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1. 发明申请

US20040033990A1 Treatment of cardiovascular and related pathologies 失效
标题翻译：治疗心血管及相关病理
公开(公告)号：US20040033990A1
公开(公告)日：2004-02-19
申请号：US10639877
申请日：2003-08-12
申请人： Medicure International Inc.
发明人： Rajat Sethi , Wasimul Haque
IPC分类号： A61K031/675 , A61K031/4741 , A61K031/4415
CPC分类号： A61K45/06 , A61K31/4415 , A61K2300/00
摘要： Methods for treating cardiovascular and related diseases such as myocardial infarction are described. The methods are directed to concurrently administering a compound such as pyridoxal-5null-phosphate, pyridoxamine, pyridoxal, or a 3-acylated pyridoxal analogue with a therapeutic cardiovascular compound.
摘要翻译：描述了治疗心血管和相关疾病如心肌梗塞的方法。该方法涉及与治疗性心血管化合物同时施用化合物如吡哆醛-5'-磷酸，吡哆胺，吡哆醛或3-酰化吡哆醛类似物。

2. 发明申请

US20030114678A1 Cardioprotective phosphonates and malonates 失效
公开(公告)号：US20030114678A1
公开(公告)日：2003-06-19
申请号：US10282326
申请日：2002-10-28
申请人： Medicure International Inc.
发明人： Wasimul Haque
IPC分类号： C07F009/58 , A61K031/675
CPC分类号： C07D213/66 , C07D213/65 , C07F9/58 , C07F9/6561
摘要： The present invention provides for pyridoxine phosphonate analogues such as, for example, ((2-methyl-3-hydroxy-4-hydroxymethyl-5-pyridyl)alkylphosphonates, and (2-methyl-3-hydroxy-4-hydroxymethyl-5-pyridyl)azaalkylphosphonates) and to pyridoxine malonate analogues, such as, for example, ((2-methyl-3-hydroxy-4-hydroxymethyl-5-pyridylmethyl)malonates), pharmaceutical compositions, and methods for treatment of cardiovascular and related diseases, and diabetes mellitus and related diseases.

3. 发明申请

US20040121988A1 Treatment of cerebrovascular disease 审中-公开
标题翻译：治疗脑血管疾病
公开(公告)号：US20040121988A1
公开(公告)日：2004-06-24
申请号：US10729276
申请日：2003-12-03
申请人： Medicure International Inc.
发明人： Wasimul Haque , Rajat Sethi
IPC分类号： A61K031/675 , A61K031/4415
CPC分类号： A61K31/44 , A61K31/4741 , A61K31/675
摘要： A method of treating a cerebrovascular disease, particularly stroke, is described. A method of treating a cerebrovascular disease includes administering pyridoxal-5null-phosphate, pyridoxal, pyridoxine, pyridoxamine, 3-acylated analogues of pyridoxal, 3-acylated analogues of pyriodoxal-4,5-animal, pyridoxine phosphonate analogues, or pharmaceutical compositions thereof.
摘要翻译：描述了治疗脑血管疾病，特别是中风的方法。一种治疗脑血管疾病的方法包括施用吡哆醛-5'-磷酸，吡哆醛，吡哆醇，吡哆胺，吡哆醛的3-酰化类似物，吡哆醛-4-5-动物，吡哆酮膦酸酯类似物的3-酰化类似物或其药物组合物。

4. 发明申请

US20030114677A1 Cardioprotective phosphonates and malonates 失效
公开(公告)号：US20030114677A1
公开(公告)日：2003-06-19
申请号：US10282325
申请日：2002-10-28
申请人： Medicure International Inc.
发明人： Wasimul Haque
IPC分类号： A61K031/675 , C07F009/58
CPC分类号： C07D213/66 , C07D213/65 , C07F9/58 , C07F9/6561
摘要： The present invention provides for pyridoxine phosphonate analogues such as, for example, ((2-methyl-3-hydroxy-4-hydroxymethyl-5-pyridyl)alkylphosphonates, and (2-methyl-3-hydroxy-4-hydroxymethyl-5-pyridyl)azaalkylphosphonates) and to pyridoxine malonate analogues, such as, for example, ((2-methyl-3-hydroxy-4-hydroxymethyl-5-pyridylmethyl)malonates), pharmaceutical compositions, and methods for treatment of cardiovascular and related diseases, and diabetes mellitus and related diseases.

5. 发明申请

US20180125836A1 METHOD FOR INHIBITING PLATELET AGGREGATION 审中-公开
公开(公告)号：US20180125836A1
公开(公告)日：2018-05-10
申请号：US15692894
申请日：2017-08-31
申请人： MEDICURE INTERNATIONAL INC.
发明人： Peter M. DiBATTISTE , David J. SCHNEIDER
IPC分类号： A61K31/4465 , A61K9/00 , A61K9/08
CPC分类号： A61K31/4465 , A61K9/0019 , A61K9/08
摘要： A method for inhibiting platelet aggregation in a patient in need thereof, comprising 1) administering to the patient a bolus injection of an active drug, in an amount of between about 25 μg/kg, and 2) administering to the patient, after the bolus injection, an intravenous infusion for a period of between about 12 hours and about 72 hours, of the active drug, in an amount of about 0.15 μg/kg/min, wherein the active drug is tirofiban or a salt thereof.

6. 发明申请

US20040186077A1 Novel heteroaryl phosphonates as cardioprotective agents 审中-公开
标题翻译：新型杂芳基膦酸酯作为心脏保护剂
公开(公告)号：US20040186077A1
公开(公告)日：2004-09-23
申请号：US10391056
申请日：2003-03-17
申请人： Medicure International Inc.
发明人： James Diakur , Wasimul Haque , Wenlian Zhang , Junzhi Yao , Vinh Pham
IPC分类号： A61K031/675 , A61K031/44
CPC分类号： C07F9/58
摘要： The invention teaches compound of general formula: 1 Wherein: R1 is selected from H and CH3, and R2 is selected from H and OH, or R1 and R2 together form an optionally substituted phenyl ring which is fused to the pyridine ring; and R3 is selected from H, CH3, CH2OH and 2 R4 is selected from H, CH3, CH2OH, 3 R5 is selected from H, phenyl, halogen-substituted phenyl and 4 Wherein R6 and R7 are each independently selected from H, Nanull, Knull, alkyl and optionally substituted aryl, and X and Y are each independently selected from H, OH and F, or at least one of X and Y is an heteroatom and together with R3 forms a bridge with the proviso that R4 is 5 and N-oxides thereof, and biologically acceptable salts thereof, related compounds, related pharmaceutical compositions, and methods for treating various disorders using such compositions.
摘要翻译：本发明教导了通式为的化合物：其中R1选自H和CH3，R2选自H和OH，或R1和R2一起形成与吡啶环稠合的任意取代的苯环; 并且R 3选自H，CH 3，CH 2 OH和R 4选自H，CH 3，CH 2 OH，R 5选自H，苯基，卤素取代的苯基，其中R 6和R 7各自独立地选自H， K +，烷基和任选取代的芳基，X和Y各自独立地选自H，OH和F，或者X和Y中的至少一个是杂原子，并且与R3一起形成桥，条件是R4是其N-氧化物及其生物可接受的盐，相关化合物，相关药物组合物，以及使用这些组合物治疗各种病症的方法。

7. 发明申请

US20040038945A1 Treatment of cardiovascular and related pathologies 失效
标题翻译：治疗心血管及相关病理
公开(公告)号：US20040038945A1
公开(公告)日：2004-02-26
申请号：US10639948
申请日：2003-08-12
申请人： Medicure International Inc.
发明人： Rajat Sethi , Wasimul Haque
IPC分类号： A61K031/675 , A61K031/4741 , A61K031/4415
CPC分类号： A61K45/06 , A61K31/4415 , A61K2300/00
摘要： Methods for treating cardiovascular and related diseases such as hypertrophy are described. The methods are directed to concurrently administering a compound such as pyridoxal-5null-phosphate, pyridoxamine, pyridoxal, or a 3-acylated pyridoxal analogue with a therapeutic cardiovascular compound.
摘要翻译：描述了治疗心血管和相关疾病如肥大的方法。该方法涉及与治疗性心血管化合物同时施用化合物如吡哆醛-5'-磷酸，吡哆胺，吡哆醛或3-酰化吡哆醛类似物。

8. 发明申请

US20040033993A1 Treatment of cardiovascular and related pathologies 失效
标题翻译：治疗心血管及相关病理
公开(公告)号：US20040033993A1
公开(公告)日：2004-02-19
申请号：US10639955
申请日：2003-08-12
申请人： Medicure International Inc.
发明人： Rajat Sethi , Wasimul Haque
IPC分类号： A61K031/675 , A61K031/4741 , A61K031/4415
CPC分类号： A61K45/06 , A61K31/4415 , A61K2300/00
摘要： Methods for treating cardiovascular and related diseases such as ischemia, ischemia reperfusion injuries, and myocardial ischemia, are described. The methods are directed to concurrently administering a compound such as pyridoxal-5null-phosphate, pyridoxamine, pyridoxal, or a 3-acylated pyridoxal analogue with a therapeutic cardiovascular compound.
摘要翻译：描述了治疗心血管和相关疾病如缺血，缺血再灌注损伤和心肌缺血的方法。该方法涉及与治疗性心血管化合物同时施用化合物如吡哆醛-5'-磷酸，吡哆胺，吡哆醛或3-酰化吡哆醛类似物。

9. 发明申请

US20040033991A1 Treating of cardiovascular and related pathologies 失效
标题翻译：治疗心血管及相关病理
公开(公告)号：US20040033991A1
公开(公告)日：2004-02-19
申请号：US10639949
申请日：2003-08-12
申请人： Medicure International Inc.
发明人： Rajat Sethi , Wasimul Haque
IPC分类号： A61K031/675 , A61K031/4741 , A61K031/4415
CPC分类号： A61K45/06 , A61K31/4415 , A61K2300/00
摘要： Methods for treating cardiovascular and related diseases such as blood clots are described. The methods are directed to concurrently administering a compound such as pyridoxal-5null-phosphate, pyridoxamine, pyridoxal, or a 3-acylated pyridoxal analogue with a therapeutic cardiovascular compound.
摘要翻译：描述了治疗心血管和相关疾病如血块的方法。该方法涉及与治疗性心血管化合物同时施用化合物如吡哆醛-5'-磷酸，吡哆胺，吡哆醛或3-酰化吡哆醛类似物。

10. 发明申请

US20040033989A1 Treatment of cardiovascular and related pathologies 失效
标题翻译：治疗心血管及相关病理
公开(公告)号：US20040033989A1
公开(公告)日：2004-02-19
申请号：US10639876
申请日：2003-08-12
申请人： Medicure International Inc.
发明人： Rajat Sethi , Wasimul Haque
IPC分类号： A61K031/675 , A61K031/4741 , A61K031/4415
CPC分类号： A61K45/06 , A61K31/4415 , A61K2300/00
摘要： Methods for treating cardiovascular and related diseases such as arrhythmia are described. The methods are directed to concurrently administering a compound such as pyridoxal-5null-phosphate, pyridoxamine, pyridoxal, or a 3-acylated pyridoxal analogue with a therapeutic cardiovascular compound.
摘要翻译：描述了治疗心血管和相关疾病如心律失常的方法。该方法涉及与治疗性心血管化合物同时施用化合物如吡哆醛-5'-磷酸，吡哆胺，吡哆醛或3-酰化吡哆醛类似物。

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