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1. 发明申请

US20120053211A1 TREATMENT OF PANCREATIC CANCER 审中-公开
标题翻译：治疗胰腺癌
公开(公告)号：US20120053211A1
公开(公告)日：2012-03-01
申请号：US13255331
申请日：2010-03-11
申请人： Mark S. Chapman
发明人： Mark S. Chapman
IPC分类号： A61K31/4412 , A61P35/04 , A61P35/00 , A61K31/18 , C12N5/09
CPC分类号： A61K31/18 , A61K31/4412
摘要： The present invention relates to the field of oncology and relates to use of (S)-N-(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-6-methoxyphenyl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide or a pharmaceutically acceptable salt thereof or N-(4-(2-fluoro-4-iodophenylamino)-1,5-dimethyl-6-oxo-1,6-dihydropyridin-3-yl)cyclopropanesulfonamide or a polymorph thereof, or a pharmaceutically acceptable salt thereof, or pharmaceutical compositions comprising the same, for the preparation of a medicament for the treatment of pancreatic cancer. Further, the present invention provides methods for administering a compound disclosed herein to an individual in need thereof by administering (S)-N-(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-6-methoxyphenyl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide or a pharmaceutically acceptable salt thereof or N-(4-(2-fluoro-4-iodophenylamino)-1,5-dimethyl-6-oxo-1,6-dihydropyridin-3-yl)cyclopropanesulfonamide, or a polymoph thereof, or a pharmaceutically acceptable salt thereof, or pharmaceutical compositions comprising the same.
摘要翻译：本发明涉及肿瘤学领域，涉及（S）-N-（3,4-二氟-2-（2-氟-4-碘苯基氨基）-6-甲氧基苯基）-1-（2,3 - 二羟基丙基）环丙烷-1-磺酰胺或其药学上可接受的盐或N-（4-（2-氟-4-碘苯基氨基）-1,5-二甲基-6-氧代-1,6-二氢吡啶-3-基）环丙磺酰胺或其多晶型物，或其药学上可接受的盐，或其药物组合物，用于制备用于治疗胰腺癌的药物。此外，本发明提供了通过给予（S）-N-（3,4-二氟-2-（2-氟-4-碘苯基氨基）-6-甲氧基苯基）（S）-N- -1-（2,3-二羟基丙基）环丙烷-1-磺酰胺或其药学上可接受的盐或N-（4-（2-氟-4-碘苯基氨基）-1,5-二甲基-6-氧代-1,6 - 二氢吡啶-3-基）环丙烷磺酰胺或其多晶型物或其药学上可接受的盐，或包含其的药物组合物。

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