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1. 发明申请

US20050158281A1 Compositions and methods for systemic nucleic acid sequence delivery 有权
标题翻译：全身核酸序列递送的组合物和方法
公开(公告)号：US20050158281A1
公开(公告)日：2005-07-21
申请号：US10988723
申请日：2004-11-15
申请人： Jeffrey Chamberlain , Paul Gregorevic , Michael Blankinship , James Allen
发明人： Jeffrey Chamberlain , Paul Gregorevic , Michael Blankinship , James Allen
IPC分类号： A01N43/04 , A61K31/70 , A61K48/00 , C12N15/861 , C12Q20060101
CPC分类号： C12N15/86 , A61K48/00 , C12N2750/14143
摘要： The present invention provides systemic nucleic acid sequence delivery without conventional systemic administration aids (SAAs). In certain embodiments, vascular permeability agents (VPAs), such as VEGF, are used in conjunction with nucleic acid viral vectors, such as adeno-associated virus (AAV). The present invention also provides methods of treating disease by co-administration of nucleic cid sequences encoding Igf-1 and dystrophin or dystrophin-like proteins.
摘要翻译：本发明提供全身核酸序列，而不需要常规的全身给药辅助剂（SAA）。在某些实施方案中，血管通透性试剂（例如VEGF）与核酸病毒载体如腺相关病毒（AAV）结合使用。本发明还提供了通过共同给予编码Igf-1和肌营养不良蛋白或肌营养不良蛋白样蛋白的核酸序列来治疗疾病的方法。

2. 发明授权

US09095118B1 Pelletized tree nut animal litter and method of making same 有权
标题翻译：造粒的树皮动物垃圾及其制作方法
公开(公告)号：US09095118B1
公开(公告)日：2015-08-04
申请号：US13029890
申请日：2011-02-17
申请人： Michael Blankinship , Raymond L. John , Helen I. Cantrell
发明人： Michael Blankinship , Raymond L. John , Helen I. Cantrell
IPC分类号： A01K1/015
CPC分类号： A01K1/0154 , A01K1/0152 , A01K1/0155
摘要： A method of making animal litter from a tree nuts, such as from a walnut composition of shells, pelica and membrane, by grinding or crushing the walnut composition, removing all or almost all of the shells from the walnut composition by vibration and aspiration to form muller, adding any desired additives to the muller (e.g. fragrances, fillers and extenders, clumping agent such as guar bean, mold inhibitor agent such as calcium propionate, etc.), and pelletizing the muller by heating and compressing the muller through small apertures and cutting the muller exiting the apertures at desired lengths. The heating and compression of the muller results in pellets that have odor absorbing characteristics that outperform commercial animal litters.
摘要翻译：通过研磨或粉碎核桃组合物，从树仁制成动物垃圾的方法，例如通过研磨或粉碎核桃组合物，从胡桃木核桃组合物制成动物垃圾，通过振动和抽吸从核桃组合物中除去所有或几乎所有的壳，形成将所需的添加剂添加到研磨机（例如香料，填充剂和增量剂，凝结剂如瓜尔豆，霉菌抑制剂如丙酸钙等）中，并通过加热和压缩通过小孔的熔化器造粒，切割以所需长度离开孔的熔化器。研磨机的加热和压缩导致具有优于商业动物窝的气味吸收特性的丸粒。

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