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1. 发明授权

US5978740A Molecules comprising a calcineurin-like binding pocket and encoded data storage medium capable of graphically displaying them 失效
公开(公告)号：US5978740A
公开(公告)日：1999-11-02
申请号：US512815
申请日：1995-08-09
申请人： David M. Armistead , Matthew James Fitzgibbon , Mark Andrew Fleming , James P. Griffith , Eunice E. Kim , Joseph L. Kim , Michael D. Sintchak , John Allan Thomson , Keith P. Wilson
发明人： David M. Armistead , Matthew James Fitzgibbon , Mark Andrew Fleming , James P. Griffith , Eunice E. Kim , Joseph L. Kim , Michael D. Sintchak , John Allan Thomson , Keith P. Wilson
IPC分类号： C12N9/16 , G06F17/50 , G06F19/00
CPC分类号： C07K14/705 , C12N9/16
摘要： The present invention relates to crystallized molecules and molecular complexes which comprise the active site binding pocket or the FKBP12/FK506 binding pocket of calcineurin or close structural homologues to either binding pocket. This invention also relates to a data storage material encoded with the corresponding structure coordinates of those crystallized molecules or molecular complexes. Such data storage material is capable of displaying such molecules and molecular complexes as a graphical three-dimensional representation on a computer screen. In addition, this invention relates to methods of using the structure coordinates of those molecules or molecular complexes to solve the structure of homologous proteins. This invention also relates to methods of using the structure coordinates to screen and design compounds that bind to calcineurin or homologues thereof.

2. 发明授权

US07216041B1 Methods of using the structure coordinates of molecules comprising an IMPDH-like binding pocket 失效
标题翻译：使用包含IMPDH样结合口袋的分子的结构坐标的方法
公开(公告)号：US07216041B1
公开(公告)日：2007-05-08
申请号：US09678016
申请日：2000-10-02
申请人： Keith P. Wilson , Michael D. Sintchak , Mark Andrew Fleming , David M. Armistead
发明人： Keith P. Wilson , Michael D. Sintchak , Mark Andrew Fleming , David M. Armistead
IPC分类号： G06F19/00
CPC分类号： C12Q1/32 , C07K2299/00 , C12N9/0006 , C12Y101/01205 , G06F19/706
摘要： The present invention relates to a data storage medium encoded with the corresponding structure coordinates of molecules and molecular complexes which comprise the active site binding pockets of IMPDH. Such data storage material is capable of displaying such molecules and molecular complexes, or their structural homologues, as a graphical three-dimensional representation on a computer screen. This invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. In addition, this invention relates to methods of using the structure coordinates to screen and design compounds, including inhibitory compounds, that bind to IMPDH or homologues thereof. This invention also relates to molecules and molecular complexes which comprise the active site binding pockets of IMPDH or close structural homologues of the active site binding pockets. This invention also relates to compounds and pharmaceutical compositions which are inhibitors of IMPDH.
摘要翻译：本发明涉及用包含IMPDH的活性位点结合口袋的分子和分子复合物的相应结构坐标编码的数据存储介质。这样的数据存储材料能够在计算机屏幕上显示这样的分子和分子复合物或其结构同系物作为图形三维表示。本发明还涉及使用结构坐标来解决同源蛋白质或蛋白质复合物的结构的方法。此外，本发明涉及使用结构坐标来筛选和设计结合IMPDH或其同系物的化合物（包括抑制性化合物）的方法。本发明还涉及包含IMPDH的活性位点结合袋或活性位点结合口袋的紧密结构同系物的分子和分子复合物。本发明还涉及作为IMPDH抑制剂的化合物和药物组合物。

3. 发明授权

US06128582A Molecules comprising an IMPDH-like binding pocket and encoded data storage medium capable of graphically displaying them 失效
标题翻译：包含IMPDH样结合袋的分子和能够图形显示它们的编码数据存储介质
公开(公告)号：US06128582A
公开(公告)日：2000-10-03
申请号：US640164
申请日：1996-04-30
申请人： Keith P. Wilson , Michael D. Sintchak , Mark Andrew Fleming , David M. Armistead
发明人： Keith P. Wilson , Michael D. Sintchak , Mark Andrew Fleming , David M. Armistead
IPC分类号： A61K31/00 , A61K31/365 , A61K45/00 , A61P43/00 , C07K1/00 , C07K1/14 , C12N9/04 , C12Q1/32 , G06F17/30 , G06F17/50 , G06F19/00
CPC分类号： C12Q1/32 , C12N9/0006 , C12Y101/01205 , G06F19/706 , C07K2299/00
摘要： The present invention relates to a data storage medium encoded with the corresponding structure coordinates of molecules and molecular complexes which comprise the active site binding pockets of IMPDH. Such data storage material is capable of displaying such molecules and molecular complexes, or their structural homologues, as a graphical three-dimensional representation on a computer screen. This invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. In addition, this invention relates to methods of using the structure coordinates to screen and design compounds, including inhibitory compounds, that bind to IMPDH or homologues thereof. This invention also relates to molecules and molecular complexes which comprise the active site binding pockets of IMPDH or close structural homologues of the active site binding pockets. This invention also relates to compounds and pharmaceutical compositions which are inhibitors of IMPDH.
摘要翻译：本发明涉及用包含IMPDH的活性位点结合口袋的分子和分子复合物的相应结构坐标编码的数据存储介质。这样的数据存储材料能够在计算机屏幕上显示这样的分子和分子复合物或其结构同系物作为图形三维表示。本发明还涉及使用结构坐标来解决同源蛋白质或蛋白质复合物的结构的方法。此外，本发明涉及使用结构坐标筛选和设计结合IMPDH或其同系物的化合物（包括抑制性化合物）的方法。本发明还涉及包含IMPDH的活性位点结合袋或活性位点结合口袋的紧密结构同系物的分子和分子复合物。本发明还涉及作为IMPDH抑制剂的化合物和药物组合物。

4. 发明授权

US07527952B2 Crystals of inosine monophosphate dehydrogenase/oxidized inosine monophosphate thiomidate intermediate/mycophenolic acid (IIMPDH/XMP*/MPA) 失效
标题翻译：肌苷单磷酸脱氢酶/氧化肌苷单磷酸硫酸酯中间体/霉酚酸（IIMPDH / XMP * / MPA）
公开(公告)号：US07527952B2
公开(公告)日：2009-05-05
申请号：US11645289
申请日：2006-12-21
申请人： Keith P. Wilson , Michael D. Sintchak , Mark Andrew Fleming , David M. Armistead
发明人： Keith P. Wilson , Michael D. Sintchak , Mark Andrew Fleming , David M. Armistead
IPC分类号： C12P21/06 , C12N9/04
CPC分类号： C12Q1/32 , C07K2299/00 , C12N9/0006 , C12Y101/01205 , G06F19/706
摘要： The present invention relates to a data storage medium encoded with the corresponding structure coordinates of molecules and molecular complexes which comprise the active site binding pockets of IMPDH. Such data storage material is capable of displaying such molecules and molecular complexes, or their structural homologues, as a graphical three-dimensional representation on a computer screen. This invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. In addition, this invention relates to methods of using the structure coordinates to screen and design compounds, including inhibitory compounds, that bind to IMPDH or homologues thereof. This invention also relates to molecules and molecular complexes which comprise the active site binding pockets of IMPDH or close structural homologues of the active site binding pockets. This invention also relates to compounds and pharmaceutical compositions which are inhibitors of IMPDH.
摘要翻译：本发明涉及用包含IMPDH的活性位点结合口袋的分子和分子复合物的相应结构坐标编码的数据存储介质。这样的数据存储材料能够在计算机屏幕上显示这样的分子和分子复合物或其结构同系物作为图形三维表示。本发明还涉及使用结构坐标来解决同源蛋白质或蛋白质复合物的结构的方法。此外，本发明涉及使用结构坐标来筛选和设计结合IMPDH或其同系物的化合物（包括抑制性化合物）的方法。本发明还涉及包含IMPDH的活性位点结合袋或活性位点结合口袋的紧密结构同系物的分子和分子复合物。本发明还涉及作为IMPDH抑制剂的化合物和药物组合物。

5. 发明授权

US07065452B1 Molecules comprising a calcineurin-like binding pocket and encoded data storage medium capable of graphically displaying them 失效
标题翻译：包含钙调神经磷酸酶结合口袋的分子和能够图形显示它们的编码数据存储介质
公开(公告)号：US07065452B1
公开(公告)日：2006-06-20
申请号：US09431469
申请日：1999-11-01
申请人： David M. Armistead , Matthew James Fitzgibbon , Mark Andrew Fleming , James P. Griffith , Eunice E. Kim , Joseph L. Kim , Michael D. Sintchak , John Allan Thomson , Keith P. Wilson
发明人： David M. Armistead , Matthew James Fitzgibbon , Mark Andrew Fleming , James P. Griffith , Eunice E. Kim , Joseph L. Kim , Michael D. Sintchak , John Allan Thomson , Keith P. Wilson
IPC分类号： G06G7/48 , G06N7/06
CPC分类号： C07K14/705 , C12N9/16
摘要： The present invention relates to crystallized molecules and molecular complexes which comprise the active site binding pocket or the FKBP12/FK506 binding pocket of calcineurin or close structural homologues to either binding pocket. This invention also relates to a data storage material encoded with the corresponding structure coordinates of those crystallized molecules or molecular complexes. Such data storage material is capable of displaying such molecules and molecular complexes as a graphical three-dimensional representation on a computer screen. In addition, this invention relates to methods of using the structure coordinates of those molecules or molecular complexes to solve the structure of homologous proteins. This invention also relates to methods of using the structure coordinates to screen and design compounds that bind to calcineurin or homologues thereof.
摘要翻译：本发明涉及结晶分子和分子复合物，其包含活性位点结合口袋或钙调神经磷酸酶的FKBP12 / FK506结合口袋或紧密结构同源物至结合口袋。本发明还涉及用这些结晶分子或分子复合物的对应结构坐标编码的数据存储材料。这样的数据存储材料能够在计算机屏幕上显示作为图形三维表示的分子和分子复合物。此外，本发明涉及使用这些分子或分子复合物的结构坐标来解决同源蛋白质结构的方法。本发明还涉及使用结构坐标来筛选和设计结合钙调神经磷酸酶或其同系物的化合物的方法。

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