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1. 发明授权

US5624794A Method for extending the useful shelf-life of refrigerated red blood cells by flushing with inert gas 失效
标题翻译：通过用惰性气体冲洗来延长冷藏红细胞的有效保质期的方法
公开(公告)号：US5624794A
公开(公告)日：1997-04-29
申请号：US473675
申请日：1995-06-05
申请人： Mark W. Bitensky , Tatsuro Yoshida
发明人： Mark W. Bitensky , Tatsuro Yoshida
IPC分类号： A01N1/02 , A61K35/18 , A61M37/00
CPC分类号： A01N1/0226 , A01N1/02
摘要： Method using oxygen removal for extending the useful shelf-life of refrigerated red blood cells. A cost-effective, 4.degree. C. storage procedure that preserves red cell quality and prolongs post-transfusion in vivo survival is described. Preservation of adenosine triphosphate levels and reduction in hemolysis and in membrane vesicle production of red blood cells stored at 4.degree. C. for prolonged periods of time is achieved by removing oxygen therefrom at the time of storage; in particular, by flushing with an inert gas. Adenosine triphosphate levels of the stored red blood cells are boosted in some samples by addition of ammonium phosphate.
摘要翻译：使用除氧方法延长冷藏红细胞的有用保质期的方法。描述了保持红细胞质量并延长输血后体内存活的成本有效的4℃储存方法。通过在储存时从其中除去氧气来实现长时间保存在4℃下储存的红细胞溶血和膜囊泡生成中三磷酸腺苷水平的降低和膜囊泡生成。特别是用惰性气体冲洗。通过添加磷酸铵在一些样品中促进存储的红细胞的腺苷三磷酸水平。

2. 发明授权

US08071282B2 Method of storing red blood cells with an acidic additive solution under oxygen depletion 有权
标题翻译：在氧气耗尽下用酸性添加剂溶液储存红细胞的方法
公开(公告)号：US08071282B2
公开(公告)日：2011-12-06
申请号：US11128576
申请日：2005-05-13
申请人： Mark W Bitensky , Tatsuro Yoshida
发明人： Mark W Bitensky , Tatsuro Yoshida
IPC分类号： A01N1/02
CPC分类号： C12N5/0641 , A01N1/02 , A01N1/0226
摘要： There is provided compositions and methods for the storage of red blood cells. The compositions are additive solutions comprising adenine, dextrose, mannitol, NaH2PO4, and optionally NaCl and/or NH4Cl. Composition are preferably used with oxygen-depletion refrigerated storage of red blood cells and may optionally be employed with nutrient supplements extending the useful shelf life of stored blood.
摘要翻译：提供了用于储存红细胞的组合物和方法。组合物是包含腺嘌呤，葡萄糖，甘露醇，NaH 2 PO 4和任选的NaCl和/或NH 4 Cl的添加剂溶液。组合物优选用于红细胞的耗氧冷藏储存，并且可以任选地与延长储存血液的有用保质期的营养补充剂一起使用。

3. 发明授权

US07517453B2 Microvascular network device 有权
标题翻译：微血管网络装置
公开(公告)号：US07517453B2
公开(公告)日：2009-04-14
申请号：US10377178
申请日：2003-03-01
申请人： Mark W Bitensky , Tatsuro Yoshida , Sergey S Shevkoplyas
发明人： Mark W Bitensky , Tatsuro Yoshida , Sergey S Shevkoplyas
IPC分类号： G01N35/08 , G01N21/00 , B01D61/00 , G01N35/00
CPC分类号： B01L3/5027 , B01L2300/0861 , B01L2300/123 , G01N11/08 , Y10T436/11 , Y10T436/119163 , Y10T436/2575
摘要： A microvascular network device comprising: a substrate; at least one microchannel; at least one opening to the microchannel for sample entry; at least one opening to the microchannel for sample exit; and an aspirator which causes the sample to traverse the microchannel.
摘要翻译：一种微血管网络装置，包括：基底; 至少一个微通道; 至少一个通向微通道的开口用于进样; 至少一个开口到微通道用于样品出口; 以及使样品穿过微通道的吸气器。

4. 发明授权

US06946127B2 Decorated red blood cells 失效
标题翻译：装饰红细胞
公开(公告)号：US06946127B2
公开(公告)日：2005-09-20
申请号：US10211402
申请日：2002-08-02
申请人： Mark W. Bitensky , Tatsuro Yoshida
发明人： Mark W. Bitensky , Tatsuro Yoshida
IPC分类号： C12N5/06 , A61K9/50 , A61K35/18 , A61K47/48 , A61P43/00 , C12N5/08 , A01N63/00
CPC分类号： A61K35/18 , A61K9/5068 , A61K47/6901
摘要： Disclosed are modified red blood cells which function as deployment platforms for important biomolecules. Such modified red blood cells can confer, for example, in vivo protection against exposure to an otherwise lethal nerve agent.
摘要翻译：公开了用作重要生物分子的部署平台的改良红细胞。这种修饰的红细胞可以赋予例如体内保护以免暴露于另外的致死神经药物。

5. 发明授权

US6162396A Blood storage device and method for oxygen removal 失效
标题翻译：血液储存装置及除氧方法
公开(公告)号：US6162396A
公开(公告)日：2000-12-19
申请号：US847859
申请日：1997-04-26
申请人： Mark W. Bitensky , Tatsuro Yoshida
发明人： Mark W. Bitensky , Tatsuro Yoshida
IPC分类号： A61J1/00 , A61J1/05 , A61M1/02 , A61M1/14
CPC分类号： A61M1/0209 , A61J1/10
摘要： The present invention relates to a storage device and method for the long-term storage of blood and, more particularly, to a blood storage device and method capable of removing oxygen from the stored blood and thereby prolonging the storage life of the deoxygenated blood.
摘要翻译：本发明涉及一种用于长期储存血液的储存装置和方法，更具体地涉及一种能够从储存的血液中除去氧气并从而延长脱氧血液的储存寿命的血液储存装置和方法。

6. 发明授权

US5789151A Prolonged cold storage of red blood cells by oxygen removal and additive usage 失效
标题翻译：通过除氧和添加剂使用长期冷藏红细胞
公开(公告)号：US5789151A
公开(公告)日：1998-08-04
申请号：US857474
申请日：1997-05-15
申请人： Mark W. Bitensky , Tatsuro Yoshida
发明人： Mark W. Bitensky , Tatsuro Yoshida
IPC分类号： A61K35/18 , A01N1/00 , A01N1/02 , A61K35/14 , A61M37/00
CPC分类号： A01N1/02 , A01N1/0226 , A61M2202/0429
摘要： Prolonged cold storage of red blood cells by oxygen removal and additive usage. A cost-effective, 4.degree. C. storage procedure that preserves red cell quality and prolongs post-transfusion in vivo survival is described. The improved in vivo survival and the preservation of adenosine triphosphate levels, along with reduction in hemolysis and membrane vesicle production of red blood cells stored at 4.degree. C. for prolonged periods of time, is achieved by reducing the oxygen level therein at the time of storage; in particular, by flushing the cells with an inert gas, and storing them in an aqueous solution which includes adenine, dextrose, mannitol, citrate ion, and dihydrogen phosphate ion, but no sodium chloride, in an oxygen-permeable container which is located in an oxygen-free environment containing oxygen-scavenging materials.
摘要翻译：通过除氧和添加剂使用长期冷藏红细胞。描述了保持红细胞质量并延长输血后体内存活的成本有效的4℃储存方法。通过改善体内存活和三磷酸腺苷水平的保持，以及在4℃下储存的红细胞的溶血和膜囊泡产生减少延长的时间段，可以通过降低其中的氧水平来实现存储; 特别是通过用惰性气体冲洗细胞并将它们储存在含有腺嘌呤，葡萄糖，甘露糖醇，柠檬酸根离子和磷酸二氢根离子但不含氯化钠的水溶液中，该容器位于含氧清除材料的无氧环境。

7. 发明申请

US20120077182A1 ADDITIVE SOLUTION FOR BLOOD PRESERVATION 审中-公开
标题翻译：用于血液保存的补充溶液
公开(公告)号：US20120077182A1
公开(公告)日：2012-03-29
申请号：US13310289
申请日：2011-12-02
申请人： MARK W. BITENSKY , Tatsuro Yoshida
发明人： MARK W. BITENSKY , Tatsuro Yoshida
IPC分类号： C12N5/078
CPC分类号： C12N5/0641 , A01N1/02 , A01N1/0226
摘要： A method for the storage of red blood cells provides for mixing an additive solution with packed red blood cells to create a suspension of red blood cells. The method further provides for reducing the oxygen in the suspension of red blood cells; and storing the suspension of red blood cells under oxygen-depleted storage.
摘要翻译：用于储存红细胞的方法提供将添加剂溶液与填充的红细胞混合以产生红细胞的悬浮液。该方法进一步提供了减少红细胞悬浮液中的氧气; 并将红细胞的悬浮液储存在耗尽氧的存储下。

8. 发明授权

US07723017B2 Method for extending the useful shelf-life of refrigerated red blood cells by nutrient supplementation 有权
标题翻译：通过营养补充来延长冷藏红细胞的有效保质期的方法
公开(公告)号：US07723017B2
公开(公告)日：2010-05-25
申请号：US11138135
申请日：2005-05-26
申请人： Mark W Bitensky , Tatsuro Yoshida
发明人： Mark W Bitensky , Tatsuro Yoshida
IPC分类号： A01N1/02
CPC分类号： A01N1/0226 , A01N1/02
摘要： There are provided methods and compositions for the storage of red blood cells. The compositions are metabolic supplements that are preferably added to refrigerated red blood cells suspended in an additive solution. Red blood cells are preferably stored under conditions of oxygen-depletion. Metabolic compositions comprises pyruvate, inosine, adenine, and optionally dibasic sodium phosphate and/or monobasic sodium phosphate.
摘要翻译：提供了用于储存红细胞的方法和组合物。组合物是代谢补充剂，其优选加入到悬浮在添加剂溶液中的冷冻红细胞中。红细胞优选在氧耗尽的条件下储存。代谢组合物包括丙酮酸，肌苷，腺嘌呤和任选的磷酸氢二钠和/或磷酸二氢钠。

9. 发明授权

US07208120B2 Cellular diagnostic arrays, methods of using and processing for producing same 有权
标题翻译：蜂窝诊断阵列，使用和处理方法来生产它
公开(公告)号：US07208120B2
公开(公告)日：2007-04-24
申请号：US09965644
申请日：2001-09-27
申请人： Mark W. Bitensky , Tatsuro Yoshida , Michael G. Frank , Christopher V Gabel , Jure Derganc
发明人： Mark W. Bitensky , Tatsuro Yoshida , Michael G. Frank , Christopher V Gabel , Jure Derganc
IPC分类号： G01N15/06 , G01N33/00 , G01N33/48 , C12M1/34 , C12M3/00
CPC分类号： C12M41/46 , B01J2219/00596 , B01J2219/00657 , B01J2219/00659 , B01J2219/00702 , B01J2219/0074 , C12M23/16 , G01N15/1463 , G01N33/54366 , G01N2015/0076 , G01N2015/1486 , G01N2015/1495 , G01N2015/1497
摘要： A cellular diagnostic array has been developed that provides accurate and reproducible measurements of the physical parameters of individual cells en masse, including cell membrane surface area, cell volume, and excess membrane. Three differing patterns are employed. In the first design, a gradient array having rectangular shaped channels is used to capture cells and readily show the ratio of volume to surface area for the captured cell. The second silicone rubber array provided by the present invention employs an array of wedge shaped pipettes, each of which captures an individual cell. The position of the cell within a wedge is enough to rapidly determine the cell's actual surface area and volume. A third type of cellular diagnostic array according to the present invention employs an array of channels designed to deform a cell to study how well the cell responds to repeated deformations.
摘要翻译：已经开发了一种细胞诊断阵列，其提供了对各个细胞的物理参数的精确和可再现的测量，包括细胞膜表面积，细胞体积和过量的膜。采用三种不同的模式。在第一种设计中，使用具有矩形通道的梯度阵列来捕获细胞并且容易地显示捕获的细胞的体积与表面积的比率。由本发明提供的第二硅橡胶阵列采用楔形移液管阵列，其中每一个捕获单个细胞。电池在楔形件内的位置足以快速确定电池的实际表面积和体积。根据本发明的第三类型的细胞诊断阵列使用设计成使细胞变形以研究细胞对重复变形的响应程度的通道阵列。

10. 发明授权

US06506381B1 Modified red blood cell that has surface molecules that neutralize chemical agents 有权
标题翻译：具有中和化学试剂的表面分子的改性红细胞
公开(公告)号：US06506381B1
公开(公告)日：2003-01-14
申请号：US09609482
申请日：2000-07-05
申请人： Mark W. Bitensky , Tatsuro Yoshida
发明人： Mark W. Bitensky , Tatsuro Yoshida
IPC分类号： A01N6300
CPC分类号： A61K35/18 , A61K9/5068 , A61K47/6901
摘要： Disclosed are modified red blood cells which function as deployment platforms for important biomolecules. Such modified red blood cells can confer, for example, in vivo protection against exposure to an otherwise lethal nerve agent.
摘要翻译：公开了用作重要生物分子的部署平台的改良红细胞。这种修饰的红细胞可以赋予例如体内保护以免暴露于另外的致死神经药物。

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