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1. 发明申请

US20150065508A1 INHIBITORS OF THE 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 ENZYME 有权
公开(公告)号：US20150065508A1
公开(公告)日：2015-03-05
申请号：US14226615
申请日：2014-03-26
申请人： R. Scott Bitner , Kaitlin E. Browman , Michael E. Brune , Steven Fung , Peer B. Jacobson , Lynne E. Rueter , Marina I. Strakhova , Jiahong Wang , Jyoti R. Patel , Qi Shuai , James T. Link , Jeffrey J. Rohde , Jurgen Dinges , Bryan K. Sorensen , Martin Winn , Hong Yong , Vince S. Yeh
发明人： R. Scott Bitner , Kaitlin E. Browman , Michael E. Brune , Steven Fung , Peer B. Jacobson , Lynne E. Rueter , Marina I. Strakhova , Jiahong Wang , Jyoti R. Patel , Qi Shuai , James T. Link , Jeffrey J. Rohde , Jurgen Dinges , Bryan K. Sorensen , Martin Winn , Hong Yong , Vince S. Yeh
IPC分类号： C07C235/14 , C07C235/22 , C07C271/28 , C07D295/088 , C07D207/48 , C07D257/04 , C07D401/04 , C07D261/08 , C07C237/24 , C07C311/46
CPC分类号： C07C235/14 , A61K31/165 , A61K31/19 , A61K31/4439 , C07C235/22 , C07C237/24 , C07C271/28 , C07C311/46 , C07C2601/14 , C07C2601/18 , C07C2603/74 , C07D207/48 , C07D257/04 , C07D261/08 , C07D295/088 , C07D401/04
摘要： The present invention relates to inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme and their use in treatment of non-insulin dependent type 2 diabetes, insulin resistance, obesity, lipid disorders, metabolic syndrome, central nervous system disorders, and diseases and conditions that are related to excessive glucocorticoids.

2. 发明授权

US08774554B1 Bias and plateau limited advanced contrast enhancement 有权
标题翻译：偏倚和高原限制了先进的对比度增强
公开(公告)号：US08774554B1
公开(公告)日：2014-07-08
申请号：US13352765
申请日：2012-01-18
申请人： Stuart Martin Winn
发明人： Stuart Martin Winn
IPC分类号： G06K9/00 , G06K9/40 , G06T5/40 , G06T5/50
CPC分类号： G06T5/40 , G06T5/008 , G06T5/50 , G06T2207/10016 , G06T2207/20012 , G06T2207/20021
摘要： A method of enhancing an image. This includes the steps of: dividing the image into multiple tiles and constructing a histogram for each tile, wherein the histogram represents a distribution of pixel intensity values in each tile. In addition, the method applies a bias value to the histogram and a plateau value to the histogram. A cumulative histogram is constructed after applying the bias value and the plateau value to the histogram. The method transforms each pixel in the image, by weighing four cumulative histograms, respectively, in four adjacent and closest tiles to the pixel under consideration. The pixel under consideration is modified based on a weighted cumulative histogram.
摘要翻译：一种增强图像的方法。这包括以下步骤：将图像划分成多个瓦片并为每个瓦片构建直方图，其中直方图表示每个瓦片中的像素强度值的分布。此外，该方法对直方图应用偏置值，并对直方图应用平台值。在将偏差值和平台值应用于直方图之后构建累积直方图。该方法通过将四个累积直方图分别称为所考虑的像素的四个相邻和最近的平铺中，从而对图像中的每个像素进行变换。基于加权累积直方图修改所考虑的像素。

3. 发明授权

US08716345B2 Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme 有权
标题翻译： 11-β-羟基类固醇脱氢酶1型酶的抑制剂
公开(公告)号：US08716345B2
公开(公告)日：2014-05-06
申请号：US13530422
申请日：2012-06-22
申请人： R. Scott Bitner , Kaitlin E. Browman , Michael E. Brune , Steven Fung , Peer B. Jacobson , Lynne E. Rueter , Marina I. Strakhova , Jiahong Wang , Jyoti R. Patel , Qi Shuai , James T. Link , Jeffrey J. Rohde , Jurgen Dinges , Bryan K. Sorensen , Martin Winn , Hong Yong , Vince S. Yeh
发明人： R. Scott Bitner , Kaitlin E. Browman , Michael E. Brune , Steven Fung , Peer B. Jacobson , Lynne E. Rueter , Marina I. Strakhova , Jiahong Wang , Jyoti R. Patel , Qi Shuai , James T. Link , Jeffrey J. Rohde , Jurgen Dinges , Bryan K. Sorensen , Martin Winn , Hong Yong , Vince S. Yeh
IPC分类号： A61K31/16 , C07C239/00
CPC分类号： C07C235/14 , A61K31/165 , A61K31/19 , A61K31/4439 , C07C235/22 , C07C237/24 , C07C271/28 , C07C311/46 , C07C2601/14 , C07C2601/18 , C07C2603/74 , C07D207/48 , C07D257/04 , C07D261/08 , C07D295/088 , C07D401/04
摘要： The present invention relates to inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme and their use in treatment of non-insulin dependent type 2 diabetes, insulin resistance, obesity, lipid disorders, metabolic syndrome, central nervous system disorders, and diseases and conditions that are related to excessive glucocorticoids.
摘要翻译：本发明涉及11-β-羟基类固醇脱氢酶1型酶的抑制剂及其在治疗非胰岛素依赖性2型糖尿病，胰岛素抵抗，肥胖症，脂质障碍，代谢综合征，中枢神经系统疾病和疾病中的用途，以及与过量糖皮质激素有关的病症。

4. 发明授权

US07880001B2 Inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme 有权
标题翻译： 11-β-羟基类固醇脱氢酶1型酶的抑制剂
公开(公告)号：US07880001B2
公开(公告)日：2011-02-01
申请号：US11119022
申请日：2005-04-29
申请人： James T. Link , Yixian Chen , Hwan-Soo Jae , Jyoti R. Patel , Marina A. Pliushchev , Jeffrey J. Rohde , Qi Shuai , Bryan K. Sorensen , Martin Winn , Dariusz Wodka , Hong Yong
发明人： James T. Link , Yixian Chen , Hwan-Soo Jae , Jyoti R. Patel , Marina A. Pliushchev , Jeffrey J. Rohde , Qi Shuai , Bryan K. Sorensen , Martin Winn , Dariusz Wodka , Hong Yong
IPC分类号： A61K31/496 , C07D401/04
CPC分类号： C07D213/75 , C07D205/04 , C07D207/12 , C07D209/44 , C07D211/42 , C07D231/12 , C07D239/42 , C07D277/82 , C07D295/14 , C07D307/68 , C07D403/12 , C07D413/12 , C07D487/18 , C07D491/056
摘要： The present invention relates to compounds which are inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme. The present invention further relates to the use of inhibitors of 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme for the treatment of non-insulin dependent type 2 diabetes, insulin resistance, obesity, lipid disorders, metabolic syndrome, and other diseases and conditions that are mediated by excessive glucocorticoid action.
摘要翻译：本发明涉及作为11-β-羟基类固醇脱氢酶1型酶抑制剂的化合物。本发明还涉及11-β-羟基类固醇脱氢酶1型抑制剂用于治疗非胰岛素依赖性2型糖尿病，胰岛素抵抗，肥胖症，脂质障碍，代谢综合征以及其它疾病和病症的用途由过度的糖皮质激素作用介导。

5. 发明申请

US20090131434A1 Inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme 有权
标题翻译： 11-β-羟基类固醇脱氢酶1型酶的抑制剂
公开(公告)号：US20090131434A1
公开(公告)日：2009-05-21
申请号：US12355909
申请日：2009-01-19
申请人： Michael E. Brune , Peer B. Jacobson , James T. Link , Jyoti R. Patel , Jeffrey J. Rohde , Qi Shuai , Martin Winn , Vince S. Yeh , Hong Yong
发明人： Michael E. Brune , Peer B. Jacobson , James T. Link , Jyoti R. Patel , Jeffrey J. Rohde , Qi Shuai , Martin Winn , Vince S. Yeh , Hong Yong
IPC分类号： A61K31/5377 , C07C233/01 , C07D413/02 , A61P3/10 , A61K31/16
CPC分类号： C07C233/23 , C07C235/14 , C07C237/24 , C07C255/31 , C07C255/47 , C07C259/16 , C07C311/08 , C07C311/29 , C07C311/46 , C07C311/51 , C07C317/22 , C07C317/30 , C07C317/44 , C07C323/41 , C07C323/60 , C07C2601/04 , C07C2601/14 , C07C2601/18 , C07C2602/08 , C07C2602/10 , C07C2603/74 , C07D207/48 , C07D213/64 , C07D233/64 , C07D257/04 , C07D261/08
摘要： The present invention relates to compounds which are inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme. The present invention further relates to the use of inhibitors of 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme for the treatment of non-insulin dependent type 2 diabetes, insulin resistance, obesity, lipid disorders, metabolic syndrome and other diseases and conditions that are mediated by excessive glucocorticoid action.
摘要翻译：本发明涉及作为11-β-羟基类固醇脱氢酶1型酶抑制剂的化合物。本发明还涉及11-β-羟基类固醇脱氢酶1型抑制剂用于治疗非胰岛素依赖性2型糖尿病，胰岛素抵抗，肥胖症，脂质障碍，代谢综合征和其他介导的疾病和病症的用途由过度的糖皮质激素作用。

6. 发明申请

US20090054426A1 TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS 审中-公开
标题翻译：中枢神经系统疾病的治疗
公开(公告)号：US20090054426A1
公开(公告)日：2009-02-26
申请号：US12195937
申请日：2008-08-21
申请人： R. Scott Bitner , Kaitlin E. Browman , Michael E. Brune , Yixian Chen , Jurgen Dinges , Karla Drescher , Peer Jacobson , Hwan-soo Jae , Ravi Kurukulasuriya , James T. Link , David J. Madar , Jyoti R. Patel , Marina A. Pliushchev , Jeffrey J. Rohde , Lynne E. Rueter , Qi Shuai , Bryan K. Sorensen , Jiahong Wang , Karsten M. Wicke , Martin Winn , Dariusz Wodka , Vince Yeh , Hong Yong
发明人： R. Scott Bitner , Kaitlin E. Browman , Michael E. Brune , Yixian Chen , Jurgen Dinges , Karla Drescher , Peer Jacobson , Hwan-soo Jae , Ravi Kurukulasuriya , James T. Link , David J. Madar , Jyoti R. Patel , Marina A. Pliushchev , Jeffrey J. Rohde , Lynne E. Rueter , Qi Shuai , Bryan K. Sorensen , Jiahong Wang , Karsten M. Wicke , Martin Winn , Dariusz Wodka , Vince Yeh , Hong Yong
IPC分类号： A61K31/496 , A61P25/00 , A61K31/5375 , A61K31/445 , A61K31/16
CPC分类号： C07D403/12 , A61K31/44 , A61K31/495 , C07D207/267 , C07D401/12 , C07D401/14
摘要： A method for treating a patient suffering from disorders and deficits of the central nervous system associated with diabetes, associated with aging and neurodegeneration, comprising attention deficit disorder in general, attention deficit hyperactivity disorder (ADHD), Alzheimer's disease (AD), mild cognitive impairment, senile dementia, AIDS dementia, neurodegeneration, depression, and schizophrenia, comprising administering to a patient in need of such treatment an effective amount of a selective inhibitor of the 11-β-hydroxysteroid dehydrogenase Type 1 enzyme activity.
摘要翻译：一种治疗患有与老化和神经变性相关的糖尿病中枢神经系统紊乱和缺陷的患者的方法，包括注意力缺陷障碍，注意力缺陷多动障碍（ADHD），阿尔茨海默病（AD），轻度认知障碍老年性痴呆，艾滋病痴呆，神经变性，抑郁和精神分裂症，包括向需要这种治疗的患者施用有效量的11-β-羟基类固醇脱氢酶1型酶活性的选择性抑制剂。

7. 发明申请

US20060281773A1 Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme 有权
公开(公告)号：US20060281773A1
公开(公告)日：2006-12-14
申请号：US11325965
申请日：2006-01-05
申请人： Jyoti Patel , Qi Shuai , James Link , Jeffrey Rohde , Jurgen Dinges , Bryan Sorensen , Martin Winn , Hong Yong , Vince Yeh
发明人： Jyoti Patel , Qi Shuai , James Link , Jeffrey Rohde , Jurgen Dinges , Bryan Sorensen , Martin Winn , Hong Yong , Vince Yeh
IPC分类号： A61K31/505 , A61K31/401 , A61K31/41 , A61K31/195 , A61K31/277
CPC分类号： C07C233/23 , C07C235/14 , C07C237/24 , C07C255/31 , C07C255/47 , C07C259/16 , C07C311/08 , C07C311/29 , C07C311/46 , C07C311/51 , C07C317/22 , C07C317/30 , C07C317/44 , C07C323/41 , C07C323/60 , C07C2601/04 , C07C2601/14 , C07C2601/18 , C07C2602/08 , C07C2602/10 , C07C2603/74 , C07D207/48 , C07D213/64 , C07D233/64 , C07D257/04 , C07D261/08
摘要： The present invention relates to compounds which are inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme. The present invention further relates to the use of inhibitors of 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme for the treatment of non-insulin dependent type 2 diabetes, insulin resistance, obesity, lipid disorders, metabolic syndrome and other diseases and conditions that are mediated by excessive glucocorticoid action.

8. 发明申请

US20050250768A1 Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds 审中-公开
标题翻译：细胞粘附抑制抗炎和免疫抑制化合物
公开(公告)号：US20050250768A1
公开(公告)日：2005-11-10
申请号：US10921965
申请日：2004-08-20
申请人： James Link , Gang Liu , ZhongHua Pei , Tom Geldern , Martin Winn , Zhili Xin , Steven Boyd , Gui-Dong Zhu , Jennifer Freeman , Indrani Gunawardana , Michael Staeger , Hwan-Soo Jae , John Lynch , Sheldon Wang
发明人： James Link , Gang Liu , ZhongHua Pei , Tom Geldern , Martin Winn , Zhili Xin , Steven Boyd , Gui-Dong Zhu , Jennifer Freeman , Indrani Gunawardana , Michael Staeger , Hwan-Soo Jae , John Lynch , Sheldon Wang
IPC分类号： A61K31/454 , A61K31/495 , A61K31/496 , A61K31/537 , A61K31/54 , C07C323/62 , C07D205/04 , C07D207/09 , C07D207/14 , C07D207/26 , C07D207/27 , C07D209/08 , C07D211/20 , C07D211/46 , C07D211/60 , C07D213/40 , C07D213/81 , C07D217/06 , C07D241/04 , C07D295/185 , C07D295/26 , C07D401/04 , C07D521/00
CPC分类号： C07D207/27 , A61K31/454 , A61K31/495 , A61K31/496 , A61K31/537 , A61K31/54 , C07C323/62 , C07C2601/02 , C07D205/04 , C07D207/09 , C07D207/14 , C07D209/08 , C07D211/20 , C07D211/46 , C07D211/60 , C07D213/40 , C07D213/81 , C07D217/06 , C07D231/12 , C07D233/56 , C07D241/04 , C07D249/08 , C07D295/185 , C07D295/26 , C07D401/04
摘要： The present invention relates to novel cinnamide compounds that are useful for treating inflammatory and immune diseases, to pharmaceutical compositions containing these compounds, and to methods of inhibiting inflammation or suppressing immune response in a mammal.
摘要翻译：本发明涉及可用于治疗炎症和免疫疾病的新颖的肉桂酰胺化合物，含有这些化合物的药物组合物，以及抑制哺乳动物炎症或抑制免疫反应的方法。

9. 发明申请

US20050245533A1 Inhibitors of the 11-beta-hydroxysteroid dehydrogenaseType 1 enzyme and their therapeutic application 审中-公开
标题翻译： 11-β-羟基类固醇脱氢酶1型酶的抑制剂及其治疗应用
公开(公告)号：US20050245533A1
公开(公告)日：2005-11-03
申请号：US10965239
申请日：2004-10-14
申请人： Ethan Hoff , James Link , Marina Pliushchev , Jeffrey Rohde , Martin Winn
发明人： Ethan Hoff , James Link , Marina Pliushchev , Jeffrey Rohde , Martin Winn
IPC分类号： A61K31/445 , A61K31/495 , A61K31/496
CPC分类号： A61K31/445 , A61K31/495 , A61K31/496
摘要： The present invention relates to the use of inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme. The present invention further relates to the use of inhibitors of 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme for the treatment or prophylactically treatment of non-insulin dependent type 2 diabetes, insulin resistance, obesity, lipid disorders, metabolic syndrome, and other diseases and conditions mediated by excessive glucocorticoid action.
摘要翻译：本发明涉及11-β-羟基类固醇脱氢酶1型酶抑制剂的用途。本发明还涉及11-β-羟基类固醇脱氢酶1型酶抑制剂用于治疗或预防性治疗非胰岛素依赖性2型糖尿病，胰岛素抵抗，肥胖症，脂质障碍，代谢综合征和其它疾病的用途，以及过度糖皮质激素作用介导的病症。

10. 发明授权

US06836881B2 Remote tracing of data processing nodes in an asynchronous messaging network 失效
标题翻译：远程跟踪异步消息传递网络中的数据处理节点
公开(公告)号：US06836881B2
公开(公告)日：2004-12-28
申请号：US09817832
申请日：2001-03-26
申请人： Stephen John Beynon , Brian Kenneth Mihell , Andrew Mark Swinson , Geoffrey Martin Winn
发明人： Stephen John Beynon , Brian Kenneth Mihell , Andrew Mark Swinson , Geoffrey Martin Winn
IPC分类号： G06F944
CPC分类号： H04L43/00
摘要： Remote tracing from a local data processing node of the execution of a process within an application program running on a remote data processing node in a distributed data processing network. The application program includes its own local trace facility and the nodes communicate by asynchronous messaging via mailboxes. Each node includes process-provate interrupt handling means for indicating the presence of a command for the respective process in the mailboxes.
摘要翻译：从本地数据处理节点远程跟踪在分布式数据处理网络中的远程数据处理节点上运行的应用程序中的进程执行。应用程序包括自己的本地跟踪设备，节点通过邮箱通过异步消息进行通信。每个节点包括用于指示邮箱中相应进程的命令的存在的处理证明中断处理装置。

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