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1. 发明申请

US20110033852A1 PRESENT INVENTION RELATES TO METHODS FOR PREDICTION OF THE THERAPEUTIC SUCCESS OF BREAST CANCER THERAPY 审中-公开
标题翻译：本发明涉及用于预测乳腺癌治疗效果的方法
公开(公告)号：US20110033852A1
公开(公告)日：2011-02-10
申请号：US12745110
申请日：2008-11-14
申请人： Ralph Markus Wirtz , Karin Milde-Langosch , Maike Ihnen , Christine Schroder
发明人： Ralph Markus Wirtz , Karin Milde-Langosch , Maike Ihnen , Christine Schroder
IPC分类号： C12Q1/68 , C07K16/18 , C07H21/00 , A61K38/18
CPC分类号： G01N33/57442 , C12Q1/6886 , C12Q2600/106 , G01N33/57411 , G01N33/57415 , G01N33/57449 , G01N2333/485 , G01N2333/51 , G01N2333/70546 , G01N2333/96411 , G01N2800/52
摘要： The present invention relates to a method for predicting a clinical response of a patient suffering from or at risk of developing gynecologic cancer towards a given mode of treatment, said method comprising the steps of: a) obtaining a biological sample from said patient; b) determining the expression level of at least one gene selected from the group comprising ALCAM, Osteopontin, Her-2/neu, EGFR, uPA/PAI-1 and/or ESR1, in particular of ALCAM and/or Osteopontin, in said sample; c) comparing the pattern of expression level (s) determined in (b) with one or several reference pattern (s) of expression levels; and d) predicting therapeutic success for said given mode of treatment in said patient or implementing therapeutic regimen in said patient from the outcome of the comparison in step (c).
摘要翻译：本发明涉及一种用于预测患有或处于发展妇科癌症风险的患者的临床反应朝向给定治疗方式的方法，所述方法包括以下步骤：a）从所述患者获得生物样品; b）确定所述样品中至少一种选自ALCAM，骨桥蛋白，Her-2 / neu，EGFR，uPA / PAI-1和/或ESR1，特别是ALCAM和/或骨桥蛋白的基因的表达水平 ; c）将（b）中确定的表达水平的模式与一种或多种表达水平的参考模式进行比较; 以及d）根据步骤（c）中的比较结果预测所述患者中所述给定治疗方式的治疗成功或实施所述患者的治疗方案。

2. 发明申请

US20080311567A1 Tumor Markers for Use in the Diagnosis of Colorectal Carcinomas and/or Metastases Originating Therefrom 审中-公开
标题翻译：肿瘤标志物用于诊断结肠直肠癌和/或转移起源于其中
公开(公告)号：US20080311567A1
公开(公告)日：2008-12-18
申请号：US11659250
申请日：2005-07-29
申请人： Wolfgang Michael Bruckl , Axel Wein , Marc Munnes , Ralph Markus Wirtz
发明人： Wolfgang Michael Bruckl , Axel Wein , Marc Munnes , Ralph Markus Wirtz
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/158
摘要： The invention relates to a method (i) for detecting a carcinoma, especially an adenocarcinoma, preferably a gastrointestinal carcinoma and more preferably a colorectal carcinoma, (ii) for predicting metastases, preferably liver metastases, depending on a primary colon carcinoma and/or (iii) for predicting the response of metastases to a 5-fluorouracil-containing chemotherapy. The inventive method comprises determining a gene expression profile of 120 marker genes or a selection thereof.
摘要翻译：本发明涉及一种用于检测癌症，特别是腺癌，优选胃肠癌，更优选结肠直肠癌的方法（i），（ii）根据原发性结肠癌和/或（...）的预测转移，优选肝转移， iii）预测转移至含有5-氟尿嘧啶的化疗的反应。本发明的方法包括确定120个标记基因的基因表达谱或其选择。

3. 发明申请

US20080261227A1 Kinetic Pcr Assay for Quantification of Gene Amplification on Chromosome 17 审中-公开
标题翻译：用于定量染色体17上的基因扩增的动力学Pcr测定
公开(公告)号：US20080261227A1
公开(公告)日：2008-10-23
申请号：US12093603
申请日：2006-11-28
申请人： Lu Ping Shen , Marc Munnes , Ralph Markus Wirtz , Daryn Kenny , Charlene E. Bush-Donovan
发明人： Lu Ping Shen , Marc Munnes , Ralph Markus Wirtz , Daryn Kenny , Charlene E. Bush-Donovan
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/16
摘要： Provided is a kinetic PCR (“kPCR”) assay for determining gene copy number of a target gene located on chromosome 17. The kPCR assay uses the MMP-28 gene located at the 17q11.2-17q12 loci as a control and thus, is capable of detecting gene copy number of any gene on chromosome 17 in both singleplex and multiplex format without the need for a standard curve. The kPCR assay is useful for determining the gene copy number of the HER2/neu gene located at loci 17q12-17q21.32, which is a requirement for determining if a breast cancer patient is a candidate for anti-HER2/neu gene therapy.
摘要翻译：提供了用于确定位于染色体17上的靶基因的基因拷贝数的动力学PCR（“kPCR”）测定.kPCR测定使用位于17q11.2-17q12位点的MMP-28基因作为对照，因此是能够以单一和多重格式检测染色体17上的任何基因的基因拷贝数，而不需要标准曲线。 kPCR测定可用于确定位于位点17q12-17q21.32处的HER2 / neu基因的基因拷贝数，这是确定乳腺癌患者是否为抗HER2 / neu基因治疗的候选者的要求。

4. 发明授权

US09932639B2 Method for predicting therapy responsiveness in basal like tumors 有权
公开(公告)号：US09932639B2
公开(公告)日：2018-04-03
申请号：US12745668
申请日：2008-11-06
申请人： Ralph Markus Wirtz , Ralf Kronenwett
发明人： Ralph Markus Wirtz , Ralf Kronenwett
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158
摘要： The present invention is related to a method for analyzing a clinical response of a patient suffering from or at risk of developing a neoplastic disease towards at least one given mode of treatment, said method comprising the steps of: a) obtaining a biological sample from said patient; b) determining, on a non protein basis, the expression level of three genes of interest, said genes being correlated with the Estrogen receptor (ESR) status in the sample, c) comparing the pattern of expression levels determined in (b) with one or several reference pattern(s) of expression levels; and d) predicting therapeutic success for said given mode of treatment in said patient from the outcome of the comparison in step (c); and treating based on said outcome.

5. 发明申请

US20140221638A1 MATRIX AND METHOD FOR PURIFYING AND/OR ISOLATING NUCLEIC ACIDS 审中-公开
标题翻译：用于净化和/或分离核酸的基质和方法
公开(公告)号：US20140221638A1
公开(公告)日：2014-08-07
申请号：US14166759
申请日：2014-01-28
申请人： Ralph Markus Wirtz
发明人： Ralph Markus Wirtz
IPC分类号： C12N15/10
CPC分类号： C12N15/101 , C12N15/1006 , C12Q2563/137 , C12Q2563/143 , C12Q2563/155
摘要： The present invention relates to matrix materials suitable for use in purifying and/or isolating nucleic acids from a biological sample, which matrix comprises a surface comprising at least one element selected from the group consisting of Germanium, Tin and/or Lead, or at least one salt thereof, and methods related therewith.
摘要翻译：本发明涉及适用于纯化和/或分离来自生物样品的核酸的基质材料，该基质包含包含至少一种选自锗，锡和/或铅的元素的表面，或至少一种盐及其相关方法。

6. 发明授权

US08747839B2 Tracking of bone marrow cells for metastasis screening 失效
标题翻译：跟踪骨髓细胞进行转移筛选
公开(公告)号：US08747839B2
公开(公告)日：2014-06-10
申请号：US12974214
申请日：2010-12-21
申请人： Christian Geppert , Arne Hengerer , Sven Meyburg , Sebastian Schmidt , Susanne Schmolke , Ralph Markus Wirtz
发明人： Christian Geppert , Arne Hengerer , Sven Meyburg , Sebastian Schmidt , Susanne Schmolke , Ralph Markus Wirtz
IPC分类号： A01N63/02 , A61K35/32 , A61K51/02 , A61B5/055
CPC分类号： G01N33/574 , A61K49/1896 , A61K51/1203 , C12N5/0669 , C12N2503/00
摘要： At least one embodiment of the invention relates to bone marrow precursor cells or bone marrow cells of a patient, the cells labeled with at least one contrast agent suitable for an imaging method, for use in an imaging method for diagnosing a metastasizing cancer, wherein the local accumulation of the labeled precursor cells or bone marrow cells indicates the presence of a metastasizing tumor growth. At least one embodiment also relates to a method for imaging a metastasizing tumor tissue in a patient, wherein a) bone marrow precursor cells or bone marrow cells are extracted from a patient, b) these precursor cells or bone marrow cells are labeled with at least one contrast agent suitable for an imaging method, c) the precursor cells or bone marrow cells thus labeled are retransplanted or reinjected into the patient, and d) the presence of metastasizing tumor cells is depicted with an imaging method. At least one embodiment also relates a method for imaging a metastasizing tumor tissue, wherein a suitable imaging method is used to image bone marrow precursor cells and/or bone marrow cells that are accumulated in a metastasizing tumor tissue and labeled with at least one contrast agent suitable for an imaging method.
摘要翻译：本发明的至少一个实施方案涉及患者的骨髓前体细胞或骨髓细胞，所述细胞用适于成像方法的至少一种造影剂标记，用于诊断转移性癌症的成像方法，其中标记的前体细胞或骨髓细胞的局部积累表明存在转移性肿瘤生长。至少一个实施方案还涉及用于对患者的转移性肿瘤组织进行成像的方法，其中a）从患者中提取骨髓前体细胞或骨髓细胞，b）至少标记这些前体细胞或骨髓细胞一种适用于成像方法的造影剂，c）将如此标记的前体细胞或骨髓细胞重新移植或重新注入患者体内，d）用成像方法描绘转移肿瘤细胞的存在。至少一个实施方案还涉及用于成像转移肿瘤组织的方法，其中使用合适的成像方法来成像骨髓前体细胞和/或骨髓细胞，所述骨髓前体细胞和/或骨髓细胞积聚在转移肿瘤组织中并用至少一种造影剂适合成像方法。

7. 发明申请

US20110229414A1 Contrast Agents For Detecting Protease Activity By Means Of Hyperpolarization And For Stratifying Patients 审中-公开
标题翻译：用于通过超极化和分层患者检测蛋白酶活性的对比剂
公开(公告)号：US20110229414A1
公开(公告)日：2011-09-22
申请号：US13013127
申请日：2011-01-25
申请人： Christian Geppert , Arne Hengerer , Sven Meyburg , Sebastian Schmidt , Susanne Schmolke , Ralph Markus Wirtz
发明人： Christian Geppert , Arne Hengerer , Sven Meyburg , Sebastian Schmidt , Susanne Schmolke , Ralph Markus Wirtz
IPC分类号： A61K49/08 , C07K2/00 , A61K49/00 , C07K7/06 , A61P43/00
CPC分类号： A61K49/06
摘要： A contrast agent is disclosed for imaging methods. In at least one embodiment the contrast agent includes a construct including i) at least two copies of a substrate for at least one tumor-specific protease, and ii) at least one linker having at least one recognition site for at least one tumor-specific protease, wherein a hyperpolarization site is located at the N and/or C terminus of the substrate, and wherein the linker is configured such that the hydrophobic ends of the substrate interact and form a central core by means of noncovalent interactions with the lipophilic residues, and the contrast agent together with a parahydrogen metal template for use in an imaging method for diagnosing a tumor. At least one embodiment of the invention further relates to a method for imaging a tumor tissue, wherein the above-described contrast agent accumulated in a tumor tissue is imaged using a suitable imaging method after hyperpolarization by way of contact with a parahydrogen metal template, and also to a method for imaging a tumor tissue in a patient, wherein a) a contrast agent as described above is administered to a patient, b) a parahydrogen metal template is administered to the patient, and c) the presence of a tumor is depicted using an imaging method.
摘要翻译：公开了用于成像方法的造影剂。在至少一个实施方案中，造影剂包括构建体，其包括i）用于至少一种肿瘤特异性蛋白酶的底物的至少两个拷贝，和ii）至少一个具有至少一个肿瘤特异性的识别位点的接头蛋白酶，其中超极化位点位于底物的N和/或C末端，并且其中接头被配置为使得底物的疏水末端通过与亲脂性残基的非共价相互作用相互作用并形成中心核心，和造影剂以及用于诊断肿瘤的成像方法中的副氢金属模板。本发明的至少一个实施方案还涉及一种用于对肿瘤组织进行成像的方法，其中通过与超临界金属模板的接触在超极化之后，使用合适的成像方法将累积在肿瘤组织中的上述造影剂成像，并且还涉及对患者的肿瘤组织进行成像的方法，其中a）对患者施用如上所述的造影剂，b）向患者施用副氢金属模板，和c）描绘肿瘤的存在使用成像方法。

8. 发明申请

US20110150758A1 TRACKING OF BONE MARROW CELLS FOR METASTASIS SCREENING 失效
标题翻译：跟踪用于METASTASIS筛选的骨髓细胞
公开(公告)号：US20110150758A1
公开(公告)日：2011-06-23
申请号：US12974214
申请日：2010-12-21
申请人： Christian Geppert , Arne Hengerer , Sven Meyburg , Sebastian Schmidt , Susanne Schmolke , Ralph Markus Wirtz
发明人： Christian Geppert , Arne Hengerer , Sven Meyburg , Sebastian Schmidt , Susanne Schmolke , Ralph Markus Wirtz
IPC分类号： A61K51/02 , C12N5/071 , A61K49/08 , C12Q1/02 , B82Y15/00
CPC分类号： G01N33/574 , A61K49/1896 , A61K51/1203 , C12N5/0669 , C12N2503/00
摘要： At least one embodiment of the invention relates to bone marrow precursor cells or bone marrow cells of a patient, the cells labeled with at least one contrast agent suitable for an imaging method, for use in an imaging method for diagnosing a metastasizing cancer, wherein the local accumulation of the labeled precursor cells or bone marrow cells indicates the presence of a metastasizing tumor growth. At least one embodiment also relates to a method for imaging a metastasizing tumor tissue in a patient, wherein a) bone marrow precursor cells or bone marrow cells are extracted from a patient, b) these precursor cells or bone marrow cells are labeled with at least one contrast agent suitable for an imaging method, c) the precursor cells or bone marrow cells thus labeled are retransplanted or reinjected into the patient, and d) the presence of metastasizing tumor cells is depicted with an imaging method. At least one embodiment also relates a method for imaging a metastasizing tumor tissue, wherein a suitable imaging method is used to image bone marrow precursor cells and/or bone marrow cells that are accumulated in a metastasizing tumor tissue and labeled with at least one contrast agent suitable for an imaging method.
摘要翻译：本发明的至少一个实施方案涉及患者的骨髓前体细胞或骨髓细胞，所述细胞用适于成像方法的至少一种造影剂标记，用于诊断转移性癌症的成像方法，其中标记的前体细胞或骨髓细胞的局部积累表明存在转移性肿瘤生长。至少一个实施方案还涉及用于对患者的转移性肿瘤组织进行成像的方法，其中a）从患者中提取骨髓前体细胞或骨髓细胞，b）至少标记这些前体细胞或骨髓细胞一种适用于成像方法的造影剂，c）将如此标记的前体细胞或骨髓细胞重新移植或重新注入患者体内，d）用成像方法描绘转移肿瘤细胞的存在。至少一个实施方案还涉及用于成像转移肿瘤组织的方法，其中使用合适的成像方法来成像骨髓前体细胞和/或骨髓细胞，所述骨髓前体细胞和/或骨髓细胞积聚在转移肿瘤组织中并用至少一种造影剂适合成像方法。

9. 发明申请

US20110039275A1 Method for Predicting a Clinical Response of a Patient Suffering from or at Risk of Developing Cancer Towards a Given Mode of Treatment 有权
标题翻译：预测发展中癌症患者或患有治疗风险的患者的临床反应的方法
公开(公告)号：US20110039275A1
公开(公告)日：2011-02-17
申请号：US12989969
申请日：2009-03-27
申请人： Ralph Markus Wirtz , Wolfgang Michael Bruckl
发明人： Ralph Markus Wirtz , Wolfgang Michael Bruckl
IPC分类号： C12Q1/68 , G01N33/53 , C07H21/04
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/112
摘要： The present invention relates to a method for predicting a clinical response of a patient suffering from or at risk of developing cancer, preferably colorectal cancer, towards a given mode of treatment, said method comprising the steps of: a) obtaining a biological sample from said patient; b) determining the expression level of at least SPON-2, and optionally determining the expression level of SPON-1, in said sample; c) comparing the expression level or expression levels determined in (b) with one or several reference expression levels; and d) predicting therapeutic success for said given mode of treatment in said patient or implementing therapeutic regimen in said subject from the outcome of the comparison in step (C).
摘要翻译：本发明涉及一种用于预测患有或具有发展癌症（优选结肠直肠癌）的风险的患者对于给定治疗方式的临床反应的方法，所述方法包括以下步骤：a）从所述方法获得生物样品患者; b）确定所述样品中至少SPON-2的表达水平，并任选地确定SPON-1的表达水平; c）将（b）中测定的表达水平或表达水平与一个或多个参考表达水平进行比较; 以及d）根据步骤（C）中比较的结果预测所述患者中所述给定治疗方式的治疗成功或实施所述受试者的治疗方案。

10. 发明授权

US09683229B2 Matrix and method for purifying and/or isolating nucleic acids 有权
公开(公告)号：US09683229B2
公开(公告)日：2017-06-20
申请号：US14166759
申请日：2014-01-28
申请人： Ralph Markus Wirtz
发明人： Ralph Markus Wirtz
IPC分类号： C07H21/00 , C01G49/08 , C04B35/26 , C04B35/64 , C12N15/10
CPC分类号： C12N15/101 , C12N15/1006 , C12Q2563/137 , C12Q2563/143 , C12Q2563/155
摘要： The present invention relates to matrix materials suitable for use in purifying and/or isolating nucleic acids from a biological sample, which matrix comprises a surface comprising at least one element selected from the group consisting of Germanium, Tin and/or Lead, or at least one salt thereof, and methods related therewith.

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