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1. 发明申请

US20050282168A1 Cell surface molecules as markers and therapeutic agents against kidney cancers 审中-公开
标题翻译：细胞表面分子作为肾癌的标志物和治疗剂
公开(公告)号：US20050282168A1
公开(公告)日：2005-12-22
申请号：US10671740
申请日：2003-09-29
申请人： Wei Liu , Maryann Whitley , Donna Slonim , Steven Howes
发明人： Wei Liu , Maryann Whitley , Donna Slonim , Steven Howes
IPC分类号： A61K47/48 , G01N33/574 , C12Q1/68
CPC分类号： G01N33/57438 , A61K47/6809 , A61K47/6849 , G01N2333/70596
摘要： Human cell surface molecules CD70 and CD203c are expressed at higher levels in kidney carcinomas, particularly renal cell carcinomas and clear cell renal cell carcinomas, yet are expressed at low levels in normal kidney and other diseased kidney tissue, and at low levels in other tissues. CD70 and CD203c show specificity towards kidney carcinomas, particularly renal cell carcinomas and clear cell renal cell carcinomas and thus can be used as diagnostic markers and therapeutic targets for these diseases. In addition, antibodies or small molecules against these molecules could be used in treatments towards these diseases.
摘要翻译：人类细胞表面分子CD70和CD203c在肾癌，特别是肾细胞癌和透明细胞肾细胞癌中的表达水平较高，但在正常肾脏和其他患病肾组织中表达较低，而在其他组织中呈低水平。 CD70和CD203c对肾癌，特别是肾细胞癌和透明细胞肾细胞癌具有特异性，因此可用作这些疾病的诊断标志物和治疗靶标。此外，针对这些分子的抗体或小分子可用于治疗这些疾病。

2. 发明申请

US20050014142A1 Hybridization normalization methods 审中-公开
标题翻译：杂交归一化方法
公开(公告)号：US20050014142A1
公开(公告)日：2005-01-20
申请号：US10479866
申请日：2002-06-06
申请人： Uwe Scherf , Michael Elashoff , Yasmin Beazer-Barclay , Kristen Antonellis , Scott Jelinsky , Maryann Whitley , Eugene Brown
发明人： Uwe Scherf , Michael Elashoff , Yasmin Beazer-Barclay , Kristen Antonellis , Scott Jelinsky , Maryann Whitley , Eugene Brown
IPC分类号： C12Q1/68 , C12Q1/6832 , C12Q1/6837
CPC分类号： C12Q1/6832 , C12Q1/6837 , C12Q2545/113
摘要： The present invention includes methods of normalizing hybridization reactions that are designed to select normalization control genes, specifically 5′-3′-, and middle portions of the these genes, that hybridize similarly to a probe array and that produce the most consistently linear curve of hybridization signal over a range of normalization control gene segment concentrations. These methods have applicability across a broad spectrum of hybridization formats.
摘要翻译：本发明包括归一化杂交反应的方法，其被设计用于选择归一化对照基因，特别是这些基因的5'-3'-和中间部分，其与探针阵列类似地杂交并产生最一致的线性曲线杂交信号在一系列归一化控制基因片段浓度。这些方法在广泛的杂交格式中具有适用性。

3. 发明申请

US20070031850A1 Nucleic acid arrays for detecting multiple strains of a non-viral species 审中-公开
标题翻译：用于检测非病毒物种的多种菌株的核酸阵列
公开(公告)号：US20070031850A1
公开(公告)日：2007-02-08
申请号：US10859198
申请日：2004-06-03
申请人： William Mounts , Maryann Whitley , Ellen Murphy
发明人： William Mounts , Maryann Whitley , Ellen Murphy
IPC分类号： C12Q1/68 , C12M1/34
CPC分类号： C40B30/04 , C12Q1/6837 , C12Q1/689 , C12Q2600/158 , C12Q2525/15
摘要： Nucleic acid arrays and methods of using the same for concurrent or discriminable detection of different strains of a non-viral species. In many embodiments, the nucleic acid arrays of the present invention include probes that are specific to different respective strains of a non-viral species. In many other embodiments, the nucleic acid arrays of the present invention include probes that are common to two or more different strains of the non-viral species. In one embodiment, the non-viral species is Staphylococcus aureus, and the different Staphylococcus aureus strains include COL, N315, Mu50, EMRSA-16, MSSA-476, and 8325 strains. In another embodiment, a nucleic acid array of the present invention includes polynucleotide probes capable of hybridizing under stringent or nucleic acid array hybridization conditions to respective sequences selected from SEQ ID NOs: 1 to 7,852, or the complements thereof.
摘要翻译：核酸阵列及其用于同时或可区分检测非病毒物种的不同菌株的方法。在许多实施方案中，本发明的核酸阵列包括对非病毒物种的不同相应菌株特异的探针。在许多其它实施方案中，本发明的核酸阵列包括两种或多种非病毒物种的不同菌株共有的探针。在一个实施方案中，非病毒物种是金黄色葡萄球菌，不同的金黄色葡萄球菌菌株包括COL，N315，Mu50，EMRSA-16，MSSA-476和8325菌株。在另一个实施方案中，本发明的核酸阵列包括能够在严格或核酸阵列杂交条件下与选自SEQ ID NO：1至7,852的各序列或其互补序列杂交的多核苷酸探针。

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