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1. 发明申请

US20060246210A1 Method for making a covered drug-eluting stent 审中-公开
标题翻译：制作覆盖药物洗脱支架的方法
公开(公告)号：US20060246210A1
公开(公告)日：2006-11-02
申请号：US11119367
申请日：2005-04-29
申请人： Kobi Iki , Marshall Tsuruda , Teodoro Tecson , Angelica Alvarado , Jasbir Badesha
发明人： Kobi Iki , Marshall Tsuruda , Teodoro Tecson , Angelica Alvarado , Jasbir Badesha
IPC分类号： A61L33/00
CPC分类号： A61L31/16 , A61F2/88 , A61F2/885 , A61F2220/005 , A61F2250/0067 , A61L2300/00
摘要： A stent, having openings, is mounted onto a mandrel. An agent-containing film is applied onto the stent and the two are pressed against one another so that at least a portion of the film is pressed at least partially into the openings. The film is adhered to the stent. Any excess film is removed to create a stent/film combination which is removed from the mandrel and enclosed within a sleeve of porous material to create a covered agent-eluting stent.
摘要翻译：具有开口的支架安装在心轴上。将含药剂的膜施加到支架上，并且将两者压靠在一起，使得至少一部分膜被至少部分地压入开口中。胶片粘附在支架上。去除任何多余的膜以产生从心轴移除并封闭在多孔材料的套管内以形成覆盖剂洗脱支架的支架/膜组合。

2. 发明申请

US20070068274A1 Peripheral artery medical device durability tester and method 审中-公开
标题翻译：周边动脉医疗器械耐久性试验机及方法
公开(公告)号：US20070068274A1
公开(公告)日：2007-03-29
申请号：US11364825
申请日：2006-02-28
申请人： Jonathan Olson , Peter Rosario , Donald Cabaluna , Guruswami Ravichandran , George Hermann , Marshall Tsuruda
发明人： Jonathan Olson , Peter Rosario , Donald Cabaluna , Guruswami Ravichandran , George Hermann , Marshall Tsuruda
IPC分类号： G01N3/00
CPC分类号： A61F2/06 , A61F2/82 , A61F2240/008 , G01N3/32 , G01N2203/0005 , G01N2203/0023 , G01N2203/0028 , G01N2203/0037 , G01N2203/0073 , G01N2203/0226
摘要： Apparatus tests the durability of a peripheral artery medical device based upon anatomical loading conditions. A peripheral artery medical device is mounted to a support element, typically a hollow tube, having first and second end portions. End holding elements are mounted to a base and are secured to the first and second end portions. The apparatus further comprises means for applying a plurality of cycles of at least one of the following loading conditions to the medical device support element at the location of the peripheral artery medical device: torsion, tension/compression, bending and pinching. In some embodiments the apparatus comprises an environmental chamber housing at least the support element so to mimic the service temperature environment of the medical device. A method for testing the durability of a peripheral artery medical device based upon anatomical loading conditions is also disclosed.
摘要翻译：装置根据解剖学载荷条件测试外周动脉医疗装置的耐久性。外周动脉医疗装置安装到具有第一和第二端部的支撑元件，通常为中空管。端部保持元件安装到基座并固定到第一和第二端部。该装置还包括用于在周围动脉医疗装置的位置处向医疗装置支撑元件施加以下装载条件中的至少一个的多个循环的装置：扭转，张力/压缩，弯曲和夹紧。在一些实施例中，该装置包括至少容纳支撑元件的环境室，以模拟医疗装置的使用温度环境。还公开了一种基于解剖学载荷条件来测试外周动脉医疗装置的耐久性的方法。

3. 发明申请

US20060058870A1 Covered stent with controlled therapeutic agent diffusion 失效
标题翻译：具有受控治疗剂扩散的覆盖支架
公开(公告)号：US20060058870A1
公开(公告)日：2006-03-16
申请号：US10941064
申请日：2004-09-14
申请人： Kobi Iki , Marshall Tsuruda
发明人： Kobi Iki , Marshall Tsuruda
IPC分类号： A61F2/06
CPC分类号： A61F2/91 , A61F2/88 , A61F2250/0068
摘要： A covered stent includes a generally tubular stent body having inner and outer stent body surfaces. A sleeve of porous material encloses the stent body and has inner and outer portions opposed to the inner and outer stent body surfaces. A therapeutic agent is located along the stent body, the agent being diffusible through the material. A diffusion barrier is located between the inner material portion and the agent along the stent. The diffusion barrier prevents passage of at least a significant amount the agent through the inner portion of the sleeve of porous material. A diffusion restrictor is located between the outer portion of the sleeve of porous material and the agent along the stent. The diffusion restrictor permits passage of the agent through the inner material portion at a therapeutic level.
摘要翻译：覆盖的支架包括具有内部和外部支架体表面的大体上管状的支架体。多孔材料的套管包围支架主体并且具有与内和外支架体表面相对的内部和外部部分。治疗剂沿着支架体定位，该药剂通过该材料可扩散。扩散阻挡物沿支架位于内部材料部分和试剂之间。扩散阻挡层防止至少大量的试剂通过多孔材料套筒的内部。扩散限制器位于多孔材料套管的外部和沿着支架的试剂之间。扩散限制器允许药剂以治疗水平通过内部材料部分。

4. 发明申请

US20060058869A1 Coiled ladder stent 审中-公开
标题翻译：螺旋梯支架
公开(公告)号：US20060058869A1
公开(公告)日：2006-03-16
申请号：US10941057
申请日：2004-09-14
申请人： Jonathan Olson , Peter Rosario , Guruswami Ravichandran , Marshall Tsuruda
发明人： Jonathan Olson , Peter Rosario , Guruswami Ravichandran , Marshall Tsuruda
IPC分类号： A61F2/06
CPC分类号： A61F2/88 , A61F2/91 , A61F2/915 , A61F2002/9155
摘要： A coiled ladder stent comprises first and second rails and rungs connecting the rails. At least one rung has lower strength portion or is an enhanced flexibility rung, or both. The lower strength portion is positioned at a reduced strength fracture location along the rung so to promote any fracture of the ladder stent at the fracture location along the rung to help prevent fracture of a rail. One way to make the lower strength portion is to make the cross-sectional area of the lower strength portion less than the average cross-sectional area of the rung. The enhanced flexibility aspect helps to accommodate relative movement between the first and second rails. Doing so helps to prevent fracture of the rails and rungs. In some embodiments of the invention the enhanced flexibility rung comprises one or more nonlinear, such as generally S-shaped or generally U-shaped, portions.
摘要翻译：盘绕的梯形支架包括连接轨道的第一和第二轨道和梯级。至少一个梯级具有较低的强度部分或是增强的柔性梯级，或两者。较低强度部分位于沿着梯级的减小的强度断裂位置，以便促进梯形支架在沿着横梁的断裂位置处的任何断裂，以帮助防止轨道断裂。制造低强度部分的一种方式是使下部强度部分的横截面面积小于梯级的平均横截面面积。增强的灵活性方面有助于适应第一和第二轨道之间的相对运动。这样做有助于防止轨道和梯级断裂。在本发明的一些实施例中，增强的柔性梯级包括一个或多个非线性，例如大致S形或大致U形的部分。

5. 发明申请

US20100023056A1 TETHER-ANCHOR ASSEMBLIES 审中-公开
公开(公告)号：US20100023056A1
公开(公告)日：2010-01-28
申请号：US12505332
申请日：2009-07-17
申请人： Peter K. JOHANSSON , Marshall TSURUDA
发明人： Peter K. JOHANSSON , Marshall TSURUDA
IPC分类号： A61B17/04
CPC分类号： A61B17/0401 , A61B17/00234 , A61B17/06166 , A61B17/064 , A61B17/068 , A61B17/0682 , A61B17/072 , A61B2017/00243 , A61B2017/00783 , A61B2017/00867 , A61B2017/0409 , A61B2017/0414 , A61B2017/0437 , A61B2017/0464 , A61B2017/07221 , A61F2/2445 , Y10T29/49826
摘要： Anchors, tethers, knot configurations and other coupling mechanisms used to secure tethers to anchors or other implants are described. The knot configurations described may provide enhanced knot security and/or tensile strength, while also occupying relatively little volume. In some variations, the surfaces of a tether and/or an anchor or other implant may be at least partially coated with one or more agents and/or may be at least partially textured.
摘要翻译：描述了用于将系绳固定到锚固器或其他植入物的锚固件，系绳，结结构和其它联接机构。所描述的结结构可以提供增强的结安全性和/或拉伸强度，同时也占据相对较小的体积。在一些变型中，系链和/或锚固体或其它植入物的表面可以至少部分地涂覆有一种或多种药剂和/或可以至少部分地被纹理化。

6. 发明申请

US20060136035A1 Coiled endoluminal prosthesis system and delivery catheter 审中-公开
标题翻译：盘管腔内假体系统和输送导管
公开(公告)号：US20060136035A1
公开(公告)日：2006-06-22
申请号：US11175112
申请日：2005-07-05
申请人： George Hermann , Jonathan Olson , Marshall Tsuruda , D. Modesitt , Peter Rosario , Donald Cabaluna , Guruswami Ravichandran
发明人： George Hermann , Jonathan Olson , Marshall Tsuruda , D. Modesitt , Peter Rosario , Donald Cabaluna , Guruswami Ravichandran
IPC分类号： A61F2/06
CPC分类号： A61F2/88 , A61F2/95 , A61F2002/9511 , A61F2002/9517
摘要： A coiled endoluminal prosthesis system may include means for rotating a delivery catheter while axially releasing a coiled endoluminal prosthesis from the delivery catheter. A release element may be retracted simultaneously with rotation of the delivery catheter. The coiled endoluminal prosthesis may have a first direction of spiral in a first rotational direction. The delivery catheter may be rotated in a second rotational direction while axially releasing the coiled endoluminal prosthesis from the delivery catheter. The endoluminal prosthesis may be configured to reduce or eliminate any difference between the length of the endoluminal prosthesis when in the reduced diameter state and when in the expanded diameter state.
摘要翻译：盘绕的腔内假体系统可以包括用于旋转输送导管的装置，同时从输送导管轴向释放卷曲的腔内假体。释放元件可以在输送导管的旋转的同时被缩回。盘绕的腔内假体可具有沿第一旋转方向的第一螺旋方向。递送导管可以沿着第二旋转方向旋转，同时沿着从输送导管释放卷曲的腔内假体。腔内假体可以构造成在直径减小的状态和扩张直径状态时减小或消除内腔假体的长度之间的任何差异。

7. 发明申请

US20060136034A1 Delivery catheter and method 审中-公开
标题翻译：输送导管和方法
公开(公告)号：US20060136034A1
公开(公告)日：2006-06-22
申请号：US11175111
申请日：2005-07-05
申请人： D. Modesitt , George Hermann , Jonathan Olson , Marshall Tsuruda , Peter Rosario , Donald Cabaluna
发明人： D. Modesitt , George Hermann , Jonathan Olson , Marshall Tsuruda , Peter Rosario , Donald Cabaluna
IPC分类号： A61F2/06
CPC分类号： A61F2/88 , A61F2/95 , A61F2002/9511 , A61F2002/9517
摘要： A delivery catheter comprises a first, flexible, polymer-based tube and a second, metal tube at the first tube distal end. The second tube has flexibility enhancing relief areas along its length to provide localized areas of reduced bending stiffness to enhance the bending flexibility while retaining good torsional stiffness. A notched catheter has a lumen and a notched outer surface intersecting the lumen with a filament-containing layer adjacent to the outer surface. A part of the filament-containing layer is capturable between the notched surface portion and an elongate element extendable through the lumen. A generally helically coiled endoluminal prosthesis may be mounted on a pre-torqued delivery catheter to tighten the coiled endoluminal prosthesis onto the delivery catheter.
摘要翻译：输送导管包括在第一管远端处的第一柔性聚合物基管和第二金属管。第二个管具有灵活性，增强沿其长度的减震区域，以提供弯曲刚度降低的局部区域，以提高弯曲柔韧性，同时保持良好的扭转刚度。缺口导管具有与内腔相交的内腔和切口外表面，与外表面相邻的含有细丝的层。含有细丝的层的一部分在凹口表面部分和可通过内腔延伸的细长元件之间被遮蔽。通常螺旋卷曲的腔内假体可以安装在预扭转的输送导管上，以将盘绕的腔内假体紧固到递送导管上。

8. 发明申请

US20060136033A1 Coiled stent delivery system and method 审中-公开
标题翻译：螺旋支架输送系统及方法
公开(公告)号：US20060136033A1
公开(公告)日：2006-06-22
申请号：US11018563
申请日：2004-12-20
申请人： George Hermann , Jonathan Olson , Marshall Tsuruda
发明人： George Hermann , Jonathan Olson , Marshall Tsuruda
IPC分类号： A61F2/06
CPC分类号： A61F2/88 , A61F2/95 , A61F2002/9511
摘要： A coiled endoluminal prosthesis delivery assembly includes a catheter and a generally helical endoluminal prosthesis. The endoluminal prosthesis is placeable in a radially contracted state on the catheter. The assembly also comprises means for engaging proximal, intermediate and distal portions of the endoluminal prosthesis to maintain it in the first state, and means for controllably releasing the proximal, distal and intermediate portions to permit the endoluminal prosthesis to move towards a radially expanded state in a controlled manner. A method controllably releases the endoluminal prosthesis from the catheter within a hollow body structure. The method may include permitting at most 50%, and more preferably at most 25%, of the length of the endoluminal prosthesis to simultaneously move to the radially expanded state in contact with the hollow body structure.
摘要翻译：盘管腔内假体输送组件包括导管和大体上螺旋的腔内假体。腔内假体可放置在导管上的径向收缩状态。组件还包括用于接合内腔假体的近端部分，中间部分和远端部分以将其保持在第一状态的装置，以及用于可控制地释放近端部分，远端部分和中间部分的装置，以允许内腔假体向径向膨胀状态移动受控的方式。一种方法在空心体结构内可控地从导管释放内腔假体。该方法可以包括允许内腔假体的长度的至多50％，更优选至多25％同时移动到与中空体结构接触的径向膨胀状态。

9. 发明申请

US20070219616A1 Notched catheter 审中-公开
标题翻译：缺口导管
公开(公告)号：US20070219616A1
公开(公告)日：2007-09-20
申请号：US11748913
申请日：2007-05-15
申请人： D. Modesitt , George Hermann , Jonathan Olson , Marshall Tsuruda , Peter Rosario , Donald Cabaluna
发明人： D. Modesitt , George Hermann , Jonathan Olson , Marshall Tsuruda , Peter Rosario , Donald Cabaluna
IPC分类号： A61F2/06
CPC分类号： A61F2/88 , A61F2/95 , A61F2002/9511 , A61F2002/9517
摘要： A notched catheter has a lumen and a notched outer surface intersecting the lumen with a filament-containing layer adjacent to the outer surface. A part of the filament-containing layer is capturable between the notched surface portion and an elongate element extendable through the lumen.
摘要翻译：缺口导管具有与内腔相交的内腔和切口外表面，与外表面相邻的含有细丝的层。含有细丝的层的一部分在凹口表面部分和可通过内腔延伸的细长元件之间被遮蔽。

10. 发明授权

US07063720B2 Covered stent with controlled therapeutic agent diffusion 失效
公开(公告)号：US07063720B2
公开(公告)日：2006-06-20
申请号：US10941064
申请日：2004-09-14
申请人： Kobi Iki , Marshall Tsuruda
发明人： Kobi Iki , Marshall Tsuruda
IPC分类号： A61F2/06
CPC分类号： A61F2/91 , A61F2/88 , A61F2250/0068
摘要： A covered stent includes a generally tubular stent body having inner and outer stent body surfaces. A sleeve of porous material encloses the stent body and has inner and outer portions opposed to the inner and outer stent body surfaces. A therapeutic agent is located along the stent body, the agent being diffusible through the material. A diffusion barrier is located between the inner material portion and the agent along the stent. The diffusion barrier prevents passage of at least a significant amount the agent through the inner portion of the sleeve of porous material. A diffusion restrictor is located between the outer portion of the sleeve of porous material and the agent along the stent. The diffusion restrictor permits passage of the agent through the inner material portion at a therapeutic level.

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