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1. 发明授权

US07820430B2 Micro device for cell culture 有权
标题翻译：用于细胞培养的微型装置
公开(公告)号：US07820430B2
公开(公告)日：2010-10-26
申请号：US11503123
申请日：2006-08-14
申请人： Yu-Shi Weng , Ming-Cheng Shih , Rung-Jiun Gau
发明人： Yu-Shi Weng , Ming-Cheng Shih , Rung-Jiun Gau
IPC分类号： C12M3/00
CPC分类号： C12M23/16 , C12M23/12 , C12M23/58 , C12M41/40
摘要： A micro device for cell culture is disclosed, which cooperates with a fluid and includes: a top plate having an inlet port; a orifice plate having a plurality of orifices; a culture plate having a plurality of culture wells and a plurality of injection ports; and a bottom plate having at least one collecting well and at least one collecting flow channel, wherein, the culture plate is placed between the orifice plate and the bottom plate. The collecting flow channel connects to all regulating orifices in the culture wells and guides the fluid from the culture wells, then receives the fluid in the collecting well. The fluid flows into the orifice plate from the inlet port of the top plate, and then diversifies into the culture plate, then arrives at each culture well by way of the injection ports, and finally collects in the collecting well of the bottom plate.
摘要翻译：公开了一种用于细胞培养的微型装置，其与流体协作并且包括：顶板，其具有入口; 具有多个孔口的孔板; 具有多个培养孔和多个注射口的培养板; 以及具有至少一个收集井和至少一个收集流动通道的底板，其中，所述培养板被放置在所述孔板和所述底板之间。收集流通道连接到培养井中的所有调节孔，并引导来自培养井的流体，然后在收集井中接收流体。流体从顶板的入口流入孔板，然后分散到培养板中，然后通过注射口到达每个培养井，最后收集在底板的收集井中。

2. 发明申请

US20090004731A1 Cell culture apparatus and a fabricating method of the same 有权
标题翻译：细胞培养装置及其制造方法
公开(公告)号：US20090004731A1
公开(公告)日：2009-01-01
申请号：US12155785
申请日：2008-06-10
申请人： Ming-Cheng Shih , Chin-Fu Chen , Rung-Jiun Gau , Yu-Shih Weng , Ya-Jen Yu , Shao-Jen Yeh
发明人： Ming-Cheng Shih , Chin-Fu Chen , Rung-Jiun Gau , Yu-Shih Weng , Ya-Jen Yu , Shao-Jen Yeh
IPC分类号： C12M1/00 , G03F7/20
CPC分类号： C12M25/14
摘要： A cell culture apparatus and a method for fabricating the cell culture apparatus are disclosed, the method comprises forming at least one fillister on a biomaterial composite layer by photolithography, wherein the biomaterial composite layer contains two gel materials. One is a bio-compatible hydrogel composition having various weight ratio of: 2-hydroxyethylmathacrylate (HEMA), bisphenol A and glycidyl methacrylate (bis-GMA), triethylene glycol dimethacrylate (TEGDMA), r-methacryloxypropyl trimethoxysilane (MAPTMS), α,α-diethoxyacetophenone (DEAP), and the other one is a photo-sensitive silica gel composition.
摘要翻译：公开了一种细胞培养装置和细胞培养装置的制造方法，该方法包括通过光刻法在生物材料复合层上形成至少一个填充物，其中生物材料复合层含有两种凝胶材料。一种是具有各种重量比的生物相容性水凝胶组合物：2-羟乙基甲基丙烯酸酯（HEMA），双酚A和甲基丙烯酸缩水甘油酯（双-GMA），三乙二醇二甲基丙烯酸酯（TEGDMA），γ-甲基丙烯酰氧基丙基三甲氧基硅烷（MAPTMS），α，α 二乙氧基苯乙酮（DEAP），另一种是光敏硅胶组合物。

3. 发明授权

US08129188B2 Cell culture apparatus and method of fabricating the apparatus 有权
标题翻译：细胞培养装置及其制造方法
公开(公告)号：US08129188B2
公开(公告)日：2012-03-06
申请号：US12155785
申请日：2008-06-10
申请人： Ming-Cheng Shih , Chin-Fu Chen , Rung-Jiun Gau , Yu-Shih Weng , Ya-Jen Yu , Shao-Jen Yeh
发明人： Ming-Cheng Shih , Chin-Fu Chen , Rung-Jiun Gau , Yu-Shih Weng , Ya-Jen Yu , Shao-Jen Yeh
IPC分类号： C12N5/07 , C12N11/08 , C12M1/00
CPC分类号： C12M25/14
摘要： A cell culture apparatus and a method for fabricating the cell culture apparatus are disclosed, the method comprises forming at least one fillister on a biomaterial composite layer by photolithography, wherein the biomaterial composite layer contains two gel materials. One is a bio-compatible hydrogel composition having various weight ratio of: 2-hydroxyethylmathacrylate (HEMA), bisphenol A and glycidyl methacrylate (bis-GMA), triethylene glycol dimethacrylate (TEGDMA), r-methacryloxypropyl trimethoxysilane (MAPTMS), α,α-diethoxyacetophenone (DEAP), and the other one is a photo-sensitive silica gel composition.
摘要翻译：公开了一种细胞培养装置和细胞培养装置的制造方法，该方法包括通过光刻法在生物材料复合层上形成至少一个填充物，其中生物材料复合层含有两种凝胶材料。一种是具有以下重要比例的生物相容性水凝胶组合物：2-羟乙基甲基丙烯酸酯（HEMA），双酚A和甲基丙烯酸缩水甘油酯（双-GMA），三乙二醇二甲基丙烯酸酯（TEGDMA），γ-甲基丙烯酰氧基丙基三甲氧基硅烷（MAPTMS），α，α 二乙氧基苯乙酮（DEAP），另一种是光敏硅胶组合物。

4. 发明申请

US20110038052A1 Prismatic Laminate and Method for Making The Same 有权
标题翻译：棱镜层压板及其制作方法
公开(公告)号：US20110038052A1
公开(公告)日：2011-02-17
申请号：US12652216
申请日：2010-01-05
申请人： Whey-Bin Lor , Kuang-Lin Yuan , Ru-Ping Huang , Chia-Chu Lin , Tsung-Sung Tsai , Ming-Hsiang Lee , Ching-Hung Lin , Ming-Cheng Shih
发明人： Whey-Bin Lor , Kuang-Lin Yuan , Ru-Ping Huang , Chia-Chu Lin , Tsung-Sung Tsai , Ming-Hsiang Lee , Ching-Hung Lin , Ming-Cheng Shih
IPC分类号： G02B27/10 , B05D5/06 , C23C14/28
CPC分类号： G02B5/0278 , G02B5/0231
摘要： A method for making a prismatic laminate includes the steps of: a) forming a back-coating roller having a roller surface with a plurality of recesses arranged in a predetermined pattern and produced by laser holography; b) preparing a prismatic structure including a plate body having a first surface and a second surface opposite to the first surface, and a plurality of prismatic strips formed on the first surface of the plate body; c) applying a coating containing a resin component and an antistatic agent on the second surface of the plate body; and d) embossing the coating with the back-coating roller to form an optical layer including a plurality of microstructures protruding in a direction away from the second surface of the plate body and having a pattern corresponding to that of the recesses in the roller surface.
摘要翻译：制造棱镜层压体的方法包括以下步骤：a）形成具有辊表面的背涂辊，所述辊表面具有以预定图案布置的多个凹槽，并通过激光全息术产生; b）制备棱柱结构，包括具有第一表面和与第一表面相对的第二表面的板体，以及形成在板体的第一表面上的多个棱柱条; c）在所述板体的第二表面上涂布含有树脂组分和抗静电剂的涂层; 以及d）用所述背涂辊对所述涂层进行压花以形成包括多个微结构的光学层，所述多个微结构在远离所述板体的第二表面的方向上突出并且具有与所述辊表面中的所述凹部相对应的图案。

5. 发明授权

US07749761B2 Hydrogel composition for cell culture apparatus 有权
标题翻译：用于细胞培养装置的水凝胶组合物
公开(公告)号：US07749761B2
公开(公告)日：2010-07-06
申请号：US11446207
申请日：2006-06-05
申请人： Ming-Cheng Shih , Chin-Fu Chen , Rung-Jiun Gau , Yu-Shih Weng , Ya-Jen Yu , Shao-Jen Yeh
发明人： Ming-Cheng Shih , Chin-Fu Chen , Rung-Jiun Gau , Yu-Shih Weng , Ya-Jen Yu , Shao-Jen Yeh
IPC分类号： C12N5/00 , C12M1/00
CPC分类号： C12M25/14
摘要： A cell culture apparatus and a method for fabricating the cell culture apparatus are disclosed, the method comprises forming at least one fillister on a biomaterial composite layer by photolithography, wherein the biomaterial composite layer contains two gel materials. One is a bio-compatible hydrogel composition having various weight ratio of: 2-hydroxyethylmathacrylate (HEMA), bisphenolA and glycidyl methacrylate (bis-GMA), triethylene glycol dimethacrylate (TEGDMA), r-methacryloxypropyl trimethoxysilane (MAPTMS), α,α-diethoxyacetophenone (DEAP), and the other one is a photo-sensitive silica gel composition.
摘要翻译：公开了一种细胞培养装置和细胞培养装置的制造方法，该方法包括通过光刻法在生物材料复合层上形成至少一个填充物，其中生物材料复合层含有两种凝胶材料。一种是具有以下重量比的生物相容性水凝胶组合物：2-羟乙基甲基丙烯酸酯（HEMA），双酚A和甲基丙烯酸缩水甘油酯（双-GMA），三乙二醇二甲基丙烯酸酯（TEGDMA），γ-甲基丙烯酰氧基丙基三甲氧基硅烷（MAPTMS），α，二乙氧基苯乙酮（DEAP），另一种是光敏硅胶组合物。

6. 发明申请

US20070072288A1 Cell culture apparatus and a fabricating method of the same 有权
标题翻译：细胞培养装置及其制造方法
公开(公告)号：US20070072288A1
公开(公告)日：2007-03-29
申请号：US11446207
申请日：2006-06-05
申请人： Ming-Cheng Shih , Yu-Shih Weng , Chin-Fu Chen , Rung-Jiun Gau , Ya-Jen Yu , Shao-Jen Yeh
发明人： Ming-Cheng Shih , Yu-Shih Weng , Chin-Fu Chen , Rung-Jiun Gau , Ya-Jen Yu , Shao-Jen Yeh
IPC分类号： C12M3/00
CPC分类号： C12M25/14
摘要： A cell culture apparatus and a method for fabricating the cell culture apparatus are disclosed, the method comprises forming at least one fillister on a biomaterial composite layer by photolithography, wherein the biomaterial composite layer contains two gel materials. One is a bio-compatible hydrogel composition having various weight ratio of:2-hydroxyethylmathacrylate(HEMA),bisphenolA and glycidyl methacrylate (bis-GMA), triethylene glycol dimethacrylate (TEGDMA), r-methacryloxypropyl trimethoxysilane (MAPTMS), α,α-diethoxyacetophenone (DEAP), and the other one is a photo-sensitive silica gel composition.
摘要翻译：公开了一种细胞培养装置和细胞培养装置的制造方法，该方法包括通过光刻法在生物材料复合层上形成至少一个填充物，其中生物材料复合层含有两种凝胶材料。一种是具有以下重量比的生物相容性水凝胶组合物：2-羟乙基甲基丙烯酸酯（HEMA），双酚A和甲基丙烯酸缩水甘油酯（双-GMA），三乙二醇二甲基丙烯酸酯（TEGDMA），γ-甲基丙烯酰氧基丙基三甲氧基硅烷（MAPTMS），α，二乙氧基苯乙酮（DEAP），另一种是光敏硅胶组合物。

7. 发明授权

US08089697B2 Prismatic laminate and method for making the same 有权
标题翻译：棱镜层压板及其制作方法
公开(公告)号：US08089697B2
公开(公告)日：2012-01-03
申请号：US12652216
申请日：2010-01-05
申请人： Whey-Bin Lor , Kuang-Lin Yuan , Ru-Ping Huang , Chia-Chu Lin , Tsung-Sung Tsai , Ming-Hsiang Lee , Ching-Hung Lin , Ming-Cheng Shih
发明人： Whey-Bin Lor , Kuang-Lin Yuan , Ru-Ping Huang , Chia-Chu Lin , Tsung-Sung Tsai , Ming-Hsiang Lee , Ching-Hung Lin , Ming-Cheng Shih
IPC分类号： G02B27/10 , F21V5/02 , B05D5/06
CPC分类号： G02B5/0278 , G02B5/0231
摘要： A method for making a prismatic laminate includes the steps of: a) forming a back-coating roller having a roller surface with a plurality of recesses arranged in a predetermined pattern and produced by laser holography; b) preparing a prismatic structure including a plate body having a first surface and a second surface opposite to the first surface, and a plurality of prismatic strips formed on the first surface of the plate body; c) applying a coating containing a resin component and an antistatic agent on the second surface of the plate body; and d) embossing the coating with the back-coating roller to form an optical layer including a plurality of microstructures protruding in a direction away from the second surface of the plate body and having a pattern corresponding to that of the recesses in the roller surface.
摘要翻译：制造棱镜层压体的方法包括以下步骤：a）形成具有辊表面的背涂辊，所述辊表面具有以预定图案布置的多个凹槽，并通过激光全息术产生; b）制备棱柱结构，包括具有第一表面和与第一表面相对的第二表面的板体，以及形成在板体的第一表面上的多个棱柱条; c）在所述板体的第二表面上涂布含有树脂组分和抗静电剂的涂层; 以及d）用所述背涂辊对所述涂层进行压花以形成包括多个微结构的光学层，所述多个微结构在远离所述板体的第二表面的方向上突出并且具有与所述辊表面中的所述凹部相对应的图案。

8. 发明公开

US20230248253A1 CHINESE PULSE WAVE MEASURING DEVICE AND USE METHOD THEREOF 审中-公开
公开(公告)号：US20230248253A1
公开(公告)日：2023-08-10
申请号：US18098729
申请日：2023-01-19
申请人： Ming-Cheng Shih
发明人： Ming-Cheng Shih
IPC分类号： A61B5/0255 , A61B5/024 , A61B5/00
CPC分类号： A61B5/0255 , A61B5/02427 , A61B5/7225
摘要： A Chinese pulse wave measuring device is provided, which includes an airbag, a pressure control module, a displacement sensing module, a scanning position control module, and a computing device. The above-mentioned pressure control module, displacement sensing module, and scanning position control module are respectively communicationally connected to the computing device, and the pump of the pressure control module is connected to the airbag through gas tube and valve. A method of using the above-mentioned pulse wave measuring device is also provided.

9. 发明申请

US20070122897A1 Micro device for cell culture 有权
标题翻译：用于细胞培养的微型装置
公开(公告)号：US20070122897A1
公开(公告)日：2007-05-31
申请号：US11503123
申请日：2006-08-14
申请人： Yu-Shi Weng , Ming-Cheng Shih , Rung-Jiun Gau
发明人： Yu-Shi Weng , Ming-Cheng Shih , Rung-Jiun Gau
IPC分类号： C12M1/34 , C12M3/00
CPC分类号： C12M23/16 , C12M23/12 , C12M23/58 , C12M41/40
摘要： A micro device for cell culture is disclosed, which cooperates with a fluid and includes: a top plate having an inlet port; a orifice plate having a plurality of orifices; a culture plate having a plurality of culture wells and a plurality of injection ports; and a bottom plate having at least one collecting well and at least one collecting flow channel, wherein, the culture plate is placed between the orifice plate and the bottom plate. The collecting flow channel connects to all regulating orifices in the culture wells and guides the fluid from the culture wells, then receives the fluid in the collecting well. The fluid flows into the orifice plate from the inlet port of the top plate, and then diversifies into the culture plate, then arrives at each culture well by way of the injection ports, and finally collects in the collecting well of the bottom plate.
摘要翻译：公开了一种用于细胞培养的微型装置，其与流体协作并且包括：具有入口的顶板; 具有多个孔口的孔板; 具有多个培养孔和多个注射口的培养板; 以及具有至少一个收集井和至少一个收集流动通道的底板，其中，所述培养板被放置在所述孔板和所述底板之间。收集流通道连接到培养井中的所有调节孔，并引导来自培养井的流体，然后在收集井中接收流体。流体从顶板的入口流入孔板，然后分散到培养板中，然后通过注射口到达每个培养井，最后收集在底板的收集井中。

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