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1. 发明申请

US20080242733A1 (-)-Pseudoephedrine as a sympathomimetic drug 审中-公开
标题翻译：（ - ） - 伪麻黄素作为拟交感神经药物
公开(公告)号：US20080242733A1
公开(公告)日：2008-10-02
申请号：US11485928
申请日：2006-07-13
申请人： Anthony Booth , William T. Sherman , Peter Raven , James L. Caffrey , Thomas Yorio , Michael Forster , Patricia Gwirtz
发明人： Anthony Booth , William T. Sherman , Peter Raven , James L. Caffrey , Thomas Yorio , Michael Forster , Patricia Gwirtz
IPC分类号： A61K31/137 , A61P11/00
CPC分类号： A61K31/137
摘要： The present invention provides pharmaceutical compositions which include (−)-pseudoephedrine and a pharmaceutically acceptable carrier, wherein the (−)-pseudoephedrine is substantially-free of (+)-pseudoephedrine. In another embodiment, the present invention provides methods of relieving nasal and bronchial congestion and of inducing pupil dilation which include administering a pharmaceutically effective amount of (−)-pseudoephedrine to a mammal. The (−)-pseudoephedrine used in the present methods is substantially free of (+)-pseudoephedrine and also substantially free of side effects caused by administration of (+)-pseudoephedrine.
摘要翻译：本发明提供包含（ - ） - 伪麻黄碱和药学上可接受的载体的药物组合物，其中（ - ） - 伪麻黄碱基本上不含（+） - 伪麻黄碱。在另一个实施方案中，本发明提供减轻鼻和支气管充血并诱导瞳孔扩张的方法，其包括向哺乳动物施用药学有效量的（ - ） - 伪麻黄碱。本方法中使用的（ - ） - 伪麻黄素基本上不含（+） - 伪麻黄碱，并且基本上没有由（+） - 伪麻黄碱施用引起的副作用。

2. 发明申请

US20070097566A1 Control and protection methodologies for a motor control module 有权
标题翻译：电机控制模块的控制和保护方法
公开(公告)号：US20070097566A1
公开(公告)日：2007-05-03
申请号：US11543990
申请日：2006-10-06
申请人： Samuel Woods , Jason Leh , David Beers , Michael Forster , John Vanko , William Gallagher , William Kalbfleisch , Robert Usselman , Zallie Privett
发明人： Samuel Woods , Jason Leh , David Beers , Michael Forster , John Vanko , William Gallagher , William Kalbfleisch , Robert Usselman , Zallie Privett
IPC分类号： H02H7/09
CPC分类号： H02P25/14 , B24B23/028 , B24B55/00 , H02H5/04 , H02H7/08 , H02K11/33 , H02M5/2573 , H02P29/02 , Y10T408/65
摘要： A motor control module designed to control operation of a plurality of different motors in a plurality of different tools a power tool uses an electronic clutch in the module in conjunction with a mechanical clutch in the tool to protect the tool against an overload event. The module is adapted to implement methods to provide aural and/or tactile feedback to a tool user as a warning of an impending or current fault condition in the tool. The module can prevent power from inadvertently turning on either after an overload event has cleared with the tool plugged in and its power switch on, or after plugging in the tool within the power switch on. The control module is adapted to provide torque control for the power tool, to estimate tool motor temperature and to inform a tool user when a servicing need in the tool is required.
摘要翻译：一种电动机控制模块，其设计成控制多个不同工具中的多个不同电动机的操作，电动工具使用模块中的电子离合器与工具中的机械离合器相结合，以保护工具免受过载事件的影响。该模块适于实现用于向工具用户提供听觉和/或触觉反馈的方法，作为工具中即将发生或当前故障状况的警告。在插入工具并打开电源开关或插入电源开关中的工具后，过载事件清除后，模块可以防止电源无意中打开。控制模块适用于为电动工具提供扭矩控制，以估计工具电机的温度，并在需要工具中的维修需要时通知工具用户。

3. 发明申请

US20050218186A1 Method for sizing a motor for a power tool 有权
标题翻译：电动工具电机的尺寸调整方法
公开(公告)号：US20050218186A1
公开(公告)日：2005-10-06
申请号：US11095726
申请日：2005-03-31
申请人： Michael Forster
发明人： Michael Forster
IPC分类号： B25C1/00 , B25C1/06
CPC分类号： B25C1/06
摘要： A tool with a motor assembly and a driver. The motor assembly can include a flywheel that is driven by an electric motor. The driver can be selectively engaged by an edge of the flywheel to transmit energy therebetween to cause the driver to translate along an axis. The electric motor has a ke value that is between about 0.85 to about 0.55. A method for sizing a motor for a power tool is also provided.
摘要翻译：具有电机组件和驱动器的工具。马达组件可以包括由电动马达驱动的飞轮。驾驶员可以选择性地与飞轮的边缘接合以在其间传递能量，以使驾驶员沿轴线平移。电动机的ke值在约0.85至约0.55之间。还提供了一种用于电动工具的电动机的尺寸的方法。

4. 发明申请

US20050217875A1 Method for controlling a power driver 有权
标题翻译：控制电源驱动器的方法
公开(公告)号：US20050217875A1
公开(公告)日：2005-10-06
申请号：US11095723
申请日：2005-03-31
申请人： Michael Forster , Craig Schell , Paul Gross , Charles Bradenbaugh , Nathan Cruise , Erik Ekstrom
发明人： Michael Forster , Craig Schell , Paul Gross , Charles Bradenbaugh , Nathan Cruise , Erik Ekstrom
IPC分类号： B25C1/00 , B25C1/06 , B25D1/00 , H01H15/02 , H02K7/02
CPC分类号： B25C1/06
摘要： A driving tool having a driver, a power source, a sensor and a controller. The power source selectively provides an input to the driver to cause the driver to translate along an axis. The sensor senses a condition in the power source that is indicative of a level of kinetic energy of an element in the power source and generates a sensor signal in response thereto. The controller is coupled to the power source and the sensor and is responsive to the sensor signal for deactivating the power source to inhibit the power source from providing the input to the driver when the level of kinetic energy of the element in the power source is below a predetermined threshold. A method for operating a driving tool is also provided.
摘要翻译：具有驱动器，电源，传感器和控制器的驱动工具。电源选择性地向驾驶员提供输入以使驾驶员沿着轴平移。传感器感测电源中的状态，其表示电源中的元件的动能水平，并响应于此产生传感器信号。控制器耦合到电源和传感器，并且当电源中的元件的动能水平低于电源时，响应于传感器信号以停用电源以禁止电源向驱动器提供输入预定阈值。还提供了一种用于操作驱动工具的方法。

5. 发明授权

US06653299B1 Labelled factor XIIIa substrates 失效
标题翻译：标记因子XIIIa底物
公开(公告)号：US06653299B1
公开(公告)日：2003-11-25
申请号：US09341915
申请日：1999-10-04
申请人： Alan Michael Forster , Peter Knox , Marivi Mendizabal , Timothy Charles Richardson , Anthony Eamon Storey , Ian Andrew Wilson , Susan Champion , Alex Gibson , Benedicte Guilbert
发明人： Alan Michael Forster , Peter Knox , Marivi Mendizabal , Timothy Charles Richardson , Anthony Eamon Storey , Ian Andrew Wilson , Susan Champion , Alex Gibson , Benedicte Guilbert
IPC分类号： A61K3128
CPC分类号： A61K51/0482 , A61K51/0478 , A61K2123/00
摘要： A complex of a radiometal or paramagnetic metal ion with a metal chelating agent such as a diaminedioxime has attached thereto a substituent of formula —(Y)m—A—NHR, can function as a substrate for the fibrin-stabilizing Factor XIIIa. The complex is useful for the diagnosis or therapy of thrombosis, embolism, atherosclerosis, inflammation or cancer.
摘要翻译：放射性金属或顺磁性金属离子与金属螯合剂如二胺肟的络合物与式 - （Y）m-A-NHR的取代基连接，可用作纤维蛋白稳定因子XIIIa的底物。该复合物可用于血栓形成，栓塞，动脉粥样硬化，炎症或癌症的诊断或治疗。

6. 发明授权

US06601058B2 Data exploration system and method 有权
标题翻译：数据探索系统及方法
公开(公告)号：US06601058B2
公开(公告)日：2003-07-29
申请号：US09166556
申请日：1998-10-05
申请人： Michael Forster , Lindsay Spratt
发明人： Michael Forster , Lindsay Spratt
IPC分类号： G06F1730
CPC分类号： G06F17/30286 , Y10S707/99932 , Y10S707/99933
摘要： Preferred embodiments of the invention provide a system for, and method of, exploring relationships in data stored in a computer readable medium. A query is received having at least one operator chosen from a set of operators that includes relational operators and having at least one input and output associated with the operator and defined as a table having at least one domain having a type associated therewith. The query is transformed into a set program having at least one operation structure, corresponding to the operator and having logic for type-independently performing an operation, corresponding to the operator, and having a data relation structure, cooperating with the operation structure, for handling all data access and storage associated with the operation.
摘要翻译：本发明的优选实施例提供了一种用于探索存储在计算机可读介质中的数据关系的系统和方法。接收到具有从包括关系运算符的一组运算符中选择的至少一个运算符的查询，并且具有与运算符相关联的至少一个输入和输出，并被定义为具有与其相关联的类型的至少一个域的表。该查询被转换为具有至少一个操作结构的设置程序，对应于操作者并具有与操作者相对应的类型独立地执行操作的逻辑，并具有与操作结构协作的数据关系结构，用于处理与操作相关的所有数据访问和存储。

7. 发明授权

US06375926B1 Labelled elastase inhibitors 失效
标题翻译：标记弹性蛋白酶抑制剂
公开(公告)号：US06375926B1
公开(公告)日：2002-04-23
申请号：US09254541
申请日：2000-05-16
申请人： Karen Jane Barnes , Gary Robert Bower , Alan Michael Forster , Peter Knox , Marivi Mendizabal , Anthony Eamon Storey
发明人： Karen Jane Barnes , Gary Robert Bower , Alan Michael Forster , Peter Knox , Marivi Mendizabal , Anthony Eamon Storey
IPC分类号： A61K5100
CPC分类号： A61K51/088 , A61K49/085 , A61K49/14 , A61K51/0444 , A61K51/0455 , A61K51/0459 , A61K2121/00 , A61K2123/00
摘要： A human leucocyte elastase (HLE) inhibitor labelled with a detector moiety where the inhibitor is synthetic and has a molecular weight of less than 2000, is useful for the diagnostic imaging of sites of inflammation of infection in vivo, for labelling leucocytes in vitro, or for radiotherapy of rthritis. The HLE inhibitor is preferably a &bgr;-lactam or an azetidinone.
摘要翻译：用抑制剂合成且分子量小于2000的检测器部分标记的人类白细胞弹性蛋白酶（HLE）抑制剂可用于体外感染炎症部位的诊断成像，用于体外标记白细胞，或用于放射治疗关节炎。 HLE抑制剂优选为β-内酰胺或氮杂环丁酮。

8. 发明授权

US08863084B2 Methods, apparatuses, and computer-readable media for computing checksums for effective caching in continuous distributed builds 有权
标题翻译：用于计算校验和以实现连续分布式构建中有效缓存的方法，设备和计算机可读介质
公开(公告)号：US08863084B2
公开(公告)日：2014-10-14
申请号：US13284432
申请日：2011-10-28
申请人： Michael Forster , Ulf Adams , Steffi Scherzinger , Christian Karl Kemper
发明人： Michael Forster , Ulf Adams , Steffi Scherzinger , Christian Karl Kemper
IPC分类号： G06F9/44
CPC分类号： G06F8/71 , G06F8/70
摘要： Methods, systems, and computer-readable media for determining whether dependencies of configuration files have changed such that the compilation strategy should be recomputed. Local build checksums are computed for individual configuration files. The local build checksums are computed by sorting input paths to the configuration files plus data indicating whether the path refers to a file or a directory and a checksum computed on the configuration file itself. The transitive closure of local build checksums are then used to compute a global build checksum: the local build checksums are sorted in order to compute the global build checksum. If the global build checksum is different from a previously computed global build checksum, then the compilation strategy should be recomputed, since this is a signal that the compilation strategy may not be valid anymore, e.g. because some dependencies in the configuration files have changed.
摘要翻译：用于确定配置文件的依赖性是否已改变的方法，系统和计算机可读介质，以便重新计算编译策略。为单个配置文件计算本地构建校验和。本地构建校验和通过将配置文件的输入路径排序，以及指示路径是引用文件还是目录以及在配置文件本身计算的校验和的数据来计算。然后使用本地构建校验和的传递闭包来计算全局构建校验和：对本地构建校验和进行排序以计算全局构建校验和。如果全局构建校验和与先前计算的全局构建校验和不同，则应重新计算编译策略，因为这是编译策略可能不再有效的信号，例如，因为配置文件中的某些依赖关系已更改。

9. 发明申请

US20130245958A1 ACCURATE COMPARISON AND VALIDATION OF SINGLE NUCLEOTIDE VARIANTS 审中-公开
标题翻译：准确的比较和验证单核苷酸变体
公开(公告)号：US20130245958A1
公开(公告)日：2013-09-19
申请号：US13795492
申请日：2013-03-12
申请人： Michael FORSTER , Andre FRANKE , Andreas KELLER
发明人： Michael FORSTER , Andre FRANKE , Andreas KELLER
IPC分类号： G06F19/22
CPC分类号： G16B30/00
摘要： A method is disclosed for validation of single nucleotide variants (SNV) in a sequence of interest. In at least one embodiment, the method includes: interrogating a BAM-file of the sequence of interest and a reference sequence file and producing a summary table for genomic coordinates of interest; generating a plurality of sequence reads from a sample of said sequence of interest; filtering sequence reads using a plurality of filter levels; extracting SNV counts for each strand for a genomic region of interest within the sequence of interest, resulting in ten SNV counts; for each genomic region of interest determining a rule based genotype decision and inferring a best genotype from the 10 counts; and creating a single consensus file for said sequence of interest including information of best genotype and a best quality for each genomic region of interest.
摘要翻译：公开了一种在感兴趣的序列中验证单核苷酸变体（SNV）的方法。在至少一个实施例中，所述方法包括：询问感兴趣序列的BAM文件和参考序列文件，并产生用于感兴趣的基因组坐标的汇总表; 从所述感兴趣的序列的样本生成多个序列读数; 过滤序列使用多个滤波器级别读取; 提取感兴趣序列中感兴趣的基因组区域的每条链的SNV计数，得到十个SNV计数; 对于每个感兴趣的基因组区域，确定基于规则的基因型决定并从10个计数推断最佳基因型; 以及为所述感兴趣的序列创建单一的共同文件，包括针对感兴趣的每个基因组区域的最佳基因型和最佳质量的信息。

10. 发明授权

US08347978B2 Method for controlling a power driver 有权
标题翻译：控制电源驱动器的方法
公开(公告)号：US08347978B2
公开(公告)日：2013-01-08
申请号：US11095723
申请日：2005-03-31
申请人： Michael Forster , Craig A. Schell , Paul Gross , Charles L. Bradenbaugh, IV , Nathan Cruise , Erik Ekstrom
发明人： Michael Forster , Craig A. Schell , Paul Gross , Charles L. Bradenbaugh, IV , Nathan Cruise , Erik Ekstrom
IPC分类号： B25B21/02
CPC分类号： B25C1/06
摘要： A driving tool having a driver, a power source, a sensor and a controller. The power source selectively provides an input to the driver to cause the driver to translate along an axis. The sensor senses a condition in the power source that is indicative of a level of kinetic energy of an element in the power source and generates a sensor signal in response thereto. The controller is coupled to the power source and the sensor and is responsive to the sensor signal for deactivating the power source to inhibit the power source from providing the input to the driver when the level of kinetic energy of the element in the power source is below a predetermined threshold. A method for operating a driving tool is also provided.
摘要翻译：具有驱动器，电源，传感器和控制器的驱动工具。电源选择性地向驾驶员提供输入以使驾驶员沿着轴平移。传感器感测电源中的状态，其表示电源中的元件的动能水平，并响应于此产生传感器信号。控制器耦合到电源和传感器，并且当电源中的元件的动能水平低于电源时，响应于传感器信号以停用电源以禁止电源向驱动器提供输入预定阈值。还提供了一种用于操作驱动工具的方法。

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