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1. 发明授权

US4464358A Homocyclic derivatives 失效
标题翻译：环状衍生物
公开(公告)号：US4464358A
公开(公告)日：1984-08-07
申请号：US412905
申请日：1982-08-30
申请人： Michael T. Cox
发明人： Michael T. Cox
IPC分类号： A61K31/215 , A61K31/195 , A61K31/275 , A61K38/00 , A61P25/02 , C07C45/51 , C07C49/753 , C07C67/00 , C07C229/50 , C07C253/00 , C07C255/14 , C07D295/155 , C07D307/52 , C07K1/00 , C07K1/113 , C07K14/70 , A61K37/00 , A01N37/10 , A01N43/02 , C07C101/44 , C07C103/52 , C07C121/50
CPC分类号： C07D295/155 , C07C45/516 , C07C49/753 , C07D307/52 , C07K14/70 , A61K38/00
摘要： Compounds of the formula: ##STR1## wherein R.sup.1 stands for hydrogen or a defined hydrocarbyl or halogenoalkenyl radical, R.sup.2 stands for a defined hydrocarbyl, halogenoalkenyl or furylmethyl radical, R.sup.3 is a substituent at position (a) or (b) and stands for a hydroxy or defined alkoxy or alkanoyloxy radical, R.sup.4 stands for a defined alkoxy, cyanoalkoxy or alkenyloxy radical or a defined amino acid residue or peptide residue, and n stands for 1, 2 or 3, and pharmaceutically-acceptable salts thereof. Processes for the manufacture of the compounds. Pharmaceutical compositions comprising one of the compounds and a pharmaceutical diluent or carrier. The compounds are antagonists at the opiate receptors, and most of them are selective .delta.-receptor antagonists.
摘要翻译：下式的化合物其中R 1代表氢或被定义的烃基或卤代烯基，R 2表示定义的烃基，卤代烯基或呋喃基甲基，R 3是（a）或（b）位的取代基，代表羟基或定义的烷氧基或烷酰氧基，R4表示定义的烷氧基，氰基烷氧基或烯氧基或定义的氨基酸残基或肽残基，n表示1,2或3及其药学上可接受的盐。用于制造化合物的方法。包含化合物之一和药物稀释剂或载体的药物组合物。这些化合物是阿片受体的拮抗剂，其中大多数是选择性的δ-受体拮抗剂。

2. 发明授权

US5185452A Benzheterocyclyl sulphones 失效
标题翻译：苯甲酰胆碱
公开(公告)号：US5185452A
公开(公告)日：1993-02-09
申请号：US474940
申请日：1990-02-05
申请人： David R. Brittain , Michael T. Cox
发明人： David R. Brittain , Michael T. Cox
IPC分类号： C07D333/54 , A61K31/34 , A61K31/343 , A61K31/38 , A61K31/381 , A61K31/382 , A61K31/403 , A61K31/404 , A61K31/405 , A61K31/47 , A61P3/08 , C07D209/08 , C07D209/34 , C07D215/06 , C07D215/08 , C07D215/36 , C07D307/79 , C07D311/22 , C07D311/58 , C07D313/08 , C07D335/06
CPC分类号： C07D335/06 , C07D209/08 , C07D209/34 , C07D215/06 , C07D215/08 , C07D311/22 , C07D313/08
摘要： The invention concerns novel, pharmaceutically useful, benzheterocyclyl sulphones of the formula I: ##STR1## in which ring A may bear optional halogeno, (1-4C)alkyl or fluoro(1-4C)alkyl substituents; X is oxygen, or a group of the formula --S(O).sub.n -- or --NR.sup.1 -- in which n is zero, 1 or 2 and R.sup.1 is hydrogen, (1-4C)alkyl, (1-6C)alkanoyl, benzoyl or phenyl(1-4C)alkyl, the last two optionally substituted; Y is various linking groups defined hereinafter, such as ethylene or trimethylene; and in which the group --SO.sub.2 CH.sub.2 NO.sub.2 is located at position a, b or c in ring A; together with the non-toxic thereof. Other aspects of the invention include the production of the novel compounds by analogy processes and pharmaceutical compositions of the novel compounds for use in the treatment of diabetic complications.
摘要翻译：本发明涉及式I的新颖的药学上可用的苯并环基砜：其中环A可以带有任选的卤代（1-4C）烷基或氟（1-4C）烷基取代基; X为氧，或其中n为0,1或2且R 1为氢的式-S（O）n - 或-NR 1 - 的基团，（1-4C）烷基，（1-6C）烷酰基，苯甲酰基或苯基（1-4C）烷基，最后两个任选被取代; Y是下文定义的各种连接基团，例如乙烯或三亚甲基; 并且其中基团-SO 2 CH 2 NO 2位于环A中的位置a，b或c; 连同无毒的。本发明的其它方面包括通过类似方法生产新化合物和用于治疗糖尿病并发症的新化合物的药物组合物。

3. 发明申请

US20090063617A1 SYSTEMS, METHODS AND COMPUTER PRODUCTS FOR THROTTLING CLIENT ACCESS TO SERVERS 审中-公开
标题翻译：用于客户端访问服务器的系统，方法和计算机产品
公开(公告)号：US20090063617A1
公开(公告)日：2009-03-05
申请号：US11846053
申请日：2007-08-28
申请人： Jeff Calow , Michael T. Cox , William J. Masek
发明人： Jeff Calow , Michael T. Cox , William J. Masek
IPC分类号： G06F15/16
CPC分类号： H04L12/66
摘要： Systems, methods and computer products for throttling client access to servers. Exemplary embodiments include a method to throttle client access to servers, the method including maintaining local state information on active and pending requests, receiving a delay call from a client, calculating a delay, incrementing a pending operation count, p, returning the delay value to the client, decrementing the pending operation count, p, and incrementing an active operation count, a, in response to a start of an operation by a client, decrementing the active operation count in response to a operation finishing, recording a timestamp to record when a last pending operation should start, and resetting the pending operation count to 0, in response to a next delay request being received after the timestamp is recorded.
摘要翻译：用于限制客户端访问服务器的系统，方法和计算机产品。示例性实施例包括限制客户端对服务器的访问的方法，所述方法包括维护关于活动和未决请求的本地状态信息，从客户端接收延迟呼叫，计算延迟，递增未决操作计数p，将延迟值返回到客户端，响应于客户端的操作开始，递减待执行的操作计数p和递增活动操作计数a，响应于操作结束而递减活动操作计数，记录时间戳以记录何时响应于在记录时间戳之后接收的下一个延迟请求，应该开始最后一个等待操作，并将待处理操作计数重置为0。

4. 发明授权

US5446954A Method for manufacturing a frequency control device 失效
标题翻译：频率控制装置的制造方法
公开(公告)号：US5446954A
公开(公告)日：1995-09-05
申请号：US128790
申请日：1993-09-30
申请人： Thomas A. Knecht , Jean-Robert Achille , Charles K. Adams , Michael T. Cox
发明人： Thomas A. Knecht , Jean-Robert Achille , Charles K. Adams , Michael T. Cox
IPC分类号： H01L27/04 , H01L21/822 , H01L41/09 , H03B5/32 , H03H3/02 , H03H9/02 , H03H9/05 , H03H9/10 , H01L41/22 , H01L41/053
CPC分类号： H03H9/02102 , H03H9/0514 , H03H9/0528 , H03H9/0547 , H03H9/1014 , H03H2003/0414 , Y10T29/42
摘要： A method of manufacturing is employed to produce a size-reduced frequency control device (300), according to the present invention. A temperature compensation circuit (304) and an unsealed piezoelectric element (302) are disposed on a substrate (306) such that the compensation circuit and the unsealed piezoelectric element are electrically connected. A hermetic seal (318) is established between a lid (308) and the substrate such that the unsealed piezoelectric element and at least a temperature sensitive portion of the temperature compensation circuit occupy a sealed environment (320). In this manner, dimensions (322, 324) of the frequency control device are reduced.
摘要翻译：根据本发明，采用制造方法来制造尺寸减小的频率控制装置（300）。温度补偿电路（304）和非密封压电元件（302）设置在基板（306）上，使得补偿电路和非密封压电元件电连接。在盖（308）和基板之间建立气密密封（318），使得非密封压电元件和温度补偿电路的至少温度敏感部分占据密封环境（320）。以这种方式，减小了频率控制装置的尺寸（322,324）。

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