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1. 发明申请

US20120222961A1 SYSTEM, METHOD, AND APPARATUS FOR LEACHING CAST COMPONENTS 有权
标题翻译：系统，方法和装置用于浸出铸件组件
公开(公告)号：US20120222961A1
公开(公告)日：2012-09-06
申请号：US13338811
申请日：2011-12-28
申请人： Michel Shawn Smallwood , Tab Michael Heffernan , Mark Steven McCormick , Randolph Clifford Helmink , Matthew Kush
发明人： Michel Shawn Smallwood , Tab Michael Heffernan , Mark Steven McCormick , Randolph Clifford Helmink , Matthew Kush
IPC分类号： C23C28/00 , C25D17/00
CPC分类号： B22D29/002 , B22D29/006 , C23G1/00
摘要： A method includes removing a casting shell and core from a cast component, which may be a gas turbine blade. The method further includes utilizing a focused removal technique, such as a water jet or laser drill, to remove a portion of a virtual pattern cast (VPC) shell from the cast component. The cast component is then exposed to a leaching solution and high pressure water wash to remove an internal core material and a portion of the VPC shell remainder from the cast component. The method further includes exposing the cast component to a high agitation leaching solution and to the high pressure water wash for a minimal time. An electroless nickel-boron coating is then applied to the cast component, and an electrolytic palladium coating is further applied to the cast component. The cast component is further exposed to a high agitation leaching solution for an extended period.
摘要翻译：一种方法包括从可以是燃气轮机叶片的铸造部件移除铸造壳和芯。该方法还包括利用诸如水射流或激光钻孔的聚焦去除技术来从铸造部件移除虚拟图案铸造（VPC）壳的一部分。然后将铸造组件暴露于浸出溶液和高压水洗以从铸造组件除去内部芯材料和VPC壳的一部分剩余部分。该方法还包括将铸造组分暴露于高搅拌浸出溶液和高压水洗涤最短时间。然后将无电镀镍 - 硼涂层施加到铸造部件上，并且电镀钯涂层进一步施加到铸造部件上。将浇铸组分进一步暴露于高搅拌浸出溶液中。

2. 发明授权

US08086665B1 Technique for enabling a plurality of software components to communicate in a software component matrix environment 有权
标题翻译：用于使多个软件组件能够在软件组件矩阵环境中进行通信的技术
公开(公告)号：US08086665B1
公开(公告)日：2011-12-27
申请号：US10224417
申请日：2002-08-21
申请人： Martin Soukup , Gregory Hughes , Michael Heffernan
发明人： Martin Soukup , Gregory Hughes , Michael Heffernan
IPC分类号： G06F15/16
CPC分类号： H04L67/16 , G06F9/541 , G06F9/547 , H04L67/42
摘要： A technique for enabling a plurality of software components to communicate in a software component matrix environment is disclosed. In one particular exemplary embodiment, the technique may be realized by a method for enabling a plurality of software components to communicate in a software component matrix environment comprising the steps of encoding a request at a client side; communicating the request to a server at a server side via a communication interface; comparing the request to a plurality of operations supported at the server side; determining whether a function match exists at the server side; and returning a response comprising the function match to the client side in response to the request via the communication interface wherein the response is mapped to a data model of a client.
摘要翻译：公开了一种使多个软件组件能够在软件组件矩阵环境中进行通信的技术。在一个特定示例性实施例中，该技术可以通过使多个软件组件能够在软件组件矩阵环境中进行通信的方法来实现，该方法包括以下步骤：在客户端侧对请求进行编码; 通过通信接口将请求传送到服务器端的服务器; 将所述请求与在所述服务器侧支持的多个操作进行比较; 确定服务器端是否存在功能匹配; 以及响应于经由所述通信接口的所述请求，将包括所述功能匹配的响应返回给所述客户端，其中所述响应被映射到客户端的数据模型。

3. 发明申请

US20080207593A1 Antihistamine Combination 审中-公开
标题翻译：抗组胺药组合
公开(公告)号：US20080207593A1
公开(公告)日：2008-08-28
申请号：US11841438
申请日：2007-08-20
申请人： Michael Heffernan , Jane C. Hirsh , Roman V. Rariy
发明人： Michael Heffernan , Jane C. Hirsh , Roman V. Rariy
IPC分类号： A61K31/4545 , A61K31/135 , A61K31/40 , A61K31/4402 , A61K31/4439 , A61K31/506 , A61K31/55 , A61P37/08 , A61P17/00 , A61K31/5415 , A61K31/495 , A61K31/45 , A61K31/451 , A61K31/4535
CPC分类号： A61K45/06 , A61K31/135 , A61K31/40 , A61K31/4184 , A61K31/44 , A61K31/445 , A61K31/45 , A61K31/4535 , A61K31/454 , A61K31/4545 , A61K31/495 , A61K31/497 , A61K31/5415 , A61K2300/00
摘要： A once daily formulation containing the combination of a non-sedating or selective antihistamine (Loratadine) with a sedating or non-selective antihistamine (Chlorpheniramine) administered at bed-time has demonstrated greater efficacy in relieving allergic symptoms than Loratadine alone.
摘要翻译：含有非镇静剂或选择性抗组胺药（氯雷他定）与睡眠时间给药的镇静剂或非选择性抗组胺药（氯苯那敏）组合的每日一次制剂，比单独使用氯雷他定，具有更好的缓解过敏症状的功效。

4. 发明申请

US20080135146A1 SYSTEM AND METHOD FOR BALANCING A TIRE AND RIM ASSEMBLY 审中-公开
标题翻译：用于平衡轮胎和轮胎组件的系统和方法
公开(公告)号：US20080135146A1
公开(公告)日：2008-06-12
申请号：US11928946
申请日：2007-10-30
申请人： Michael Heffernan , Russell J. Freeman
发明人： Michael Heffernan , Russell J. Freeman
IPC分类号： F16F15/36 , B23P17/00
CPC分类号： F16F15/363 , Y10T29/49494
摘要： A self-balancing wheel assembly includes a rim, a tire mounted to the rim and defining an inflatable chamber between the rim and the tire, and a valve mounted to the rim for inflating and deflating the tire. The valve includes a housing having a channel therein extending between an outer surface of the housing and the chamber. The valve includes a stopper movable within the channel between an open and a closed position for allowing and blocking fluid flow through the channel, the stopper being narrower in width than the channel. The assembly further includes balancing media in the chamber, the balancing media comprising solid particles sized sufficiently large to inhibit passage of the solid particles past the stopper. The assembly can be used in wheels having integral TPMS modules, and having aluminum valve stems connected to the modules and short, nickel plated valve cores mounted in the stems.
摘要翻译：自平衡轮组件包括轮辋，安装到轮辋并且限定轮辋和轮胎之间的可充气室的轮胎和安装到轮辋上的用于使轮胎充气和放气的阀。阀包括壳体，该壳体具有在壳体的外表面和腔室之间延伸的通道。该阀包括可在通道内在打开和关闭位置之间移动的止动件，用于允许和阻止流体流过通道，止动器的宽度比通道窄。组件还包括室中的平衡介质，平衡介质包括固体颗粒，其尺寸足够大以阻止固体颗粒通过塞子。该组件可用于具有整体TPMS模块的车轮中，并且具有连接到模块的铝阀杆和安装在杆中的短的镀镍阀芯。

5. 发明申请

US20060024366A1 Modified release compositions of milnacipran 审中-公开
标题翻译：米那普仑的改性释放组合物
公开(公告)号：US20060024366A1
公开(公告)日：2006-02-02
申请号：US11192885
申请日：2005-07-29
申请人： Jane Hirsh , Roman Rariy , Shubha Chungi , Srinivas Rao , Michael Heffernan
发明人： Jane Hirsh , Roman Rariy , Shubha Chungi , Srinivas Rao , Michael Heffernan
IPC分类号： A61K9/22
CPC分类号： A61K9/2054 , A61K9/2846
摘要： A once-a-day oral milnacipran modified release formulation has been developed. The formulation comprises an extended release dosage unit (optionally containing the immediate release portion) coated with delayed release coating. The milnacipran composition, when administered orally, first passes through the stomach releasing from zero to less than 10% of the total milnacipran dose and then enters the intestines where drug is released slowly over an extended period of time. The release profile is characterized by a 0.05-4 hours lag time period during which less than 10% of the total milnacipran dose is released followed by a slow or extended release of the remaining drug over a defined period of time. The composition provides in vivo drug plasma levels characterized by Tmax at 4-10 hours and an approximately linear drop-off thereafter and Cmax below 3000 ng/ml, preferably below 2000 ng/ml, and most preferably below 1000 ng/ml. The composition provides a therapeutic effect over approximately 24 hours, when administered to a patient in need, resulting in diminished incidence or decreased intensity of common milnacipran side effects such as sleep disturbance, nausea, vomiting, headache, tremulousness, anxiety, panic attacks, palpitations, urinary retention, orthostatic hypotension, diaphoresis, chest pain, rash, weight gain, back pain, constipation, vertigo, increased sweating, agitation, hot flushes, tremors, fatigue, somnolence, dyspepsia, dysoria, nervousness, dry mouth, abdominal pain, irritability, and insomnia.
摘要翻译：已经开发了一天一次的口服米那普仑改性释放制剂。该制剂包含用延迟释放包衣涂覆的延长释放剂量单位（任选地含有速释部分）。当口服给药时，米那普仑组合物首先通过胃从零释放至总的米那普仑剂量的10％，然后进入肠道，药物在较长时间内缓慢释放。释放曲线的特征在于0.05-4小时的滞后时间，在此期间，释放总的米那普仑总量的不到10％，然后在规定的时间段内缓慢或延长释放剩余的药物。该组合物在4-10小时时提供特征为T max max的体内药物血浆水平，此后大约线性下降，低于3000ng / ml，优选低于 2000ng / ml，最优选低于1000ng / ml。当给予需要的患者时，该组合物在约24小时内提供治疗效果，导致常见的米那普仑副作用的发生率降低或强度降低，例如睡眠障碍，恶心，呕吐，头痛，惊恐，焦虑，惊恐发作，心悸，尿潴留，直立性低血压，尿频，胸痛，皮疹，体重增加，背痛，便秘，眩晕，出汗增加，激动，潮红，震颤，疲劳，嗜睡，消化不良，呕吐，紧张，口干，腹痛，烦躁不安和失眠。

6. 发明授权

US06896483B2 Blade track assembly 失效
标题翻译：刀片轨道组件
公开(公告)号：US06896483B2
公开(公告)日：2005-05-24
申请号：US10189121
申请日：2002-07-02
申请人： Douglas D. Dierksmeier , Tab Michael Heffernan , James C. Muskat
发明人： Douglas D. Dierksmeier , Tab Michael Heffernan , James C. Muskat
IPC分类号： F01D11/18
CPC分类号： F01D11/18 , F05D2240/40 , F05D2300/50212 , Y10T403/21 , Y10T403/213 , Y10T403/217
摘要： The clearances between an array of turbine blades and its surrounding blade track may be controlled by an expansion control material system supporting the blade tracks. The blade track support hoop is placed in tension by the expansion control material placed therein and the expansion control material is placed in compression.
摘要翻译：涡轮叶片阵列及其周围的叶片轨道之间的间隙可以由支撑叶片轨道的膨胀控制材料系统来控制。刀片轨道支撑环通过放置在其中的膨胀控制材料而被张紧，膨胀控制材料被压缩。

7. 发明授权

US6129797A Tire balancing 有权
标题翻译：轮胎平衡
公开(公告)号：US6129797A
公开(公告)日：2000-10-10
申请号：US211211
申请日：1998-12-14
申请人： Michael Heffernan , Russell J. Freeman
发明人： Michael Heffernan , Russell J. Freeman
IPC分类号： F16F15/36 , G01M1/36 , G01M1/30
CPC分类号： G01M1/36 , B60C19/003 , F16F15/363 , G01M1/365
摘要： A method and composition of matter for balancing tire and rim assemblies of vehicles is disclosed wherein the composition of matter has rounded balancing elements of different size to line the interior of a tire casing and to move over the lining to offset points of imbalance.
摘要翻译：公开了一种用于平衡车辆的轮胎和轮辋组件的物质的方法和组合物，其中物质的组成具有不同尺寸的圆形平衡元件以对轮胎外壳的内部进行排列并且在衬里上移动到不平衡的偏移点。

8. 发明授权

US5706257A Preprogrammed medication reminder 失效
标题翻译：预编程药物提示
公开(公告)号：US5706257A
公开(公告)日：1998-01-06
申请号：US681934
申请日：1996-07-29
申请人： Michael Rothman , Michael Heffernan , Dixon Newbold
发明人： Michael Rothman , Michael Heffernan , Dixon Newbold
IPC分类号： A61J7/04 , G04B47/00 , G07F11/00
CPC分类号： A61J7/0481
摘要： A device and method for encouraging proper timing compliance in accordance with a medication prescription regimen. The device is preprogrammed so as to be tailored for the particular prescription regimen to be complied with. Appropriate circuitry is provided in order to generate a dosage signal, which dosage signal persists and changes in an easily recognizable manner until compliance with that dosage requirement is indicated by interacting with the device. Also included is circuitry for prompting compliance with refill requirements of the prescription. The device includes a casing which can have members for facilitating stand-up display or hang-up display of the device.
摘要翻译：一种用于根据药物处方方案鼓励适当的时间顺应性的装置和方法。该装置被预编程，以便根据要遵守的特定处方方案进行定制。提供适当的电路以产生剂量信号，该剂量信号持续存在并以易于识别的方式改变，直到通过与该装置相互作用来指示与该剂量需求的顺应性为止。还包括促进符合处方的补充要求的电路。该装置包括可以具有用于促进装置的立式显示或挂起显示的构件的壳体。

9. 发明授权

US08828214B2 System, method, and apparatus for leaching cast components 有权
标题翻译：用于浸出铸件的系统，方法和装置
公开(公告)号：US08828214B2
公开(公告)日：2014-09-09
申请号：US13338811
申请日：2011-12-28
申请人： Michel Shawn Smallwood , Tab Michael Heffernan , Mark Steven McCormick , Randolph Clifford Helmink , Matthew Kush
发明人： Michel Shawn Smallwood , Tab Michael Heffernan , Mark Steven McCormick , Randolph Clifford Helmink , Matthew Kush
IPC分类号： C23C28/02 , C25D3/56 , C25D3/50 , B22D29/00 , C23G1/00
CPC分类号： B22D29/002 , B22D29/006 , C23G1/00
摘要： A method includes removing a casting shell and core from a cast component, which may be a gas turbine blade. The method further includes utilizing a focused removal technique, such as a water jet or laser drill, to remove a portion of a virtual pattern cast (VPC) shell from the cast component. The cast component is then exposed to a leaching solution and high pressure water wash to remove an internal core material and a portion of the VPC shell remainder from the cast component. The method further includes exposing the cast component to a high agitation leaching solution and to the high pressure water wash for a minimal time. An electroless nickel-boron coating is then applied to the cast component, and an electrolytic palladium coating is further applied to the cast component. The cast component is further exposed to a high agitation leaching solution for an extended period.
摘要翻译：一种方法包括从可以是燃气轮机叶片的铸造部件移除铸造壳和芯。该方法还包括利用诸如水射流或激光钻孔的聚焦去除技术来从铸造部件移除虚拟图案铸造（VPC）壳的一部分。然后将铸造组件暴露于浸出溶液和高压水洗以从铸造组件除去内部芯材料和VPC壳的一部分剩余部分。该方法还包括将铸造组分暴露于高搅拌浸出溶液和高压水洗涤最短时间。然后将无电镀镍 - 硼涂层施加到铸造部件上，并且电镀钯涂层进一步施加到铸造部件上。将浇铸组分进一步暴露于高搅拌浸出溶液中。

10. 发明授权

US08512751B2 Pharmaceutical compositions for sleep disorders 有权
标题翻译：睡眠障碍药物组合物
公开(公告)号：US08512751B2
公开(公告)日：2013-08-20
申请号：US11793392
申请日：2005-12-20
申请人： Roman V. Rariy , Michael Heffernan
发明人： Roman V. Rariy , Michael Heffernan
IPC分类号： A61K31/4164
CPC分类号： A61K31/4178 , A61K9/209 , A61K9/28 , A61K9/2846 , A61K9/2866 , A61K9/2886 , A61K9/4808 , A61K31/135 , A61K31/137 , A61K31/138 , A61K31/164 , A61K31/381 , A61K45/06 , A61K2300/00
摘要： Pharmaceutical compositions are provided for the pharmacological treatment of breathing disorders and, more specifically, to compositions containing agents having serotonin receptor modulating activity for the alleviation of sleep apnea (central and obstructive) and other sleep-related breathing disorders wherein the active ingredients are released such as to extend effective blood plasma concentrations across the period of sleep.
摘要翻译：提供药物组合物用于呼吸障碍的药理学治疗，更具体地，涉及含有具有5-羟色胺受体调节活性用于缓解睡眠呼吸暂停（中枢和阻塞性）和其它睡眠相关呼吸障碍的药剂的组合物，其中活性成分被释放以延长整个睡眠期的有效血浆浓度。

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