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1. 发明授权

US10583043B2 Backing having three-layer structure and aqueous patch using the backing 有权
公开(公告)号：US10583043B2
公开(公告)日：2020-03-10
申请号：US13807427
申请日：2011-07-11
申请人： Sadanobu Shirai , Masahiro Inazuki , Miho Ishigure , Hideo Isoda , Hiroyuki Sakamoto , Takashi Koida , Hiroyasu Sakaguchi
发明人： Sadanobu Shirai , Masahiro Inazuki , Miho Ishigure , Hideo Isoda , Hiroyuki Sakamoto , Takashi Koida , Hiroyasu Sakaguchi
IPC分类号： A61F13/02 , A61K31/192 , A61K31/167 , A61K9/70 , B32B3/26
摘要： The present invention relates to a backing having a three-layer structure prepared by sticking together an inner fiber layer for holding a pasty preparation, a film layer having through-holes, and an air-permeable outer fiber layer which prevents leaking out of the pasty preparation or a liquid component exuded from the pasty preparation, and also relates to an aqueous patch using the backing which can be applied for a long time.

2. 发明授权

US09861598B2 Ketoprofen lysine salt-containing aqueous patch 有权
公开(公告)号：US09861598B2
公开(公告)日：2018-01-09
申请号：US12934443
申请日：2009-03-24
申请人： Masahiro Inazuki
发明人： Masahiro Inazuki
IPC分类号： A61K47/10 , A61K31/192 , A61K9/70
CPC分类号： A61K31/192 , A61K9/7061 , A61K47/10
摘要： A ketoprofen-containing aqueous patch is provided in which not only operational efficiency in producing is improved, but also the aqueous patch has excellent storage stability and transdermal absorption of ketoprofen. The ketoprofen lysine salt-containing aqueous patch includes a backing layer and an adhesive (paste) layer laminated thereon. The aqueous patch includes as a main active ingredient a ketoprofen lysine salt completely dissolved in a paste including not glycerin but a polyethylene glycol having an average molecular weight of 1000 or less. In the ketoprofen lysine salt-containing aqueous patch, the polyethylene glycol having an average molecular weight of 1000 or less is one or more polyethylene glycols selected from the group consisting of Polyethylene glycol 200, Polyethylene glycol 400, Polyethylene glycol 600, and Polyethylene glycol 1000.

3. 发明授权

US09884030B2 Patch backing for water-based pasty preparation 有权
公开(公告)号：US09884030B2
公开(公告)日：2018-02-06
申请号：US13809549
申请日：2011-07-11
申请人： Hideo Isoda , Hiroyuki Sakamoto , Takashi Koida , Hiroyasu Sakaguchi , Sadanobu Shirai , Masahiro Inazuki , Miho Ishigure
发明人： Hideo Isoda , Hiroyuki Sakamoto , Takashi Koida , Hiroyasu Sakaguchi , Sadanobu Shirai , Masahiro Inazuki , Miho Ishigure
IPC分类号： A61K9/70 , B32B3/26 , B32B5/22
CPC分类号： A61K9/703 , A61K9/70 , Y10T428/24322
摘要： The present invention relates to a backing for a water-based patch consisting of the following constituents, wherein the backing is excellent in pasty preparation retention and moisture retention, improves the persistence of drug efficacy by inhibiting the sublimation of the drug, gives neither restrained feeling nor rough feeling due to a thin thickness and an excellent elasticity, controls the moisture permeability, gives almost no sticky feeling and thereby gives an excellent feeling in application. A patch backing for a water-based pasty preparation consisting of a laminate, wherein the laminate consists of three layers, a film layer having through-holes is laminated between a nonwoven fabric layer A and a nonwoven fabric layer B, said film layer consists of a resin containing an olefin elastomer, the through-hole area per a hole is 0.02-0.18 mm2, and the opening ratio of the through-hole is 1-10%.

4. 发明申请

US20130138057A1 BACKING HAVING THREE-LAYER STRUCTURE AND AQUEOUS PATCH USING THE BACKING 审中-公开
标题翻译：使用背部支撑三层结构和水US ING
公开(公告)号：US20130138057A1
公开(公告)日：2013-05-30
申请号：US13807427
申请日：2011-07-11
申请人： Sadanobu Shirai , Masahiro Inazuki , Miho Ishigure , Hideo Isoda , Hiroyuki Sakamoto , Takashi Koida , Hiroyasu Sakaguchi
发明人： Sadanobu Shirai , Masahiro Inazuki , Miho Ishigure , Hideo Isoda , Hiroyuki Sakamoto , Takashi Koida , Hiroyasu Sakaguchi
IPC分类号： A61F13/02 , B32B3/26
摘要： The present invention relates to a backing having a three-layer structure prepared by sticking together an inner fiber layer for holding a pasty preparation, a film layer having through-holes, and an air-permeable outer fiber layer which prevents leaking out of the pasty preparation or a liquid component exuded from the pasty preparation, and also relates to an aqueous patch using the backing which can be applied for a long time.
摘要翻译：本发明涉及一种背衬，其具有通过将用于保持糊状制剂的内纤维层粘合在一起而制成的三层结构，具有通孔的膜层和防止从糊状物渗出的透气性外纤维层制剂或从糊状制剂中渗出的液体组分，并且还涉及使用可以长时间施用的背衬的水性贴剂。

5. 发明申请

US20130164495A1 PATCH BACKING FOR WATER-BASED PASTY PREPARATION 有权
标题翻译：用于基于水的过程准备的补丁
公开(公告)号：US20130164495A1
公开(公告)日：2013-06-27
申请号：US13809549
申请日：2011-07-11
申请人： Hideo Isoda , Hiroyuki Sakamoto , Takashi Koida , Hiroyasu Sakaguchi , Sadanobu Shirai , Masahiro Inazuki , Miho Ishigure
发明人： Hideo Isoda , Hiroyuki Sakamoto , Takashi Koida , Hiroyasu Sakaguchi , Sadanobu Shirai , Masahiro Inazuki , Miho Ishigure
IPC分类号： A61K9/70
CPC分类号： A61K9/703 , A61K9/70 , Y10T428/24322
摘要： The present invention relates to a backing for a water-based patch consisting of the following constituents, wherein the backing is excellent in pasty preparation retention and moisture retention, improves the persistence of drug efficacy by inhibiting the sublimation of the drug, gives neither restrained feeling nor rough feeling due to a thin thickness and an excellent elasticity, controls the moisture permeability, gives almost no sticky feeling and thereby gives an excellent feeling in application. A patch backing for a water-based pasty preparation consisting of a laminate, wherein the laminate consists of three layers, a film layer having through-holes is laminated between a nonwoven fabric layer A and a nonwoven fabric layer B, said film layer consists of a resin containing an olefin elastomer, the through-hole area per a hole is 0.02-0.18 mm2, and the opening ratio of the through-hole is 1-10%.
摘要翻译：本发明涉及一种由以下成分构成的水性贴剂的背衬，其中，背衬具有优异的糊状制剂保持性和保湿性，通过抑制药物升华改善药物功效的持久性，既不抑制药物的抑制作用由于薄的厚度和优异的弹性，也不会产生粗糙的感觉，控制透湿性，几乎不产生粘性，从而给人以极好的使用感。一种由层压板构成的水性糊状制剂的贴剂背衬，其中层压体由三层构成，在无纺布层A和无纺布层B之间层叠具有通孔的膜层，所述膜层由含有烯烃弹性体的树脂，每个孔的通孔面积为0.02〜0.18mm 2，通孔的开口率为1-10％。

6. 发明申请

US20110184066A1 Ketoprofen Lysine Salt-Containing Aqueous Patch 有权
标题翻译：酮洛芬赖氨酸盐含水补片
公开(公告)号：US20110184066A1
公开(公告)日：2011-07-28
申请号：US12934443
申请日：2009-03-24
申请人： Masahiro Inazuki
发明人： Masahiro Inazuki
IPC分类号： A61K31/19 , A61P29/00
CPC分类号： A61K31/192 , A61K9/7061 , A61K47/10
摘要： A ketoprofen-containing aqueous patch is provided in which not only operational efficiency in producing is improved, but also the aqueous patch has excellent storage stability and transdermal absorption of ketoprofen. The ketoprofen lysine salt-containing aqueous patch includes a backing layer and an adhesive (paste) layer laminated thereon. The aqueous patch includes as a main active ingredient a ketoprofen lysine salt completely dissolved in a paste including not glycerin but a polyethylene glycol having an average molecular weight of 1000 or less. In the ketoprofen lysine salt-containing aqueous patch, the polyethylene glycol having an average molecular weight of 1000 or less is one or more polyethylene glycols selected from the group consisting of Polyethylene glycol 200, Polyethylene glycol 400, Polyethylene glycol 600, and Polyethylene glycol 1000.
摘要翻译：提供了含酮洛芬的水性贴剂，其中不仅提高了生产中的操作效率，而且水性贴剂还具有优异的储存稳定性和酮洛芬的经皮吸收。含酮洛芬赖氨酸盐的水性贴剂包括背衬层和层压在其上的粘合剂（糊）层。水性贴剂作为主要活性成分包含完全溶解在不含甘油的糊剂中的酮洛芬赖氨酸盐，但平均分子量为1000以下的聚乙二醇。在含酮洛芬赖氨酸盐的水性贴剂中，平均分子量为1000以下的聚乙二醇是选自聚乙二醇200，聚乙二醇400，聚乙二醇600，聚乙二醇1000中的一种以上的聚乙二醇。

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