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1. 发明申请

US20090192229A1 2-Aminoalcohols for the Treatment of Neurodegenerative Diseases 失效
标题翻译：用于治疗神经退行性疾病的2-氨基醇
公开(公告)号：US20090192229A1
公开(公告)日：2009-07-30
申请号：US12066904
申请日：2006-09-21
申请人： Robin Mark Bannister , Michael Harvey Lyne
发明人： Robin Mark Bannister , Michael Harvey Lyne
IPC分类号： A61K31/133 , A61P25/00
CPC分类号： A61K31/137 , Y10S514/903
摘要： Use of a compound for the manufacture of a medicament for use in therapy of a neurodegenerative condition, wherein the compound is of formula (I): wherein R1 is CHR4—OR5 or CHR4—SR5, or aryl or heteroaryi optionally substituted with one or more groups R6; R2 is alkyl or is part of a ring with R3; R3 is H, alkyl or CH2 (when forming part of a ring with R2); R4 is H or alkyl or is part of a ring with R5; R5 is aryl or heteroaryi optionally substituted with R7; each R6 is independently alkyl, CF3, OH, Oalkyl, OCOalkyl, CONH2, CN, halogen, NH2, NO2, NHCHO, NHCONH2, NHSO2alkyl, CONH2, SOMe, SO2NH2, Salkyl, CH2SO2alkyl or OCONalkyl2; R7 is R8 or (CH2)nOR8, R9, CF3, OH, OR9, OCOR9, COR9, COOR9, CONH2, CH2CONH2, CN, halogen, NH2, NO2, NHCHO, NHCONH2, NHCONHR7, NHCON(R9)2, NHCOR9, NHCOaryl, NHSO2Me, CONH2, SMe, SOMe or SO2NH2; R8 is (CH2)nOR9, (CH)nOR9, (CH2)nCOOR9 or (CH2)nCOaryl; R9 is alkyl or cycloalkyl; and n is 1 to 4; or a salt thereof.
摘要翻译：用于制备用于治疗神经变性病症的药物的化合物的用途，其中所述化合物为式（I）：其中R 1为CHR 4 -OR 5或CHR 4 -SR 5，或任选被一个或多个取代基取代的芳基或杂芳基 R6组; R2是烷基或是与R3的环的一部分; R3是H，烷基或CH2（当与R2形成环的一部分时）; R4是H或烷基，或是与R5的环的一部分; R 5是任选被R 7取代的芳基或杂芳基; 每个R 6独立地是烷基，CF 3，OH，O烷基，OCO烷基，CONH 2，CN，卤素，NH 2，NO 2，NHCHO，NHCONH 2，NHSO 2烷基，CONH 2，SOMe，SO 2 NH 2，S烷基，CH 2 SO 2烷基或OCON烷基2; R 7是R 8或（CH 2）nOR 8，R 9，CF 3，OH，OR 9，OCOR 9，COR 9，COOR 9，CONH 2，CH 2 CONH 2，CN，卤素，NH 2，NO 2，NHCHO，NHCONH 2，NHCONHR 7，NHCON（R 9）2，NHCOR 9，，NHSO2Me，CONH2，SMe，SOMe或SO2NH2; R8是（CH2）nOR9，（CH）nOR9，（CH2）nCOOR9或（CH2）nCOaryl; R9是烷基或环烷基; n为1〜4; 或其盐。

2. 发明申请

US20080255079A1 Therapeutic Use of Nefopam and Analogues Thereof 审中-公开
标题翻译：奈福泮及其类似物的治疗用途
公开(公告)号：US20080255079A1
公开(公告)日：2008-10-16
申请号：US11910549
申请日：2006-03-31
申请人： Michael Harvey Lyne , Robin Mark Bannister
发明人： Michael Harvey Lyne , Robin Mark Bannister
IPC分类号： A61K31/33 , A61P43/00
CPC分类号： A61K31/395
摘要： Nefopam or an analogue thereof is useful in the treatment of a syndrome characterized by chronic pain and fatigue.
摘要翻译：奈福泮或其类似物可用于治疗以慢性疼痛和疲劳为特征的综合征。

3. 发明申请

US20120269767A1 Treatment of Neurodegenerative Diseases 审中-公开
标题翻译：治疗神经退行性疾病
公开(公告)号：US20120269767A1
公开(公告)日：2012-10-25
申请号：US13460265
申请日：2012-04-30
申请人： Robin Mark Bannister , Michael Harvey Lyne
发明人： Robin Mark Bannister , Michael Harvey Lyne
IPC分类号： A61K31/137 , A61P25/16 , A61K31/42 , A61P25/28 , A61K38/21 , A61K31/56
CPC分类号： A61K31/137 , Y10S514/903
摘要： The present specification discloses beta-amino alcohols and methods of treating a neurodegenerative disease using such compounds.
摘要翻译：本说明书公开了β-氨基醇和使用这些化合物治疗神经变性疾病的方法。

4. 发明授权

US08188152B2 2-aminoalcohols for the treatment of neurodegenerative diseases 失效
标题翻译： 2-氨基醇用于治疗神经变性疾病
公开(公告)号：US08188152B2
公开(公告)日：2012-05-29
申请号：US12066904
申请日：2006-09-21
申请人： Robin Mark Bannister , Michael Harvey Lyne
发明人： Robin Mark Bannister , Michael Harvey Lyne
IPC分类号： A01N27/00
CPC分类号： A61K31/137 , Y10S514/903
摘要： Use of a compound for the manufacture of a medicament for use in therapy of a neurodegenerative condition, wherein the compound is of formula (I): wherein R1 is CHR4—OR5 or CHR4—SR5, or aryl or heteroaryi optionally substituted with one or more groups R6; R2 is alkyl or is part of a ring with R3; R3 is H, alkyl or CH2 (when forming part of a ring with R2); R4 is H or alkyl or is part of a ring with R 5; R5 is aryl or heteroaryi optionally substituted with R7; each R6 is independently alkyl, CF3, OH, Oalkyl, OCOalkyl, CONH2, CN, halogen, NH2, NO2, NHCHO, NHCONH2, NHSO2alkyl, CONH2, SOMe, SO2NH2, Salkyl, CH2SO2alkyl or OCONalkyl2; R7 is R8 or (CH2)nOR8, R9, CF3, OH, OR9, OCOR9, COR9, COOR9, CONH2, CH2CONH2, CN, halogen, NH2, NO2, NHCHO, NHCONH2, NHCONHR7, NHCON(R9)2, NHCOR9, NHCOaryl, NHSO2Me, CONH2, SMe, SOMe or SO2NH2; R8 is (CH2)nOR9, (CH)nOR9, (CH2)nCOOR9 or (CH2)nCOaryl; R9 is alkyl or cycloalkyl; and n is 1 to 4; or a salt thereof.
摘要翻译：用于制备用于治疗神经变性病症的药物的化合物的用途，其中所述化合物为式（I）：其中R 1为CHR 4 -OR 5或CHR 4 -SR 5，或任选被一个或多个取代基取代的芳基或杂芳基 R6组; R2是烷基或是与R3的环的一部分; R3是H，烷基或CH2（当与R2形成环的一部分时）; R 4为H或烷基，或为R 5的环的一部分; R 5是任选被R 7取代的芳基或杂芳基; 每个R 6独立地是烷基，CF 3，OH，O烷基，OCO烷基，CONH 2，CN，卤素，NH 2，NO 2，NHCHO，NHCONH 2，NHSO 2烷基，CONH 2，SOMe，SO 2 NH 2，S烷基，CH 2 SO 2烷基或OCON烷基2; R 7是R 8或（CH 2）nOR 8，R 9，CF 3，OH，OR 9，OCOR 9，COR 9，COOR 9，CONH 2，CH 2 CONH 2，CN，卤素，NH 2，NO 2，NHCHO，NHCONH 2，NHCONHR 7，NHCON（R 9）2，NHCOR 9，，NHSO2Me，CONH2，SMe，SOMe或SO2NH2; R8是（CH2）nOR9，（CH）nOR9，（CH2）nCOOR9或（CH2）nCOaryl; R9是烷基或环烷基; n为1〜4; 或其盐。

5. 发明申请

US20100152152A1 Therapeutic Use of Nefopam 审中-公开
标题翻译：奈福泮的治疗用途
公开(公告)号：US20100152152A1
公开(公告)日：2010-06-17
申请号：US11996790
申请日：2006-07-27
申请人： Michael Harvey Lyne , Robin Mark Bannister
发明人： Michael Harvey Lyne , Robin Mark Bannister
IPC分类号： A61K31/33 , A61P25/24 , A61P25/22
CPC分类号： A61K31/395
摘要： Nefopam is used for the manufacture of a medicament for the treatment of an affective disorder such as ADD or ADHD.
摘要翻译：奈福泮用于制造用于治疗情绪障碍如ADD或ADHD的药物。

6. 发明申请

US20080306162A1 Treatment of Inflammatory Disorders and Pain 审中-公开
标题翻译：治疗炎症和疼痛
公开(公告)号：US20080306162A1
公开(公告)日：2008-12-11
申请号：US11993910
申请日：2006-06-30
申请人： Andrew Douglas Baxter , Michael Harvey Lyne , Robin Mark Bannister , Elena Lasterra
发明人： Andrew Douglas Baxter , Michael Harvey Lyne , Robin Mark Bannister , Elena Lasterra
IPC分类号： A61K31/135 , C07C215/68 , C07C215/20 , A61P25/00 , A61P11/00 , A61P29/00 , C07D215/00
CPC分类号： C07C215/68 , A61K31/133 , C07C215/30
摘要： A compound that is useful for the treatment or prevention of a condition such as pain, that is associated with T-cell proliferation or that is mediated by pro- and/or anti-inflammatory cytokines, is of formula (I) wherein R1 is aryl or heteroaryl optionally substituted with R5; R2 is H, alkyl or CH2OH and can be part of a ring with R4; R3 is H, alkyl or CH2OH and can be part of a ring with R4; R4 is H or alkyl or CH2 (when forming part of a ring with R2 or R3); and R5 is alkyl, CF3, OH, Oalkyl, OCOalkyl, CONH2, CN, F, Cl, Br, I, NH2, NHCHO, NHCONH2, NHSO2alkyl, CONH2, SOMe, CH2OH or OCONalkyl2; or a salt thereof.
摘要翻译：可用于治疗或预防与促进和/或抗炎细胞因子介导的T细胞增殖相关的疾病如疼痛的化合物是式（I），其中R 1是芳基或任选被R 5取代的杂芳基; R2是H，烷基或CH2OH，并且可以是与R4的环的一部分; R3是H，烷基或CH2OH，并且可以是与R4的环的一部分; R4是H或烷基或CH2（当与R2或R3形成环的一部分时）; 并且R 5是烷基，CF 3，OH，O烷基，OCO烷基，CONH 2，CN，F，Cl，Br，I，NH 2，NHCHO，NHCONH 2，NHSO 2烷基，CONH 2，SOMe，CH 2 OH或OCON烷基2; 或其盐。

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