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1. 发明申请

US20150005177A1 METHODS OF IDENTIFYING, ISOLATING AND USING ODORANT AND AROMA RECEPTORS 有权
标题翻译：鉴定，分离和使用气味和AROMA受体的方法
公开(公告)号：US20150005177A1
公开(公告)日：2015-01-01
申请号：US14318641
申请日：2014-06-28
申请人： Patrick PFISTER , Matthew E. ROGERS , Khalid Jerod PARRIS
发明人： Patrick PFISTER , Matthew E. ROGERS , Khalid Jerod PARRIS
IPC分类号： G01N33/50 , C07K14/705
CPC分类号： C07K14/705 , C12Q1/6809 , C12Q2600/136 , G01N33/5058 , G01N2333/705 , G01N2500/04 , G01N2570/00
摘要： Provided here are new methods to identify specific families of mammalian odorant receptors for odorants or aroma, particularly indole and skatole malodors and their use in assays that may be used to discover compounds that modulate (blocking, enhancing, masking or mimicking compounds) their activity. Orphan mouse odorant receptors are identified from olfactory sensory neurons that respond to target compounds. The resulting receptors as well as their human counterparts can be screened in assays against test compounds to confirm their identity as odorant or aroma receptors, particularly malodor receptors and subsequently discover for example modulators that inhibit the perception of the malodor in humans.
摘要翻译：这里提供了一些新方法，用于鉴定特殊家族的气味剂或香气，特别是吲哚和臭味恶臭的哺乳动物气味受体，以及它们可用于发现调节（阻断，增强，掩蔽或模拟化合物）活性的化合物的测定中的用途。从响应靶化合物的嗅觉神经元中鉴定出孤立的老鼠气味受体。可以在测试化合物的测定中筛选所得受体以及它们的人类对应物，以确认其作为气味或芳香受体，特别是恶臭受体的特征，并随后发现抑制人类恶臭感的调节剂。

2. 发明申请

US20140054118A1 Apparatus for Setting Park Brakes of a Heavy Vehicle During a Failure of a Service Brakes Holding Function of the Vehicle 有权
标题翻译：重型车辆驻车制动器在作业失效时制动车辆保持功能的装置
公开(公告)号：US20140054118A1
公开(公告)日：2014-02-27
申请号：US13594170
申请日：2012-08-24
申请人： Matthew E. Rogers , Travis G. Ramler , Timothy J. Frashure , David W. Howell
发明人： Matthew E. Rogers , Travis G. Ramler , Timothy J. Frashure , David W. Howell
IPC分类号： B60T13/58 , B60T8/17 , B60T7/12
CPC分类号： B60T13/588 , B60T8/885 , B60T13/662 , B60T13/683 , B60T2270/402
摘要： An apparatus is provided for a vehicle having components of a parking brake system and components of a service brake system. The apparatus comprises a normally-energized solenoid operatively coupled to components of the parking brake system and for, when de-energized, exhausting air pressure in at least some components of the parking brake system to set park brakes. The apparatus further comprises an electronic controller arranged to (i) monitor a combination of one or more signals indicative of a service brakes holding function, (ii) monitor a combination of one or more signals indicative of a fault condition, and (iii) provide one or more signals to de-energize the normally-energized solenoid to exhaust air pressure in at least some components of the parking brake system and thereby to set park brakes when both signals indicative of a service brakes holding function and signals indicative of a fault condition of the vehicle are detected.
摘要翻译：提供了一种用于具有驻车制动系统和行车制动系统的部件的部件的车辆的装置。该装置包括可操作地联接到驻车制动系统的部件的正常通电螺线管，并且当在停车时，在驻车制动系统的至少一些部件中排出空气压力以设定驻车制动器。该装置还包括电子控制器，其被布置为（i）监视指示维修制动器保持功能的一个或多个信号的组合，（ii）监视指示故障状况的一个或多个信号的组合，以及（iii）提供一个或多个信号，以使通常的通电螺线管断电，以排放驻车制动系统的至少一些部件中的空气压力，从而当指示行车制动器保持功能的两个信号和指示故障状态的信号时，设定驻车制动器的车辆。

3. 发明授权

US09914760B2 Methods of identifying, isolating and using odorant and aroma receptors 有权
公开(公告)号：US09914760B2
公开(公告)日：2018-03-13
申请号：US14318641
申请日：2014-06-28
申请人： Patrick Pfister , Matthew E. Rogers , Khalid Jerod Parris
发明人： Patrick Pfister , Matthew E. Rogers , Khalid Jerod Parris
IPC分类号： C12Q1/68 , C07K14/705 , G01N33/50
CPC分类号： C07K14/705 , C12Q1/6809 , C12Q2600/136 , G01N33/5058 , G01N2333/705 , G01N2500/04 , G01N2570/00
摘要： Provided here are new methods to identify specific families of mammalian odorant receptors for odorants or aroma, particularly indole and skatole malodors and their use in assays that may be used to discover compounds that modulate (blocking, enhancing, masking or mimicking compounds) their activity. Orphan mouse odorant receptors are identified from olfactory sensory neurons that respond to target compounds. The resulting receptors as well as their human counterparts can be screened in assays against test compounds to confirm their identity as odorant or aroma receptors, particularly malodor receptors and subsequently discover for example modulators that inhibit the perception of the malodor in humans.

4. 发明授权

US08820856B2 Apparatus for setting park brakes of a heavy vehicle during a failure of a service brakes holding function of the vehicle 有权
标题翻译：用于在车辆的行车制动保持功能失效期间设置重型车辆的驻车制动器的装置
公开(公告)号：US08820856B2
公开(公告)日：2014-09-02
申请号：US13594170
申请日：2012-08-24
申请人： Matthew E. Rogers , Travis G. Ramler , Timothy J. Frashure , David W. Howell
发明人： Matthew E. Rogers , Travis G. Ramler , Timothy J. Frashure , David W. Howell
IPC分类号： B60T13/66
CPC分类号： B60T13/588 , B60T8/885 , B60T13/662 , B60T13/683 , B60T2270/402
摘要： An apparatus is provided for a vehicle having components of a parking brake system and components of a service brake system. The apparatus comprises a normally-energized solenoid operatively coupled to components of the parking brake system and for, when de-energized, exhausting air pressure in at least some components of the parking brake system to set park brakes. The apparatus further comprises an electronic controller arranged to (i) monitor a combination of one or more signals indicative of a service brakes holding function, (ii) monitor a combination of one or more signals indicative of a fault condition, and (iii) provide one or more signals to de-energize the normally-energized solenoid to exhaust air pressure in at least some components of the parking brake system and thereby to set park brakes when both signals indicative of a service brakes holding function and signals indicative of a fault condition of the vehicle are detected.
摘要翻译：提供了一种用于具有驻车制动系统和行车制动系统的部件的部件的车辆的装置。该装置包括可操作地联接到驻车制动系统的部件的正常通电螺线管，并且当在停车时，在驻车制动系统的至少一些部件中排出空气压力以设定驻车制动器。该装置还包括电子控制器，其被布置为（i）监视指示维修制动器保持功能的一个或多个信号的组合，（ii）监视指示故障状况的一个或多个信号的组合，以及（iii）提供一个或多个信号，以使通常的通电螺线管断电，以排放驻车制动系统的至少一些部件中的空气压力，从而当指示行车制动器保持功能的两个信号和指示故障状态的信号时，设定驻车制动器的车辆。

5. 发明申请

US20120296543A1 AUTOMATIC WORK BRAKE 审中-公开
标题翻译：自动工作制动
公开(公告)号：US20120296543A1
公开(公告)日：2012-11-22
申请号：US13567561
申请日：2012-08-06
申请人： Matthew E. Rogers , Mark A. Bennett , Ron R. Stahl , Michael D. Tober , Kenneth A. Grolle , Richard J. Conklin , Timothy J. Frashure , David W. Howell
发明人： Matthew E. Rogers , Mark A. Bennett , Ron R. Stahl , Michael D. Tober , Kenneth A. Grolle , Richard J. Conklin , Timothy J. Frashure , David W. Howell
IPC分类号： B60T7/12
CPC分类号： B60T13/662 , Y10T137/87096
摘要： A vehicle, air brake system is presented with an improved service work brake arrangement. The arrangement may provide a service work brake function or both a service work brake function and a parking brake function for the vehicle. The arrangement may provide an improved service work brake arrangement disposed within a housing for reducing the number of components and plumbing required to achieve this functionality versus prior known systems. The arrangement may utilizes a pneumatic latching valve to deliver pressurized air for applying a vehicle's service brakes. The pneumatic latching valve opens upon receiving a pneumatic control signal from an electronically controlled valve and closes upon receiving a pneumatic control signal from another source. In addition, a controller and control logic may be provided for controlling the arrangement.
摘要翻译：车辆，空气制动系统具有改进的维修工作制动装置。该装置可以为车辆提供维修工作制动功能或者服务工作制动功能和驻车制动功能。该布置可以提供设置在壳体内的改进的维修工作制动装置，以减少与现有已知系统相比实现该功能所需的部件和管道的数量。该装置可以利用气动闭锁阀来输送用于施加车辆行驶制动器的加压空气。气动闭锁阀在接收到来自电子控制阀的气动控制信号时打开，并在接收到来自另一个源的气动控制信号时闭合。此外，可以提供控制器和控制逻辑来控制该装置。

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