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1. 发明申请

US20070053942A1 Disinfectant and/or bactericidal aqueous compositions 审中-公开
标题翻译：消毒剂和/或杀菌水性组合物
公开(公告)号：US20070053942A1
公开(公告)日：2007-03-08
申请号：US10557747
申请日：2004-05-25
申请人： Toru Nishibayashi , Tetsuya Sato , Masaaki Odomi , Kinue Ohguro , Hiroshi Ishikawa
发明人： Toru Nishibayashi , Tetsuya Sato , Masaaki Odomi , Kinue Ohguro , Hiroshi Ishikawa
IPC分类号： A01N43/04 , A01N37/30 , A01N25/00
CPC分类号： A61K31/155 , A01N47/44 , A01N25/30 , A01N2300/00
摘要： The present invention provides a disinfectant and/or bactericidal aqueous composition containing an olanexidine acid addition salt, and at least one polyoxyethylene-based nonionic surfactant selected from the group consisting of polyoxyethylene higher alkyl ethers and polyoxyethylene alkylphenyl ethers; a disinfectant and/or bactericidal aqueous composition containing an olanexidine acid addition salt at a concentration of 0.05 to 0.5 W/V %, and an alcohol at a concentration of 20 to 80 W/V %, and not containing any surfactants; and a disinfectant and/or bactericidal aqueous composition containing an olanexidine acid addition salt, and at least one member selected from the group consisting of ester-based nonionic surfactants and cyclic oligosaccharides.
摘要翻译：本发明提供一种含有奥拉西酸加成盐的消毒剂和/或杀菌水性组合物，以及选自聚氧乙烯高级烷基醚和聚氧乙烯烷基苯基醚的至少一种聚氧乙烯基非离子表面活性剂; 含有浓度为0.05〜0.5W / V％的奥兰西酸加成盐的消毒剂和/或杀菌水性组合物，浓度为20〜80W / V％的醇，不含任何表面活性剂; 以及含有奥拉西酸加成盐的消毒剂和/或杀菌性水性组合物，以及选自酯类非离子表面活性剂和环状低聚糖中的至少一种。

2. 发明授权

US5445830A Highly absorbable pharmaceutical composition 失效
标题翻译：高吸收性药物组合物
公开(公告)号：US5445830A
公开(公告)日：1995-08-29
申请号：US17443
申请日：1993-02-12
申请人： Yoshihiro Ishizue , Kozo Ishida , Masaaki Odomi , Toru Nishibayashi , Kaszuyo Koshino
发明人： Yoshihiro Ishizue , Kozo Ishida , Masaaki Odomi , Toru Nishibayashi , Kaszuyo Koshino
IPC分类号： A61K9/14 , A61K9/16 , A61K31/44
CPC分类号： A61K9/146 , A61K31/44 , A61K9/1676
摘要： A highly absorbable pharmaceutical composition containing, as the active ingredient, methyl 3-phenyl-2(E)-propenyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylate in an amorphous state and a pH-dependent type copolymer of methacrylic acid or its derivatives which composition has been prepared by dissolving the two components together in an organic solvent and thereafter removing the solvent.
摘要翻译：一种高吸收性药物组合物，含有作为活性成分的3-苯基-2（E） - 丙烯基1,4-二氢-2,6-二甲基-4-（3-硝基苯基）吡啶-3,5-二羧酸甲酯非晶状态和甲基丙烯酸或其衍生物的pH依赖型共聚物，其组成是通过将两种组分一起溶解在有机溶剂中，然后除去溶剂制备的。

3. 发明申请

US20080119568A1 Gastrointestinal Absorption Enhancer Mediated By Proton-Coupled Transporter and Its Preparing Method 审中-公开
标题翻译：通过质子耦合转运体介导的胃肠吸收增强剂及其制备方法
公开(公告)号：US20080119568A1
公开(公告)日：2008-05-22
申请号：US11971243
申请日：2008-01-09
申请人： Akira TSUJI , Ikumi Tamai , Yoshimichi Sai , Masaaki Odomi , Hidekazu Toyobuku
发明人： Akira TSUJI , Ikumi Tamai , Yoshimichi Sai , Masaaki Odomi , Hidekazu Toyobuku
IPC分类号： A61K47/30
CPC分类号： A61K47/32 , A61K9/0053 , A61K9/08 , A61K31/545 , A61K31/546
摘要： The present invention provides a pharmaceutical preparation that can improve absorption of a pharmaceutical compound in the gastrointestinal tract and that provides, through oral administration or like method, a blood concentration from which sufficient remedial effects can be expected, and a method for producing such a preparation. The invention is directed to a pharmaceutical preparation exhibiting excellent gastrointestinal absorbability comprising a compound recognized by a proton-coupled transporter and a pH-sensitive polymer in an amount sufficient for the gastrointestinal tract to acquire a pH at which the proton-coupled transporter optimally absorbs the compound into a cell.
摘要翻译：本发明提供了一种药物制剂，其可以改善胃肠道中药物化合物的吸收，并且通过口服给药或类似方法提供预期足够的补救效果的血液浓度，以及制备这种制剂的方法。本发明涉及显示出优异的胃肠吸收能力的药物制剂，其包含由质子偶联转运蛋白识别的化合物和pH敏感性聚合物，其量足以使胃肠道获得质子偶联转运蛋白最佳地吸收复合成细胞。

4. 发明申请

US20060121107A1 Agent improving proton-driven transporter-mediated absorption in digestive tract and process for producing the same 审中-公开
标题翻译：改善质子驱动的转运蛋白介导的消化道吸收及其制备方法
公开(公告)号：US20060121107A1
公开(公告)日：2006-06-08
申请号：US10541019
申请日：2004-01-08
申请人： Akira Tsuji , Ikumi Tamai , Yoshimichi Sai , Masaaki Odomi , Hidekazu Toyobuku
发明人： Akira Tsuji , Ikumi Tamai , Yoshimichi Sai , Masaaki Odomi , Hidekazu Toyobuku
IPC分类号： A61K31/401 , A61K31/198 , A61K9/20 , A61K31/716
CPC分类号： A61K47/32 , A61K9/0053 , A61K9/08 , A61K31/545 , A61K31/546
摘要： The present invention provides a pharmaceutical preparation that can improve absorption of a pharmaceutical compound in the gastrointestinal tract and that provides, through oral administration or like method, a blood concentration from which sufficient remedial effects can be expected, and a method for producing such a preparation. The invention is directed to a pharmaceutical preparation exhibiting excellent gastrointestinal absorbability comprising a compound recognized by a proton-coupled transporter and a pH-sensitive polymer in an amount sufficient for the gastrointestinal tract to acquire a pH at which the proton-coupled transporter optimally absorbs the compound into a cell.
摘要翻译：本发明提供了一种药物制剂，其可以改善胃肠道中药物化合物的吸收，并且通过口服给药或类似方法提供预期足够的补救效果的血液浓度，以及制备这种制剂的方法。本发明涉及显示出优异的胃肠吸收能力的药物制剂，其包含由质子偶联转运蛋白识别的化合物和pH敏感性聚合物，其量足以使胃肠道获得质子偶联转运蛋白最佳地吸收复合成细胞。

5. 发明授权

US06479048B2 Water-soluble dry compositions 有权
标题翻译：水溶性干组合物
公开(公告)号：US06479048B2
公开(公告)日：2002-11-12
申请号：US09902573
申请日：2001-07-12
申请人： Chikamasa Yamashita , Masaaki Odomi
发明人： Chikamasa Yamashita , Masaaki Odomi
IPC分类号： A61K4500
CPC分类号： A61K9/19 , A61K9/0019 , A61K47/183
摘要： Provisions of a foam inhibitor which effectively inhibits foaming (bubbling) caused at the time of dissolving dry compositions and of a water-soluble dry composition which comprises the foam inhibitor. The form inhibitor is suitable for inhibiting foaming caused at the time of dissolving dry compositions comprising saccharide which contain a hydrophobic amino acid as essential ingredient; and the water-soluble dry composition contains pharmacologically active proteinaceous substance, saccharide and hydrophobic amino acid having the hydropathy index of about not less than 2, wherein the concentration of the hydrophobic amino acid is in the range of 0.05 wt. % to less than 40 wt. % based on the total amount of the dry composition.
摘要翻译：泡沫抑制剂的设计，其有效地抑制了干燥组合物溶解时引起的起泡（起泡）和包含泡沫抑制剂的水溶性干组合物。形式抑制剂适用于在含有疏水性氨基酸作为必需成分的含有糖类的干燥组合物溶解时引起的发泡抑制; 所述水溶性干燥组合物含有药理活性蛋白质物质，亲水性指数为2以上的糖类和疏水性氨基酸，其中所述疏水性氨基酸的浓度为0.05重量％。％至小于40wt。基于干组合物的总量的％。

6. 发明授权

US08871818B2 Gastrointestinal absorption enhancer mediated by proton-coupled transporter and its preparing method 有权
标题翻译：由质子偶联转运蛋白介导的胃肠道吸收促进剂及其制备方法
公开(公告)号：US08871818B2
公开(公告)日：2014-10-28
申请号：US12254905
申请日：2008-10-21
申请人： Akira Tsuji , Ikumi Tamai , Yoshimichi Sai , Masaaki Odomi , Hidekazu Toyobuku
发明人： Akira Tsuji , Ikumi Tamai , Yoshimichi Sai , Masaaki Odomi , Hidekazu Toyobuku
IPC分类号： A61K47/30 , A61K9/14 , A61K47/00 , A61K38/00 , A61K38/55 , A61K47/32
CPC分类号： A61K47/32 , A61K9/0053 , A61K9/08 , A61K31/545 , A61K31/546
摘要： The present invention provides a pharmaceutical preparation that can improve absorption of a pharmaceutical compound in the gastrointestinal tract and that provides, through oral administration or like method, a blood concentration from which sufficient remedial effects can be expected, and a method for producing such a preparation. The invention is directed to a pharmaceutical preparation exhibiting excellent gastrointestinal absorbability comprising a compound recognized by a proton-coupled transporter and a pH-sensitive polymer in an amount sufficient for the gastrointestinal tract to acquire a pH at which the proton-coupled transporter optimally absorbs the compound into a cell.
摘要翻译：本发明提供了一种药物制剂，其可以改善胃肠道中药物化合物的吸收，并且通过口服给药或类似方法提供预期足够的补救效果的血液浓度，以及制备这种制剂的方法。本发明涉及显示出优异的胃肠吸收能力的药物制剂，其包含由质子偶联转运蛋白识别的化合物和pH敏感性聚合物，其量足以使胃肠道获得质子偶联转运蛋白最佳地吸收复合成细胞。

7. 发明申请

US20100331421A1 DISINFECTANT AND/OR BACTERICIDAL AQUEOUS COMPOSITIONS 审中-公开
标题翻译：消毒剂和/或杀菌剂水性组合物
公开(公告)号：US20100331421A1
公开(公告)日：2010-12-30
申请号：US12875463
申请日：2010-09-03
申请人： Toru Nishibayashi , Tetsuya Sato , Masaaki Odomi , Kinue Ohguro , Hiroshi Ishikawa
发明人： Toru Nishibayashi , Tetsuya Sato , Masaaki Odomi , Kinue Ohguro , Hiroshi Ishikawa
IPC分类号： A01N37/52 , A01P1/00
CPC分类号： A61K31/155 , A01N47/44 , A01N25/30 , A01N2300/00
摘要： The present invention provides a disinfectant and/or bactericidal aqueous composition containing an olanexidine acid addition salt and and a cyclodextrin.
摘要翻译：本发明提供含有奥拉西丁酸加成盐和环糊精的消毒剂和/或杀菌水性组合物。

8. 发明申请

US20090048350A1 GASTROINTESTINAL ABSORPTION ENHANCER MEDIATED BY PROTON-COUPLED TRANSPORTER AND ITS PREPARING METHOD 审中-公开
标题翻译：由PROTON-COUPLED TRANSPORTER介绍的吸收增强剂及其制备方法
公开(公告)号：US20090048350A1
公开(公告)日：2009-02-19
申请号：US12254905
申请日：2008-10-21
申请人： Akira Tsuji , Ikumi Tamai , Yoshimichi Sai , Masaaki Odomi , Hidekazu Toyobuku
发明人： Akira Tsuji , Ikumi Tamai , Yoshimichi Sai , Masaaki Odomi , Hidekazu Toyobuku
IPC分类号： A61K47/30
CPC分类号： A61K47/32 , A61K9/0053 , A61K9/08 , A61K31/545 , A61K31/546
摘要： The present invention provides a pharmaceutical preparation that can improve absorption of a pharmaceutical compound in the gastrointestinal tract and that provides, through oral administration or like method, a blood concentration from which sufficient remedial effects can be expected, and a method for producing such a preparation. The invention is directed to a pharmaceutical preparation exhibiting excellent gastrointestinal absorbability comprising a compound recognized by a proton-coupled transporter and a pH-sensitive polymer in an amount sufficient for the gastrointestinal tract to acquire a pH at which the proton-coupled transporter optimally absorbs the compound into a cell.
摘要翻译：本发明提供了一种药物制剂，其可以改善胃肠道中药物化合物的吸收，并且通过口服给药或类似方法提供预期足够的补救效果的血液浓度，以及制备这种制剂的方法。本发明涉及显示出优异的胃肠吸收能力的药物制剂，其包含由质子偶联转运蛋白识别的化合物和pH敏感性聚合物，其量足以使胃肠道获得质子偶联转运蛋白最佳地吸收复合成细胞。

9. 发明授权

US06337067B1 Water soluble dry compositions 有权
标题翻译：水溶性干组合物
公开(公告)号：US06337067B1
公开(公告)日：2002-01-08
申请号：US09486277
申请日：2000-02-25
申请人： Chikamasa Yamashita , Masaaki Odomi
发明人： Chikamasa Yamashita , Masaaki Odomi
IPC分类号： A61K4500
CPC分类号： A61K9/19 , A61K9/0019 , A61K47/183
摘要： Provisions of a foam inhibitor which effectively inhibits foaming (bubbling) caused at the time of dissolving dry compositions and of a water-soluble dry composition which comprises the foam inhibitor. The form inhibitor is suitable for inhibiting foaming caused at the time of dissolving dry compositions comprising saccharide which contain a hydrophobic amino acid as essential ingredient; and the water-soluble dry composition contains pharmacologically active proteinaceous substance, saccharide and hydrophobic amino acid having the hydropathy index of about not less than 2, wherein the concentration of the hydrophobic amino acid is in the range of 0.05 wt. % to less than 40 wt. % based on the total amount of the dry composition.
摘要翻译：泡沫抑制剂的设计，其有效地抑制了干燥组合物溶解时引起的起泡（起泡）和包含泡沫抑制剂的水溶性干组合物。形式抑制剂适用于在含有疏水性氨基酸作为必需成分的含有糖类的干燥组合物溶解时引起的发泡抑制; 所述水溶性干燥组合物含有药理活性蛋白质物质，亲水性指数为2以上的糖类和疏水性氨基酸，其中所述疏水性氨基酸的浓度为0.05重量％。％至小于40wt。基于干组合物的总量的％。

10. 发明授权

US06303631B1 Water-soluble eye drop 失效
标题翻译：水溶性滴眼液
公开(公告)号：US06303631B1
公开(公告)日：2001-10-16
申请号：US09582030
申请日：2000-06-21
申请人： Yuji Sugahara , Kazuya Sakata , Masaaki Odomi
发明人： Yuji Sugahara , Kazuya Sakata , Masaaki Odomi
IPC分类号： A61K3147
CPC分类号： A61K9/0048 , A61K31/4704 , A61K47/02 , A61K47/18 , A61K47/32 , Y10S514/912
摘要： A water-soluble eye drop comprising (a) at least one selected from carteolol and an acid addition salt thereof, (b) at least one acrylic polymer selected from a straight-chain type polyacrylic acid and a pharmaceutically acceptable water-soluble salt thereof, and (c) at least one selected from a water-soluble alkali metal salt and a water-soluble amine. The water soluble eye drop has a remarkably long duration time of drug efficacy, and is superior in intraocular pressure inhibition action and is effective for treatment of glaucoma.
摘要翻译：一种水溶性滴眼剂，其包含（a）选自卡多洛尔及其酸加成盐中的至少一种，（b）至少一种选自直链型聚丙烯酸及其药学上可接受的水溶性盐的丙烯酸类聚合物，和（c）选自水溶性碱金属盐和水溶性胺中的至少一种。水溶性滴眼剂药物疗效持续时间非常长，眼内压抑制作用优越，对治疗青光眼有效。

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