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1. 发明申请

US20080268423A1 Compositions and Methods Related to Flavivirus Envelope Protein Domain III Antigens 有权
标题翻译：与黄病毒包膜蛋白III型抗原相关的组成和方法
公开(公告)号：US20080268423A1
公开(公告)日：2008-10-30
申请号：US10524939
申请日：2003-08-18
申请人： Alan Barrett , David Beasley , Michael Holbrook
发明人： Alan Barrett , David Beasley , Michael Holbrook
IPC分类号： C12Q1/70 , C12N7/00 , C12N11/00
CPC分类号： G01N33/56983 , G01N2333/18 , G01N2469/20 , Y02A50/53 , Y02A50/60
摘要： The present invention concerns methods and compositions involving flavivirus envelope protein domain III antigens for the detection of virus and detection of antibodies against the virus. Such methods and compositions may be used to detect TBE serocomplex viruses or West Nile virus infection in a subject, patient, animal or biological fluid. The present invention also concerns kits for implementing such methods. In some embodiments, kits contain a recombinant TBE serocomplex virus or West Nile virus envelope protein domain III antigen.
摘要翻译：本发明涉及涉及用于检测病毒的黄病毒包膜蛋白III区抗原和检测抗病毒抗体的方法和组合物。这些方法和组合物可用于检测受试者，患者，动物或生物流体中的TBE血清复合物病毒或西尼罗河病毒感染。本发明还涉及用于实施这些方法的试剂盒。在一些实施方案中，试剂盒含有重组TBE血清复合物病毒或西尼罗病毒包膜蛋白结构域III抗原。

2. 发明授权

US07137715B2 External vehicle mirror having a self-loading pivot and an end stop 有权
标题翻译：外部车辆反射镜具有自负载枢轴和端部止挡
公开(公告)号：US07137715B2
公开(公告)日：2006-11-21
申请号：US10473270
申请日：2002-03-26
申请人： Maarten J. Schuurmans , Michael Holbrook
发明人： Maarten J. Schuurmans , Michael Holbrook
IPC分类号： G02B5/08 , A47G1/24
CPC分类号： B60R1/074 , B60R1/06 , B60R1/076
摘要： A pivot assembly for a vehicle external mirror having a mirror head mounted to a mirror base, the assembly comprising a first member (20), a second member (30), the first and second members (20, 30) mounted in or being part of the mirror base and the mirror head respectively, the first and second members (20, 30) having respectively first and second detent sides (24, 34), inner sides (26, 36) and apertures (28, 38) extending from the detent side (24, 34) to the inner sides (26, 36) respectively, detent means (56, 59), a spigot (50), a spring (60), means (56, 72) for applying a pre-load to the spring (60), the initial relative rotation between the second member (30) and the first member (20) in a first direction causes loading of the spring (60), the pre-load is maintained during subsequent relative rotations between the second (30) and the first member (20).
摘要翻译：一种用于车辆外部反射镜的枢轴组件，其具有安装在反射镜底座上的反射镜头，该组件包括第一部件（20），第二部件（30），第一和第二部件（20,30）安装在或部分所述第一和第二构件（20,30）分别具有第一和第二制动侧（24,34），内侧（26,36）和孔（28,38），所述第一和第二构件止动侧（24,34）分别设置到内侧（26,36），止动装置（56,59），接头（50），弹簧（60），用于施加预加载对于弹簧（60），在第一方向上第二构件（30）和第一构件（20）之间的初始相对旋转导致弹簧（60）的装载，在随后的相对旋转期间维持预负荷第二（30）和第一成员（20）。

3. 发明申请

US20060121489A1 High throughput screening of aptamer libraries for specific binding to proteins on viruses and other pathogens 审中-公开
标题翻译：用于特异性结合病毒和其他病原体上的蛋白质的适体文库的高通量筛选
公开(公告)号：US20060121489A1
公开(公告)日：2006-06-08
申请号：US10851947
申请日：2004-05-20
申请人： David Gorenstein , Bruce Luxon , Allan Barrett , Michael Holbrook , Suzanne Bassett , Anoma Somasunderam
发明人： David Gorenstein , Bruce Luxon , Allan Barrett , Michael Holbrook , Suzanne Bassett , Anoma Somasunderam
IPC分类号： C12Q1/68
CPC分类号： C12N15/115 , C12N15/111 , C12N2310/315 , C12N2320/11 , G01N33/6845
摘要： The present invention includes composition and methods for making and using a combinatorial library to identify thioaptamers that bind to targets on or about pathogens. Compositions, kits and methods are also provided for the identification of pathogens, e.g., viral, bacterial or other proteins related infectious disease, as well as, vaccines and vaccine adjuvants are provided that modify host immune responses.
摘要翻译：本发明包括用于制备和使用组合文库以鉴定与病原体上或其周围的靶标结合的硫代醇的组合物和方法。还提供组合物，试剂盒和方法用于鉴定病原体，例如病毒，细菌或其它与蛋白相关的传染病，以及提供修饰宿主免疫应答的疫苗和疫苗佐剂。

4. 发明申请

US20070225530A1 High Selectivity Catalysts for the Conversion of Carbon Tetrachloride to Chloroform 审中-公开
标题翻译：用于将四氯化碳转化为氯仿的高选择性催化剂
公开(公告)号：US20070225530A1
公开(公告)日：2007-09-27
申请号：US11579189
申请日：2005-05-06
申请人： Michael Holbrook , John Myers
发明人： Michael Holbrook , John Myers
IPC分类号： B01J23/42 , B01J21/04 , B01J23/46 , C07C17/00 , C07C19/04
CPC分类号： C07C17/23 , B01J21/04 , B01J23/468 , B01J35/006 , B01J35/0073 , B01J35/008 , B01J37/24 , C07C19/04
摘要： A process for the hydrodechlorination of carbon tetrachloride to produce chloroform utilizes a supported catalyst having a bimetallic components of platinum and iridium. The bimetallic catalyst may be promoted with small amounts of a third metal, such as tin, titanium, germanium, rhenium, silicon, lead, phosphorus, arsenic, antimony, bismuth or mixtures thereof. By-product production is decreased and duration of catalyst activity is improved by the use of the catalyst of this invention.
摘要翻译：用于加氢脱氯四氯化碳以产生氯仿的方法使用具有铂和铱的双金属组分的负载型催化剂。双金属催化剂可以用少量的第三金属如锡，钛，锗，铼，硅，铅，磷，砷，锑，铋或其混合物来促进。通过使用本发明的催化剂，副产物生产减少并且催化剂活性的持续时间得到改善。

5. 发明授权

US07785799B2 Compositions and methods related to flavivirus envelope protein domain III antigens 有权
标题翻译：与黄病毒包膜蛋白III区抗原相关的组成和方法
公开(公告)号：US07785799B2
公开(公告)日：2010-08-31
申请号：US10524939
申请日：2003-08-18
申请人： Alan Barrett , David Beasley , Michael Holbrook
发明人： Alan Barrett , David Beasley , Michael Holbrook
IPC分类号： G01N33/53 , A61K39/12
CPC分类号： G01N33/56983 , G01N2333/18 , G01N2469/20 , Y02A50/53 , Y02A50/60
摘要： The present invention concerns methods and compositions involving flavivirus envelope protein domain III antigens for the detection of virus and detection of antibodies against the virus. Such methods and compositions may be used to detect TBE serocomplex viruses or West Nile virus infection in a subject, patient, animal or biological fluid. The present invention also concerns kits for implementing such methods. In some embodiments, kits contain a recombinant TBE serocomplex virus or West Nile virus envelope protein domain III antigen.
摘要翻译：本发明涉及涉及用于检测病毒的黄病毒包膜蛋白III区抗原和检测抗病毒抗体的方法和组合物。这些方法和组合物可用于检测受试者，患者，动物或生物流体中的TBE血清复合物病毒或西尼罗河病毒感染。本发明还涉及用于实施这些方法的试剂盒。在一些实施方案中，试剂盒含有重组TBE血清复合物病毒或西尼罗病毒包膜蛋白结构域III抗原。

6. 发明授权

US4403914A Variable geometry device for turbomachinery 失效
标题翻译：涡轮机械的可变几何装置
公开(公告)号：US4403914A
公开(公告)日：1983-09-13
申请号：US282524
申请日：1981-07-13
申请人： Casimir Rogo , Herman N. Lenz , Michael Holbrook
发明人： Casimir Rogo , Herman N. Lenz , Michael Holbrook
IPC分类号： F01D17/14 , F04D27/00
CPC分类号： F01D17/143 , F04D29/464 , F05D2250/52
摘要： A variable geometry device is provided for use in a turbine engine having a support housing, a rotor contained within the support housing and a pair of spaced walls forming an annular and radially extending passageway open at one end to the rotor. An annular recessed channel is formed in one of the support housing walls while a ring is mounted within the channel and movable between a retracted position in which the ring is nested within the channel and an extended position in which the ring protrudes transversely into and variably restricts the passageway so that the restriction of the fluid passageway is substantially proportional to the transverse position of the ring. A plurality of circumferentially spaced vanes are secured to the ring and these vanes extend transversely across the fluid passageway and are slidably received within slots formed in the other support housing wall. In addition, the face of the ring open to the fluid passageway is contoured by meridional constriction for maximum engine efficiency.
摘要翻译：提供可变几何装置用于具有支撑壳体的涡轮发动机，包含在支撑壳体内的转子和形成在一端与转子敞开的环形和径向延伸通道的一对隔开的壁。一个环形凹槽形成在一个支承壳体壁中，同时一个环安装在通道内，并可在一个缩回位置和一个延伸位置之间移动，在该位置环之间嵌套在通道内，而延伸位置则环可横向突出并可变地限制该通道使得流体通道的限制基本上与环的横向位置成比例。多个周向间隔的叶片固定到环上，并且这些叶片横向延伸穿过流体通道，并且可滑动地容纳在形成在另一个支撑壳体壁中的槽内。此外，通过子午线收缩使通向流体通道的环的表面成为轮廓，以获得最大的发动机效率。

7. 发明申请

US20060086036A1 Trolling release device 失效
标题翻译：拖钓释放装置
公开(公告)号：US20060086036A1
公开(公告)日：2006-04-27
申请号：US10974274
申请日：2004-10-27
申请人： Michael Holbrook
发明人： Michael Holbrook
IPC分类号： A01K91/08 , A01K91/047
CPC分类号： A01K91/08
摘要： A trolling release device for use during fishing. A ring of the device has peripheral sidewalls with an aperture formed between the sidewalls and a radial slit in one of the sidewalls for extending a tow line through the sidewall. The device also has a handle rigidly mounted to the ring. The handle has peripheral sidewalls with an aperture formed between the sidewalls and a radial slit in one of the sidewalls of the handle. In operation, the ring is mounted to a tow line. A string is attached to a fishing line at one end and the opposite end is inserted into the handle aperture. When a tensile force is applied to the fishing line, such as by a fish striking a lure on the fishing line, the string is cut by a sharp edge of one of the sidewalls of the handle, opposite the ring, thereby releasing the fishing line from the trolling release device.
摘要翻译：钓鱼时使用的拖钓释放装置。该装置的环具有外围侧壁，其具有形成在侧壁之间的孔和在侧壁中的一个中的径向狭缝，用于使牵引线延伸通过侧壁。该装置还具有刚性地安装到环上的手柄。手柄具有外围侧壁，其中孔在形成于侧壁之间的一个侧壁中的径向狭缝之间形成。在操作中，环安装在拖绳上。绳子一端连接在钓鱼线上，相对端插入手柄孔中。当钓鱼线例如通过在钓鱼线上引诱诱鱼的拉力施加拉力时，该绳子由与手柄相对的手柄侧壁之一的尖锐边缘切割，从而释放钓线从拖钓释放装置。

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