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1. 发明申请

US20110098815A1 SKIN SUBSTITUTE MEMBRANE, MOLD, AND METHOD OF EVALUATING EXTERNAL PREPARATION FOR SKIN 审中-公开
标题翻译：皮肤替代膜，模具和评估皮肤外用制剂的方法
公开(公告)号：US20110098815A1
公开(公告)日：2011-04-28
申请号：US12996859
申请日：2009-03-24
申请人： Yoshimasa Miura , Hiroko Mizuno , Masato Hatao , Motoki Ooguri , Yusuke Hara
发明人： Yoshimasa Miura , Hiroko Mizuno , Masato Hatao , Motoki Ooguri , Yusuke Hara
IPC分类号： A61F2/10
CPC分类号： G01N33/5082
摘要： A skin substitute membrane includes a surface on one side including a groove-shaped depressed portion and a planar portion, the depressed portion having a cross section having a chamfered V-letter shape, the surface having an arithmetic mean roughness Sa of more than or equal to 10 μm to less than or equal to 50 μm. The depressed portion has a width of more than or equal to 50 μm to less than or equal to 500 μm and a depth of more than or equal to 30 μm to less than or equal to 150 μm. A spectral transmittance for light of more than or equal to 290 nm to less than or equal to 400 nm in wavelength is more than or equal to 50% and less than or equal to 100%.
摘要翻译：皮肤替代膜包括在一侧的包括凹槽状凹部和平面部的表面，所述凹部具有倒角V字形的横截面，所述表面的算术平均粗糙度Sa大于或等于至10μm至小于或等于50μm。凹陷部具有大于或等于50μm至小于或等于500μm的宽度和大于或等于30μm至小于或等于150μm的深度。对于波长大于或等于290nm至小于或等于400nm的光的光谱透射率大于或等于50％且小于或等于100％。

2. 发明授权

US08049179B2 Ultraviolet radiation detector and apparatus for evaluating ultraviolet radiation protection effect 有权
标题翻译：用于评估紫外线辐射防护效果的紫外线辐射探测器和装置
公开(公告)号：US08049179B2
公开(公告)日：2011-11-01
申请号：US12443829
申请日：2007-10-03
申请人： Yoshimasa Miura , Yoshihiro Takiguchi , Masayuki Shirao , Sadaki Takata , Masato Hatao , Hiroshi Fukui
发明人： Yoshimasa Miura , Yoshihiro Takiguchi , Masayuki Shirao , Sadaki Takata , Masato Hatao , Hiroshi Fukui
IPC分类号： G01J1/02
CPC分类号： G01J1/429 , A61B5/0059 , A61B5/0075 , A61B5/441 , A61B5/445 , G01J3/42 , G01N21/33
摘要： An ultraviolet radiation detector 10, detecting an ultraviolet radiation transmitted through or reflected from a measurement sample 15 from a light beam including at least the ultraviolet radiation, is characterized by spectral means 19 for spectrally splitting the ultraviolet radiation from the light beam and photodetection means 20 for detecting the ultraviolet radiation spectrally split by the spectral means 19, the photodetection means 20 including a photoelectric surface detecting only the ultraviolet radiation and formed of an element selected from In, Ga, N, Al, O and Cs.
摘要翻译：检测从至少包括紫外线辐射的光束透过或从测量样品15反射的紫外线辐射的紫外线辐射检测器10的特征在于用于光谱分解来自光束的紫外线辐射的光谱装置19和光电检测装置20 为了检测由光谱装置19光谱分割的紫外线辐射，光检测装置20包括仅检测紫外线并由选自In，Ga，N，Al，O和Cs的元素形成的光电表面。

3. 发明申请

US20100012850A1 ULTRAVIOLET RADIATION DETECTOR AND APPARATUS FOR EVALUATING ULTRAVIOLET RADIATION PROTECTION EFFECT 有权
标题翻译：超紫外线辐射检测器和评估ULTRAVIOLET辐射防护效果的设备
公开(公告)号：US20100012850A1
公开(公告)日：2010-01-21
申请号：US12443829
申请日：2007-10-03
申请人： Yoshimasa Miura , Yoshihiro Takiguchi , Masayuki Shirao , Sadaki Takata , Masato Hatao , Hiroshi Fukui
发明人： Yoshimasa Miura , Yoshihiro Takiguchi , Masayuki Shirao , Sadaki Takata , Masato Hatao , Hiroshi Fukui
IPC分类号： G01J1/42
CPC分类号： G01J1/429 , A61B5/0059 , A61B5/0075 , A61B5/441 , A61B5/445 , G01J3/42 , G01N21/33
摘要： An ultraviolet radiation detector 10, detecting an ultraviolet radiation transmitted through or reflected from a measurement sample 15 from a light beam including at least the ultraviolet radiation, is characterized by spectral means 19 for spectrally splitting the ultraviolet radiation from the light beam and photodetection means 20 for detecting the ultraviolet radiation spectrally split by the spectral means 19, the photodetection means 20 including a photoelectric surface detecting only the ultraviolet radiation and formed of an element selected from In, Ga, N, Al, O and Cs.
摘要翻译：检测从至少包括紫外线辐射的光束透过或从测量样品15反射的紫外线辐射的紫外线辐射检测器10的特征在于用于光谱分解来自光束的紫外线辐射的光谱装置19和光电检测装置20 为了检测由光谱装置19光谱分割的紫外线辐射，光检测装置20包括仅检测紫外线并由选自In，Ga，N，Al，O和Cs的元素形成的光电表面。

4. 发明申请

US20090208525A1 Antiaging method for skin using pleurotus abalonus 审中-公开
标题翻译：使用Pleurotus abalonus的皮肤抗衰老方法
公开(公告)号：US20090208525A1
公开(公告)日：2009-08-20
申请号：US12367591
申请日：2009-02-09
申请人： Takeshi Nawamura , Nobuhiko Ochiai , Masato Hatao , Mineyuki Yokoyama , Koji Kobayashi , Fumio Eguchi
发明人： Takeshi Nawamura , Nobuhiko Ochiai , Masato Hatao , Mineyuki Yokoyama , Koji Kobayashi , Fumio Eguchi
IPC分类号： A61K36/07 , A61Q19/08
CPC分类号： A61K36/07 , A61K8/9706 , A61K2800/522 , A61K2800/782 , A61Q19/02 , A61Q19/08
摘要： The present invention provides an antioxidant and a whitening agent having high safety, and a external preparation for skin using the same. The antioxidant and whitening agent comprise, as an effective component, one or more extracts from Basidiomycetes selected from the group consisting of Pleurotus abalonus, Pholiota squarrosa, Onnia orientalis, Astraeus hygrometricus and Pleurotus nebrodensis. These extracts have a free radical capturing ability and are useful for suppressing skin oxidation and for preventing and improving skin aging. In addition, the extracts have a tyrosinase activity inhibiting action and can suppress the melanin generation. Since the fruit bodies of these Basidiomycetes have been used for edible purpose and have high safety, they can be used preferably for an external preparation for skin.
摘要翻译：本发明提供了具有高安全性的抗氧化剂和增白剂，以及使用其的皮肤外用剂。抗氧化剂和增白剂作为有效成分包含一种或多种从担子菌中提取的提取物，所述提取物选自侧耳属（Pleurotus abalonus），Pholiota squarrosa，Onnia orientalis，Astraeus hygrometricus和Pleurotus nebrodensis。这些提取物具有自由基捕获能力，可用于抑制皮肤氧化和预防和改善皮肤老化。此外，提取物具有酪氨酸酶活性抑制作用，能够抑制黑色素的产生。由于这些担子菌的果实体已被用于食用，安全性高，所以可以优选用于皮肤外用剂。

5. 发明授权

US06861050B2 Method of preventing darkening of skin or inhibiting melanization of melenin monomer and polymerization inhibitor of biological dihydroxyindole compound 有权
标题翻译：防止皮肤变黑或抑制黑色素单体和生物二羟基吲哚化合物阻聚剂黑化的方法
公开(公告)号：US06861050B2
公开(公告)日：2005-03-01
申请号：US10162738
申请日：2002-06-06
申请人： Kazuhisa Maeda , Masato Hatao
发明人： Kazuhisa Maeda , Masato Hatao
IPC分类号： A61K8/72 , A61K8/49 , A61K8/67 , A61Q17/04 , A61Q19/02 , C08F2/00 , A61K7/42 , A61K7/00 , A61K7/44 , A61K31/34
CPC分类号： A61Q17/04 , A61K8/492 , A61K8/676 , A61Q19/02
摘要： A method of preventing darkening of the skin or inhibiting melanization caused by the irradiation of the melanin monomers with long wavelength ultraviolet rays having a wavelength of 320-400 nm as well as a polymerization inhibitor of a biological dihydroxyindole compound comprising 3-O-ethyl ascorbic acid and an external skin treatment composition containing the same.
摘要翻译：防止由波长320-400nm的长波长紫外线照射黑色素单体引起的皮肤变黑或抑制黑色素化的方法，以及包含抗坏血酸3-O-乙酸的生物二羟基吲哚化合物的阻聚剂酸和含有其的外用皮肤治疗组合物。

6. 发明申请

US20130169951A1 ULTRAVIOLET PROTECTION EFFECT EVALUATION METHOD, EVALUATION APPARATUS, AND RECORDING MEDIUM 有权
标题翻译：超声波保护效应评估方法，评估装置和记录介质
公开(公告)号：US20130169951A1
公开(公告)日：2013-07-04
申请号：US13823438
申请日：2011-07-13
申请人： Yoshimasa Miura , Masato Hatao
发明人： Yoshimasa Miura , Masato Hatao
IPC分类号： G01N21/59
CPC分类号： G01N21/59 , G01N17/004 , G01N21/33
摘要： An evaluation method for evaluating the ultraviolet protection effect of a measurement sample applied on a substrate includes a first step of measuring, at predetermined wavelength intervals, a change over time of a spectral transmission spectrum of the measurement sample within a predetermined wavelength range by irradiating light from a light source that includes ultraviolet light, visible light, and infrared light under a predetermined irradiation condition; a second step of establishing, based on the change over time of the spectral transmission spectrum, a correlation between a light irradiation time and an erythema effective dose per unit time, which is obtained by dividing an erythema effective dose of the measurement sample by an erythema effective dose per 1 MED; and a third step of calculating an in vitro rSPF predictive value for the measurement sample on the basis of a time until a cumulative erythema effective dose, which is obtained through time integration based on the correlation, reaches 1 MED.
摘要翻译：用于评估施加在基板上的测量样品的紫外线保护效果的评估方法包括：第一步骤，以预定波长间隔，通过照射光来测量在预定波长范围内的测量样品的光谱透射光谱随时间的变化从包含紫外光，可见光和红外光的光源在预定的照射条件下; 基于光谱透射光谱随时间的变化建立光照射时间和每单位时间的红斑有效剂量之间的相关性的第二步骤，其通过将测量样品的红斑有效剂量除以红斑每1 MED有效剂量; 以及基于通过基于相关性的时间积分获得的累积红斑有效剂量之间的时间达到1 MED的时间来计算测量样品的体外rSPF预测值的第三步骤。

7. 发明授权

US08337554B2 Skin substitute membrane, mold, and method of evaluating external preparation for skin 有权
标题翻译：皮肤替代膜，模具和皮肤外用剂评估方法
公开(公告)号：US08337554B2
公开(公告)日：2012-12-25
申请号：US13347203
申请日：2012-01-10
申请人： Yoshimasa Miura , Hiroko Mizuno , Masato Hatao , Motoki Ooguri , Yusuke Hara
发明人： Yoshimasa Miura , Hiroko Mizuno , Masato Hatao , Motoki Ooguri , Yusuke Hara
IPC分类号： A61F2/10 , B22C9/22 , A61B5/00
CPC分类号： G01N33/5082
摘要： A skin substitute membrane includes a surface on one side including a groove-shaped depressed portion and a planar portion, the depressed portion having a cross section having a chamfered V-letter shape, the surface having an arithmetic mean roughness Sa of more than or equal to 10 μm to less than or equal to 50 μm. The depressed portion has a width of more than or equal to 50 μm to less than or equal to 500 μm and a depth of more than or equal to 30 μm to less than or equal to 150 μm. A spectral transmittance for light of more than or equal to 290 nm to less than or equal to 400 nm in wavelength is more than or equal to 50% and less than or equal to 100%.
摘要翻译：皮肤替代膜包括在一侧的包括凹槽状凹部和平面部的表面，所述凹部具有倒角V字形的横截面，所述表面的算术平均粗糙度Sa大于或等于至10μm至小于或等于50μm。凹陷部具有大于或等于50μm至小于或等于500μm的宽度和大于或等于30μm至小于或等于150μm的深度。对于波长大于或等于290nm至小于或等于400nm的光的光谱透射率大于或等于50％且小于或等于100％。

8. 发明申请

US20100256924A1 METHOD, APPARATUS, PROGRAM, AND RECORDING MEDIUM FOR EVALUATING ULTRAVIOLET RADIATION PROTECTION EFFECT 有权
标题翻译：用于评估超紫外线辐射防护效果的方法，装置，程序和记录介质
公开(公告)号：US20100256924A1
公开(公告)日：2010-10-07
申请号：US12682286
申请日：2008-10-17
申请人： Yoshimasa Miura , Masato Hatao
发明人： Yoshimasa Miura , Masato Hatao
IPC分类号： G01N21/84 , G01N21/25 , G06F19/00
CPC分类号： G01N21/33
摘要： An evaluating method for evaluating an ultraviolet radiation protection effect in a measurement sample includes a first step of measuring a temporal change of the spectral transmission spectrum in the measurement sample within a predetermined wavelength range at predetermined wavelength intervals by irradiating with light including ultraviolet radiation from a light source under a predetermined light irradiating condition, a second step of setting a correlation between a light irradiating time and minimal erythema doses by predetermined time intervals based on the temporal change of the spectral transmission spectrum obtained in the first step, and a third step of calculating a predicted in vitro SPF in the measurement sample using a time until an accumulated minimal erythema dose that is obtained as a time integration of the minimal erythema doses based on the correlation obtained in the second step reaches 1 MED.
摘要翻译：用于评价测定试样的紫外线防护效果的评价方法包括：第一步骤，通过用包含紫外线辐射的光进行照射，以规定的波长间隔测定预定波长范围内的测定样品中的光谱透射光谱的时间变化光源，在第一步骤中获得的光谱透射光谱的时间变化的第二步骤，将光照射时间和最小红斑剂量之间的相关性设定预定时间间隔;第三步骤，使用一段时间计算测量样品中预测的体外SPF，直到基于在第二步骤中获得的相关性的最小红斑剂量的时间积分获得的累积最小红斑剂量达到1 MED。

9. 发明授权

US07749508B2 Skin whitening method using Pleurotus nebrodensis 失效
标题翻译：使用侧耳菇的皮肤美白方法
公开(公告)号：US07749508B2
公开(公告)日：2010-07-06
申请号：US12365985
申请日：2009-02-05
申请人： Takeshi Nawamura , Nobuhiko Ochiai , Masato Hatao , Mineyuki Yokoyama , Koji Kobayashi , Fumio Eguchi
发明人： Takeshi Nawamura , Nobuhiko Ochiai , Masato Hatao , Mineyuki Yokoyama , Koji Kobayashi , Fumio Eguchi
IPC分类号： A61K35/84
CPC分类号： A61K36/07 , A61K8/9706 , A61K2800/522 , A61K2800/782 , A61Q19/02 , A61Q19/08
摘要： The present invention provides an antioxidant and a whitening agent having high safety, and a external preparation for skin using the same. The antioxidant and whitening agent comprise, as an effective component, one or more extracts from Basidiomycetes selected from the group consisting of Pleurotus abalonus, Pholiota squarrosa, Onnia orientalis, Astraeus hygrometricus and Pleurotus nebrodensis . These extracts have a free radical capturing ability and are useful for suppressing skin oxidation and for preventing and improving skin aging. In addition, the extracts have a tyrosinase activity inhibiting action and can suppress the melanin generation. Since the fruit bodies of these Basidiomycetes have been used for edible purpose and have high safety, they can be used preferably for an external preparation for skin.
摘要翻译：本发明提供了具有高安全性的抗氧化剂和增白剂，以及使用其的皮肤外用剂。抗氧化剂和增白剂作为有效成分包含一种或多种从担子菌中提取的提取物，所述提取物选自侧耳属（Pleurotus abalonus），Pholiota squarrosa，Onnia orientalis，Astraeus hygrometricus和Pleurotus nebrodensis。这些提取物具有自由基捕获能力，可用于抑制皮肤氧化和预防和改善皮肤老化。此外，提取物具有酪氨酸酶活性抑制作用，能够抑制黑色素的产生。由于这些担子菌的果实体已被用于食用，安全性高，所以可以优选用于皮肤外用剂。

10. 发明授权

US06169114A Endermic liniment containing a thiol compound and zinc oxide 有权
标题翻译：含有硫醇化合物和氧化锌的皮肤外用剂
公开(公告)号：US06169114A
公开(公告)日：2001-01-02
申请号：US09284959
申请日：1999-05-05
申请人： Kenji Yamaguchi , Eiichiro Yagi , Masako Naganuma , Masato Hatao , Ichiro Iwai
发明人： Kenji Yamaguchi , Eiichiro Yagi , Masako Naganuma , Masato Hatao , Ichiro Iwai
IPC分类号： A61K31195
CPC分类号： A61Q19/00 , A61K8/0212 , A61K8/03 , A61K8/22 , A61K8/27 , A61K8/44 , A61K8/447 , A61K8/64 , A61Q17/04
摘要： The present invention is an endermic liniment which characteristically contains a thiol compound and zinc oxide. An endermic liniment which can contain a thiol compound in a stable manner can be provided by blending in a thiol compound and zinc oxide.
摘要翻译：本发明是特征性地含有硫醇化合物和氧化锌的皮肤外用剂。可以通过在硫醇化合物和氧化锌中共混来提供可以稳定地含有硫醇化合物的皮肤外用剂。

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