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1. 发明申请

US20060028909A1 Device and method for flow mixing of a biological fluid and a solution 审中-公开
标题翻译：用于生物流体和溶液的流动混合的装置和方法
公开(公告)号：US20060028909A1
公开(公告)日：2006-02-09
申请号：US11196706
申请日：2005-08-03
申请人： Maurice Behague
发明人： Maurice Behague
IPC分类号： G05D11/02
CPC分类号： A61M5/16827 , A61M1/024 , A61M1/0272 , A61M1/3672 , A61M2205/3393 , G05D11/131 , Y10T137/2496
摘要： The disclosure relates to a mixing machine, system, and method including: a measurement device able to measure a volume of a biological fluid; a pumping device able to pump an anticoagulant and/or preservation solution into the biological fluid; and a control system for the pumping device. The control system may include: a device for determining an actual volume of the solution previously pumped by the pumping device and an automatic control able to control a pumping speed of the pumping device. The automatic control may control the pumping speed by calculating a theoretical volume of the solution to be mixed with the biological fluid previously pumped by the pumping device as a function of a determined ratio of the biological fluid collected and the solution pumped; comparing the theoretical volume to the actual volume; and adjusting the pumping speed of the pumping device to approach the determined ratio.
摘要翻译：本公开涉及一种混合机，系统和方法，包括：能够测量生物流体体积的测量装置; 泵送装置，其能够将抗凝血剂和/或保存溶液泵入生物流体; 以及用于泵送装置的控制系统。控制系统可以包括：用于确定先前由泵送装置泵送的解决方案的实际体积的装置和能够控制泵送装置的泵送速度的自动控制装置。自动控制可以通过计算将与泵送装置先前泵送的生物流体混合的溶液的理论体积作为所确定的收集的生物流体和泵送的溶液的比例的函数来控制泵送速度; 将理论体积与实际体积进行比较; 并且调节泵送装置的泵送速度以接近所确定的比率。

2. 发明授权

US08778263B2 Irradiation apparatus for inactivating pathogens and/or leukocytes in a biological fluid and process 有权
标题翻译：用于灭活生物流体和方法中的病原体和/或白细胞的照射装置
公开(公告)号：US08778263B2
公开(公告)日：2014-07-15
申请号：US12665691
申请日：2008-06-17
申请人： Wolfram Hubert Walker , Frank Tolksdorf , Thierry Verpoort , Francis Goudaliez , Maurice Behague , Arnaud Chavatte
发明人： Wolfram Hubert Walker , Frank Tolksdorf , Thierry Verpoort , Francis Goudaliez , Maurice Behague , Arnaud Chavatte
IPC分类号： A61L2/00 , C12N7/06 , G01N23/00 , A61N5/00
CPC分类号： A61L2/0047 , A61K41/0019 , A61L2/0011 , A61L2/10 , A61M1/0277
摘要： The invention relates to an irradiation apparatus for inactivating pathogens and/or leukocytes in a biological fluid such as a platelet suspension and/or plasma comprising: a casing (2), a support member (3) for carrying at least one irradiation bag (19) containing the biological fluid, a light source (4) comprising two banks of light (5, 6) disposed above and below the support member (3), and an agitating system (25) for moving the support member (3), the light source generating UVC light of suitable intensity to inactivate pathogens and/or leukocytes and the agitation system moving the support member in an orbital path with predetermined amplitude and rotational frequency suitable to expose the whole biological fluid to UVC.
摘要翻译：本发明涉及用于灭活诸如血小板悬浮液和/或血浆的生物流体中的病原体和/或白细胞的照射装置，包括：壳体（2），用于承载至少一个照射袋（19）的支撑构件（3）），包括设置在所述支撑构件（3）上方和下方的两组光（5,6）的光源（4）和用于移动所述支撑构件（3）的搅拌系统（25）光源产生适当强度的UVC光以灭活病原体和/或白细胞，并且搅动系统使支撑构件以预定的振幅和旋转频率在轨道中移动，以适合于将整个生物流体暴露于UVC。

3. 发明授权

US07879000B2 Method, system and machine for collecting a biological fluid to which a selected ratio of solution is added 有权
标题翻译：用于收集添加了选定比例的生物流体的方法，系统和机器
公开(公告)号：US07879000B2
公开(公告)日：2011-02-01
申请号：US10750143
申请日：2003-12-31
申请人： Maurice Behague , Francis Goudaliez , Thierry Verpoort
发明人： Maurice Behague , Francis Goudaliez , Thierry Verpoort
IPC分类号： A61M37/00 , B01D11/00 , B01D61/00 , C02F1/44
CPC分类号： A61M1/3672 , A61B5/15003 , A61B5/150366 , A61B5/150389 , A61B5/150503 , A61B5/150564 , A61B5/150755 , A61B5/150809 , A61B5/150992 , A61B5/154 , A61B5/157 , A61J1/12 , A61M1/024 , A61M1/0272 , A61M1/1039 , A61M1/1086 , A61M1/3626 , A61M2205/3334 , A61M2205/502
摘要： The invention concerns a method of collecting a biological fluid, in particular blood, with an anticoagulant and/or preservation solution added, in which the biological fluid is collected by natural flow and the anticoagulant and/or preservation solution is added by pumping, the method making provision for measuring the flow of fluid collected and slaving the pumping speed to the measured flow, so as to obtain continuously during collection a given ratio between the quantity of fluid collected and the quantity of anticoagulant and/or preservation solution added. The invention also concerns a collection machine and bag system for implementing the method.
摘要翻译：本发明涉及一种采用加入的抗凝血剂和/或保存溶液来收集生物流体，特别是血液的方法，其中通过天然流量收集生物流体，通过泵送加入抗凝血剂和/或保存溶液，该方法提供用于测量所收集的流体的流量并将泵送速度降低到所测量的流量，以便在收集期间连续获得收集的流体量与添加的抗凝血剂和/或保存溶液的量之间的给定比例。本发明还涉及一种用于实现该方法的收集机和袋系统。

4. 发明申请

US20100178200A1 IRRADIATION APPARATUS FOR INACTIVATING PATHOGENS AND/OR LEUKOCYTES IN A BIOLOGICAL FLUID AND PROCESS 有权
标题翻译：用于在生物流体和过程中灭活病原体和/或白细胞介素的辐射装置
公开(公告)号：US20100178200A1
公开(公告)日：2010-07-15
申请号：US12665691
申请日：2008-06-17
申请人： Wolfram Hubert Walker , Frank Tolksdorf , Thierry Verpoort , Francis Goudaliez , Maurice Behague , Arnaud Chavatte
发明人： Wolfram Hubert Walker , Frank Tolksdorf , Thierry Verpoort , Francis Goudaliez , Maurice Behague , Arnaud Chavatte
IPC分类号： A61L2/10 , A61L2/24
CPC分类号： A61L2/0047 , A61K41/0019 , A61L2/0011 , A61L2/10 , A61M1/0277
摘要： The invention relates to an irradiation apparatus for inactivating pathogens and/or leukocytes in a biological fluid such as a platelet suspension and/or plasma comprising: a casing (2), a support member (3) for carrying at least one irradiation bag (19) containing the biological fluid, a light source (4) comprising two banks of light (5, 6) disposed above and below the support member (3), and an agitating system (25) for moving the support member (3), the light source generating UVC light of suitable intensity to inactivate pathogens and/or leukocytes and the agitation system moving the support member in an orbital path with predetermined amplitude and rotational frequency suitable to expose the whole biological fluid to UVC.
摘要翻译：本发明涉及用于灭活诸如血小板悬浮液和/或血浆的生物流体中的病原体和/或白细胞的照射装置，包括：壳体（2），用于承载至少一个照射袋（19）的支撑构件（3）），包括设置在所述支撑构件（3）上方和下方的两组光（5,6）的光源（4）和用于移动所述支撑构件（3）的搅拌系统（25）光源产生适当强度的UVC光以灭活病原体和/或白细胞，并且搅动系统使支撑构件以预定的振幅和旋转频率在轨道中移动，以适合于将整个生物流体暴露于UVC。

5. 发明授权

US07503901B2 Collection bag system with preformed loop 有权
标题翻译：收集袋系统与预制循环
公开(公告)号：US07503901B2
公开(公告)日：2009-03-17
申请号：US10749296
申请日：2003-12-31
申请人： Maurice Behague , Francis Goudaliez , Thierry Verpoort
发明人： Maurice Behague , Francis Goudaliez , Thierry Verpoort
IPC分类号： A61M39/00
CPC分类号： A61M5/1418 , A61B5/15003 , A61B5/150229 , A61B5/150366 , A61B5/150389 , A61B5/150503 , A61B5/150564 , A61B5/150755 , A61B5/150992 , A61B5/154 , A61B5/155 , Y10S604/905
摘要： The invention concerns a bag system for collecting a biological fluid the system intended for use in a collection machine including a peristaltic pump, the system including, in closed circuit, a fluid collection device, a solution bag containing an anticoagulant and/or preservation solution, and a collection bag intended to receive the fluid collected with the anticoagulant and/or preservation solution added. The collection bag is in fluid communication with the collection device by way of a first tube provided with a connector and with the solution bag by way of a second tube connected to the connector. A device for associating the first and second tubes is provided to allow, between the connector and the association device, the formation of a loop with the second tube, the conformation of the loop being arranged to enable it to be disposed around at least part of a head of a peristaltic pump.
摘要翻译：本发明涉及一种用于收集生物流体的袋系统，该系统旨在用于包括蠕动泵的收集机器中，该系统在闭路中包括流体收集装置，含有抗凝血剂和/或保存溶液的溶液袋，以及用于接收用加入的抗凝血剂和/或保存溶液收集的流体的收集袋。收集袋通过设置有连接器的第一管和通过连接到连接器的第二管与溶液袋与收集装置流体连通。提供了用于关联第一和第二管的装置，以在连接器和关联装置之间允许形成具有第二管的环，环的构型布置成使其能够围绕至少部分蠕动泵头。

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