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1. 发明授权

US5843156A Local polymeric gel cellular therapy 失效
标题翻译：局部聚合物凝胶细胞疗法
公开(公告)号：US5843156A
公开(公告)日：1998-12-01
申请号：US238931
申请日：1994-05-06
申请人： Marvin Slepian , Stephen P. Massia
发明人： Marvin Slepian , Stephen P. Massia
IPC分类号： A61L27/00 , A61F2/00 , A61F2/02 , A61F2/06 , A61F2/82 , A61F2/88 , A61L24/00 , A61L24/04 , A61L24/06 , A61L27/16 , A61L27/34 , A61L27/52 , A61L27/54 , A61L27/58 , A61L29/00 , A61L31/00 , A61L31/10 , A61L31/14 , A61L31/16 , A61M25/00 , A61M29/02 , A61M35/00 , A61F2/54
CPC分类号： A61M25/104 , A61F2/062 , A61F2/82 , A61F2/88 , A61F2/95 , A61F2/958 , A61L24/0015 , A61L24/0031 , A61L24/0042 , A61L24/046 , A61L24/06 , A61L27/16 , A61L27/34 , A61L27/52 , A61L27/54 , A61L27/58 , A61L31/10 , A61L31/145 , A61L31/16 , A61M25/0043 , A61M25/1011 , A61M35/00 , A61F2210/0004 , A61F2250/0067 , A61L2300/40 , A61L2300/602 , A61L2300/606 , A61M2025/1052 , A61M2025/1095 , Y10S623/916
摘要： A method for providing a synthetic barrier made of biocompatible polymeric materials in vivo which involves application of a material to a tissue or cellular surface such as the interior surface of a blood vessel, tissue lumen or other hollow space, is disclosed herein. The material may also be applied to tissue contacting surfaces of implantable medical devices. The polymeric materials are characterized by a fluent state which allows application to and, preferably adhesion to, tissue lumen surfaces, which can be increased or altered to a second less fluent state in situ; controlled permeability and degradability; and, in the preferred embodiments, incorporation of bioactive materials for release in vivo, either to the tissue lumen surface or to the interior of the lumen, which alter cell to cell interactions.
摘要翻译：本文公开了一种用于在体内提供由生物相容性聚合物材料制成的合成屏障的方法，其涉及将材料施用于组织或细胞表面，例如血管，组织腔或其它中空空间的内表面。该材料也可以应用于可植入医疗装置的组织接触表面。聚合物材料的特征在于流动状态，其允许施用于组织内腔表面，优选粘附于组织内腔表面，其可以原位增加或改变为第二个较不流畅的状态; 控制渗透性和降解性; 并且在优选实施方案中，将用于体内释放的生物活性材料结合到组织腔表面或内腔内部，其改变细胞与细胞的相互作用。

2. 发明授权

US5575815A Local polymeric gel therapy 失效
标题翻译：局部聚合物凝胶疗法
公开(公告)号：US5575815A
公开(公告)日：1996-11-19
申请号：US132745
申请日：1993-10-06
申请人： Marvin Slepian , Stephen P. Massia
发明人： Marvin Slepian , Stephen P. Massia
IPC分类号： A61F2/00 , A61F2/02 , A61F2/06 , A61F2/82 , A61F2/84 , A61F2/88 , A61L24/00 , A61L24/04 , A61L24/06 , A61L27/16 , A61L27/34 , A61L27/52 , A61L27/54 , A61L27/58 , A61L31/10 , A61L31/14 , A61L31/16 , A61M25/00 , A61M25/10 , A61M29/02 , A61M35/00 , A61K9/22
CPC分类号： A61M29/02 , A61L24/0015 , A61L24/0031 , A61L24/0042 , A61L24/046 , A61L24/06 , A61L27/16 , A61L27/34 , A61L27/52 , A61L27/54 , A61L27/58 , A61L31/10 , A61L31/145 , A61M25/1011 , A61L2300/41 , A61L2300/42 , A61L2300/602 , A61L2300/62 , A61L2300/64 , A61M2025/0004 , A61M2025/1052 , A61M2025/1095 , Y10S623/903
摘要： A method for providing a synthetic barrier made of biocompatible polymeric materials in vivo which involves application of a material to a tissue or cellular surface such as the interior surface of a blood vessel, tissue lumen or other hollow space, is disclosed herein. The material may also be applied to tissue contacting surfaces of implantable medical devices. The polymeric materials are characterized by a fluent state which allows application to and, preferably adhesion to, tissue lumen surfaces, which can be increased or altered to a second less fluent state in situ; controlled permeability and degradability; and, in some embodiments, incorporation of bioactive materials for release in vivo, either to the tissue lumen surface or to the interior of the lumen.
摘要翻译：本文公开了一种用于在体内提供由生物相容性聚合物材料制成的合成屏障的方法，其涉及将材料施用于组织或细胞表面，例如血管，组织腔或其它中空空间的内表面。该材料也可以应用于可植入医疗装置的组织接触表面。聚合物材料的特征在于流动状态，其允许施用于组织内腔表面，优选粘附于组织内腔表面，其可以原位增加或改变为第二个较不流畅的状态; 控制渗透性和降解性; 并且在一些实施方案中，将用于体内释放的生物活性材料结合到组织腔表面或内腔内部。

3. 发明申请

US20070166347A1 Channeled endomural therapy 审中-公开
公开(公告)号：US20070166347A1
公开(公告)日：2007-07-19
申请号：US11549545
申请日：2006-10-13
申请人： Marvin Slepian
发明人： Marvin Slepian
IPC分类号： A61K35/12 , A61M25/10
CPC分类号： A61B17/3207 , A61B17/00491 , A61B17/12022 , A61B17/12186 , A61B17/1219 , A61B17/12195 , A61B17/22 , A61B18/24 , A61B2017/00247 , A61B2017/1205 , A61B2017/22077 , A61B2018/00392 , A61K35/545
摘要： Diseases, aging, trauma, environmental exposure, infection and other events or agents can alter tissue function. In one embodiment, treatment is provided by therapeutically altering tissue function. This may be by continuing normal tissue function, suppressing tissue function, or enhancing tissue function. In a preferred embodiment, this treatment is effectuated by penetrating an organ, organ component or tissue structure and placing a supplemental material in a newly created space. This space is generally referred to herein as a “privileged space”, i.e. a space not otherwise present in native tissue. Supplemental materials can be deposited and secured within the zone. Supplemental materials include materials forming barriers, supports, and/or materials that deliver agents having a pharmacologic, biochemical, or physiologic effect in vivo. Suitable supplemental materials include polymeric and non-polymeric materials, pharmacologic agents, cells, tissue fragments, microorganisms, viral agents, or other reagents modifying tissue function. The supplemental material is typically in the form of a reservoir/depot, or continuous or discontinuous layer. In one embodiment, supplemental materials, and methods of use thereof, are provided for the continuous or discontinuous therapy of defined regions of an organ, organ component or tissue structure. The supplemental materials may be delivered directly to any one or more of the three zones, endoluminal (or ectomural, for solid organs), endomural, or ectoluminal, of organs, organ components, or tissue structures. The supplemental materials can include natural or synthetic polymeric materials that are biodegradable or non-biodegradable. The supplemental materials can also contain bioactive agents to effectuate a change in an organ or organ component in need thereof. For example, agents that result in a reduced/hyponormal response or an amplified/hypernormal response may be included in the supplemental materials.

4. 发明申请

US20050192482A1 Disposable sheath for specula 审中-公开
标题翻译：镜片一次性护套
公开(公告)号：US20050192482A1
公开(公告)日：2005-09-01
申请号：US11046611
申请日：2005-01-28
申请人： Janette Carpenter , Marvin Slepian
发明人： Janette Carpenter , Marvin Slepian
IPC分类号： A61B1/00 , A61B1/32
CPC分类号： A61B1/00142 , A61B1/32
摘要： A speculum sheath which covers a speculum and methods for using the sheath are described herein. A variety of different types of specula may be covered with the sheath, including anal, vaginal, ear, and nasal specula. The sheath is made of a compliant or partially compliant material, including latex, vinyl, natural and synthetic rubbers, silicone, nylon, polyethylene, polypropylene, and non-degradable or degradable elastomers. The material may be transparent or opaque. In the preferred embodiment, the material is transparent. The sheath may contain one or two openings. Optionally, the sheath contains an affixing means on the inside of or at least one of the openings on the sheath to prevent slippage when in contact with the speculum. Optionally, the sheath contains an active agent, such as hemostatic agents, anti-infectives, antibiotics, antimitotics anti-inflammatory, or other chemotherapeutic agents. In the preferred embodiment, the sheath is placed on a vaginal speculum and supports loose vaginal tissue when inserted into a patient. In the most preferred embodiment, the material is transparent so that medical provider may view the lumen.
摘要翻译：本文描述了覆盖窥器的窥器护套和使用护套的方法。可以用护套覆盖各种不同类型的镜片，包括肛门，阴道，耳朵和鼻睑。护套由柔顺或部分顺从的材料制成，包括胶乳，乙烯基，天然和合成橡胶，硅酮，尼龙，聚乙烯，聚丙烯和不可降解或可降解的弹性体。材料可以是透明的或不透明的。在优选实施例中，材料是透明的。护套可以包含一个或两个开口。任选地，护套在护套的内部或内部的至少一个开口上包含固定装置，以防止当与窥器接触时滑动。任选地，护套含有活性剂，例如止血剂，抗感染剂，抗生素，抗抑郁药或其他化学治疗剂。在优选实施例中，鞘被放置在阴道窥器上并且当插入患者时支撑松散的阴道组织。在最优选的实施方案中，该材料是透明的，使得医疗提供者可以观察内腔。

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