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6. 发明授权

US06187769B1 Benzoxazepine derivatives and their salts and medicaments containing the same 有权
标题翻译：苯并西泮衍生物及其盐及含有它们的药物
公开(公告)号：US06187769B1
公开(公告)日：2001-02-13
申请号：US09306995
申请日：1999-05-07
申请人： Toshio Tatsuoka , Katsuhide Kamei , Noriko Maeda , Teruyoshi Inoue , Mika Nakajima , Ichiro Hirotsu
发明人： Toshio Tatsuoka , Katsuhide Kamei , Noriko Maeda , Teruyoshi Inoue , Mika Nakajima , Ichiro Hirotsu
IPC分类号： C07D40114
CPC分类号： C07D401/04 , C07D267/14 , C07D401/14 , C07D413/12 , C07D413/14
摘要： A benzoxazepine derivative having the general formula (I) and its salts and medicaments containing the same as effective ingredients: wherein, n is an integer of 2 to 5, R1 indicates a hydrogen atom, halogen atom, C1 to C4 lower alkyl group, C1 to C4 lower alkoxyalkyl group, C1 to C4 halogenoalkyl group, cyano group, or ester group, R2 indicates a hydrogen atom, halogen atom, C1 to C4 lower alkyl group, C1 to C4 lower alkoxy group, or hydroxy group, a dotted line indicates the presence or absence of a binding bond, W indicates C, CH, or CH2 or a nitrogen atom, provided that, when W is a nitrogen atom, Z is bonded to W and the dotted line indicates the absence of a bond, and Z indicates an unsubstituted or substituted aromatic hydrocarbon ring group or an unsubstituted or substituted heterocyclic group). This benzoxazepine derivative and its salts are useful as medicaments for the treatment of anxiety neurosis, phobias, obsessive-compulsive disorders, schizophrenia, post-cardiac trauma stress, depression, psychosomatic and other psychoneurotic disorders, eating disorders, menopausal disorders, infantile autism and also emesis or disorders involving the cerebral circulatory system accompanying cerebral infarction and cerebral hemorrhage.
摘要翻译：具有通式（I）的苯并氧氮杂衍生物及其盐和药物含有效成分：其中n为2〜5的整数，R1表示氢原子，卤素原子，C1〜C4低级烷基，C1 C4低级烷氧基烷基，C1〜C4卤代烷基，氰基或酯基，R2表示氢原子，卤素原子，C1〜C4低级烷基，C1〜C4低级烷氧基或羟基，虚线表示存在或不存在结合键，W表示C，CH或CH 2或氮原子，条件是当W为氮原子时，Z与W键合，虚线表示不存在键，并且Z 表示未取代或取代的芳族烃环基团或未取代或取代的杂环基团）。该苯并氧氮杂衍生物及其盐可用作治疗焦虑性神经症，恐怖症，强迫症，精神分裂症，心脏外伤后的药物精神分裂症，抑郁症，心身和其他精神神经性疾病，进食障碍，绝经障碍，婴儿自闭症以及涉及脑梗死和脑出血的脑循环系统的呕吐或紊乱。

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