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1. 发明申请

US20080027031A1 Retinoids and Related Compounds for the Treatment of Neuroinflammatory Conditions, Diseases and Disorders 审中-公开
标题翻译：类维生素A和相关化合物，用于治疗神经炎症状况，疾病和病症
公开(公告)号：US20080027031A1
公开(公告)日：2008-01-31
申请号：US11683931
申请日：2007-03-08
申请人： Marc Hellerstein , Michael Marino , Mahalakshmi Shankaran
发明人： Marc Hellerstein , Michael Marino , Mahalakshmi Shankaran
IPC分类号： A61K31/65 , A61K31/07 , A61P29/00 , A61K31/56
CPC分类号： A61K31/00 , A61K31/203
摘要： The proliferation and activation of microglia is emerging as an important etiologic factor and target for therapeutic intervention in several CNS diseases, including Alzheimer's disease and multiple sclerosis. Here, we have discovered that retinoic acids dramatically inhibit microglial proliferation in an in vivo model including the widely-used animal model of multiple sclerosis, the experimental autoimmune encephalomyelitis (EAE) mouse model.
摘要翻译：小胶质细胞的增殖和激活正在成为几种CNS疾病（包括阿尔茨海默病和多发性硬化症）的治疗干预的重要病因因素和靶标。在这里，我们已经发现视黄酸在体内模型中显着抑制小胶质细胞增殖，包括广泛使用的多发性硬化症动物模型，实验性自身免疫性脑脊髓炎（EAE）小鼠模型。

2. 发明授权

US5460281A Safety lock screw cap and container 失效
标题翻译：安全锁螺丝帽和容器
公开(公告)号：US5460281A
公开(公告)日：1995-10-24
申请号：US306395
申请日：1994-09-15
申请人： Thomas P. Rapchak , Michael Marino
发明人： Thomas P. Rapchak , Michael Marino
IPC分类号： B65D50/04 , B65D55/12
CPC分类号： B65D50/046
摘要： A safety locking screw cap and container having locking projections on the container that are registerable with a flexible flange arm extending from the screw cap to prevent rotation and removal of the cap relative the container. The cap may be removed from the container by flexing the flanged arm away from the cap by pressing on a portion of the flanged arm thus clearing the locking projection allowing removal rotation of the cap on the threaded neck of the container.
摘要翻译：一种安全锁定螺丝帽和容器，其具有在容器上的锁定突起，其可从可旋转的螺帽延伸的柔性凸缘臂对准，以防止盖相对于容器的旋转和移除。通过按压法兰臂的一部分从而使带凸缘的臂远离盖而将容器从容器中取出，从而清除锁定突起，从而允许盖在容器的螺纹颈部上的旋转。

3. 发明授权

US1386641A Lock 失效
公开(公告)号：US1386641A
公开(公告)日：1921-08-09
申请号：US32227819
申请日：1919-09-08
申请人： MICHAEL MARINO
发明人： MICHAEL MARINO
IPC分类号： E05B63/12
CPC分类号： E05B63/128 , Y10T70/5327 , Y10T70/5354 , Y10T70/7548 , Y10T292/702

4. 发明公开

US20230278611A1 Collapsible Utility Cart 审中-公开
公开(公告)号：US20230278611A1
公开(公告)日：2023-09-07
申请号：US17684886
申请日：2022-03-02
申请人： Jeffrey Schepp , Michael Marino
发明人： Jeffrey Schepp , Michael Marino
IPC分类号： B62B1/20 , B62B1/26
CPC分类号： B62B1/208 , B62B1/266
摘要： A collapsible utility cart includes an elongate frame having upper and lower ends. A handle is formed proximate the upper end of the frame. A pair of wheels are axially rotatably connected to the frame and are pivotable between an open condition wherein the wheels are axially aligned with one another and a folded condition wherein the wheels are axially parallel to one another. Upper and lower support element are interconnected pivotally to the frame and are alternatable between collapsed conditions folded against the frame and open conditions extending forwardly from the frame. A plurality of clips are carried by the upper support element for securing a collection bag to the upper support element.

5. 发明授权

US06540114B1 Dual tamper evident dispensing closure 失效
标题翻译：双重显窃启装置
公开(公告)号：US06540114B1
公开(公告)日：2003-04-01
申请号：US09879620
申请日：2001-06-13
申请人： John Popovich , Mark Clause , Michael Marino
发明人： John Popovich , Mark Clause , Michael Marino
IPC分类号： B67D532
CPC分类号： B65D47/147 , B65D41/485 , B65D47/10
摘要： A dual tamper evident container closure for a dispensing container, the cap portion being of a type intended to be held permanently captive on the container having a nozzle dispensing opening, multiple sealing flanges and dual locking engagement beads to retain the cap portion on the container. The closure portion is registerable over the dispensing opening and retained to the cap portion by a flexible web. Both the cap portion and the closure portion have depending interconnected frangible bands that engage and are retained on the respective container and nozzle to indicate prior opening or tampering with the container closure.
摘要翻译：一种用于分配容器的双重显窃启容器封闭件，该盖部分是一种类型，其类型旨在永久性地固定在具有喷嘴分配开口的容器上，多个密封凸缘和双重锁定接合珠以将盖部分保持在容器上。封闭部分可以在分配开口上方定位，并通过柔性网将其保持在盖部分。盖部分和封闭部分都具有相互连接的易碎带，其接合并保持在相应的容器和喷嘴上，以指示事先打开或篡改容器封闭件。

6. 发明授权

US5657906A Tamper evident push pull resealable cap 失效
标题翻译：篡改明显的推拉可重复封口帽
公开(公告)号：US5657906A
公开(公告)日：1997-08-19
申请号：US536623
申请日：1995-09-28
申请人： Thomas P. Rapchak , Michael Marino
发明人： Thomas P. Rapchak , Michael Marino
IPC分类号： B65D41/34 , B65D41/48 , B65D43/10 , B65D47/24 , B67D5/33
CPC分类号： B65D41/3409 , B65D41/48 , B65D47/243 , B65D2101/0023 , B65D2101/003 , B65D2251/0015 , B65D2251/0087
摘要： A tamper evident resealable cap for use on a bottle, the cap having an upstanding spout that is registerable with an opening in the center of the cap and a sealing plug of a smaller diameter positioned thereabove on multiple upstanding legs extending from the spout. The improvement is directed towards a detachable annular ring secured to the cap by a plurality of frangible elements thereabout, the ring is arranged for restrictive registration with a locking shoulder that extends from the top of the cap body. The cap body has a tamper evident band secured to the cap by a plurality of circumferentially spaced frangible elements with a plurality of annularly spaced radially inwardly extending annular projections and is registerable with a neck portion of the bottle to prevent rotation in one direction without removal of the tamper evident ring.
摘要翻译：一种用于瓶子上的防篡改的可重新密封的盖子，该盖子具有直立的喷嘴，其可以与盖的中心处的开口对准，并且具有较小直径的密封塞，其位于从喷嘴延伸的多个直立的腿上方。改进是针对通过其周围的多个易碎元件固定到盖的可拆卸环形环，环被布置成与从帽体的顶部延伸的锁定肩部进行限制对准。盖体具有通过多个周向间隔开的易碎元件固定到盖上的防拆封带，其具有多个环形间隔开的径向向内延伸的环形突起，并且可与瓶的颈部部分对准，以防止在一个方向上旋转而不移除防篡改环。

7. 发明授权

US4991733A Closure and container having pass over inter-engaging ratchet teeth 失效
标题翻译：闭合和容器经过相互啮合的棘轮齿
公开(公告)号：US4991733A
公开(公告)日：1991-02-12
申请号：US411838
申请日：1989-09-25
申请人： Michael Marino
发明人： Michael Marino
IPC分类号： B65D41/04
CPC分类号： B65D41/0471
摘要： A closure and container having pass over inter-engaging teeth of novel configurations enable the closure to be threadably engaged on the neck finish of the container with relatively low torque rotation and removed from the container only with relatively greater torque rotation in the opposite direction.
摘要翻译：通过具有新颖结构的相互啮合的齿的闭合件和容器使得封闭件能够以相对低的扭矩旋转螺纹接合在容器的颈部上，并且仅在相反方向上以相对较大的扭矩旋转从容器中移除。

8. 发明申请

US20220292953A1 MOBILE COLLECTION OF SENSITIVE INFORMATION INCLUDING TRACKING SYSTEM AND METHOD 有权
公开(公告)号：US20220292953A1
公开(公告)日：2022-09-15
申请号：US17831124
申请日：2022-06-02
申请人： John Delaney , Reed Smith , Michael Marino
发明人： John Delaney , Reed Smith , Michael Marino
IPC分类号： G08B25/10 , H04W4/029 , G06V40/16 , G08B25/01
摘要： A method of tracking an entity includes generating data relevant to the entity at a first location, storing the data at a server, and accessing at least a portion of the data at the first location or at a second location. The data can include location information, time information, image data, text, and/or biometric data. The data can be encrypted, organized, categorized, updated, accumulated with other data, classified, and/or disseminated, and an automated search can include an image feature recognition and facial recognition search. The entity can be a person, an animal, or an object. A communications system includes a processing device and a server that includes an automated search engine. The server can be configured to perform data analysis, such as data grouping.

9. 发明申请

US20060166972A1 Treatment of movement disorders with a metabotropic glutamate 4 receptor positive allosteric modulator 审中-公开
标题翻译：用代谢型谷氨酸4受体正变构调节剂治疗运动障碍
公开(公告)号：US20060166972A1
公开(公告)日：2006-07-27
申请号：US10564029
申请日：2004-07-07
申请人： P. Conn , Anthony DiLella , Gene Kinney , Michael Marino , Guy Seabrook , David Williams
发明人： P. Conn , Anthony DiLella , Gene Kinney , Michael Marino , Guy Seabrook , David Williams
IPC分类号： A61K31/5513 , A61K31/551 , A61K31/5415 , A61K31/553 , A61K31/198 , A61K31/445 , A61K31/48
CPC分类号： A61K31/35 , A61K31/198 , A61K31/445 , A61K31/48 , A61K31/5415 , A61K31/551 , A61K31/5513 , A61K31/553
摘要： An mGluR4 receptor positive allosteric modulator is useful, alone or in combination with a neuroleptic agent, for treating or preventing movement disorders such as Parkinson's disease, dyskinesia, tardive dyskinesia, drug-induced parkinsonism, postencephalitic parkinsonism, progressive supranuclear palsy, multiple system atrophy, corticobasal degeneration, parkinsonian-ALS dementia complex, basal ganglia calcification, akinesia, akinetic-rigid syndrome, bradykinesia, dystonia, medication-induced parkinsonian, Gilles de la Tourette syndrome, Huntington's disease, tremor, chorea, myoclonus, tick disorder, and dystonia.
摘要翻译： mGluR4受体阳性变构调节剂单独使用或与精神安定药联合用于治疗或预防运动障碍如帕金森病，运动障碍，迟发性运动障碍，药物诱导的帕金森综合征，后脑卒中帕金森综合征，进行性核上性麻痹，多系统萎缩，皮质基底膜变性，帕金森病ALS痴呆复合体，基底神经节钙化，运动不良，运动障碍，运动障碍，运动迟缓，肌张力障碍，药物诱导的帕金森病，Gilles de la Tourette综合征，亨廷顿病，震颤，舞蹈病，肌阵挛，蜱疾病和肌张力障碍。

10. 发明授权

US5507416A Tamper evident push pull resealable cap 失效
标题翻译：篡改明显的推拉可重复封口帽
公开(公告)号：US5507416A
公开(公告)日：1996-04-16
申请号：US314674
申请日：1994-09-29
申请人： Thomas P. Rapchak , Michael Marino
发明人： Thomas P. Rapchak , Michael Marino
IPC分类号： B65D41/34 , B65D41/48 , B65D43/10 , B65D47/24 , B67D5/33
CPC分类号： B65D47/243 , B65D41/3409 , B65D41/48 , B65D2101/0023 , B65D2101/003 , B65D2251/0015 , B65D2251/0087
摘要： An improvement for a tamper evident resealable cap for use on a bottle, the cap having an upstanding spout that is registerable with an opening in the center of the cap and a sealing plug of a smaller diameter positioned thereabove on multiple upstanding legs extending from the spout. The improvement is directed towards a detachable annular ring secured to the cap by a plurality of frangible elements thereabout, the ring is arranged for restrictive registration with a locking shoulder that extends from the top of the cap body. The cap body has a tamper evident band secured to the cap by a plurality of circumferentially spaced frangible elements with a plurality of annularly spaced radially inwardly extending annular projections and is registerable with a neck portion of the bottle to prevent rotation in one direction without removal of the tamper evident ring.
摘要翻译：对于在瓶子上使用的防篡改的可再密封盖的改进，所述盖具有可以与所述盖的中心中的开口对齐的直立喷口和位于其上方的较小直径的密封塞，所述密封塞从所述喷口延伸出的多个直立的腿。改进是针对通过其周围的多个易碎元件固定到盖的可拆卸环形环，环被布置成与从帽体的顶部延伸的锁定肩部进行限制对准。盖体具有通过多个周向间隔开的易碎元件固定到盖上的防拆封带，其具有多个环形间隔开的径向向内延伸的环形突起，并且可与瓶的颈部部分对准，以防止在一个方向上旋转而不移除防篡改环。

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