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1. 发明授权

US09709188B2 Apparatus for regulation of the pressure of a gas 有权
公开(公告)号：US09709188B2
公开(公告)日：2017-07-18
申请号：US14910188
申请日：2014-08-01
申请人： Mark Sherman Williams , Gareth Ross Pemberton , Csaba Alfoldi
发明人： Mark Sherman Williams , Gareth Ross Pemberton , Csaba Alfoldi
IPC分类号： F16K31/12 , F16K31/60 , B23K9/32 , G05D16/10 , F17C1/00
CPC分类号： F16K31/602 , B23K9/325 , F17C1/00 , F17C2205/0329 , F17C2205/0338 , F17C2270/0745 , G05D16/10
摘要： A pressure regulator comprising a housing having an inlet in communication with a gas source, an outlet operable to supply a gas at a given pressure and flow rate, a conduit extending between the inlet and the outlet, a restriction device located in the conduit and positionable to control the flow of gas therethrough, a biasing arrangement to apply a predetermined bias to the restriction device and a selection device operable to select one of a predetermined plurality of discrete, offset configurations of the biasing arrangement and restriction device to provide a discrete selection of gas pressures at said outlet. The outlet comprises a fixed-size orifice selected from a specific group of fixed-sized orifices such that the combination of orifice and selectable position of said selection device provide a group of discrete flow rate/pressure combinations to applications downstream of said outlet.

2. 发明申请

US20070116215A1 System and method for reducing complexity in products and services 审中-公开
标题翻译：降低产品和服务复杂度的系统和方法
公开(公告)号：US20070116215A1
公开(公告)日：2007-05-24
申请号：US11449482
申请日：2006-06-08
申请人： Michael George , James Patell , Lars Maaseidvaag , Mark Sherman , Stephen Wilson
发明人： Michael George , James Patell , Lars Maaseidvaag , Mark Sherman , Stephen Wilson
IPC分类号： H04M15/00
CPC分类号： G06Q30/02
摘要： A method for measuring and reducing the cost of complexity in producing products or providing a service by comparing selected non-value added steps in the manufacturing or service process with the number of different products or services provided, so as to provide the non-value added cost of the product or service for various selected complexities. The number of products required to be processed or held in inventory for a particular demand, or the number of different specific services required for a particular demand of the service is determined by comparing the number of different product part numbers, or service categories offered, with selected non-value added steps in the respective processes. Mathematical analyses are derived from equations of motion of process improvement including the first derivative of process velocity.
摘要翻译：一种通过将制造或服务过程中选定的非增值步骤与所提供的不同产品或服务的数量进行比较来测量和降低生产产品或提供服务的复杂性成本的方法，以便提供非附加值针对各种复杂性的产品或服务的成本。通过将提供的不同产品部件号或提供的服务类别的数量与所提供的服务类别的数量进行比较，确定针对特定需求需要处理或保存在库存中的产品数量，或服务的特定需求所需的不同特定服务的数量在各个进程中选择的非增值步骤。数学分析得自流程改进运动方程，包括过程速度的一阶导数。

3. 发明申请

US20070030167A1 Surface communication apparatus and method for use with drill string telemetry 审中-公开
标题翻译：用于钻柱遥测的表面通讯装置及方法
公开(公告)号：US20070030167A1
公开(公告)日：2007-02-08
申请号：US11498847
申请日：2006-08-03
申请人： Qiming Li , David Santoso , Mark Sherman , Raghu Madhavan , Randall LeBlanc , John Thomas , Joseph Montero
发明人： Qiming Li , David Santoso , Mark Sherman , Raghu Madhavan , Randall LeBlanc , John Thomas , Joseph Montero
IPC分类号： G01V3/00
CPC分类号： G01V11/002 , E21B17/003 , E21B17/028 , E21B47/12 , E21B47/122
摘要： A system for bidirectional communication between the downhole equipment and a processor subsystem at the earth's surface, including: a section of wired drill pipes comprising at least the upper portion of a string of drill pipes, and forming at least a portion of a bidirectional communication link between downhole equipment and the top of the string of drill pipes; a drive string portion of the drill string, mechanically coupleable with the topmost wired drill pipe; a drive mechanism mechanically coupleable with said drive string portion, for rotating the drill string; a first wireless transceiver subsystem mounted on the drive string portion of the drill string, for rotation in conjunction with the drill string; a cable, electrically coupled between the top joint of the topmost wired drill pipe and the first transceiver subsystem; and a second wireless transceiver subsystem coupled with the uphole processor subsystem, the second wireless transceiver subsystem communicating bidirectionally with the first wireless transceiver subsystem.
摘要翻译：一种用于井下设备与地球表面处理器子系统之间的双向通信的系统，包括：至少包括钻杆串的上部的有线钻杆的一部分，并且形成双向通信链路的至少一部分井下设备与钻杆之间的顶部; 钻柱的驱动弦部分，与最上面的有线钻杆机械地联接; 驱动机构，其与所述驱动串部分机械地联接，用于旋转所述钻柱; 安装在钻柱的驱动串部分上的第一无线收发器子系统，用于与钻柱一起旋转; 电缆，电耦合在最上面的有线钻杆的顶部接头和第一收发器子系统之间; 以及与所述井上处理器子系统耦合的第二无线收发器子系统，所述第二无线收发器子系统与所述第一无线收发器子系统双向通信。

4. 发明申请

US20060269557A1 Humanized anti-prostate stem cell antigen monoclonal antibody 有权
公开(公告)号：US20060269557A1
公开(公告)日：2006-11-30
申请号：US11432304
申请日：2006-05-10
申请人： Mark Sherman , Anna Wu , Robert Reiter
发明人： Mark Sherman , Anna Wu , Robert Reiter
IPC分类号： A61K39/395 , C07H21/04 , C12P21/06 , C12N5/06 , C07K14/52 , C07K16/30 , C07K16/46
CPC分类号： C07K16/3069 , A61K2039/505 , C07K2317/24 , C07K2317/565
摘要： Prostate stem cell antigen (PSCA) is expressed in the majority of prostate cancer patients, making it an ideal target for cancer immunotherapy. Murine monoclonal antibody 1G8 binds to PSCA with nanomolar affinity, but its efficacy as a therapeutic agent is limited by the generation of a HAMA response. The present invention discloses humanized 1G8 antibodies in which the majority of the mouse-derived epitopes have been removed. These humanized antibodies bind PSCA with high affinity and specificity, and have been shown to reduce human bladder tumor take in a nude mouse model. These characteristics make the humanized antibodies of the present invention attractive agents for the treatment and detection of tumors expressing PSCA.

5. 发明授权

US06349547B1 Method and apparatus for freezing products 失效
标题翻译：冷冻产品的方法和装置
公开(公告)号：US06349547B1
公开(公告)日：2002-02-26
申请号：US09604873
申请日：2000-06-28
申请人： Jeremy Paul Miller , Mark Sherman Williams
发明人： Jeremy Paul Miller , Mark Sherman Williams
IPC分类号： F25D1306
CPC分类号： F25D3/11 , F25B27/00 , F25B40/02
摘要： A method of freezing a product, which method comprises the steps of vaporizing a cryogenic liquid and warming the vapor thus formed in indirect heat exchange with a product to be frozen, work expanding the warmed vapor, and using the work expanded vapor thus obtained to refrigerate the or another product.
摘要翻译：一种冷冻产品的方法，该方法包括将低温液体蒸发并使与此待形成的蒸气在待冷冻的产品间接热交换中加热蒸汽，使加热的蒸气膨胀并使用由此获得的工件膨胀蒸汽冷藏或另一种产品。

6. 发明授权

US5085753A Water purifier 失效
标题翻译：水净化器
公开(公告)号：US5085753A
公开(公告)日：1992-02-04
申请号：US510104
申请日：1990-04-17
申请人： Mark Sherman
发明人： Mark Sherman
IPC分类号： C02F1/46 , C02F1/461 , C02F1/467
CPC分类号： C02F1/46104 , C02F1/4602 , C02F1/4606 , C02F1/4672 , C02F2001/46119 , C02F2001/46133 , C02F2001/46152 , C02F2103/42 , C02F2201/4611 , C02F2201/46165 , C02F2303/04
摘要： A water purifier has a buoyant housing for supporting a purification cell below the water's surface and for supporting a solar cell array for providing power for the purification cell. The purification cell preferably has a solid cylindrical anode and a coiled wire cathode. The water purification cell operation includes electrolytic processes, electrocution and oxidation to destroy bacteria and algae in the water.
摘要翻译：净水器具有浮力的壳体，用于在水表面下面支撑净化池，并支撑太阳能电池阵列以为净化池提供动力。净化池优选具有固体圆柱形阳极和线状阴极。水净化池操作包括电解过程，触电和氧化以破坏水中的细菌和藻类。

7. 发明授权

US5059296A Portable self-contained solar powered water purifier 失效
标题翻译：便携式自备太阳能净水器
公开(公告)号：US5059296A
公开(公告)日：1991-10-22
申请号：US585511
申请日：1990-09-20
申请人： Mark Sherman
发明人： Mark Sherman
IPC分类号： C02F1/46 , C02F1/461 , C02F1/467
CPC分类号： C02F1/4606 , C02F1/4602 , C02F1/46104 , C02F1/4672 , C02F2001/46119 , C02F2001/46133 , C02F2001/46152 , C02F2103/42 , C02F2201/4611 , C02F2201/46165 , C02F2303/04 , Y10S204/05
摘要： A portable self-contained solar powered water purifier for swimming pools, spas, and other bodies of water is disclosed. The purifier includes a buoyant housing for supporting a solar cell array above the surface of water to be treated and a purification cell below the surface of water to be treated. Suitable electrical connections, between the solar cell array and purification cell, are sealed to prevent the entry of water therebetween which could result in electrical shorts and corrosion. The purification cell includes a sacrificial anode, having a metal alloy essentially composed of copper and silver and a cathode which is preferably constructed of stainless steel so as to not react adversely with the sacrificial anode. Metallic copper and silver ions are released by the sacrificial anode to prevent algae and bacterial growth. The anode and cathode are structurally interrelated and secured to each other and to the buoyant housing and the solar cell array to provide a practical, durable and long lasting unit.
摘要翻译：公开了一种用于游泳池，水疗中心和其他水体的便携式自给式太阳能净水器。净化器包括用于将待处理的水表面上的太阳能电池阵列支撑的浮力壳体和待处理水表面下方的净化池。在太阳能电池阵列和净化电池之间的适当的电连接被密封以防止其间的水进入，这可能导致电短路和腐蚀。净化单元包括具有基本上由铜和银构成的金属合金的牺牲阳极和阴极，优选由不锈钢构成，以便不与牺牲阳极反应。金属铜和银离子由牺牲阳极释放，以防止藻类和细菌生长。阳极和阴极在结构上相互关联并固定到浮力壳体和太阳能电池阵列，以提供实用的，持久的和持久的单元。

8. 发明申请

US20150060287A1 Fluid Conditioning & Ionizing System 审中-公开
标题翻译：流体调节和电离系统
公开(公告)号：US20150060287A1
公开(公告)日：2015-03-05
申请号：US14017309
申请日：2013-09-04
申请人： Mark Sherman
发明人： Mark Sherman
IPC分类号： C02F1/46
CPC分类号： C02F1/4606 , C02F1/46104 , C02F2201/004 , C02F2201/46165 , C02F2303/14 , Y02W10/37
摘要： An apparatus includes an electrode body, and an electrically conductive fastener which includes titanium, wherein the electrically conductive fastener is threadingly engaged with the electrode body to form a titanium-metal interlace to conduct current. The apparatus includes an electrically conductive coil through which the electrode body and electrically conductive fastener extend, and a strainer basket fastened to the electrode body with an electrically insulative fastener.
摘要翻译：一种设备包括电极体和包括钛的导电紧固件，其中导电紧固件与电极体螺纹接合以形成钛金属交错以传导电流。该装置包括导电线圈，电极主体和导电紧固件延伸穿过该导电线圈，以及用电绝缘紧固件固定到电极体上的过滤器篮。

9. 发明申请

US20100224409A1 SYSTEM AND METHOD OF USING A SAVER SUB IN A DRILLING SYSTEM 有权
标题翻译：在钻井系统中使用救生艇的系统和方法
公开(公告)号：US20100224409A1
公开(公告)日：2010-09-09
申请号：US12397983
申请日：2009-03-04
申请人： Shardul Sarhad , Michael Ross , Michael Sakach , Michael Mitchell , Ming Lai , Mark Sherman
发明人： Shardul Sarhad , Michael Ross , Michael Sakach , Michael Mitchell , Ming Lai , Mark Sherman
IPC分类号： E21B47/01 , E21B47/00 , B23P11/00 , G01V3/00
CPC分类号： E21B17/003 , E21B19/16 , E21B21/106 , E21B47/12 , Y10T29/49826
摘要： A technique facilitates the drilling of a wellbore by enhancing the ability to relay data. The system comprises a saver sub designed to connect a top drive unit with a wired drill pipe without requiring modification of the top drive unit. The saver sub comprises an electronics package, a battery, and an antenna coupled to a saver sub mandrel.
摘要翻译：一种技术有助于通过提高中继数据的能力来钻井井。该系统包括一个设计用于将顶部驱动单元与有线钻杆相连接的保护子，而不需要修改顶部驱动单元。保护子包括电子封装，电池和耦合到保护子心轴的天线。

10. 发明授权

US6001100A Bone block fixation implant 失效
标题翻译：骨块固定植入物
公开(公告)号：US6001100A
公开(公告)日：1999-12-14
申请号：US914137
申请日：1997-08-19
申请人： Mark Sherman , Auvo Kaikkonen , Timo Pohjonen , Pertti Tormala
发明人： Mark Sherman , Auvo Kaikkonen , Timo Pohjonen , Pertti Tormala
IPC分类号： A61F2/28 , A61F2/02 , A61F2/08 , A61F2/30 , A61B17/56
CPC分类号： A61F2/0811 , A61F2002/0858 , A61F2002/087 , A61F2002/0888 , A61F2002/2835 , A61F2002/30062 , A61F2002/30841 , A61F2210/0004
摘要： In the present invention, a bioabsorbable implant is described, which implant is manufactured of bioabsorbable polymer, copolymer, polymer alloy or fiber reinforced and/or particle filled composite, which implant is pushed into a hole or drill canal made in a bone, for fixing a bone graft into the drillhole, wherein the implant comprises: (1) at least one elongated body, (2) at least one gripping element to lock the implant into the drillhole, and (3) a platform surface for location of a bone block between the implant and the wall of the drillhole. The implant also may be equipped with (4) an additional arresting means, which effectively prevents the slipping of the bone block out of the drillhole.
摘要翻译：在本发明中，描述了一种生物可吸收的植入物，该植入物由生物可吸收的聚合物，共聚物，聚合物合金或纤维增强和/或颗粒填充的复合材料制成，该植入物被推入孔中或在骨中制成的钻杆，用于固定骨移植物进入所述钻孔，其中所述植入物包括：（1）至少一个细长体，（2）至少一个夹持元件以将所述植入物锁定到所述钻孔中，以及（3）用于定位骨块的平台表面在植入物和钻孔的壁之间。植入物还可以配备有（4）另外的止动装置，其有效地防止骨块从钻孔中滑出。

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