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    • 6. 发明授权
    • Process for optically resolving 2-(3-benzoylphenyl) propionic acid
    • 光学拆分2-(3-苯甲酰基苯基)丙酸的方法
    • US5852209A
    • 1998-12-22
    • US897500
    • 1997-06-09
    • Hiroyuki NohiraShigeya SaijoMasafumi MoriwakiShunji KamiyamaKazutoshi ToyodaJun MatsumotoKohichi MaruoTaizo Fujimoto
    • Hiroyuki NohiraShigeya SaijoMasafumi MoriwakiShunji KamiyamaKazutoshi ToyodaJun MatsumotoKohichi MaruoTaizo Fujimoto
    • C07B57/00C07C51/487C07C57/38
    • C07C51/487
    • Provided is a process for separating (S)- or (R)-2-(3-benzoylphenyl)propionic acid from a mixture of (S)- and (R)-2-(3-benzoylphenyl)propionic acid, which comprises (1) reacting the mixture of (S)- and (R)-2-(3-benzoylphenyl)propionic acid with (S)- or (R)-3-methyl-2-phenylbutylamine in a suitable solvent to form a diastereomer salt of (S)-2-(3-benzoylphenyl)propionic acid with (S)-3-methyl-2-phenylbutylamine or a diastereomer salt of (R)-2-(3-benzoylphenyl)propionic acid with (R)-3-methyl-2-phenylbutylamine; (2) separating the diastereomer salt from the reaction mixture; and (3) liberating the separated diastereomer salt to give (S)- or (R)-2-(3-benzoylphenyl)propionic acid. According to the present process, it is possible to obtain optically active (S)- or (R)-2-(3-benzoylphenyl)propionic acid having 99% or more of high optical purity in a high yield. Thus, the present process is a practical and efficient process which can simplify purification steps and can be applied for an industrial production process.
    • 提供了从(S) - 和(R)-2-(3-苯甲酰基苯基)丙酸的混合物中分离(S) - 或(R)-2-(3-苯甲酰基苯基)丙酸的方法,其包括 1)使(S) - 和(R)-2-(3-苯甲酰基苯基)丙酸的混合物与(S) - 或(R)-3-甲基-2-苯基丁胺在合适的溶剂中反应以形成非对映异构体盐 (S)-2-(3-苯甲酰基苯基)丙酸与(S)-3-甲基-2-苯基丁胺或(R)-2-(3-苯甲酰基苯基)丙酸的非对映异构体盐与(R)-3 - 甲基-2-苯基丁胺; (2)从反应混合物中分离非对映异构体盐; (3)释放分离出的非对映体盐得到(S) - 或(R)-2-(3-苯甲酰基苯基)丙酸。 根据本方法,可以以高收率得到具有99%以上的光学纯度的光学活性(S) - 或(R)-2-(3-苯甲酰基苯基)丙酸。 因此,本方法是一种实用且有效的方法,可简化纯化步骤,可应用于工业生产过程。
    • 7. 发明授权
    • Signal input sheet
    • 信号输入表
    • US5010213A
    • 1991-04-23
    • US457401
    • 1989-12-27
    • Masafumi MoriwakiShigeaki SanoKatsunori HatakeyamaHiroshi YamadaYouzou Nouno
    • Masafumi MoriwakiShigeaki SanoKatsunori HatakeyamaHiroshi YamadaYouzou Nouno
    • G06F3/02G06F3/033G06F3/045G06K11/06
    • G06F3/045
    • A signal input sheet having a flexible upper laminate and a lower laminate. The upper laminate includes either a conductive layer or a resistive layer on its lower surface as a first layer and at least one hand-written input area and at least one binary data input area on its upper surface. The lower laminate includes either a conductive layer or a resistance layer on its upper surface as a second layer, however, at least one of the first and second layer is formed as a resistive layer. Elastic insulative spacers are interposed between the first layer of the upper laminate and the second layer of the lower laminate. The spacers are arranged at desired intervals to allow the first layer to come in contact with the second layer when pressure is applied to the upper laminate from the outside. The spacing between adjacent insulative spacers is larger in the binary input area than the hand-written input area. Also, the insulative spacers are wider in the binary data input area as opposed to the hand-written input area. Means are provided for applying a voltage between the upper and lower laminates. In addition, means are provided for detecting at what position the force is applied from the outside.
    • 一种具有柔性上层压板和下层压板的信号输入板。 上层压板包括作为第一层的下表面上的导电层或电阻层,以及其上表面上至少一个手写输入区和至少一个二进制数据输入区。 下层叠体在其上表面上包括导电层或电阻层作为第二层,然而,第一层和第二层中的至少一层形成为电阻层。 弹性绝缘间隔件介于上层叠体的第一层和下层叠体的第二层之间。 间隔物以期望的间隔布置,以允许第一层从外部施加到上层压板上时与第二层接触。 二进制输入区域中相邻的绝缘间隔物之间​​的间距大于手写输入区域。 此外,与手写输入区域相反,绝缘间隔物在二进制数据输入区域中较宽。 提供了用于在上层和下层之间施加电压的装置。 此外,提供了用于检测从外部施加力的位置的装置。