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1. 发明授权

US5300280A Stabilized radiopharmaceutical kits 失效
标题翻译：稳定的放射性药物包
公开(公告)号：US5300280A
公开(公告)日：1994-04-05
申请号：US836644
申请日：1992-02-14
申请人： Mark A. DeRosch , Edward A. Deutsch , Mary M. Dyszlewski , Dennis L. Nosco
发明人： Mark A. DeRosch , Edward A. Deutsch , Mary M. Dyszlewski , Dennis L. Nosco
IPC分类号： A61K51/00 , A61K51/12 , A61K43/00 , A61K31/715 , A61K49/02
CPC分类号： A61K51/1282 , A61K2121/00
摘要： The present invention relates to the stabilization of radiopharmaceutical preparations and to the stabilization of components of radiopharmaceutical kits. In particular, the present invention relates to stabilization of lyophilized components of radiopharmaceutical kits by the addition of a cyclic oligosaccharide, such as, a modified or unmodified cyclodextrin, to the kit.
摘要翻译：本发明涉及放射性药物制剂的稳定化和放射性药物试剂盒组分的稳定化。特别地，本发明涉及通过向试剂盒中加入环状寡糖例如改性或未改性的环糊精来稳定放射性药物试剂盒的冻干组分。

2. 发明授权

US5112594A Kit for preparing a technetium-99m myocardial imaging agent 失效
标题翻译：用于制备锝-99m心肌显像剂的试剂盒
公开(公告)号：US5112594A
公开(公告)日：1992-05-12
申请号：US680446
申请日：1991-04-04
申请人： Steven R. Woulfe , Edward A. Deutsch , Mary M. Dyszlewski , William L. Neumann
发明人： Steven R. Woulfe , Edward A. Deutsch , Mary M. Dyszlewski , William L. Neumann
IPC分类号： A61K51/04 , C07B59/00
CPC分类号： C07B59/004 , A61K51/0478 , A61K51/0489 , A61K2123/00
摘要： A myocardial imaging agent for use in humans comprising a Tc(III) complex ligated in a planar position by a tetradentate ligand having incorporated therein four hard atotms and two furanone rings and in the axial positions by phosphines containing dioxanyl or ether moieties. The agent exhibits improved biodistribution, improved labeling and extremely rapid blood clearance following administration to a human. The agent has high myocardial uptake accompanied with exceptionally rapid hepatobilary clearance and extensive renal clearance to give sufficiently high heart/liver and heart/lung ratio that provide nearly ideal myocardial images in humans. A kit for producing the myocardial imaging agent is provided.
摘要翻译：一种用于人的心肌显像剂，其包含通过四齿配体连接在平面位置的Tc（III）复合物，其中掺入了四个硬聚合物和两个呋喃酮环，并且在轴向位置处含有二烷基或醚部分的膦。该药物在施用于人后表现出改善的生物分布，改进的标记和极快的血液清除。该药物具有高心肌摄取，伴随着非常快速的肝胆清除和广泛的肾清除，以提供足够高的心/肝和心/肺比，其在人体中提供几乎理想的心肌图像。提供了用于制备心肌显像剂的试剂盒。

3. 发明授权

US06926883B1 Group (VII) transition-metal complexes with multidentate aminopolycarboxylate ligands and a kit for producing them 失效
标题翻译：具有多齿氨基多羧酸盐配体的（VII）族过渡金属配合物和用于制备它们的试剂盒
公开(公告)号：US06926883B1
公开(公告)日：2005-08-09
申请号：US10030741
申请日：2000-06-28
申请人： Mary M. Dyszlewski , Roger Alberto , Joseph E. Bugaj
发明人： Mary M. Dyszlewski , Roger Alberto , Joseph E. Bugaj
IPC分类号： A61K49/00 , A61K51/04 , C07F5/00 , C07F13/00
CPC分类号： C07F13/005 , A61K51/0497
摘要： The invention relates to novel aminocarboxylate ligands that are suitable for complexing with a radionuclide, and are useful as imaging agents for diagnostic purposes. In accordance with the present invention, a method of preparing a compound of formula (I): fac-[M(CO)3(OH2)3]+, wherein M is Mn, 99mTc, 186Re or 188Re, involves reacting a metal in permetallate form with carbon monoxide and a reducing agent, wherein a mixture of a basic borate buffer and a reducing agent soluble in water but not substantially decomposed by water is solved in a water containing solvent system containing a solution of the metal in permanganate, pertechnetate or perrhenate form in the presence of carbon monoxide. The compound of formula (I) can be reacted with a ligand Lx to form a compound of formula (II): fac-[M(CO)3(X)2L1]n, wherein M is as defined above Lx is a multidentate ligand, and n is a charge of the ligand Lx increased with one + charge. The invention also is directed to novel compounds, and kits for carrying out the disclosed methods.
摘要翻译：本发明涉及适用于与放射性核素络合的新型氨基羧酸酯配体，并且可用作诊断目的的成像剂。根据本发明，制备式（I）化合物的方法：fac- [M（CO）3'（OH 2）3）其中M是Mn，99m Tc，186 Re或188 Re，包括使具有一氧化碳和还原剂的多金属盐形式的金属，其中碱性硼酸盐缓冲剂和可溶于水但基本上不被水分解的还原剂的混合物溶解在含有金属溶液在高锰酸盐溶液中的含水溶剂体系中，高铁酸盐或高铼酸盐形式存在一氧化碳。式（I）化合物可以与配体L x x化合物反应以形成式（II）化合物：fac- [M（CO）3（X）其中M如上所定义，L x X是多齿配体，n是配体L x x的电荷随着+电荷而增加。本发明还涉及用于实施所公开的方法的新化合物和试剂盒。

4. 发明授权

US5112595A 99MTC(III) myocardial imaging agents and method of use 失效
标题翻译： 99MTC（III）心肌成像剂及使用方法
公开(公告)号：US5112595A
公开(公告)日：1992-05-12
申请号：US632285
申请日：1990-12-21
申请人： Steven R. Woulfe , Edward A. Deutsch , Mary M. Dyszlewski , William L. Neumann
发明人： Steven R. Woulfe , Edward A. Deutsch , Mary M. Dyszlewski , William L. Neumann
IPC分类号： A61K51/04 , C07B59/00
CPC分类号： C07B59/004 , A61K51/0478 , A61K2123/00
摘要： A myocardial imaging agent for use in humans comprising a Tc(III) complex ligated in a planar position by a tetradentate ligand having incorporated therein four hard atoms and two furanone rings and in the axial positions by phosphines containing dioxanyl or ether moieties. The agent exhibits improved biodistribution, improved labeling and extremely rapid blood clearance following administration to a human. The agent has high myocardial uptake accompanied with exceptionally rapid hepatobilary clearance and extensive renal clearance to give sufficiently high heart/liver and heart/lung ratio that provide nearly ideal myocardial images in humans.
摘要翻译：一种用于人的心肌显像剂，其包含通过四齿配体连接在平面位置的Tc（III）复合物，其四个硬原子和两个呋喃酮环，并且在轴向位置由含有二烷基或醚部分的膦。该药物在施用于人后表现出改善的生物分布，改进的标记和极快的血液清除。该药物具有高心肌摄取，伴随着非常快速的肝胆清除和广泛的肾清除，以提供足够高的心/肝和心/肺比，其在人体中提供几乎理想的心肌图像。

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