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1. 发明申请

US20130023723A1 SYSTEMS AND METHODS FOR TREATMENT OF FECAL INCONTINENCE 审中-公开
标题翻译：用于治疗鼻窦炎的系统和方法
公开(公告)号：US20130023723A1
公开(公告)日：2013-01-24
申请号：US13475628
申请日：2012-05-18
申请人： Ravinder Mittal , Matthew T. Yurek , Bryan Knodel
发明人： Ravinder Mittal , Matthew T. Yurek , Bryan Knodel
IPC分类号： A61F2/02
CPC分类号： A61F2/0036 , A61B17/0401 , A61B17/0686 , A61B17/072 , A61B2017/00805 , A61B2017/0409 , A61B2017/0414 , A61B2017/0417 , A61B2017/0464 , A61B2017/306
摘要： Disclosed herein are systems and methods of performing a sphincter repair in a patient. The methods can include inserting a stabilization and an anchor deployment tool into the patient, positioning the stabilization tool to access a muscle associated with a sphincter, stabilizing tissue with the stabilization tool, the tissue including or in communication with the muscles associated with the sphincter, advancing the anchor deployment tool into the tissue cavity, advancing the plurality of tissue anchors out of the anchor deployment tool and transmurally through the tissue; tensioning the anchors to shorten the muscle associated with the sphincter, and withdrawing the stabilization tool from the patient.
摘要翻译：这里公开了在患者体内执行括约肌修复的系统和方法。所述方法可以包括将稳定和锚定展开工具插入到患者体内，定位稳定工具以接近与括约肌相关的肌肉，用稳定工具稳定组织，所述组织包括或与与括约肌相关联的肌肉连通，将锚定展开工具推进到组织空腔中，将多个组织锚固件推出锚定展开工具并透射穿过组织; 张紧锚点以缩短与括约肌相关联的肌肉，并从患者身上取出稳定工具。

2. 发明授权

US07374532B2 High vapor pressure attenuation device 有权
标题翻译：高蒸气压衰减装置
公开(公告)号：US07374532B2
公开(公告)日：2008-05-20
申请号：US11314601
申请日：2005-12-20
申请人： Kevin G. Connors , William L. Pintauro , Sheila K. Wallin , John T. Kilcoyne , Hung H. Cao , Khoi M. Nguyen , Matthew T. Yurek
发明人： Kevin G. Connors , William L. Pintauro , Sheila K. Wallin , John T. Kilcoyne , Hung H. Cao , Khoi M. Nguyen , Matthew T. Yurek
IPC分类号： A61F2/00
CPC分类号： A61F2/02 , A61F2/042 , A61F9/00781 , A61F2250/0067
摘要： Disclosed herein is an attenuation device, comprising a flexible housing and a high vapor pressure media having a vapor pressure approximately equal to the intravesical pressure of the bladder and a permeability of less than 1 ml/day at body temperature through the outer wall of the flexible housing. In one embodiment, the high vapor pressure media comprises perfluorooctylbromide. In another embodiment, the high vapor pressure media comprises perfluorohexane. In yet another embodiment, the high vapor pressure media comprises perfluorodecalin. Also disclosed herein is a method of treating a patient, comprising providing a compressible attenuation device and introducing within the attenuation device at least one high vapor pressure media.
摘要翻译：本文公开了一种衰减装置，其包括柔性壳体和高蒸汽压介质，其具有大约等于膀胱的膀胱内压的蒸气压，并且在体温下通过柔性外壁的渗透率小于1ml /天住房。在一个实施方案中，高蒸气压介质包含全氟辛基溴。在另一个实施方案中，高蒸气压介质包括全氟己烷。在另一个实施方案中，高蒸气压介质包括全氟萘烷。本文还公开了一种治疗患者的方法，包括提供可压缩衰减装置并在所述衰减装置内引入至少一个高蒸气压介质。

3. 发明授权

US5690644A Apparatus for deploying body implantable stent 失效
标题翻译：用于部署植入式支架的装置
公开(公告)号：US5690644A
公开(公告)日：1997-11-25
申请号：US603683
申请日：1996-02-20
申请人： Matthew T. Yurek , Steven J. Healy
发明人： Matthew T. Yurek , Steven J. Healy
IPC分类号： A61F2/82 , A61F2/06 , A61F2/84 , A61M25/12 , A61F11/00 , A61M29/00
CPC分类号： A61F2/958 , A61F2/95 , A61F2/966 , A61F2002/9528 , A61F2002/9583 , A61F2002/9665
摘要： A stent deployment device includes a flexible, elongate interior catheter and a retaining structure cooperating with the catheter to support a stent along a distal end support region of the catheter. The stent is supported in a reduced radius delivery state to facilitate delivery to a treatment site in a body lumen, by advancing the device over a previously positioned guidewire. An opening at the distal end of the device receives the guidewire into a guidewire lumen of the interior catheter. A second opening through the catheter wall just proximally of the support region allows passage of the guidewire to the exterior of the catheter, whereby the guidewire is contained within the device only along the distal end region. A retainer for the stent can include an exterior catheter surrounding the interior catheter and stent, and moveable axially relative to the interior catheter. A portion of the guidewire proximally of the second opening is contained between the catheters, and can be removed from the exterior catheter through a slit running axially along the exterior catheter. Alternatively, the stent retainer can include a pair of spaced apart sleeves integral with the interior catheter and frictionally retaining opposite ends of the stent, to maintain the stent in the delivery state. In this case the catheter further supports a dilatation balloon surrounded by the stent. The balloon is expanded to free the stent from the sleeves.
摘要翻译：支架展开装置包括柔性细长的内部导管和与导管配合的保持结构，以沿着导管的远端支撑区域支撑支架。通过将装置推进在先前定位的导丝上，支架以减小的半径递送状态被支撑以便于输送到体腔内的治疗部位。设备远端处的开口将导丝接纳到内导管的导丝管腔中。通过靠近支撑区域的导管壁的第二开口允许导丝通过导管的外部，由此导丝仅沿着远端区域容纳在装置内。用于支架的保持器可以包括围绕内部导管和支架的外部导管，并且可相对于内部导管轴向移动。在第二开口的近侧的导丝的一部分被容纳在导管之间，并且可以通过沿着外部导管轴向运动的狭缝从外部导管移除。或者，支架保持器可以包括与内部导管成一体并且摩擦地保持支架的相对端的一对间隔开的套筒，以将支架保持在输送状态。在这种情况下，导管还支撑由支架包围的扩张气囊。将气囊膨胀以从袖子释放支架。

4. 发明授权

US07691051B2 Attenuation device for treating glaucoma 失效
标题翻译：用于治疗青光眼的衰减装置
公开(公告)号：US07691051B2
公开(公告)日：2010-04-06
申请号：US11676248
申请日：2007-02-16
申请人： Kevin G. Connors , William L. Pintauro , Sheila K. Wallin , John T. Kilcoyne , Hung H. Cao , Khoi M. Nguyen , Matthew T. Yurek
发明人： Kevin G. Connors , William L. Pintauro , Sheila K. Wallin , John T. Kilcoyne , Hung H. Cao , Khoi M. Nguyen , Matthew T. Yurek
IPC分类号： A61F2/00
CPC分类号： A61F2/02 , A61F2/042 , A61F9/00781 , A61F2250/0067
摘要： Disclosed herein is an attenuation device, comprising a flexible housing and a high vapor pressure media having a permeability of less than 1 ml/day at body temperature through the outer wall of the flexible housing. In one embodiment, the high vapor pressure media comprises perfluorooctylbromide. In another embodiment, the high vapor pressure media comprises perfluorohexane. In yet another embodiment, the high vapor pressure media comprises perfluorodecalin. Also disclosed herein is a method of treating a patient, comprising providing a compressible attenuation device and introducing within the attenuation device at least one high vapor pressure media.
摘要翻译：本文公开了一种衰减装置，其包括柔性壳体和高温蒸气压介质，其通过柔性壳体的外壁在体温下具有小于1ml /天的渗透性。在一个实施方案中，高蒸气压介质包含全氟辛基溴。在另一个实施方案中，高蒸气压介质包括全氟己烷。在另一个实施方案中，高蒸气压介质包括全氟萘烷。本文还公开了一种治疗患者的方法，包括提供可压缩衰减装置并在所述衰减装置内引入至少一个高蒸气压介质。

5. 发明授权

US06755855B2 Apparatus for deploying body implantable stents 失效
标题翻译：用于部署身体可植入支架的装置
公开(公告)号：US06755855B2
公开(公告)日：2004-06-29
申请号：US10100944
申请日：2002-03-19
申请人： Matthew T. Yurek , Steven J. Healy
发明人： Matthew T. Yurek , Steven J. Healy
IPC分类号： A61F206
CPC分类号： A61F2/958 , A61F2/95 , A61F2/966 , A61F2002/9528 , A61F2002/9583 , A61F2002/9665
摘要： A stent deployment device includes a flexible, elongate interior catheter and a retaining structure cooperating with the catheter to support a stent along a distal end support region of the catheter. The stent is supported in a reduced radius delivery state to facilitate delivery to a treatment site in a body lumen, by advancing the device over a previously positioned guidewire. An opening at the distal end of the device receives the guidewire into a guidewire lumen of the interior catheter. A second opening through the catheter wall just proximally of the support region allows passage of the guidewire to the exterior of the catheter, whereby the guidewire is contained within the device only along the distal end region. The retaining structure can include an exterior catheter surrounding the interior catheter and stent, and moveable axially relative to the interior catheter. A portion of the guidewire proximally of the second opening is contained between the catheters, and can be removed from the exterior catheter through a slit running axially along the exterior catheter. Alternatively, the retaining means can include a pair of spaced apart sleeves integral with the interior catheter and frictionally retaining opposite ends of the stent, to maintain the stent in the delivery state. In this case the catheter further supports a dilatation balloon surrounded by the stent. The balloon is expanded to free the stent from the sleeves.
摘要翻译：支架展开装置包括柔性细长的内部导管和与导管配合的保持结构，以沿着导管的远端支撑区域支撑支架。通过将装置推进在先前定位的导丝上，支架以减小的半径递送状态被支撑以便于输送到体腔内的治疗部位。设备远端处的开口将导丝接纳到内导管的导丝管腔中。通过靠近支撑区域的导管壁的第二开口允许导丝通过导管的外部，由此导丝仅沿着远端区域容纳在装置内。保持结构可以包括围绕内部导管和支架的外部导管，并且可相对于内部导管轴向移动。在第二开口的近侧的导丝的一部分被容纳在导管之间，并且可以通过沿着外部导管轴向运动的狭缝从外部导管移除。或者，保持装置可以包括与内部导管成一体的一对间隔开的套筒，并摩擦地保持支架的相对端部，以将支架保持在输送状态。在这种情况下，导管还支撑由支架包围的扩张气囊。将气囊膨胀以从袖子释放支架。

6. 发明授权

US5662703A Rolling membrane stent delivery device 失效
标题翻译：滚膜支架输送装置
公开(公告)号：US5662703A
公开(公告)日：1997-09-02
申请号：US716052
申请日：1996-09-19
申请人： Matthew T. Yurek , Richard S. Kusleika
发明人： Matthew T. Yurek , Richard S. Kusleika
IPC分类号： A61F2/82 , A61F2/00 , A61F2/06 , A61F2/84
CPC分类号： A61F2/966 , A61F2/95 , A61F2210/0019
摘要： A device for deploying radially self-expanded stents and other radially expandable stents includes an inner catheter, an outer catheter surrounding the inner catheter, and a tubular stent retaining sheath formed of a rolling membrane. The sheath is doubled over upon itself to provide an inner sheath layer attached to the inner catheter, and an outer sheath layer attached to the outer catheter. The sheath layers extend along and surround a radially self-expanding stent, to maintain the stent distally of the inner catheter and in a radially compressed, axially elongated state. Distally of the stent, the inner and outer sheath layers converge and are narrowed in the distal direction to define a tapered distal tip. To release the stent, the outer catheter is moved proximally to roll the membrane away from its surrounding relation to the stent, whereupon the stent radially self-expands progressively, beginning at its distal end. When completely retracted after stent release, the sheath surrounds a distal region of the inner catheter, and can provide a protective layer between arterial tissue and a dilatation balloon supported along the distal region. As an alternative, a stent formed of a recovery metal can be plastically deformed into a reduced radius state for delivery, which facilitates use of a more flexible stent retaining sheath. A further alternative involves securing the sheath proximally of the dilatation balloon, so that sheath retraction leaves the dilatation balloon exposed, rather than covered by the sheath.
摘要翻译：用于展开径向自扩张支架和其他可径向扩张的支架的装置包括内导管，围绕内导管的外导管和由滚动膜形成的管状支架护套。护套自身加倍，以提供附接到内导管的内护套层和附接到外导管的外护套层。护套层沿径向自扩张支架延伸并围绕径向自扩张支架，以将支架保持在远离内导管并且处于径向压缩的轴向细长状态。在支架的远侧，内鞘层和外护套层在远端方向收敛并变窄以限定锥形远端尖端。为了释放支架，外导管向近侧移动以使膜远离其与支架的周围关系滚动，于是支架从其远端开始逐渐自动扩张。当支架释放后完全缩回时，护套围绕内导管的远端区域，并且可以在动脉组织与沿着远侧区域支撑的扩张球囊之间提供保护层。作为替代方案，由回收金属形成的支架可以塑性变形到用于输送的减小的半径状态，这有助于使用更灵活的支架保持护套。另外的替代方案是将护套固定在扩张球囊的近侧，使得护套缩回使膨胀气球暴露而不是被护套覆盖。

7. 发明授权

US5201757A Medial region deployment of radially self-expanding stents 失效
标题翻译：径向自扩张支架的内侧部位
公开(公告)号：US5201757A
公开(公告)日：1993-04-13
申请号：US863231
申请日：1992-04-03
申请人： Lawrence R. Heyn , Liann M. Johnson , Matthew T. Yurek , Peter A. Basile , Robert L. Berger
发明人： Lawrence R. Heyn , Liann M. Johnson , Matthew T. Yurek , Peter A. Basile , Robert L. Berger
IPC分类号： A61F2/84 , A61F2/06 , A61F2/82
CPC分类号： A61F2/95 , A61F2/97 , A61F2002/9511 , A61F2002/9517
摘要： An apparatus for deploying a radially self-expanding stent includes proximal and distal sleeves respectively containing proximal and distal end portions of the stent in a reduced radius delivery configuration. The sleeves can abut one another and thus contain the entire length of the stent, or may be used in combination with an outer catheter surrounding the sleeves and containing the medial region of the stent. In either event, once the stent and sleeves are positioned at the intended fixation site, the sleeves are moved axially with respect to one another to permit radial self-expansion of the stent only over its medial region, while the sleeves continue to contain the axially outward regions of the stent. Eventually, upon sufficient movement of the sleeves axially relative to one another, the stent becomes totally free of the sleeves, resulting in radial expansion over the entire stent length. The axial relative movement of the sleeves can be controlled by two or more catheters mounted movably with respect to one another, one catheter integral with each of the sleeves. Alternative arrangements for separating the sleeves include an externally threaded inner catheter, and a dilatation balloon or membrane expandable to force the sleeves apart from one another.
摘要翻译：用于部署径向自扩张支架的装置包括分别容纳缩小的半径递送构造的支架的近端部分和远端部分的近端和远端套管。袖子可以彼此邻接并因此包含支架的整个长度，或者可以与围绕套管的外导管并且包含支架的内侧区域组合使用。在任一情况下，一旦支架和套管定位在预期的固定位置，套筒就相对于彼此轴向移动，以允许支架径向自膨胀仅在其内侧区域上，而套筒继续容纳轴向支架外侧区域。最终，当套筒相对于彼此轴向地充分移动时，支架完全没有套筒，导致整个支架长度上的径向膨胀。袖子的轴向相对运动可以通过相对于彼此可移动地安装的两个或更多个导管来控制，一个导管与每个套筒成一体。用于分离套筒的替代布置包括外螺纹内导管和可膨胀以使套管彼此分开的膨胀球囊或膜。

8. 发明授权

US07185657B1 Method and device for treating gastroesophageal reflux disease 有权
标题翻译：治疗胃食管反流病的方法和装置
公开(公告)号：US07185657B1
公开(公告)日：2007-03-06
申请号：US09702002
申请日：2000-10-30
申请人： George M. Johnson , John T. Kilcoyne , Ross Tsukashima , Matthew T. Yurek , Scott Harris , Philip J. Simpson
发明人： George M. Johnson , John T. Kilcoyne , Ross Tsukashima , Matthew T. Yurek , Scott Harris , Philip J. Simpson
IPC分类号： A61B19/00
CPC分类号： A61B17/3478 , A61B17/3468 , A61B2017/00269 , A61B2017/00827
摘要： Disclosed is a delivery device for controllably delivering a prosthetic bulking device below a tissue surface such as below the mucosa to treat gastroesophageal reflux disease. The delivery device may be embodied in a deployment catheter, an endoscope, or an endoscope attachment. The bulking device may additionally be explanted from beneath the mucosa. In one embodiment, the bulking device comprises a hydrogel.
摘要翻译：公开了一种输送装置，用于在诸如粘膜下方的组织表面下方可控地输送假体膨胀装置以治疗胃食管反流疾病。输送装置可以体现在展开导管，内窥镜或内窥镜附件中。另外可以从粘膜下方移出膨胀装置。在一个实施方案中，膨胀装置包括水凝胶。

9. 发明授权

US07074178B2 Treatment of patients with a compressible attenuation device 有权
公开(公告)号：US07074178B2
公开(公告)日：2006-07-11
申请号：US10391447
申请日：2003-03-17
申请人： Kevin G. Connors , William L. Pintauro , Sheila K. Wallin , John T. Kilcoyne , Hung H. Cao , Khoi M. Nguyen , Matthew T. Yurek
发明人： Kevin G. Connors , William L. Pintauro , Sheila K. Wallin , John T. Kilcoyne , Hung H. Cao , Khoi M. Nguyen , Matthew T. Yurek
IPC分类号： A61F2/00
CPC分类号： A61F2/0027 , A61B1/307 , A61B5/205 , A61B5/6852 , A61B5/72 , A61B17/3468 , A61F2/004 , A61F2/042 , A61F2/06 , A61F2002/068 , A61M25/10 , A61M25/1002 , A61M2025/0076 , A61M2210/1078 , A61M2210/1085
摘要： Disclosed herein are methods of treating a patient, comprising providing a compressible attenuation device that is moveable from a first, introduction configuration to a second, implanted configuration. The attenuation device is introduced into a treatment site. In one embodiment, the treatment site is the bladder. In another embodiment, the treatment site is the abdominal cavity. The volume of the attenuation devices changes in response to pressure changes in the treatment site and attenuates pressure changes in the bladder.

10. 发明授权

US06988983B2 Implantable self-inflating attenuation device 有权
公开(公告)号：US06988983B2
公开(公告)日：2006-01-24
申请号：US10391450
申请日：2003-03-17
申请人： Kevin G. Connors , William L. Pintauro , Sheila K. Wallin , John T. Kilcoyne , Hung H. Cao , Khoi M. Nguyen , Matthew T. Yurek
发明人： Kevin G. Connors , William L. Pintauro , Sheila K. Wallin , John T. Kilcoyne , Hung H. Cao , Khoi M. Nguyen , Matthew T. Yurek
IPC分类号： A61F2/00
CPC分类号： A61F2/0027 , A61B5/205 , A61F2/042 , A61F2/06 , A61F2002/068 , A61M25/10 , A61M25/1002 , A61M2025/0076 , A61M2210/1078 , A61M2210/1085
摘要： Disclosed herein is an attenuation device comprising a flexible housing and a medium capable of transformation to inflate the housing from the first configuration to the second configuration. Also disclose herein are methods of treating a patient, comprising: providing a self-inflating expandable attenuation device, containing a medium which is transformable from a first, reduced volume to a second, expanded volume; positioning the attenuation device within the patient at a treatment site; and transforming the medium from the first volume to the second volume. In one embodiment, a self-inflating expandable attenuation device is used to treat urinary tract dysfunction. In another embodiment, a self-inflating expandable attenuation device is used to treat benign hypertrophy of the prostate.

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