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1. 发明授权

US07265097B2 Methods of drug delivery using sulphated chitinous polymers 有权
标题翻译：使用硫酸化几丁质聚合物的药物递送方法
公开(公告)号：US07265097B2
公开(公告)日：2007-09-04
申请号：US10224173
申请日：2002-08-20
申请人： Agis Kydonieus , Clive Elson , Maya Thanou
发明人： Agis Kydonieus , Clive Elson , Maya Thanou
IPC分类号： A01N43/04 , A01N61/00
CPC分类号： A61K31/727 , A61K45/06 , A61K47/24 , A61K47/36 , A61K48/00
摘要： The present invention provides methods and compositions for delivering a therapeutic agent across a membrane that has limited permeability for the therapeutic agent. The method includes delivering the therapeutic agent to the membrane in a composition which includes a sulphated chitinous polymer as a primary carrier.
摘要翻译：本发明提供了用于递送治疗剂的方法和组合物，所述方法和组合物跨越对治疗剂具有有限渗透性的膜。该方法包括将治疗剂递送到包含硫酸化壳多糖聚合物作为主要载体的组合物中的膜上。

2. 发明授权

US08017595B2 Methods of drug delivery using sulphated chitinous polymers 有权
标题翻译：使用硫酸化几丁质聚合物的药物递送方法
公开(公告)号：US08017595B2
公开(公告)日：2011-09-13
申请号：US11899172
申请日：2007-09-04
申请人： Agis Kydonieus , Clive Elson , Maya Thanou
发明人： Agis Kydonieus , Clive Elson , Maya Thanou
IPC分类号： A01N43/04 , A01N61/00
CPC分类号： A61K31/727 , A61K45/06 , A61K47/24 , A61K47/36 , A61K48/00
摘要： The present invention provides methods and compositions for delivering a therapeutic agent across a membrane that has limited permeability for the therapeutic agent. The method includes delivering the therapeutic agent to the membrane in a composition which includes a sulphated chitinous polymer as a primary carrier.
摘要翻译：本发明提供了用于递送治疗剂的方法和组合物，所述方法和组合物跨越对治疗剂具有有限渗透性的膜。该方法包括将治疗剂递送到包含硫酸化壳多糖聚合物作为主要载体的组合物中的膜上。

3. 发明申请

US20100297023A1 Lipid 审中-公开
标题翻译：脂质
公开(公告)号：US20100297023A1
公开(公告)日：2010-11-25
申请号：US12520261
申请日：2007-12-21
申请人： Andrew David Miller , Patrick Arbuthnot , Michael Jorgensen , Michael Keller , Nazila Kamaly , Abderrahim Aissaoui , Maya Thanou
发明人： Andrew David Miller , Patrick Arbuthnot , Michael Jorgensen , Michael Keller , Nazila Kamaly , Abderrahim Aissaoui , Maya Thanou
IPC分类号： A61K47/18 , C07C237/22 , A61K31/713 , A61K48/00 , A61K49/10 , C12N5/02
CPC分类号： C07C237/22 , A01K2267/0337 , A61K9/1272 , A61K47/34 , A61K47/543 , A61K47/6907 , A61K47/6911 , A61K48/0025 , C12N15/111 , C12N15/88 , C12N2310/14 , C12N2320/32 , C12N2730/10111 , Y10T428/2984
摘要： The present invention provides a lipid of the formula (I) R3R4N—[Y]q—(CpH2p)—X-Linker-NR1R2 (I) wherein R3 and R4 are independently selected from H and hydrocarbyl groups; q is an integer selected from 1 to 10; Y represents a group (CnH2n)NR5, wherein (i) when q is 1, n is 2, or (ii) when q is greater than 1, each Y may be the same or different and each n is an integer independently selected from 1 to 10, with the proviso that for at least one unit Y, n is 2, and (iii) each R5 is independently selected from H and hydrocarbyl groups; p is an integer selected from 1 to 10; X is an optional group selected from —NR7—, —C(═O)—NR8—, —NR9—C(═O)—, —C(═O)—, —O—, and NR10—C(=0)0-, wherein each R7, R8, R9 and R10 is independently selected from H and hydrocarbyl groups, Linker is an optional group selected from amino acid residues, peptide residues and groups of the formula —(OCH2CH2)1-10, —NR6-(CvH2v)—C(═O)—, wherein R6 is H or a hydrocarbyl group and v is an integer selected from 1 to 11, and —C(=0)-(CH2)0-10—CH2—C(=0)-; R1 is selected from acyclic groups having from 4 to 30 carbon atoms; and R2 is selected from H and acyclic groups having from 4 to 30 carbon atoms. Said lipids can be used in a delivery vehicle (e.g. micelle or liposome) for the delivery of one or more (therapeutic or diagnostic) agents.
摘要翻译：本发明提供式（I）R3R4N- [Y] q-（CpH2p）-X-连接子-NR1R2（I）的脂质，其中R3和R4独立地选自H和烃基; q是选自1至10的整数; Y表示基团（C n H 2n）NR 5，其中（i）当q为1时，n为2，或（ii）当q大于1时，每个Y可以相同或不同，并且每个n是独立地选自 1至10，条件是对于至少一个单元Y，n为2，和（iii）每个R 5独立地选自H和烃基; p是选自1至10的整数; X是选自-NR 7 - ， - C（= O）-NR 8 - ， - NR 9 -C（= O） - ， - C（= O） - ， - O-和NR 10 -C（= O ）0-，其中每个R 7，R 8，R 9和R 10独立地选自H和烃基，连接子是选自氨基酸残基，肽残基和式 - （OCH 2 CH 2）1-10，-NR 6 - （CvH2v）-C（= O） - ，其中R6是H或烃基，v是选自1至11的整数，和-C（= O） - （CH 2）0-10-CH 2 -C = 0） - ; R1选自具有4至30个碳原子的无环基团; 并且R 2选自H和具有4至30个碳原子的无环基。所述脂质可用于递送载体（例如胶束或脂质体）中以递送一种或多种（治疗或诊断）试剂。

4. 发明申请

US20130129636A1 Novel Liposome Nanoparticles for Tumor Magnetic Resonance Imaging 审中-公开
标题翻译：用于肿瘤磁共振成像的新型脂质体纳米颗粒
公开(公告)号：US20130129636A1
公开(公告)日：2013-05-23
申请号：US13511126
申请日：2010-11-19
申请人： Nazila Kamaly , Tammy Louise Kalber , Gavin David Kenny , Maya Thanou , Andrew David Miller , Jimmy Bell
发明人： Nazila Kamaly , Tammy Louise Kalber , Gavin David Kenny , Maya Thanou , Andrew David Miller , Jimmy Bell
IPC分类号： A61K49/18
CPC分类号： A61K49/1812 , B82Y5/00 , Y10S977/773
摘要： The present invention provides novel liposomes comprising Gd.DOTA.DSA (gadolinium(III)2-{4,7-bis-carboxymethyl-10-[(N,N-distearylamidomethyl-N′-amido-methyl]-1,4,7,10-tetra-azacyclododec-1-yl}-acetic acid), characterised in that said liposome further comprises a neutral, fully saturated phospholipid component (e.g. DSPC (1,2-distearoyl-sn-glycero-3-phosphocholine]), which are of particular use in the preparation of magnetic resonance contrast agents for enhancing a magnetic resonance image of tumours in a mammal.
摘要翻译：本发明提供了包含Gd.DOTA.DSA（钆（III）2- {4,7-双 - 羧甲基-10 - [（N，N-二硬脂酰氨基甲基-N'-酰氨基 - 甲基] 7,10-四氮杂环十二烷-1-基} - 乙酸），其特征在于所述脂质体还包含中性完全饱和的磷脂组分（例如DSPC（1,2-二硬脂酰-sn-甘油-3-磷酸胆碱）），其特别用于制备用于增强哺乳动物肿瘤的磁共振图像的磁共振造影剂。

5. 发明申请

US20080076704A1 Methods of drug delivery using sulphated chitinous polymers 有权
标题翻译：使用硫酸化几丁质聚合物的药物递送方法
公开(公告)号：US20080076704A1
公开(公告)日：2008-03-27
申请号：US11899172
申请日：2007-09-04
申请人： Agis Kydonieus , Clive Elson , Maya Thanou
发明人： Agis Kydonieus , Clive Elson , Maya Thanou
IPC分类号： A61K38/02 , A61K31/7052 , A61K47/36 , A61K31/727
CPC分类号： A61K31/727 , A61K45/06 , A61K47/24 , A61K47/36 , A61K48/00
摘要： The present invention provides methods and compositions for delivering a therapeutic agent across a membrane that has limited permeability for the therapeutic agent. The method includes delivering the therapeutic agent to the membrane in a composition which includes a sulphated chitinous polymer as a primary carrier.
摘要翻译：本发明提供了用于递送治疗剂的方法和组合物，所述方法和组合物跨越对治疗剂具有有限渗透性的膜。该方法包括将治疗剂递送到包含硫酸化壳多糖聚合物作为主要载体的组合物中的膜上。

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