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1. 发明申请

US20120054879A1 HCV Coreceptor and Methods of Use Thereof 失效
标题翻译： HCV受体及其使用方法
公开(公告)号：US20120054879A1
公开(公告)日：2012-03-01
申请号：US13215820
申请日：2011-08-23
申请人： Charles Rice , Matthew J. Evans , Thomas Von Hahn
发明人： Charles Rice , Matthew J. Evans , Thomas Von Hahn
IPC分类号： A01K67/027 , C07K2/00 , A61P31/14 , A61K31/7088 , A61K38/17 , A61K39/395 , C07H21/00 , C07K14/47
CPC分类号： C07K16/28 , C07K16/2896 , C07K2317/76
摘要： The invention relates to the discovery that the Claudin-1 protein functions as a co-receptor for entry of HCV into cells. Methods of inhibiting, preventing or mitigating HCV infections by inhibiting HCV interactions with Claudin-1 are provided. Methods of identifying agents or compounds that interfere with HCV interactions with Claudin-1 are also provided. Finally, useful kits, cell culture compositions, agents, and compounds related to the inhibition of HCV interactions with Claudin-1 are also disclosed.
摘要翻译：本发明涉及发现紧密连接蛋白-1蛋白质作为HCV进入细胞的共同受体。提供了通过抑制与Claudin-1的HCV相互作用来抑制，预防或减轻HCV感染的方法。还提供了鉴定干扰HCV与Claudin-1相互作用的试剂或化合物的方法。最后，还公开了与抑制与Claudin-1的HCV相互作用相关的有用的试剂盒，细胞培养组合物，试剂和化合物。

2. 发明申请

US20100062419A1 Infectious, Chimeric Hepatitis C Virus, Methods of Producing the Same and Methods of Use Thereof 审中-公开
标题翻译：传染性，嵌合丙型肝炎病毒，其生产方法及其使用方法
公开(公告)号：US20100062419A1
公开(公告)日：2010-03-11
申请号：US12581597
申请日：2009-10-19
申请人： Charles Rice , Matthew J. Evans , Brett D. Lindenbach , Christopher Jones
发明人： Charles Rice , Matthew J. Evans , Brett D. Lindenbach , Christopher Jones
IPC分类号： C12Q1/70 , C12N7/00 , C07H21/04
CPC分类号： C12N7/00 , A61K2039/525 , C07K2319/61 , C12N15/86 , C12N2770/24243 , C12N2770/24251 , C12N2840/203 , C12Q1/18 , G01N33/5767 , G01N2333/18 , G01N2500/00
摘要： The present invention provides infectious recombinant Hepatitis C Viruses (HCV), and vectors, cells and animals comprising the same. The present invention provides methods of producing infectious recombinant HCV, and their use in identifying anti-HCV therapeutic agents, as well as sequences of HCV associated with HCV pathogenesis.
摘要翻译：本发明提供感染性重组丙型肝炎病毒（HCV），以及包含其的载体，细胞和动物。本发明提供生产感染性重组HCV的方法及其在鉴定抗HCV治疗剂中的用途以及与HCV发病机制相关的HCV序列。

3. 发明申请

US20090098123A1 HCV CORECEPTOR AND METHODS OF USE THEREOF 有权
标题翻译： HCV CORECEPTOR及其使用方法
公开(公告)号：US20090098123A1
公开(公告)日：2009-04-16
申请号：US12299439
申请日：2007-05-04
申请人： Charles Rice , Matthew J. Evans , Thomas Von Hahn
发明人： Charles Rice , Matthew J. Evans , Thomas Von Hahn
IPC分类号： A61K39/395 , A61K39/42 , A61K38/16 , C12Q1/70 , C07K2/00 , C12N7/00 , C07K14/00 , C07K16/18 , C40B30/04 , A61K38/02
CPC分类号： C07K16/28 , C07K16/2896 , C07K2317/76
摘要： The invention relates to the discovery that the Claudin-1 protein functions as a co-receptor for entry of HCV into cells. Methods of inhibiting, preventing or mitigating HCV infections by inhibiting HCV interactions with Claudin-1 are provided. Methods of identifying agents or compounds that interfere with HCV interactions with Claudin-1 are also provided. Finally, useful kits, cell culture compositions, agents, and compounds related to the inhibition of HCV interactions with Claudin-1 are also disclosed.
摘要翻译：本发明涉及发现紧密连接蛋白-1蛋白质作为HCV进入细胞的共同受体。提供了通过抑制与Claudin-1的HCV相互作用来抑制，预防或减轻HCV感染的方法。还提供了鉴定干扰HCV与Claudin-1相互作用的试剂或化合物的方法。最后，还公开了与抑制与Claudin-1的HCV相互作用相关的有用的试剂盒，细胞培养组合物，试剂和化合物。

4. 发明授权

US5715868A Spout with hub 失效
标题翻译：喷口与轮毂
公开(公告)号：US5715868A
公开(公告)日：1998-02-10
申请号：US807849
申请日：1997-02-26
申请人： Fred Y. F. Ching , Matthew J. Evans , Christopher G. Gurr
发明人： Fred Y. F. Ching , Matthew J. Evans , Christopher G. Gurr
IPC分类号： E03C1/04 , E03C1/02
CPC分类号： E03C1/0404 , E03C2001/0416 , Y10T137/8807 , Y10T137/9464
摘要： A single-piece tube 20 is formed to include a hub 30 at first end 26 of the tube with a spout 44 extending from the hub to a second 28 of the tube. A tapered transition surface 38 extends between the hub 30 and the spout 44. A bevel 34 is formed at the base of the hub 30 on an outer surface 22 thereof adjacent the end 26 of the tube 20. An annular bead 36 is formed on the outer surface 22 of the hub 30 at a location spaced from the bevel 34 to define a space 46 between the bevel and the bead. A pair of bends 40 and 42 are formed in spaced portions of the spout 44. In another embodiment, an annular groove 50 is formed in the outer surface 22 of the hub 30 instead of the bevel 34 and the bead 36. An O-ring 48 can be located in the space 46 or the groove 50. The single-piece tube 20 formed with the hub 30 and the spout 44 can be assembled with a water mixing facility 56.
摘要翻译：单件管20形成为在管的第一端26处包括轮毂30，其具有从轮毂延伸到管的第二个28的喷口44。锥形过渡表面38在轮毂30和喷口44之间延伸。斜面34形成在轮毂30的基部上，其外表面22邻近管子20的端部26.环形胎圈36形成在轮毂30的外表面22在与斜面34隔开的位置处以在斜面和珠之间限定空间46。一对弯曲部40和42形成在喷口44的间隔部分中。在另一个实施例中，环形凹槽50形成在轮毂30的外表面22中，而不是斜面34和凸缘36. O形圈 48可以位于空间46或槽50中。形成有轮毂30和喷口44的单件管20可以与水混合设备56组装。

5. 发明授权

US08703149B2 HCV coreceptor and methods of use thereof 失效
标题翻译： HCV共受体及其使用方法
公开(公告)号：US08703149B2
公开(公告)日：2014-04-22
申请号：US13215820
申请日：2011-08-23
申请人： Charles Rice , Matthew J. Evans , Thomas Von Hahn
发明人： Charles Rice , Matthew J. Evans , Thomas Von Hahn
IPC分类号： A61K39/29 , A61K39/395 , C07K16/00
CPC分类号： C07K16/28 , C07K16/2896 , C07K2317/76
摘要： The invention relates to the discovery that the Claudin-1 protein functions as a co-receptor for entry of HCV into cells. Methods of inhibiting, preventing or mitigating HCV infections by inhibiting HCV interactions with Claudin-1 are provided. Methods of identifying agents or compounds that interfere with HCV interactions with Claudin-1 are also provided. Finally, useful kits, cell culture compositions, agents, and compounds related to the inhibition of HCV interactions with Claudin-1 are also disclosed.
摘要翻译：本发明涉及发现紧密连接蛋白-1蛋白质作为HCV进入细胞的共同受体。提供了通过抑制与Claudin-1的HCV相互作用来抑制，预防或减轻HCV感染的方法。还提供了鉴定干扰HCV与Claudin-1相互作用的试剂或化合物的方法。最后，还公开了与抑制与Claudin-1的HCV相互作用相关的有用的试剂盒，细胞培养组合物，试剂和化合物。

6. 发明授权

US08021835B2 HCV coreceptor and methods of use thereof 有权
标题翻译： HCV共受体及其使用方法
公开(公告)号：US08021835B2
公开(公告)日：2011-09-20
申请号：US12299439
申请日：2007-05-04
申请人： Charles Rice , Matthew J. Evans , Thomas Von Hahn
发明人： Charles Rice , Matthew J. Evans , Thomas Von Hahn
IPC分类号： C12Q1/70 , A61K39/29
CPC分类号： C07K16/28 , C07K16/2896 , C07K2317/76
摘要： The invention relates to the discovery that the Claudin-1 protein functions as a co-receptor for entry of HCV into cells. Methods of inhibiting, preventing or mitigating HCV infections by inhibiting HCV interactions with Claudin-1 are provided. Methods of identifying agents or compounds that interfere with HCV interactions with Claudin-1 are also provided. Finally, useful kits, cell culture compositions, agents, and compounds related to the inhibition of HCV interactions with Claudin-1 are also disclosed.
摘要翻译：本发明涉及发现紧密连接蛋白-1蛋白质作为HCV进入细胞的共同受体。提供了通过抑制与Claudin-1的HCV相互作用来抑制，预防或减轻HCV感染的方法。还提供了鉴定干扰HCV与Claudin-1相互作用的试剂或化合物的方法。最后，还公开了与抑制与Claudin-1的HCV相互作用相关的有用的试剂盒，细胞培养组合物，试剂和化合物。

7. 发明授权

US07674612B2 Infectious, chimeric hepatitis C virus, methods of producing the same and methods of use thereof 有权
标题翻译：传染性，嵌合型丙型肝炎病毒，其制备方法及其使用方法
公开(公告)号：US07674612B2
公开(公告)日：2010-03-09
申请号：US11366839
申请日：2006-03-03
申请人： Charles Rice , Brett D Lindenbach , Matthew J Evans , Christopher Jones
发明人： Charles Rice , Brett D Lindenbach , Matthew J Evans , Christopher Jones
IPC分类号： C12N15/09 , C12N15/51 , C12N7/00 , C12N7/01 , C12N7/04 , C07H21/00 , C12N15/00
CPC分类号： C12N7/00 , A61K2039/525 , C07K2319/61 , C12N15/86 , C12N2770/24243 , C12N2770/24251 , C12N2840/203 , C12Q1/18 , G01N33/5767 , G01N2333/18 , G01N2500/00
摘要： The present invention provides infectious recombinant Hepatitis C Viruses (HCV), and vectors, cells and animals comprising the same. The present invention provides methods of producing infectious recombinant HCV, and their use in identifying anti-HCV therapeutic agents, as well as sequences of HCV associated with HCV pathogenesis.
摘要翻译：本发明提供感染性重组丙型肝炎病毒（HCV），以及包含其的载体，细胞和动物。本发明提供生产感染性重组HCV的方法及其在鉴定抗HCV治疗剂中的用途以及与HCV发病机制相关的HCV序列。

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