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1. 发明申请

US20110015409A1 SYNTHESIS OF CYCLIC CARBONATES 审中-公开
公开(公告)号：US20110015409A1
公开(公告)日：2011-01-20
申请号：US12921264
申请日：2009-03-06
申请人： Michael North
发明人： Michael North
IPC分类号： C07D317/38 , C07F5/06
CPC分类号： C07D317/38 , C07B2200/11 , C07D317/34 , C07D317/36 , C07F5/069
摘要： A dimeric aluminium(salen) catalyst of formula I: wherein: Y-Q is CRC1═N or CRC1RC2—NRN1, where RC1, RC2 and RN1 are independently selected from H, halo, optionally substituted C1-20 alkyl, optionally substituted C5-20 aryl, ether and nitro; each of the substituents R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, and R16, is independently selected from H, halo, optionally substituted C1-20 alkyl, optionally substituted C5-20 aryl, optionally substituted C3-20 heterocyclyl, ether and nitro; X1 and X2 are independently either (i) a C2-5 alkylene chain, which is optionally substituted by one or more groups selected from C1-4 alkyl and C5-7 aryl, or a C1-3 bisoxyalkylene chain, which is optionally substituted by one or more groups selected from C1-4 alkyl and C5-7 aryl or (ii) represent a divalent group selected from C5-7 arylene, C5-7 cyclic alkylene and C3-7 heterocyclylene, which may be optionally substituted; (i) (a) at least one of R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, and R16 is selected from L-A, where L is a single bond or a C1-10 alkylene group and A is an ammonium group paired with a counterion selected from Cl, Br and I; and/or (b) at least one of X1 and X2 is a divalent C3-7 heterocyclene group, containing a ring atom which is a quaternary nitrogen atom paired with a counterion selected from Cl, Br and I; and/or (c) at least one of X1 and X2 is a C2-5 alkylene chain or a C1-3 bisoxyalkylene chain, substituted by a group -Q-L-A, where Q is either —C(═O)—O—, —C(═O)—NH—, or a single bond; and/or (ii) (a) one of R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, and R16 is L-A′, where L is as defined above and A′ is a ammonium linking group bound to a solid support and paired with a counterion selected from Cl, Br and I; or (b) one of X1 and X2 is a divalent C3-7 heterocyclene group, containing a ring atom which is a quaternary nitrogen forming part of an ammonium linking group bound to a solid support and paired with a counterion selected from Cl, Br and I; or (c) one of X1 and X2 is a C2-5 alkylene chain or a C1-3 bisoxyalkylene chain, substituted by a group -Q-L-A′.

2. 发明授权

US07675628B2 Synchronous frequency-shift mechanism in Fizeau interferometer 有权
标题翻译： Fizeau干涉仪中的同步变频机构
公开(公告)号：US07675628B2
公开(公告)日：2010-03-09
申请号：US11899883
申请日：2007-09-07
申请人： James E. Millerd , Michael North-Morris
发明人： James E. Millerd , Michael North-Morris
IPC分类号： G01B9/02
CPC分类号： G01B9/02057 , G01B9/02002 , G01B9/02045 , G01B9/02065 , G01B9/0209 , G01B2290/70
摘要： An optical device for characterizing a test surface combines a Fizeau interferometer with a polarization frequency-shifting element. Two substantially collinear, orthogonally polarized beams having respective frequencies differing by a predetermined frequency shift are generated by the polarization frequency-shifting element and projected into the Fizeau optical cavity to produce a pair of test beams and a pair of reference beams, wherein the beams in each pair have orthogonal polarization states and have frequencies differing by the predetermined frequency shift. A second, substantially equal frequency shift is introduced in the Fizeau cavity on either one of the pairs of test and reference beams, thereby generating a four-beam collinear output that produces an interferogram without tilt or short-coherence light. The invention may also be implemented by reversing the order of the Fizeau cavity and the polarization frequency-shifting element in the optical train.
摘要翻译：用于表征测试表面的光学装置将Fizeau干涉仪与偏振频移元件组合。通过偏振频移元件产生具有不同频率预定频移的两个基本上共线的正交偏振光束，并投射到菲索光学腔中以产生一对测试光束和一对参考光束，其中光束每对具有正交偏振状态并且具有与预定频移不同的频率。第二个基本上相等的频移在Fizeau腔中的任一个测试和参考光束中被引入，从而产生产生没有倾斜或短相干光的干涉图的四光束共线输出。本发明还可以通过使光纤列中的Fizeau腔和极化频移元件的顺序颠倒来实现。

3. 发明申请

US20080086364A1 Methods of creating and using a virtual consumer packaged goods marketplace 审中-公开
标题翻译：创建和使用虚拟消费品包装商品市场的方法
公开(公告)号：US20080086364A1
公开(公告)日：2008-04-10
申请号：US11973053
申请日：2007-10-05
申请人： June Hahn , Michael North
发明人： June Hahn , Michael North
IPC分类号： G06Q10/00
CPC分类号： G06Q10/04 , G06Q30/0202
摘要： An agent-based computer model having consumer agents, retailer agents, and manufacturer agents represents the major participants in consumer packaged goods markets.
摘要翻译：具有消费者代理商，零售商代理商和制造商代理的基于代理的计算机模型代表消费品包装市场的主要参与者。

4. 发明申请

US20050192454A1 Process for the cyanation aldehydes 失效
标题翻译：氰化醛的工艺
公开(公告)号：US20050192454A1
公开(公告)日：2005-09-01
申请号：US11114068
申请日：2005-04-26
申请人： Michael North , Yuri Belokon
发明人： Michael North , Yuri Belokon
IPC分类号： B01J31/18 , B01J31/22 , C07B53/00 , C07C253/00 , C07C255/14 , C07C255/15 , C07C255/38 , C07C253/08
CPC分类号： B01J31/2208 , B01J31/2243 , B01J2231/341 , B01J2531/0216 , B01J2531/0252 , B01J2531/46 , B01J2531/56 , C07B53/00 , C07C253/00 , C07C255/38 , C07C255/14 , C07C255/15
摘要： A process for cyanating an aldehyde is provided. The process comprises reacting the aldehyde with: i) a cyanide source which does not comprise a Si—CN bond or a C—(C═O)—CN moiety; and ii) a substrate susceptible to nucleophilic attack not comprising a halogen leaving group; in the presence of a chiral catalyst. Preferably, the chiral catalyst is a chiral vanadium or titanium catalyst. The cyanide source is preferably an alkali metal cyanide and the substrate susceptible to nucleophilic attack not comprising a halogen leaving group is a carboxylic anhydride.
摘要翻译：提供了一种氰化醛的方法。该方法包括使醛与：i）不包含Si-CN键或C-（C-O）-CN部分的氰化物源反应; 和ii）对不包含卤素离去基团的亲核攻击敏感的底物; 在手性催化剂的存在下。优选地，手性催化剂是手性钒或钛催化剂。氰化物源优选为碱金属氰化物，并且对不含卤素离去基团的亲核侵袭敏感的底物是羧酸酐。

5. 发明授权

US5770432A Obesity associated genes 失效
公开(公告)号：US5770432A
公开(公告)日：1998-06-23
申请号：US630592
申请日：1996-04-10
申请人： Patsy Nishina , Konrad Noben-Trauth , Juergen Naggert , Michael North
发明人： Patsy Nishina , Konrad Noben-Trauth , Juergen Naggert , Michael North
IPC分类号： A61K38/00 , C07K14/47 , C07H21/04 , C12N15/74 , C12N15/85 , C12Q1/68
CPC分类号： C07K14/47 , A01K2217/05 , A61K38/00
摘要： The gene responsible for the autosomal recessive mouse obesity mutation tub was identified by positional cloning. The homologous human gene is also provided. The genes are used to produce tubby protein; in screening for compositions that modulate the expression or function of the tubby protein; and in studying associated physiological pathways. The DNA is further used as a diagnostic for genetic predisposition to obesity, retinal degeneration or cochlear degeneration. The mutation responsible for the tub phenotype is a G to T transversion that abolishes a donor splice site in the 3' coding region and results in a larger transcript containing the unspliced intron. A second, prematurely truncated transcript arises from the introduction of a premature polyadenylation site in the unspliced intron.

6. 发明授权

US09242955B2 Synthesis of cyclic carbonates 有权
标题翻译：环状碳酸酯的合成
公开(公告)号：US09242955B2
公开(公告)日：2016-01-26
申请号：US12597417
申请日：2008-04-25
申请人： Michael North
发明人： Michael North
IPC分类号： C07D317/12 , C07D317/14 , C07F5/06
CPC分类号： C07D317/12 , C07F5/069
摘要： A process for the production of cyclic carbonates comprising contacting an epoxide with carbon dioxide in the presence of a dimeric aluminum(salen) catalyst, and a co-catalyst capable of supplying Y−, where Y is selected from Cl, Br and I, where the dimeric aluminum(salen) catalyst is of formula I:
摘要翻译：一种生产环状碳酸酯的方法，包括在二聚铝（salen）催化剂存在下使环氧化物与二氧化碳接触，以及能够提供Y-的助催化剂，其中Y选自Cl，Br和I，其中二聚铝（salen）催化剂具有式I：

7. 发明申请

US20080198618A1 NETWORKING CABLE WITH LIGHTING SYSTEM FOR CABLE TRACING 有权
标题翻译：具有电缆跟踪照明系统的网络电缆
公开(公告)号：US20080198618A1
公开(公告)日：2008-08-21
申请号：US11675798
申请日：2007-02-16
申请人： Todd Michael North
发明人： Todd Michael North
IPC分类号： G02B6/00
CPC分类号： G02B6/447 , G02B6/001 , G02B6/4469
摘要： A cable includes a waveguide with a lighting system removeably attached to it. The lighting system includes a plurality of light emitters extending along the waveguide and connected together with conductive lines. The lighting system also includes light emitter connectors which can be engaged with a power source to activate the light emitters. The activation of the light emitters is useful in cable tracing because it indicates where the waveguide extends.
摘要翻译：电缆包括具有可移除地附接到其上的照明系统的波导。照明系统包括沿着波导延伸并与导电线连接在一起的多个发光体。照明系统还包括能够与电源接合以激活光发射器的发光器连接器。光发射器的激活在电缆跟踪中是有用的，因为它指示波导延伸的位置。

8. 发明授权

US07326312B1 Process for laying fiber tape 有权
标题翻译：铺设纤维胶带的工艺
公开(公告)号：US07326312B1
公开(公告)日：2008-02-05
申请号：US10936964
申请日：2004-09-09
申请人： Ralph John Rust , Michael North Grimshaw , James Richard Hecht
发明人： Ralph John Rust , Michael North Grimshaw , James Richard Hecht
IPC分类号： B32B37/00
CPC分类号： B29C70/388 , B29C70/545 , B29C2793/0027 , Y10T156/1064 , Y10T156/1085
摘要： The process for laying a non-full width course of fiber composite tape in a part is designed to ensure that all of the scrap portion of the tape surrounding the non-full width course is deposited in the scrap area and not in the part. An extra cut is made in tape downstream of the non-full width course, between the non-full width course and next course. After the tape head attempts to lay the scrap in the scrap area in the forward direction, the tape head makes a pass in the scrap area with the tape feed and the tape head moving in the reverse direction, and the scrap is laid beginning from the portion of the tape having the extra cut, and progressing to the non-full width course. The method may be used to remove scrap from around non-full width courses having any shape.
摘要翻译：将纤维复合带的非全宽度路线放置在部件中的过程被设计成确保围绕非全宽度线的带的所有废料部分都沉积在废料区而不是部分中。在非全宽度路线的下游，在非全宽度路线和下一个路线之间进行额外的切割。在磁带头试图将废料在向前方向上放置在废料区域中之后，带头在带进料和带头沿相反方向移动的同时在废料区域通过，并且废料从磁带的一部分具有额外的切口，并且前进到非全宽度。该方法可用于从具有任何形状的非全宽度路线周围去除废料。

9. 发明申请

US20070065444A1 Human monoclonal antibodies to activin receptor-like kinase-1 有权
标题翻译：人类激活素受体样激酶-1的单克隆抗体
公开(公告)号：US20070065444A1
公开(公告)日：2007-03-22
申请号：US11517530
申请日：2006-09-06
申请人： Michael North , Karin Amundson , Vahe Bedian , Shelley Belouski , Dana Hu-Lowe , Xin Jiang , Shannon Karlicek , Sirid Kellermann , James Thomson , Jianying Wang , Grant Wickman , Jingchuan Zhang
发明人： Michael North , Karin Amundson , Vahe Bedian , Shelley Belouski , Dana Hu-Lowe , Xin Jiang , Shannon Karlicek , Sirid Kellermann , James Thomson , Jianying Wang , Grant Wickman , Jingchuan Zhang
IPC分类号： A61K39/395 , C07K16/40
CPC分类号： C07K16/40 , A61K2039/505 , C07K16/2863 , C07K2317/21 , C07K2317/33 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/77 , C07K2317/92
摘要： The present invention relates to antibodies including human antibodies and antigen-binding portions thereof that bind to the extracellular domain (ECD) of activin receptor-like kinase-1 (ALK-1) and that function to abrogate the ALK-1/TGF-beta-1/Smad1 signaling pathway. The invention also relates to heavy and light chain immunoglobulins derived from human anti-ALK-1 antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human anti-ALK-1 antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions. The invention also relates to transgenic animals or plants comprising nucleic acid molecules of the present invention.
摘要翻译：本发明涉及包含结合活化素受体样激酶-1（ALK-1）的细胞外结构域（ECD）的人抗体及其抗原结合部分的抗体，其功能是消除ALK-1 / TGF-β -1 / Smad1信号通路。本发明还涉及源自人抗ALK-1抗体的重链和轻链免疫球蛋白和编码这种免疫球蛋白的核酸分子。本发明还涉及制备人抗ALK-1抗体的方法，包含这些抗体的组合物和使用抗体和组合物的方法。本发明还涉及包含本发明的核酸分子的转基因动物或植物。

10. 发明申请

US20060153696A1 Screw pump 审中-公开
标题翻译：螺杆泵
公开(公告)号：US20060153696A1
公开(公告)日：2006-07-13
申请号：US10531558
申请日：2003-10-10
申请人： Kevin Ransom , Clive Lloyd , John Skeates , Cliff Palmer , Michael North
发明人： Kevin Ransom , Clive Lloyd , John Skeates , Cliff Palmer , Michael North
IPC分类号： F04B39/06
CPC分类号： F04C28/28 , F01C21/102 , F04C29/04
摘要： A pump comprises a stator and at lest one rotor mounted within a housing. The housing comprises a first fluid channel extending about the rotor, the rotor comprising at least one second fluid channel. A first sensor is configured to output a signal indicative of the temperature of the stator, and a second sensor is configured to output a signal indicative of the temperature of the rotor. The temperature of fluid in the channel is controlled depending on the magnitude of signals output from the sensors.
摘要翻译：泵包括定子，并且至少一个转子安装在壳体内。壳体包括围绕转子延伸的第一流体通道，转子包括至少一个第二流体通道。第一传感器被配置为输出指示定子的温度的信号，并且第二传感器被配置为输出指示转子的温度的信号。通道中的流体温度根据从传感器输出的信号的大小来控制。

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