extract from the 3D image. Vertices of a triangulated isosurface are obtained from the transverse slice. The vertices are transformed to correct positions of unaligned slices in the bone structure. A surface normal of the vertices is calculated according to the correct positions. The triangulated isosurface is reconstructed by interpolating according to the vertices.
摘要翻译：一种基于非对齐横切片图像分析的脊柱疾病诊断方法，重建骨骼结构的3D图像。从3D图像提取至少一个横向切片。三角形等值面的顶点从横向切片获得。顶点被转换为正确的骨骼结构中未对齐切片的位置。根据正确的位置计算顶点的表面法线。通过根据顶点进行内插重建三角形等值面。

5. 发明申请

US20110066406A1 Method for Generating Real-Time Haptic Response Information for a Haptic Simulating Device 审中-公开
标题翻译：用于产生触觉模拟装置的实时触觉响应信息的方法
公开(公告)号：US20110066406A1
公开(公告)日：2011-03-17
申请号：US12848578
申请日：2010-08-02
申请人： Ming-Dar Tsai , Ming-Shium Hsieh
发明人： Ming-Dar Tsai , Ming-Shium Hsieh
IPC分类号： G06F17/50 , G06F17/10 , H04B3/36
CPC分类号： G06T19/00 , G06F3/016 , G06T2210/28 , G06T2210/41
摘要： A method is provided for generating real-time haptic response information for a haptic simulating device during a surgery simulation performed by a virtual tool on an object volume that includes tissue voxels, null voxels, and object boundary points. The method includes: (a) receiving a select input of a selected virtual tool type; (b) obtaining tool boundary points of the virtual tool; (c) obtaining a current reference position of the virtual tool; (d) determining a current tool subvolume; and (e) when the current tool subvolume has at least one tissue voxel, (e-1) determining positions of the tool boundary points within the subvolume, (e-2) updating labels of the voxels within the subvolume and replacing an original set of the object boundary points within the subvolume with a new set of the object boundary points, (e-3) determining force-contributing ones of the tool boundary points, and (e-4) providing force information of a force to be generated by the haptic simulating device.
摘要翻译：提供了一种用于在由虚拟工具在包括组织体素，零体素和对象边界点的对象体积上执行的手术模拟期间产生用于触觉模拟装置的实时触觉响应信息的方法。该方法包括：（a）接收所选虚拟工具类型的选择输入; （b）获取虚拟工具的工具边界点; （c）获得虚拟工具的当前参考位置; （d）确定当前工具子体积; （e）当当前工具子体积具有至少一个组织体素时，（e-1）确定子体积内的工具边界点的位置，（e-2）更新子体积内的体素的标签并替换原始组（e-3）确定力作用的工具边界点，（e-4）提供由力产生的力的信息，触觉模拟装置。

6. 发明申请

US20100070254A1 Method for Generating Real-Time Haptic Response Information for a Haptic Simulating Device 审中-公开
标题翻译：用于产生触觉模拟装置的实时触觉响应信息的方法
公开(公告)号：US20100070254A1
公开(公告)日：2010-03-18
申请号：US12559607
申请日：2009-09-15
申请人： Ming-Dar Tsai , Ming-Shium Hsieh
发明人： Ming-Dar Tsai , Ming-Shium Hsieh
IPC分类号： G06G7/48 , G06T17/00 , G09G5/00
CPC分类号： G06T19/00 , G06F3/016 , G06T2210/28 , G06T2210/41
摘要： A method is provided for generating real-time haptic response information for a haptic simulating device during a surgery simulation performed on an object volume by a virtual tool that is associated with the haptic simulating device. The object volume includes tissue voxels, null voxels, and object boundary points located between corresponding adjacent pairs of the tissue and null voxels. The method includes: (a) obtaining a current center position of the virtual tool; (b) determining a current tool subvolume of the object volume; and (c) upon determining that the current tool subvolume has at least one tissue voxel, performing the sub-steps of: (c-1) determining positions of tool boundary points within the current tool subvolume, (c-2) updating labeling of the voxels within the current tool subvolume and replacing an original set of the object boundary points within the current tool subvolume with a new set of the object boundary points, and (c-3) providing force information of a force to be generated by the haptic simulating device.
摘要翻译：提供了一种用于在通过与触觉模拟装置相关联的虚拟工具对对象体积执行的手术模拟期间产生用于触觉模拟装置的实时触觉响应信息的方法。对象体积包括组织体素，零体素和位于组织的相应相邻对和零体素之间的对象边界点。该方法包括：（a）获得虚拟工具的当前中心位置; （b）确定目标体积的当前工具子体积; （c）在确定当前工具子体积具有至少一个组织体素时，执行以下子步骤：（c-1）确定当前工具子体积内的工具边界点的位置，（c-2）更新标签当前工具中的体素子体积，并用一组新的对象边界点替换当前工具子体积中的原始对象边界点集合，（c-3）提供由触觉产生的力的力信息模拟装置。

7. 发明授权

US07359539B2 Method for herniated inter-vertebral disc diagnosis based on image analysis of transverse sections 失效
标题翻译：基于横断面图像分析的椎间盘突出诊断方法
公开(公告)号：US07359539B2
公开(公告)日：2008-04-15
申请号：US10458362
申请日：2003-06-11
申请人： Ming-Dar Tsai , Ming-Shium Hsieh
发明人： Ming-Dar Tsai , Ming-Shium Hsieh
IPC分类号： G06K9/00
CPC分类号： G06T7/0012 , G06T2207/30008
摘要： An image analysis method that uses automatic algorithms for the evaluation of herniation classification and geometry in the diagnosis of a herniated inter-vertebral disc (HIVD). Based on a transverse section, the method utilizes a B-spline curve to approximate a circle-like disc boundary and excludes the herniation from other normal parts of the disc boundary. The method therefor attains to feature recognition that classifies the herniation, and the herniation reconstruction that infers the 3D geometry from one or more transverse section. With enhanced resolution provided by the method, a higher diagnostic rate of HIVD is achieved.
摘要翻译：一种使用自动算法评估突出椎间盘（HIVD）诊断中的突出分类和几何形状的图像分析方法。基于横截面，该方法利用B样条曲线近似圆形圆盘边界，并将椎间盘从其他正常部分排除。其方法实现了对突出进行分类的特征识别和从一个或多个横截面推断3D几何的突出重建。通过该方法提供的增强分辨率，可实现更高的HIVD诊断率。

8. 发明申请

US20070036416A1 Image analysis method for vertebral compression curvature 审中-公开
标题翻译：图像分析方法用于椎体压缩曲率
公开(公告)号：US20070036416A1
公开(公告)日：2007-02-15
申请号：US11515002
申请日：2006-09-05
申请人： Ming-Dar Tsai , Ming-Shium Hsieh
发明人： Ming-Dar Tsai , Ming-Shium Hsieh
IPC分类号： G06K9/00 , A61B5/05
CPC分类号： G06T7/0012 , G06T7/64 , G06T2207/10081 , G06T2207/10088 , G06T2207/20044 , G06T2207/30012
摘要： An image analysis method for vertebral compression curvature is disclosed for providing diagnosis analysis of the compression curvature. It makes use of the transverse sectional image with a concave feature of a vertebral body. After B-spline curves are approximated as ellipse-like surfaces, the method further evaluates the compression curvature of the canal. On the other hand, the center of the ellipse-like surface boundary obtained by approximation from different transverse sectional images of the vertebral body is used to reconstruct the centerline of the vertebral body by linear restoration. Such information is used to determine the curvature of the vertebral body. Moreover, the method can use the above-mentioned reconstructed vertebral body centerline to compare with other adjacent vertebral centerlines that have normal curvatures. In this manner, the method can help determine the type and extent of the spine under pressure or having a fracture.
摘要翻译：公开了用于提供压缩曲率的诊断分析的用于椎体压缩曲率的图像分析方法。它利用具有椎体的凹形特征的横截面图像。在B样条曲线近似为椭圆形曲面之后，该方法进一步评估了运河的压缩曲率。另一方面，通过从椎体的不同横截面图像近似获得的椭圆形表面边界的中心用于通过线性恢复来重建椎体的中心线。这些信息用于确定椎体的曲率。此外，该方法可以使用上述重建的椎体中心线与具有正常曲率的其他相邻椎骨中心线进行比较。以这种方式，该方法可以帮助确定在压力下或有骨折的脊柱的类型和程度。

9. 发明授权

US08445456B2 Use of RNA interference for treating or reducing pain 有权
标题翻译：使用RNA干扰治疗或减轻疼痛
公开(公告)号：US08445456B2
公开(公告)日：2013-05-21
申请号：US13182707
申请日：2011-07-14
申请人： Ming-Dar Tsai , Yih-Jing Lee
发明人： Ming-Dar Tsai , Yih-Jing Lee
IPC分类号： A61K31/70 , C07H21/04
CPC分类号： C07H21/02 , A61K31/713
摘要： A use of a nucleic acid molecule mediating RNA interference for treating or reducing pain is disclosed. The nucleic acid molecule has a sequence selected from the group consisting of SEQ ID NO:1, SEQ ID NO:2, SEQ ID NO:3 and SEQ ID NO:4, and is used for effectively inhibiting expression of bradykinin B2 receptor, treating or reducing pain and preparing a pharmaceutical composition for reducing neuropathic pain.
摘要翻译：公开了介导RNA干扰的核酸分子用于治疗或减轻疼痛的用途。核酸分子具有选自SEQ ID NO：1，SEQ ID NO：2，SEQ ID NO：3和SEQ ID NO：4的序列，用于有效抑制缓激肽B2受体的表达，治疗或减轻疼痛并制备用于减少神经性疼痛的药物组合物。

10. 发明授权

US07121832B2 Three-dimensional surgery simulation system 有权
标题翻译：三维手术模拟系统
公开(公告)号：US07121832B2
公开(公告)日：2006-10-17
申请号：US10379135
申请日：2003-03-04
申请人： Ming-Shium Hsieh , Ming-Dar Tsai
发明人： Ming-Shium Hsieh , Ming-Dar Tsai
IPC分类号： G09B23/28
CPC分类号： G09B23/28 , G06F19/00
摘要： A three-dimensional surgery simulation system is provided for generating a three-dimensional surgery simulation result of an anatomical part undergoing a simulated surgical procedure. The system includes a display unit, a three-dimensional visual imaging unit, a storage unit for storing a plurality of voxelized three-dimensional model image data sets, an input unit for controlling progress of the simulated surgical procedure, and a computing unit for computing the simulation result data in accordance with the voxelized three-dimensional model image data sets and under the control of the input unit, and for controlling the display unit to permit viewing of the surgery simulation result in three-dimensional form thereon by an operator wearing the visual imaging unit.
摘要翻译：提供三维手术模拟系统，用于产生经历模拟外科手术的解剖部位的三维手术模拟结果。该系统包括显示单元，三维可视成像单元，用于存储多个体素化三维模型图像数据组的存储单元，用于控制模拟外科手术进程的输入单元，以及用于计算所述模拟结果数据根据所述体素化三维模型图像数据集并且在所述输入单元的控制下，并且用于控制所述显示单元，以允许所述显示单元通过佩戴所述显示单元在其上以三维形式观看所述手术模拟结果视觉成像单元。

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