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1. 发明授权

US08404806B2 Isolated BRCA1 peptides and method of use 有权
标题翻译：分离的BRCA1肽及其使用方法
公开(公告)号：US08404806B2
公开(公告)日：2013-03-26
申请号：US12849261
申请日：2010-08-03
申请人： Martina Buck
发明人： Martina Buck
IPC分类号： C07K1/00 , C07K14/00 , A61K38/00 , A61P35/00 , C07H21/02 , C07H21/04
CPC分类号： C07K14/4702 , A61K38/1709 , A61K38/1761 , C07K14/4747
摘要： The invention provides isolated peptides of a BRCA1 domain, which bind to p53 cognate DNA and stimulate transcription activities and cancer cell apoptosis. Nucleic acids encoding the peptides, and methods of expression thereof, are also provided. The invention provides pharmaceutical compositions, and methods of use thereof, for treating breast and ovarian cancer using the peptides.
摘要翻译：本发明提供BRCA1结构域的分离肽，其结合p53同源DNA并刺激转录活性和癌细胞凋亡。还提供了编码肽的核酸及其表达方法。本发明提供药物组合物及其使用方法，用于使用肽治疗乳腺癌和卵巢癌。

2. 发明申请

US20110097332A1 Composition and Method of Use for HCV Immunization 审中-公开
标题翻译：用于HCV免疫的组合物和方法
公开(公告)号：US20110097332A1
公开(公告)日：2011-04-28
申请号：US12672656
申请日：2008-08-06
申请人： Martina Buck
发明人： Martina Buck
IPC分类号： A61K39/395 , C12N9/12 , C07K16/10 , A61K39/29 , A61P37/04 , A61P31/14
CPC分类号： C07K16/40 , A61K38/00 , C07K16/109 , C07K2317/34 , C07K2317/77 , C12N9/1205
摘要： Isolated HCY E2 kinase phospho-peptides that contain one or more immunogenic fragments of a HCV E2 kinase motif and antibodies which are cross-reactive with the isolated HCV E2 kinase phospho-peptides are provided. Also disclosed are pharmaceutical compositions and/or methods to passively and/or actively immunize against HCV using the isolated HCY E2 kinase phospho-peptides and antibodies.
摘要翻译：提供了含有HCV E2激酶基序的一个或多个免疫原性片段和与分离的HCV E2激酶磷酸肽交叉反应的抗体的分离的HCY E2激酶磷酸肽。还公开了使用分离的HCY E2激酶磷酸肽和抗体被动和/或主动地免疫HCV的药物组合物和/或方法。

3. 发明申请

US20100035825A1 Treatment Of Disease By Inducing Cell Apoptosis 有权
标题翻译：通过诱导细胞凋亡来治疗疾病
公开(公告)号：US20100035825A1
公开(公告)日：2010-02-11
申请号：US12189526
申请日：2008-08-11
申请人： Mario Chojkier , Martina Buck
发明人： Mario Chojkier , Martina Buck
IPC分类号： A61K38/07 , A61P35/00
CPC分类号： A61K38/07
摘要： The present invention relates generally to the treatment and prevention of diseases characterized by excess cell proliferation and/or activation. In particular, the present invention provides compositions and methods to suppress the activation and/or proliferation of various cells. In some preferred embodiments, the present invention provides compositions and methods to suppress the activation and/or proliferation of mesenchymally derived cells (including, but not limited to hepatic stellate cells), as well as cells with abnormal growth characteristics. In some particularly preferred embodiments, the present invention provides compositions and methods to inhibit or eliminate fibrosis. In alternative preferred embodiments, the present invention provides compositions and methods to induce fibrosis. In still further embodiments, the present invention provides methods and compositions to treat and/or prevent cancer.
摘要翻译：本发明一般涉及以过量的细胞增殖和/或活化为特征的疾病的治疗和预防。特别地，本发明提供抑制各种细胞的活化和/或增殖的组合物和方法。在一些优选的实施方案中，本发明提供抑制间充质衍生细胞（包括但不限于肝星状细胞）以及具有异常生长特征的细胞的活化和/或增殖的组合物和方法。在一些特别优选的实施方案中，本发明提供抑制或消除纤维化的组合物和方法。在替代的优选实施方案中，本发明提供诱导纤维化的组合物和方法。在另外的实施方案中，本发明提供了治疗和/或预防癌症的方法和组合物。

4. 发明授权

US07655472B2 Treatment of disease by inducing cell apoptosis 失效
标题翻译：通过诱导细胞凋亡治疗疾病
公开(公告)号：US07655472B2
公开(公告)日：2010-02-02
申请号：US12166907
申请日：2008-07-02
申请人： Mario Chojkier , Martina Buck
发明人： Mario Chojkier , Martina Buck
IPC分类号： G01N33/00 , C07K16/00 , C07K17/00 , C07K5/00 , C07K14/00 , C07K2/00 , C07K4/00
CPC分类号： A61K38/1709
摘要： The present invention relates generally to the treatment and prevention of diseases characterized by excess cell proliferation and/or activation. In particular, the present invention provides compositions and methods to suppress the activation and/or proliferation of various cells. In preferred embodiments, the present invention provides compositions and methods to suppress the activation and/or proliferation of mesenchymally derived cells (including, but not limited to hepatic stellate cells), as well as cells with abnormal growth characteristics. In particularly preferred embodiments, the present invention provides compositions and methods to inhibit or eliminate fibrosis. In alternative preferred embodiments, the present invention provides compositions and methods to induce fibrosis.
摘要翻译：本发明一般涉及以过量的细胞增殖和/或活化为特征的疾病的治疗和预防。特别地，本发明提供抑制各种细胞的活化和/或增殖的组合物和方法。在优选的实施方案中，本发明提供抑制间充质衍生细胞（包括但不限于肝星状细胞）以及具有异常生长特征的细胞的活化和/或增殖的组合物和方法。在特别优选的实施方案中，本发明提供抑制或消除纤维化的组合物和方法。在替代的优选实施方案中，本发明提供诱导纤维化的组合物和方法。

5. 发明授权

US07402567B2 Treatment of disease by inducing cell apoptosis 失效
标题翻译：通过诱导细胞凋亡治疗疾病
公开(公告)号：US07402567B2
公开(公告)日：2008-07-22
申请号：US10415325
申请日：2001-10-26
申请人： Mario Chojkier , Martina Buck
发明人： Mario Chojkier , Martina Buck
IPC分类号： A61K38/00 , A61K38/43 , C07K14/00
CPC分类号： A61K38/1709
摘要： The present invention relates generally to the treatment and prevention of diseases characterized by excess cell proliferation and/or activation. In particular, the present invention provides compositions and methods to suppress the activation and/or proliferation of various cells. In preferred embodiments, the present invention provides compositions and methods to suppress the activation and/or proliferation of mesenchymally derived cells (including, but not limited to hepatic stellate cells), as well as cells with abnormal growth characteristics. In particularly preferred embodiments, the present invention provides compositions and methods to induce fibrosis.
摘要翻译：本发明一般涉及以过量的细胞增殖和/或活化为特征的疾病的治疗和预防。特别地，本发明提供抑制各种细胞的活化和/或增殖的组合物和方法。在优选的实施方案中，本发明提供抑制间充质衍生细胞（包括但不限于肝星状细胞）以及具有异常生长特征的细胞的活化和/或增殖的组合物和方法。在特别优选的实施方案中，本发明提供诱导纤维化的组合物和方法。

6. 发明授权

US06811988B2 Compositions and methods for diagnosing Alzheimer's disease 失效
标题翻译：用于诊断阿尔茨海默病的组合物和方法
公开(公告)号：US06811988B2
公开(公告)日：2004-11-02
申请号：US10278181
申请日：2002-10-21
申请人： Mario Chojkier , Martina Buck
发明人： Mario Chojkier , Martina Buck
IPC分类号： C12P1900
CPC分类号： G01N33/6896 , C07K14/4711 , C07K16/18 , G01N2333/4709 , G01N2800/2821 , G01N2800/52
摘要： The present invention provides methods and compositions for the diagnosis of Alzheimer's disease. In particular, the present invention provides modified beta-amyloid peptides, antibodies that specifically bind to the modified beta-amyloid peptides, and methods for using these compositions in the diagnosis of Alzheimer's disease, as well as methods to monitor treatment and/or disease progression of Alzheimer's disease in patients. The present invention also provides compositions and methods useful in research involving amyloid precursor protein (APP) metabolism and Alzheimer's disease.
摘要翻译：本发明提供了用于诊断阿尔茨海默病的方法和组合物。特别地，本发明提供了修饰的β-淀粉样蛋白肽，与修饰的β-淀粉样蛋白肽特异性结合的抗体，以及使用这些组合物来诊断阿尔茨海默氏病的方法，以及监测治疗和/或疾病进展的方法的阿尔茨海默病。本发明还提供了用于涉及淀粉样蛋白前体蛋白（APP）代谢和阿尔茨海默病的研究中的组合物和方法。

7. 发明申请

US20100317598A1 Isolated BRCA1 Peptides and Method of Use 有权
标题翻译：分离的BRCA1肽及其使用方法
公开(公告)号：US20100317598A1
公开(公告)日：2010-12-16
申请号：US12849261
申请日：2010-08-03
申请人： Martina Buck
发明人： Martina Buck
IPC分类号： A61K38/17 , C07K14/435 , C12N5/09 , A61P35/00
CPC分类号： C07K14/4702 , A61K38/1709 , A61K38/1761 , C07K14/4747
摘要： The invention provides isolated peptides of a BRCA1 domain, which bind to p53 cognate DNA and stimulate transcription activities and cancer cell apoptosis. Nucleic acids encoding the peptides, and methods of expression thereof, are also provided. The invention provides pharmaceutical compositions, and methods of use thereof, for treating breast and ovarian cancer using the peptides.
摘要翻译：本发明提供BRCA1结构域的分离肽，其结合p53同源DNA并刺激转录活性和癌细胞凋亡。还提供了编码肽的核酸及其表达方法。本发明提供药物组合物及其使用方法，用于使用肽治疗乳腺癌和卵巢癌。

8. 发明授权

US06495335B2 Compositions and methods for diagnosing alzheimer's disease 有权
标题翻译：用于诊断阿尔茨海默病的组合物和方法
公开(公告)号：US06495335B2
公开(公告)日：2002-12-17
申请号：US09731460
申请日：2000-12-07
申请人： Mario Chojkier , Martina Buck
发明人： Mario Chojkier , Martina Buck
IPC分类号： G01N3353
CPC分类号： G01N33/6896 , C07K14/4711 , C07K16/18 , G01N2333/4709 , G01N2800/2821 , G01N2800/52
摘要： The present invention provides methods and compositions for the diagnosis of Alzheimer's disease. In particular, the present invention provides modified beta-amyloid peptides, antibodies that specifically bind to the modified beta-amyloid peptides, and methods for using these compositions in the diagnosis of Alzheimer's disease, as well as methods to monitor treatment and/or disease progression of Alzheimer's disease in patients. The present invention also provides compositions and methods useful in research involving amyloid precursor protein (APP) metabolism and Alzheimer's disease.
摘要翻译：本发明提供了用于诊断阿尔茨海默病的方法和组合物。特别地，本发明提供了修饰的β-淀粉样蛋白肽，与修饰的β-淀粉样蛋白肽特异性结合的抗体，以及使用这些组合物来诊断阿尔茨海默氏病的方法，以及监测治疗和/或疾病进展的方法的阿尔茨海默病。本发明还提供了用于涉及淀粉样蛋白前体蛋白（APP）代谢和阿尔茨海默病的研究中的组合物和方法。

9. 发明授权

US08129349B2 Treatment of disease by inducing cell apoptosis 有权
标题翻译：通过诱导细胞凋亡治疗疾病
公开(公告)号：US08129349B2
公开(公告)日：2012-03-06
申请号：US12189526
申请日：2008-08-11
申请人： Mario Chojkier , Martina Buck
发明人： Mario Chojkier , Martina Buck
IPC分类号： A61K38/07
CPC分类号： A61K38/07
摘要： The present invention relates generally to the treatment and prevention of diseases characterized by excess cell proliferation and/or activation. In particular, the present invention provides compositions and methods to suppress the activation and/or proliferation of various cells. In some preferred embodiments, the present invention provides compositions and methods to suppress the activation and/or proliferation of mesenchymally derived cells (including, but not limited to hepatic stellate cells), as well as cells with abnormal growth characteristics. In some particularly preferred embodiments, the present invention provides compositions and methods to inhibit or eliminate fibrosis. In alternative preferred embodiments, the present invention provides compositions and methods to induce fibrosis. In still further embodiments, the present invention provides methods and compositions to treat and/or prevent cancer.
摘要翻译：本发明一般涉及以过量的细胞增殖和/或活化为特征的疾病的治疗和预防。特别地，本发明提供抑制各种细胞的活化和/或增殖的组合物和方法。在一些优选的实施方案中，本发明提供抑制间充质衍生细胞（包括但不限于肝星状细胞）以及具有异常生长特征的细胞的活化和/或增殖的组合物和方法。在一些特别优选的实施方案中，本发明提供抑制或消除纤维化的组合物和方法。在替代的优选实施方案中，本发明提供诱导纤维化的组合物和方法。在另外的实施方案中，本发明提供了治疗和/或预防癌症的方法和组合物。

10. 发明申请

US20090220490A1 Compositions and Assays for Inhibiting HCV Infection 审中-公开
标题翻译：抑制HCV感染的组成和分析
公开(公告)号：US20090220490A1
公开(公告)日：2009-09-03
申请号：US12280367
申请日：2007-02-23
申请人： Martina Buck
发明人： Martina Buck
IPC分类号： A61K39/395 , C07K2/00 , C07K16/00 , A61K38/16 , A61K38/00 , A61K39/00 , C12N5/08 , A61P31/12
CPC分类号： C07K14/47 , C07K14/005 , C12N2770/24222
摘要： The present invention provides isolated compounds, peptides, antibodies, vaccines that inhibit one or more functional domains of HCV E2 protein from interacting with associated proteins selected from the group consisting of AP-50, HSC70, Cyclin A, and Cyclin G. Pharmaceutical compositions and method of use thereof comprising the same for inhibiting HCV infection are also provided. The present invention further provides a primary hepatocyte cell culture comprising hepatocytes from a health individual and bodily fluid from a HCV infected individual, and method of use thereof, for screening compounds for inhibiting HCV infection.
摘要翻译：本发明提供分离的化合物，肽，抗体，疫苗，其抑制HCV E2蛋白的一个或多个功能结构域与选自AP-50，HSC70，细胞周期蛋白A和细胞周期蛋白G的相关蛋白相互作用。药物组合物和还提供了包含其用于抑制HCV感染的方法。本发明还提供了包含来自健康个体的肝细胞和来自HCV感染个体的体液及其使用方法的初级肝细胞培养物，用于筛选用于抑制HCV感染的化合物。

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